Abstract
All Ca2+ channels are regulated by Ca2+, a feature that allows them to respond to their own activity and to the activities of neighboring Ca2+ channels. Inhibition by Ca2+ protects cells from potentially hazardous increases in cytosolic [Ca2+], and stimulation can mediate facilitation and regenerative propagation of Ca2+ signals. Calmodulin is emerging as a key player in regulation of Ca2+ channels by Ca2+, but its role is more complex and more beautiful than might have been imagined.
- Received May 11, 2004.
- Accepted May 13, 2004.
- The American Society for Pharmacology and Experimental Therapeutics
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