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Molecular Pharmacology

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Table of Contents

June 01, 2004; Volume 65,Issue 6

Minireview

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    Probing Receptor Structure/Function with Chimeric G-Protein-Coupled Receptors
    Dezhong Yin, Shai Gavi, Hsien-yu Wang and Craig C. Malbon
    Molecular Pharmacology June 2004, 65 (6) 1323-1332; DOI: https://doi.org/10.1124/mol.65.6.1323

Perspective

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    Getting Past the Asterisk: the Subunit Composition of Presynaptic Nicotinic Receptors That Modulate Striatal Dopamine Release
    Charles W. Luetje
    Molecular Pharmacology June 2004, 65 (6) 1333-1335; DOI: https://doi.org/10.1124/mol.65.6.1333

Articles

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    Discovery of Novel Selective Inhibitors of Human Intestinal Carboxylesterase for the Amelioration of Irinotecan-Induced Diarrhea: Synthesis, Quantitative Structure-Activity Relationship Analysis, and Biological Activity
    Randy M. Wadkins, Janice L Hyatt, Kyoung Jin P. Yoon, Christopher L. Morton, Richard E. Lee, Komath Damodaran, Paul Beroza, Mary K. Danks and Philip M. Potter
    Molecular Pharmacology June 2004, 65 (6) 1336-1343; DOI: https://doi.org/10.1124/mol.65.6.1336
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    Herbimycin A Abrogates Nuclear Factor-κB Activation by Interacting Preferentially with the IκB Kinase β Subunit
    Shinichi Ogino, Kazuhiro Tsuruma, Takashi Uehara and Yasuyuki Nomura
    Molecular Pharmacology June 2004, 65 (6) 1344-1351; DOI: https://doi.org/10.1124/mol.65.6.1344
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    Insulin Activates Native and Recombinant Large Conductance Ca2+-Activated Potassium Channels via a Mitogen-Activated Protein Kinase-Dependent Process
    Dervla O'Malley and Jenni Harvey
    Molecular Pharmacology June 2004, 65 (6) 1352-1363; DOI: https://doi.org/10.1124/mol.65.6.1352
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    Kv1.3-Blocking 5-Phenylalkoxypsoralens: A New Class of Immunomodulators
    Julia Vennekamp, Heike Wulff, Christine Beeton, Peter A. Calabresi, Stephan Grissmer, Wolfram Hänsel and K. George Chandy
    Molecular Pharmacology June 2004, 65 (6) 1364-1374; DOI: https://doi.org/10.1124/mol.65.6.1364
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    Mutations of Charged Amino Acids in or near the Transmembrane Helices of the Second Membrane Spanning Domain Differentially Affect the Substrate Specificity and Transport Activity of the Multidrug Resistance Protein MRP1 (ABCC1)
    Anass Haimeur, Gwenaëlle Conseil, Roger G. Deeley and Susan P.C. Cole
    Molecular Pharmacology June 2004, 65 (6) 1375-1385; DOI: https://doi.org/10.1124/mol.65.6.1375
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    Adenosine Triphosphate Acts as Both a Competitive Antagonist and a Positive Allosteric Modulator at Recombinant N-Methyl-D-aspartate Receptors
    Anna Kloda, John D. Clements, Richard J. Lewis and David J. Adams
    Molecular Pharmacology June 2004, 65 (6) 1386-1396; DOI: https://doi.org/10.1124/mol.65.6.1386
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    The Constitutive Active/Androstane Receptor Regulates Phenytoin Induction of Cyp2c29
    Jonathan P. Jackson, Stephen S. Ferguson, Rick Moore, Masahiko Negishi and Joyce A. Goldstein
    Molecular Pharmacology June 2004, 65 (6) 1397-1404; DOI: https://doi.org/10.1124/mol.65.6.1397
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    Interaction of Heterogeneous Nuclear Ribonucleoprotein A1 with Cytochrome P450 2A6 mRNA: Implications for Post-Transcriptional Regulation of the CYP2A6 Gene
    Kyle Christian, Matti Lang, Patrick Maurel and Françoise Raffalli-Mathieu
    Molecular Pharmacology June 2004, 65 (6) 1405-1414; DOI: https://doi.org/10.1124/mol.65.6.1405
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    Capsaicin Potentiates Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Currents
    Tomohiko Ai, Silvia G. Bompadre, Xiaohui Wang, Shenghui Hu, Min Li and Tzyh-Chang Hwang
    Molecular Pharmacology June 2004, 65 (6) 1415-1426; DOI: https://doi.org/10.1124/mol.65.6.1415
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    Signal Transducer and Activator of Transcription 3 Activation by the δ-Opioid Receptor via Gα14 Involves Multiple Intermediates
    Rico K. H. Lo and Yung H. Wong
    Molecular Pharmacology June 2004, 65 (6) 1427-1439; DOI: https://doi.org/10.1124/mol.65.6.1427
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    Down-Regulation of Soluble Guanylyl Cyclase Expression by Cyclic AMP Is Mediated by mRNA-Stabilizing Protein HuR
    Stephan Klöss, Rashi Srivastava and Alexander Mülsch
    Molecular Pharmacology June 2004, 65 (6) 1440-1451; DOI: https://doi.org/10.1124/mol.65.6.1440
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    Transmembrane Domains I and II of the γ-Aminobutyric Acid Transporter GAT-4 Contain Molecular Determinants of Substrate Specificity
    Nir Melamed and Baruch I. Kanner
    Molecular Pharmacology June 2004, 65 (6) 1452-1461; DOI: https://doi.org/10.1124/mol.65.6.1452
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    Adenosine Receptor, Protein Kinase G, and p38 Mitogen-Activated Protein Kinase-Dependent Up-Regulation of Serotonin Transporters Involves Both Transporter Trafficking and Activation
    Chong-Bin Zhu, William A. Hewlett, Igor Feoktistov, Italo Biaggioni and Randy D. Blakely
    Molecular Pharmacology June 2004, 65 (6) 1462-1474; DOI: https://doi.org/10.1124/mol.65.6.1462
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    Ceramide Negatively Regulates Glutathione S-transferase Gene Transactivation via Repression of Hepatic Nuclear Factor-1 That Is Degraded by the Ubiquitin Proteasome System
    I-Na Park, Il Je Cho and Sang Geon Kim
    Molecular Pharmacology June 2004, 65 (6) 1475-1484; DOI: https://doi.org/10.1124/mol.65.6.1475
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    High-Affinity Interaction of Tyrosine Kinase Inhibitors with the ABCG2 Multidrug Transporter
    Csilla Özvegy-Laczka, Tamás Hegedűs, György Várady, Olga Ujhelly, John D. Schuetz, András Váradi, György Kéri, László Őrfi, Katalin Német and Balázs Sarkadi
    Molecular Pharmacology June 2004, 65 (6) 1485-1495; DOI: https://doi.org/10.1124/mol.65.6.1485
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    DNA Damage-Processing Pathways Involved in the Eukaryotic Cellular Response to Anticancer DNA Cross-Linking Drugs
    Vladimir Beljanski, Luigi G. Marzilli and Paul W. Doetsch
    Molecular Pharmacology June 2004, 65 (6) 1496-1506; DOI: https://doi.org/10.1124/mol.65.6.1496
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    Activation of Cyclic AMP-Dependent Protein Kinase Inhibits the Desensitization and Internalization of Metabotropic Glutamate Receptors 1a and 1b
    Stuart J. Mundell, Giordano Pula, Julia C. A. More, David E. Jane, Peter J. Roberts and Eamonn Kelly
    Molecular Pharmacology June 2004, 65 (6) 1507-1516; DOI: https://doi.org/10.1124/mol.65.6.1507
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    Alternative Processing Events in Human FMO Genes
    Virginie Lattard, Jun Zhang and John R. Cashman
    Molecular Pharmacology June 2004, 65 (6) 1517-1525; DOI: https://doi.org/10.1124/mol.65.6.1517
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    Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice
    Outi Salminen, Karen L. Murphy, J. Michael McIntosh, John Drago, Michael J. Marks, Allan C. Collins and Sharon R. Grady
    Molecular Pharmacology June 2004, 65 (6) 1526-1535; DOI: https://doi.org/10.1124/mol.65.6.1526
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    Function of the ABC Signature Sequences in the Human Multidrug Resistance Protein 1
    Xiao-Qin Ren, Tatsuhiko Furukawa, Misako Haraguchi, Tomoyuki Sumizawa, Shunji Aoki, Motomasa Kobayashi and Shin-ichi Akiyama
    Molecular Pharmacology June 2004, 65 (6) 1536-1542; DOI: https://doi.org/10.1124/mol.65.6.1536
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Molecular Pharmacology: 65 (6)
Molecular Pharmacology
Vol. 65, Issue 6
1 Jun 2004
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  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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