Table of Contents

Articles

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  Justicidin A Inhibits the Transport of Tumor Necrosis Factor-α to Cell Surface in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages

  Lo-Ti Tsao, Chun-Nan Lin and Jih-Pyang Wang

  Molecular Pharmacology May 2004, 65 (5) 1063-1069; DOI: https://doi.org/10.1124/mol.65.5.1063
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  Tumor Cell Responses to a Novel Glutathione S-Transferase–Activated Nitric Oxide-Releasing Prodrug

  Victoria J. Findlay, Danyelle M. Townsend, Joseph E. Saavedra, Gregory S. Buzard, Michael L. Citro, Larry K. Keefer, Xinhua Ji and Kenneth D. Tew

  Molecular Pharmacology May 2004, 65 (5) 1070-1079; DOI: https://doi.org/10.1124/mol.65.5.1070
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  Elevated Rac1 Activity Changes the M₃ Muscarinic Acetylcholine Receptor-Mediated Inhibition of Proliferation to Induction of Cell Death

  Shulamith H. Shafer and Carol L. Williams

  Molecular Pharmacology May 2004, 65 (5) 1080-1091; DOI: https://doi.org/10.1124/mol.65.5.1080
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  Nuclear Factor-κB Mediates Up-Regulation of Cathepsin B by Doxorubicin in Tumor Cells

  Sandra Bien, Christoph A. Ritter, Matthias Gratz, Bernhard Sperker, Jürgen Sonnemann, James F. Beck and Heyo K. Kroemer

  Molecular Pharmacology May 2004, 65 (5) 1092-1102; DOI: https://doi.org/10.1124/mol.65.5.1092
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  Regulation of mGlu4 Metabotropic Glutamate Receptor Signaling by Type-2 G-Protein Coupled Receptor Kinase (GRK2)

  L. Iacovelli, L. Capobianco, M. Iula, V. Di Giorgi Gerevini, A. Picascia, J. Blahos, D. Melchiorri, F. Nicoletti and A. De Blasi

  Molecular Pharmacology May 2004, 65 (5) 1103-1110; DOI: https://doi.org/10.1124/mol.65.5.1103
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  Inhibition of cGMP-Dependent Protein Kinase by the Cell-Permeable Peptide DT-2 Reveals a Novel Mechanism of Vasoregulation

  Mark S. Taylor, Chris Okwuchukwuasanya, Christian K. Nickl, Werner Tegge, Joseph E. Brayden and Wolfgang R. G. Dostmann

  Molecular Pharmacology May 2004, 65 (5) 1111-1119; DOI: https://doi.org/10.1124/mol.65.5.1111
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  Molecular Determinants for High-Affinity Block of Human EAG Potassium Channels by Antiarrhythmic Agents

  Guido Gessner, Martin Zacharias, Susanne Bechstedt, Roland Schönherr and Stefan H. Heinemann

  Molecular Pharmacology May 2004, 65 (5) 1120-1129; DOI: https://doi.org/10.1124/mol.65.5.1120
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  Nitric Oxide Inhibits Matrix Metalloproteinase-2 Expression via the Induction of Activating Transcription Factor 3 in Endothelial Cells

  Hsuan-Hsu Chen and Danny Ling Wang

  Molecular Pharmacology May 2004, 65 (5) 1130-1140; DOI: https://doi.org/10.1124/mol.65.5.1130
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  The Role of Glycine Residues in the Function of Human Organic Anion Transporter 4

  Fanfan Zhou, Kunihiko Tanaka, Zui Pan, Jianjie Ma and Guofeng You

  Molecular Pharmacology May 2004, 65 (5) 1141-1147; DOI: https://doi.org/10.1124/mol.65.5.1141
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  Cloning, Expression, and Characterization of Three New Mouse Cytochrome P450 Enzymes and Partial Characterization of Their Fatty Acid Oxidation Activities

  Hong Wang, Yun Zhao, J. Alyce Bradbury, Joan P. Graves, Julie Foley, Joyce A. Blaisdell, Joyce A. Goldstein and Darryl C. Zeldin

  Molecular Pharmacology May 2004, 65 (5) 1148-1158; DOI: https://doi.org/10.1124/mol.65.5.1148
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  Activators of the Rat Pregnane X Receptor Differentially Modulate Hepatic and Intestinal Gene Expression

  Dylan P. Hartley, Xudong Dai, Yudong D. He, Edward J. Carlini, Bonnie Wang, Su-er W. Huskey, Roger G. Ulrich, Thomas H. Rushmore, Raymond Evers and David C. Evans

  Molecular Pharmacology May 2004, 65 (5) 1159-1171; DOI: https://doi.org/10.1124/mol.65.5.1159
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  Isoflurane Preconditioning Induces Neuroprotection against Ischemia via Activation of P38 Mitogen-Activated Protein Kinases

  Shuqiu Zheng and Zhiyi Zuo

  Molecular Pharmacology May 2004, 65 (5) 1172-1180; DOI: https://doi.org/10.1124/mol.65.5.1172
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  Synergistic Contributions of the Functional Groups of Epinephrine to Its Affinity and Efficacy at the β₂ Adrenergic Receptor

  George Liapakis, Wai Chi Chan, Maria Papadokostaki and Jonathan A. Javitch

  Molecular Pharmacology May 2004, 65 (5) 1181-1190; DOI: https://doi.org/10.1124/mol.65.5.1181
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  Selective Antagonism of 5α-Reduced Neurosteroid Effects at GABA_A Receptors

  Steven Mennerick, Yejun He, Xin Jiang, Brad D. Manion, Mingde Wang, Amanda Shute, Ann Benz, Alex S. Evers, Douglas F. Covey and Charles F. Zorumski

  Molecular Pharmacology May 2004, 65 (5) 1191-1197; DOI: https://doi.org/10.1124/mol.65.5.1191
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  The Nucleotide-Binding Domains of Sulfonylurea Receptor 2A and 2B Play Different Functional Roles in Nicorandil-Induced Activation of ATP-Sensitive K⁺ Channels

  Mitsuhiko Yamada and Yoshihisa Kurachi

  Molecular Pharmacology May 2004, 65 (5) 1198-1207; DOI: https://doi.org/10.1124/mol.65.5.1198
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  Flavonoids Are Inhibitors of Breast Cancer Resistance Protein (ABCG2)-Mediated Transport

  Shuzhong Zhang, Xinning Yang and Marilyn E. Morris

  Molecular Pharmacology May 2004, 65 (5) 1208-1216; DOI: https://doi.org/10.1124/mol.65.5.1208
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  Down-Regulation and Altered Localization of γ-Catenin in Cisplatin-Resistant Adenocarcinoma Cells

  Xing-Jie Liang, Ding-Wu Shen and Michael M. Gottesman

  Molecular Pharmacology May 2004, 65 (5) 1217-1224; DOI: https://doi.org/10.1124/mol.65.5.1217
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  Oral Exposure to Benzo[a]pyrene in the Mouse: Detoxication by Inducible Cytochrome P450 Is More Important Than Metabolic Activation

  Shigeyuki Uno, Timothy P. Dalton, Sandrine Derkenne, Christine P. Curran, Marian L. Miller, Howard G. Shertzer and Daniel W. Nebert

  Molecular Pharmacology May 2004, 65 (5) 1225-1237; DOI: https://doi.org/10.1124/mol.65.5.1225
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  NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger

  David Siegel, Daniel L. Gustafson, Donna L. Dehn, Jin Yi Han, Preecha Boonchoong, Lawrence J. Berliner and David Ross

  Molecular Pharmacology May 2004, 65 (5) 1238-1247; DOI: https://doi.org/10.1124/mol.65.5.1238
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  Different Structural States of the Proteolipid Membrane Are Produced by Ligand Binding to the Human δ-Opioid Receptor as Shown by Plasmon-Waveguide Resonance Spectroscopy

  Isabel D. Alves, Scott M. Cowell, Zdzislaw Salamon, Savitha Devanathan, Gordon Tollin and Victor J. Hruby

  Molecular Pharmacology May 2004, 65 (5) 1248-1257; DOI: https://doi.org/10.1124/mol.65.5.1248
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  Functional Regulation of the Cardiac Ryanodine Receptor by Suramin and Calmodulin Involves Multiple Binding Sites

  Adam Parker Hill, Olivia Kingston and Rebecca Sitsapesan

  Molecular Pharmacology May 2004, 65 (5) 1258-1268; DOI: https://doi.org/10.1124/mol.65.5.1258
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  Ca_v1.3 Is Preferentially Coupled to Glucose-Induced [Ca²⁺]_i Oscillations in the Pancreatic β Cell Line INS-1

  Guohong Liu, Nathan Hilliard and Gregory H. Hockerman

  Molecular Pharmacology May 2004, 65 (5) 1269-1277; DOI: https://doi.org/10.1124/mol.65.5.1269
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  Activation of the Anticancer Prodrugs Cyclophosphamide and Ifosfamide: Identification of Cytochrome P450 2B Enzymes and Site-Specific Mutants with Improved Enzyme Kinetics

  Chong-Sheng Chen, Jack T. Lin, Kendrick A. Goss, You-ai He, James R. Halpert and David J. Waxman

  Molecular Pharmacology May 2004, 65 (5) 1278-1285; DOI: https://doi.org/10.1124/mol.65.5.1278
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  Acetylation of Nuclear Factor-κB in Rat Amygdala Improves Long-Term but not Short-Term Retention of Fear Memory

  Shiu-Hwa Yeh, Chia-Ho Lin and Po-Wu Gean

  Molecular Pharmacology May 2004, 65 (5) 1286-1292; DOI: https://doi.org/10.1124/mol.65.5.1286
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  Regulations of Methamphetamine Reward by Extracellular Signal-Regulated Kinase 1/2/ets-Like Gene-1 Signaling Pathway via the Activation of Dopamine Receptors

  Hiroyuki Mizoguchi, Kiyofumi Yamada, Makoto Mizuno, Tomoko Mizuno, Atsumi Nitta, Yukihiro Noda and Toshitaka Nabeshima

  Molecular Pharmacology May 2004, 65 (5) 1293-1301; DOI: https://doi.org/10.1124/mol.65.5.1293
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  Induction of CYP3A by 2,3-Oxidosqualene:Lanosterol Cyclase Inhibitors Is Mediated by an Endogenous Squalene Metabolite in Primary Cultured Rat Hepatocytes

  Sarita D. Shenoy, Thomas A. Spencer, Nancy A. Mercer-Haines, Masumeh Abdolalipour, William L. Wurster, Melissa Runge-Morris and Thomas A. Kocarek

  Molecular Pharmacology May 2004, 65 (5) 1302-1312; DOI: https://doi.org/10.1124/mol.65.5.1302
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  Epinephrine Activates Both G_s and G_i Pathways, but Norepinephrine Activates Only the G_s Pathway through Human β₂-Adrenoceptors Overexpressed in Mouse Heart

  Jürgen F. Heubach, Ursula Ravens and Alberto J. Kaumann

  Molecular Pharmacology May 2004, 65 (5) 1313-1322; DOI: https://doi.org/10.1124/mol.65.5.1313