Table of Contents

Articles

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  Defective Adult Neurogenesis in CB1 Cannabinoid Receptor Knockout Mice

  Kunlin Jin, Lin Xie, Sun Hee Kim, Sophie Parmentier-Batteur, Yunjuan Sun, Xiao Ou Mao, Jocelyn Childs and David A. Greenberg

  Molecular Pharmacology August 2004, 66 (2) 204-208; DOI: https://doi.org/10.1124/mol.66.2.204
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  Ligand-Binding Residues Integrate Affinity and Efficacy in the NMDA Receptor

  Trisha L. Kalbaugh, Hendrika M. A. VanDongen and Antonius M. J. VanDongen

  Molecular Pharmacology August 2004, 66 (2) 209-219; DOI: https://doi.org/10.1124/mol.66.2.209
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  Reduction of Renal Ischemia-Reperfusion Injury in 5-Lipoxygenase Knockout Mice and by the 5-Lipoxygenase Inhibitor Zileuton

  Nimesh S. A. Patel, Salvatore Cuzzocrea, Prabal K. Chatterjee, Rosanna Di Paola, Lidia Sautebin, Domenico Britti and Christoph Thiemermann

  Molecular Pharmacology August 2004, 66 (2) 220-227; DOI: https://doi.org/10.1124/mol.66.2.220
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  High-Affinity Interactions between Human α_1A-Adrenoceptor C-Terminal Splice Variants Produce Homo- and Heterodimers but Do Not Generate the α_1L-Adrenoceptor

  Douglas Ramsay, I. Craig Carr, John Pediani, Juan F. Lopez-Gimenez, Richard Thurlow, Mark Fidock and Graeme Milligan

  Molecular Pharmacology August 2004, 66 (2) 228-239; DOI: https://doi.org/10.1124/mol.66.2.228
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  Structural Determinants of HERG Channel Block by Clofilium and Ibutilide

  Matthew Perry, Marcel J. de Groot, Ray Helliwell, Derek Leishman, Martin Tristani-Firouzi, Michael C. Sanguinetti and John Mitcheson

  Molecular Pharmacology August 2004, 66 (2) 240-249; DOI: https://doi.org/10.1124/mol.104.000117
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  Identification of a Novel Site within G Protein α Subunits Important for Specificity of Receptor-G Protein Interaction

  Arne Heydorn, Richard J. Ward, Rasmus Jorgensen, Mette M. Rosenkilde, Thomas M. Frimurer, Graeme Milligan and Evi Kostenis

  Molecular Pharmacology August 2004, 66 (2) 250-259; DOI: https://doi.org/10.1124/mol.66.2.250
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  Cholinergic Stimulation of Salivary Secretion Studied with M₁ and M₃ Muscarinic Receptor Single- and Double-Knockout Mice

  Dinesh Gautam, Thomas S. Heard, Yinghong Cui, Georgina Miller, Lanh Bloodworth and Jürgen Wess

  Molecular Pharmacology August 2004, 66 (2) 260-267; DOI: https://doi.org/10.1124/mol.66.2.260
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  Strategies for Inhibition of MDR1 Gene Expression

  Dong Xu, Hyunmin Kang, Michael Fisher and R. L. Juliano

  Molecular Pharmacology August 2004, 66 (2) 268-275; DOI: https://doi.org/10.1124/mol.66.2.268
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  The N-terminal Ca²⁺-Independent Calmodulin-Binding Site on the Inositol 1,4,5-trisphosphate Receptor Is Responsible for Calmodulin Inhibition, Even Though This Inhibition Requires Ca²⁺

  Nael Nadif Kasri, Geert Bultynck, Jeremy Smyth, Karolina Szlufcik, Jan B. Parys, Geert Callewaert, Ludwig Missiaen, Rafael A. Fissore, Katsuhiko Mikoshiba and Humbert de Smedt

  Molecular Pharmacology August 2004, 66 (2) 276-284; DOI: https://doi.org/10.1124/mol.66.2.276
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  Synergistic Antitumor Activity of Troxacitabine and Camptothecin in Selected Human Cancer Cell Lines

  Tracy E. Kim, Shin-Young Park, Chih-Hung Hsu, Ginger E. Dutschman and Yung-Chi Cheng

  Molecular Pharmacology August 2004, 66 (2) 285-292; DOI: https://doi.org/10.1124/mol.66.2.285
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  Prostaglandin E₂ Inhibits the Phospholipase D Pathway Stimulated by Formyl-methionyl-leucyl-phenylalanine in Human Neutrophils. Involvement of EP₂ Receptors and Phosphatidylinositol 3-kinase γ

  Chantal Burelout, Nathalie Thibault, Sylvain Levasseur, Sébastien Simard, Paul H. Naccache and Sylvain G. Bourgoin

  Molecular Pharmacology August 2004, 66 (2) 293-301; DOI: https://doi.org/10.1124/mol.66.2.293
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  p38 Mitogen-Activated Protein Kinase Mediates Synergistic Induction of Inducible Nitric-Oxide Synthase by Lipopolysaccharide and Interferon-γ through Signal Transducer and Activator of Transcription 1 Ser727 Phosphorylation in Murine Aortic Endothelial Cells

  Hong Huang, Jane L. Rose and Dale G. Hoyt

  Molecular Pharmacology August 2004, 66 (2) 302-311; DOI: https://doi.org/10.1124/mol.66.2.302
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  Preferential Formation of MT₁/MT₂ Melatonin Receptor Heterodimers with Distinct Ligand Interaction Properties Compared with MT₂ Homodimers

  Mohammed A. Ayoub, Angélique Levoye, Philippe Delagrange and Ralf Jockers

  Molecular Pharmacology August 2004, 66 (2) 312-321; DOI: https://doi.org/10.1124/mol.104.000398
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  Tumor Necrosis Factor-α Differentially Regulates the Expression of Proinflammatory Genes in Human Airway Smooth Muscle Cells by Activation of Interferon-β–Dependent CD38 Pathway

  Omar Tliba, Reynold A. Panettieri, Samira Tliba, Timothy F. Walseth and Yassine Amrani

  Molecular Pharmacology August 2004, 66 (2) 322-329; DOI: https://doi.org/10.1124/mol.104.001040
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  Unexpected Mexiletine Responses of a Mutant Cardiac Na⁺ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

  Koji Sasaki, Naomasa Makita, Akihiko Sunami, Harumizu Sakurada, Nobumasa Shirai, Hisataka Yokoi, Akinori Kimura, Noritsugu Tohse, Masayasu Hiraoka and Akira Kitabatake

  Molecular Pharmacology August 2004, 66 (2) 330-336; DOI: https://doi.org/10.1124/mol.66.2.330
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  Interleukin-1β–Induced Mucin Production in Human Airway Epithelium Is Mediated by Cyclooxygenase-2, Prostaglandin E₂ Receptors, and Cyclic AMP-Protein Kinase A Signaling

  Thomas Gray, Paul Nettesheim, Charles Loftin, Ja-Seok Koo, James Bonner, Shyamal Peddada and Robert Langenbach

  Molecular Pharmacology August 2004, 66 (2) 337-346; DOI: https://doi.org/10.1124/mol.66.2.337
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  Differential Modulation of β2 and β4 Subunits of Human Neuronal Nicotinic Acetylcholine Receptors by Acidification

  Galya Abdrakhmanova, Lars Cleemann, Jon Lindstrom and Martin Morad

  Molecular Pharmacology August 2004, 66 (2) 347-355; DOI: https://doi.org/10.1124/mol.66.2.347
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  “Induced-Fit” Mechanism for Catecholamine Binding to the β₂-Adrenergic Receptor

  Renata Del Carmine, Paola Molinari, Maria Sbraccia, Caterina Ambrosio and Tommaso Costa

  Molecular Pharmacology August 2004, 66 (2) 356-363; DOI: https://doi.org/10.1124/mol.66.2.356