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Molecular Pharmacology

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Table of Contents

May 01, 2004; Volume 65,Issue 5

Minireview

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    Regulation of Uterine Function: a Biochemical Conundrum in the Regulation of Smooth Muscle Relaxation
    Iain L. O. Buxton
    Molecular Pharmacology May 2004, 65 (5) 1051-1059; DOI: https://doi.org/10.1124/mol.65.5.1051

Perspective

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    Agonist Binding: A Multistep Process
    Brian Kobilka
    Molecular Pharmacology May 2004, 65 (5) 1060-1062; DOI: https://doi.org/10.1124/mol.65.5.1060

Articles

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    Justicidin A Inhibits the Transport of Tumor Necrosis Factor-α to Cell Surface in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages
    Lo-Ti Tsao, Chun-Nan Lin and Jih-Pyang Wang
    Molecular Pharmacology May 2004, 65 (5) 1063-1069; DOI: https://doi.org/10.1124/mol.65.5.1063
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    Tumor Cell Responses to a Novel Glutathione S-Transferase–Activated Nitric Oxide-Releasing Prodrug
    Victoria J. Findlay, Danyelle M. Townsend, Joseph E. Saavedra, Gregory S. Buzard, Michael L. Citro, Larry K. Keefer, Xinhua Ji and Kenneth D. Tew
    Molecular Pharmacology May 2004, 65 (5) 1070-1079; DOI: https://doi.org/10.1124/mol.65.5.1070
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    Elevated Rac1 Activity Changes the M3 Muscarinic Acetylcholine Receptor-Mediated Inhibition of Proliferation to Induction of Cell Death
    Shulamith H. Shafer and Carol L. Williams
    Molecular Pharmacology May 2004, 65 (5) 1080-1091; DOI: https://doi.org/10.1124/mol.65.5.1080
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    Nuclear Factor-κB Mediates Up-Regulation of Cathepsin B by Doxorubicin in Tumor Cells
    Sandra Bien, Christoph A. Ritter, Matthias Gratz, Bernhard Sperker, Jürgen Sonnemann, James F. Beck and Heyo K. Kroemer
    Molecular Pharmacology May 2004, 65 (5) 1092-1102; DOI: https://doi.org/10.1124/mol.65.5.1092
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    Regulation of mGlu4 Metabotropic Glutamate Receptor Signaling by Type-2 G-Protein Coupled Receptor Kinase (GRK2)
    L. Iacovelli, L. Capobianco, M. Iula, V. Di Giorgi Gerevini, A. Picascia, J. Blahos, D. Melchiorri, F. Nicoletti and A. De Blasi
    Molecular Pharmacology May 2004, 65 (5) 1103-1110; DOI: https://doi.org/10.1124/mol.65.5.1103
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    Inhibition of cGMP-Dependent Protein Kinase by the Cell-Permeable Peptide DT-2 Reveals a Novel Mechanism of Vasoregulation
    Mark S. Taylor, Chris Okwuchukwuasanya, Christian K. Nickl, Werner Tegge, Joseph E. Brayden and Wolfgang R. G. Dostmann
    Molecular Pharmacology May 2004, 65 (5) 1111-1119; DOI: https://doi.org/10.1124/mol.65.5.1111
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    Molecular Determinants for High-Affinity Block of Human EAG Potassium Channels by Antiarrhythmic Agents
    Guido Gessner, Martin Zacharias, Susanne Bechstedt, Roland Schönherr and Stefan H. Heinemann
    Molecular Pharmacology May 2004, 65 (5) 1120-1129; DOI: https://doi.org/10.1124/mol.65.5.1120
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    Nitric Oxide Inhibits Matrix Metalloproteinase-2 Expression via the Induction of Activating Transcription Factor 3 in Endothelial Cells
    Hsuan-Hsu Chen and Danny Ling Wang
    Molecular Pharmacology May 2004, 65 (5) 1130-1140; DOI: https://doi.org/10.1124/mol.65.5.1130
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    The Role of Glycine Residues in the Function of Human Organic Anion Transporter 4
    Fanfan Zhou, Kunihiko Tanaka, Zui Pan, Jianjie Ma and Guofeng You
    Molecular Pharmacology May 2004, 65 (5) 1141-1147; DOI: https://doi.org/10.1124/mol.65.5.1141
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    Cloning, Expression, and Characterization of Three New Mouse Cytochrome P450 Enzymes and Partial Characterization of Their Fatty Acid Oxidation Activities
    Hong Wang, Yun Zhao, J. Alyce Bradbury, Joan P. Graves, Julie Foley, Joyce A. Blaisdell, Joyce A. Goldstein and Darryl C. Zeldin
    Molecular Pharmacology May 2004, 65 (5) 1148-1158; DOI: https://doi.org/10.1124/mol.65.5.1148
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    Activators of the Rat Pregnane X Receptor Differentially Modulate Hepatic and Intestinal Gene Expression
    Dylan P. Hartley, Xudong Dai, Yudong D. He, Edward J. Carlini, Bonnie Wang, Su-er W. Huskey, Roger G. Ulrich, Thomas H. Rushmore, Raymond Evers and David C. Evans
    Molecular Pharmacology May 2004, 65 (5) 1159-1171; DOI: https://doi.org/10.1124/mol.65.5.1159
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    Isoflurane Preconditioning Induces Neuroprotection against Ischemia via Activation of P38 Mitogen-Activated Protein Kinases
    Shuqiu Zheng and Zhiyi Zuo
    Molecular Pharmacology May 2004, 65 (5) 1172-1180; DOI: https://doi.org/10.1124/mol.65.5.1172
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    Synergistic Contributions of the Functional Groups of Epinephrine to Its Affinity and Efficacy at the β2 Adrenergic Receptor
    George Liapakis, Wai Chi Chan, Maria Papadokostaki and Jonathan A. Javitch
    Molecular Pharmacology May 2004, 65 (5) 1181-1190; DOI: https://doi.org/10.1124/mol.65.5.1181
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    Selective Antagonism of 5α-Reduced Neurosteroid Effects at GABAA Receptors
    Steven Mennerick, Yejun He, Xin Jiang, Brad D. Manion, Mingde Wang, Amanda Shute, Ann Benz, Alex S. Evers, Douglas F. Covey and Charles F. Zorumski
    Molecular Pharmacology May 2004, 65 (5) 1191-1197; DOI: https://doi.org/10.1124/mol.65.5.1191
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    The Nucleotide-Binding Domains of Sulfonylurea Receptor 2A and 2B Play Different Functional Roles in Nicorandil-Induced Activation of ATP-Sensitive K+ Channels
    Mitsuhiko Yamada and Yoshihisa Kurachi
    Molecular Pharmacology May 2004, 65 (5) 1198-1207; DOI: https://doi.org/10.1124/mol.65.5.1198
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    Flavonoids Are Inhibitors of Breast Cancer Resistance Protein (ABCG2)-Mediated Transport
    Shuzhong Zhang, Xinning Yang and Marilyn E. Morris
    Molecular Pharmacology May 2004, 65 (5) 1208-1216; DOI: https://doi.org/10.1124/mol.65.5.1208
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    Down-Regulation and Altered Localization of γ-Catenin in Cisplatin-Resistant Adenocarcinoma Cells
    Xing-Jie Liang, Ding-Wu Shen and Michael M. Gottesman
    Molecular Pharmacology May 2004, 65 (5) 1217-1224; DOI: https://doi.org/10.1124/mol.65.5.1217
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    Oral Exposure to Benzo[a]pyrene in the Mouse: Detoxication by Inducible Cytochrome P450 Is More Important Than Metabolic Activation
    Shigeyuki Uno, Timothy P. Dalton, Sandrine Derkenne, Christine P. Curran, Marian L. Miller, Howard G. Shertzer and Daniel W. Nebert
    Molecular Pharmacology May 2004, 65 (5) 1225-1237; DOI: https://doi.org/10.1124/mol.65.5.1225
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    NAD(P)H:Quinone Oxidoreductase 1: Role as a Superoxide Scavenger
    David Siegel, Daniel L. Gustafson, Donna L. Dehn, Jin Yi Han, Preecha Boonchoong, Lawrence J. Berliner and David Ross
    Molecular Pharmacology May 2004, 65 (5) 1238-1247; DOI: https://doi.org/10.1124/mol.65.5.1238
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    Different Structural States of the Proteolipid Membrane Are Produced by Ligand Binding to the Human δ-Opioid Receptor as Shown by Plasmon-Waveguide Resonance Spectroscopy
    Isabel D. Alves, Scott M. Cowell, Zdzislaw Salamon, Savitha Devanathan, Gordon Tollin and Victor J. Hruby
    Molecular Pharmacology May 2004, 65 (5) 1248-1257; DOI: https://doi.org/10.1124/mol.65.5.1248
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    Functional Regulation of the Cardiac Ryanodine Receptor by Suramin and Calmodulin Involves Multiple Binding Sites
    Adam Parker Hill, Olivia Kingston and Rebecca Sitsapesan
    Molecular Pharmacology May 2004, 65 (5) 1258-1268; DOI: https://doi.org/10.1124/mol.65.5.1258
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    Cav1.3 Is Preferentially Coupled to Glucose-Induced [Ca2+]i Oscillations in the Pancreatic β Cell Line INS-1
    Guohong Liu, Nathan Hilliard and Gregory H. Hockerman
    Molecular Pharmacology May 2004, 65 (5) 1269-1277; DOI: https://doi.org/10.1124/mol.65.5.1269
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    Activation of the Anticancer Prodrugs Cyclophosphamide and Ifosfamide: Identification of Cytochrome P450 2B Enzymes and Site-Specific Mutants with Improved Enzyme Kinetics
    Chong-Sheng Chen, Jack T. Lin, Kendrick A. Goss, You-ai He, James R. Halpert and David J. Waxman
    Molecular Pharmacology May 2004, 65 (5) 1278-1285; DOI: https://doi.org/10.1124/mol.65.5.1278
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    Acetylation of Nuclear Factor-κB in Rat Amygdala Improves Long-Term but not Short-Term Retention of Fear Memory
    Shiu-Hwa Yeh, Chia-Ho Lin and Po-Wu Gean
    Molecular Pharmacology May 2004, 65 (5) 1286-1292; DOI: https://doi.org/10.1124/mol.65.5.1286
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    Regulations of Methamphetamine Reward by Extracellular Signal-Regulated Kinase 1/2/ets-Like Gene-1 Signaling Pathway via the Activation of Dopamine Receptors
    Hiroyuki Mizoguchi, Kiyofumi Yamada, Makoto Mizuno, Tomoko Mizuno, Atsumi Nitta, Yukihiro Noda and Toshitaka Nabeshima
    Molecular Pharmacology May 2004, 65 (5) 1293-1301; DOI: https://doi.org/10.1124/mol.65.5.1293
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    Induction of CYP3A by 2,3-Oxidosqualene:Lanosterol Cyclase Inhibitors Is Mediated by an Endogenous Squalene Metabolite in Primary Cultured Rat Hepatocytes
    Sarita D. Shenoy, Thomas A. Spencer, Nancy A. Mercer-Haines, Masumeh Abdolalipour, William L. Wurster, Melissa Runge-Morris and Thomas A. Kocarek
    Molecular Pharmacology May 2004, 65 (5) 1302-1312; DOI: https://doi.org/10.1124/mol.65.5.1302
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    Epinephrine Activates Both Gs and Gi Pathways, but Norepinephrine Activates Only the Gs Pathway through Human β2-Adrenoceptors Overexpressed in Mouse Heart
    Jürgen F. Heubach, Ursula Ravens and Alberto J. Kaumann
    Molecular Pharmacology May 2004, 65 (5) 1313-1322; DOI: https://doi.org/10.1124/mol.65.5.1313
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Molecular Pharmacology: 65 (5)
Molecular Pharmacology
Vol. 65, Issue 5
1 May 2004
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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