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Research ArticleArticle

Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Koji Sasaki, Naomasa Makita, Akihiko Sunami, Harumizu Sakurada, Nobumasa Shirai, Hisataka Yokoi, Akinori Kimura, Noritsugu Tohse, Masayasu Hiraoka and Akira Kitabatake
Molecular Pharmacology August 2004, 66 (2) 330-336; DOI: https://doi.org/10.1124/mol.66.2.330
Koji Sasaki
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Naomasa Makita
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Akihiko Sunami
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Harumizu Sakurada
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Nobumasa Shirai
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Hisataka Yokoi
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Akinori Kimura
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Noritsugu Tohse
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Masayasu Hiraoka
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Akira Kitabatake
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Article Information

vol. 66 no. 2 330-336
DOI 
https://doi.org/10.1124/mol.66.2.330
PubMed 
15266024

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received February 2, 2004
  • Accepted May 20, 2004
  • Published online July 20, 2004.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Koji Sasaki,
  2. Naomasa Makita,
  3. Akihiko Sunami,
  4. Harumizu Sakurada,
  5. Nobumasa Shirai,
  6. Hisataka Yokoi,
  7. Akinori Kimura,
  8. Noritsugu Tohse,
  9. Masayasu Hiraoka and
  10. Akira Kitabatake
  1. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan (K.S., N.M., N.S., H.Y., A.Kit.); Departments of Clinical Pharmacology (A.S.), Molecular Pathogenesis (A.Kim.), and Cardiovascular Diseases (M.H.), Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Department of Cardiology, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan (H.S.); and Department of Physiology, Sapporo Medical University, Sapporo, Japan (N.T.)
  1. Address correspondence to:
    Dr. Naomasa Makita, Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Kita-15, Nishi-7, Kita-Ku, Sapporo, 060-8638, Japan. E-mail: makitan{at}med.hokudai.ac.jp
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Molecular Pharmacology: 66 (2)
Molecular Pharmacology
Vol. 66, Issue 2
1 Aug 2004
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Research ArticleArticle

Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Koji Sasaki, Naomasa Makita, Akihiko Sunami, Harumizu Sakurada, Nobumasa Shirai, Hisataka Yokoi, Akinori Kimura, Noritsugu Tohse, Masayasu Hiraoka and Akira Kitabatake
Molecular Pharmacology August 1, 2004, 66 (2) 330-336; DOI: https://doi.org/10.1124/mol.66.2.330

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Research ArticleArticle

Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Koji Sasaki, Naomasa Makita, Akihiko Sunami, Harumizu Sakurada, Nobumasa Shirai, Hisataka Yokoi, Akinori Kimura, Noritsugu Tohse, Masayasu Hiraoka and Akira Kitabatake
Molecular Pharmacology August 1, 2004, 66 (2) 330-336; DOI: https://doi.org/10.1124/mol.66.2.330
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