Table of Contents

Articles

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  Discovery of Novel Selective Inhibitors of Human Intestinal Carboxylesterase for the Amelioration of Irinotecan-Induced Diarrhea: Synthesis, Quantitative Structure-Activity Relationship Analysis, and Biological Activity

  Randy M. Wadkins, Janice L Hyatt, Kyoung Jin P. Yoon, Christopher L. Morton, Richard E. Lee, Komath Damodaran, Paul Beroza, Mary K. Danks and Philip M. Potter

  Molecular Pharmacology June 2004, 65 (6) 1336-1343; DOI: https://doi.org/10.1124/mol.65.6.1336
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  Herbimycin A Abrogates Nuclear Factor-κB Activation by Interacting Preferentially with the IκB Kinase β Subunit

  Shinichi Ogino, Kazuhiro Tsuruma, Takashi Uehara and Yasuyuki Nomura

  Molecular Pharmacology June 2004, 65 (6) 1344-1351; DOI: https://doi.org/10.1124/mol.65.6.1344
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  Insulin Activates Native and Recombinant Large Conductance Ca²⁺-Activated Potassium Channels via a Mitogen-Activated Protein Kinase-Dependent Process

  Dervla O'Malley and Jenni Harvey

  Molecular Pharmacology June 2004, 65 (6) 1352-1363; DOI: https://doi.org/10.1124/mol.65.6.1352
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  Kv1.3-Blocking 5-Phenylalkoxypsoralens: A New Class of Immunomodulators

  Julia Vennekamp, Heike Wulff, Christine Beeton, Peter A. Calabresi, Stephan Grissmer, Wolfram Hänsel and K. George Chandy

  Molecular Pharmacology June 2004, 65 (6) 1364-1374; DOI: https://doi.org/10.1124/mol.65.6.1364
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  Mutations of Charged Amino Acids in or near the Transmembrane Helices of the Second Membrane Spanning Domain Differentially Affect the Substrate Specificity and Transport Activity of the Multidrug Resistance Protein MRP1 (ABCC1)

  Anass Haimeur, Gwenaëlle Conseil, Roger G. Deeley and Susan P.C. Cole

  Molecular Pharmacology June 2004, 65 (6) 1375-1385; DOI: https://doi.org/10.1124/mol.65.6.1375
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  Adenosine Triphosphate Acts as Both a Competitive Antagonist and a Positive Allosteric Modulator at Recombinant N-Methyl-D-aspartate Receptors

  Anna Kloda, John D. Clements, Richard J. Lewis and David J. Adams

  Molecular Pharmacology June 2004, 65 (6) 1386-1396; DOI: https://doi.org/10.1124/mol.65.6.1386
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  The Constitutive Active/Androstane Receptor Regulates Phenytoin Induction of Cyp2c29

  Jonathan P. Jackson, Stephen S. Ferguson, Rick Moore, Masahiko Negishi and Joyce A. Goldstein

  Molecular Pharmacology June 2004, 65 (6) 1397-1404; DOI: https://doi.org/10.1124/mol.65.6.1397
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  Interaction of Heterogeneous Nuclear Ribonucleoprotein A1 with Cytochrome P450 2A6 mRNA: Implications for Post-Transcriptional Regulation of the CYP2A6 Gene

  Kyle Christian, Matti Lang, Patrick Maurel and Françoise Raffalli-Mathieu

  Molecular Pharmacology June 2004, 65 (6) 1405-1414; DOI: https://doi.org/10.1124/mol.65.6.1405
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  Capsaicin Potentiates Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Currents

  Tomohiko Ai, Silvia G. Bompadre, Xiaohui Wang, Shenghui Hu, Min Li and Tzyh-Chang Hwang

  Molecular Pharmacology June 2004, 65 (6) 1415-1426; DOI: https://doi.org/10.1124/mol.65.6.1415
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  Signal Transducer and Activator of Transcription 3 Activation by the δ-Opioid Receptor via Gα₁₄ Involves Multiple Intermediates

  Rico K. H. Lo and Yung H. Wong

  Molecular Pharmacology June 2004, 65 (6) 1427-1439; DOI: https://doi.org/10.1124/mol.65.6.1427
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  Down-Regulation of Soluble Guanylyl Cyclase Expression by Cyclic AMP Is Mediated by mRNA-Stabilizing Protein HuR

  Stephan Klöss, Rashi Srivastava and Alexander Mülsch

  Molecular Pharmacology June 2004, 65 (6) 1440-1451; DOI: https://doi.org/10.1124/mol.65.6.1440
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  Transmembrane Domains I and II of the γ-Aminobutyric Acid Transporter GAT-4 Contain Molecular Determinants of Substrate Specificity

  Nir Melamed and Baruch I. Kanner

  Molecular Pharmacology June 2004, 65 (6) 1452-1461; DOI: https://doi.org/10.1124/mol.65.6.1452
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  Adenosine Receptor, Protein Kinase G, and p38 Mitogen-Activated Protein Kinase-Dependent Up-Regulation of Serotonin Transporters Involves Both Transporter Trafficking and Activation

  Chong-Bin Zhu, William A. Hewlett, Igor Feoktistov, Italo Biaggioni and Randy D. Blakely

  Molecular Pharmacology June 2004, 65 (6) 1462-1474; DOI: https://doi.org/10.1124/mol.65.6.1462
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  Ceramide Negatively Regulates Glutathione S-transferase Gene Transactivation via Repression of Hepatic Nuclear Factor-1 That Is Degraded by the Ubiquitin Proteasome System

  I-Na Park, Il Je Cho and Sang Geon Kim

  Molecular Pharmacology June 2004, 65 (6) 1475-1484; DOI: https://doi.org/10.1124/mol.65.6.1475
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  High-Affinity Interaction of Tyrosine Kinase Inhibitors with the ABCG2 Multidrug Transporter

  Csilla Özvegy-Laczka, Tamás Hegedűs, György Várady, Olga Ujhelly, John D. Schuetz, András Váradi, György Kéri, László Őrfi, Katalin Német and Balázs Sarkadi

  Molecular Pharmacology June 2004, 65 (6) 1485-1495; DOI: https://doi.org/10.1124/mol.65.6.1485
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  DNA Damage-Processing Pathways Involved in the Eukaryotic Cellular Response to Anticancer DNA Cross-Linking Drugs

  Vladimir Beljanski, Luigi G. Marzilli and Paul W. Doetsch

  Molecular Pharmacology June 2004, 65 (6) 1496-1506; DOI: https://doi.org/10.1124/mol.65.6.1496
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  Activation of Cyclic AMP-Dependent Protein Kinase Inhibits the Desensitization and Internalization of Metabotropic Glutamate Receptors 1a and 1b

  Stuart J. Mundell, Giordano Pula, Julia C. A. More, David E. Jane, Peter J. Roberts and Eamonn Kelly

  Molecular Pharmacology June 2004, 65 (6) 1507-1516; DOI: https://doi.org/10.1124/mol.65.6.1507
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  Alternative Processing Events in Human FMO Genes

  Virginie Lattard, Jun Zhang and John R. Cashman

  Molecular Pharmacology June 2004, 65 (6) 1517-1525; DOI: https://doi.org/10.1124/mol.65.6.1517
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  Subunit Composition and Pharmacology of Two Classes of Striatal Presynaptic Nicotinic Acetylcholine Receptors Mediating Dopamine Release in Mice

  Outi Salminen, Karen L. Murphy, J. Michael McIntosh, John Drago, Michael J. Marks, Allan C. Collins and Sharon R. Grady

  Molecular Pharmacology June 2004, 65 (6) 1526-1535; DOI: https://doi.org/10.1124/mol.65.6.1526
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  Function of the ABC Signature Sequences in the Human Multidrug Resistance Protein 1

  Xiao-Qin Ren, Tatsuhiko Furukawa, Misako Haraguchi, Tomoyuki Sumizawa, Shunji Aoki, Motomasa Kobayashi and Shin-ichi Akiyama

  Molecular Pharmacology June 2004, 65 (6) 1536-1542; DOI: https://doi.org/10.1124/mol.65.6.1536