Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Koji Sasaki; Naomasa Makita; Akihiko Sunami; Harumizu Sakurada; Nobumasa Shirai; Hisataka Yokoi; Akinori Kimura; Noritsugu Tohse; Masayasu Hiraoka; Akira Kitabatake

doi:10.1124/mol.66.2.330

Research ArticleArticle

Unexpected Mexiletine Responses of a Mutant Cardiac Na⁺ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Koji Sasaki, Naomasa Makita, Akihiko Sunami, Harumizu Sakurada, Nobumasa Shirai, Hisataka Yokoi, Akinori Kimura, Noritsugu Tohse, Masayasu Hiraoka and Akira Kitabatake

Molecular Pharmacology August 2004, 66 (2) 330-336; DOI: https://doi.org/10.1124/mol.66.2.330

Koji Sasaki

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Naomasa Makita

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Akihiko Sunami

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Harumizu Sakurada

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Nobumasa Shirai

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Hisataka Yokoi

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Akinori Kimura

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Noritsugu Tohse

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Masayasu Hiraoka

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Akira Kitabatake

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Molecular Pharmacology

Vol. 66, Issue 2

1 Aug 2004

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Research ArticleArticle

Unexpected Mexiletine Responses of a Mutant Cardiac Na⁺ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Koji Sasaki, Naomasa Makita, Akihiko Sunami, Harumizu Sakurada, Nobumasa Shirai, Hisataka Yokoi, Akinori Kimura, Noritsugu Tohse, Masayasu Hiraoka and Akira Kitabatake

Molecular Pharmacology August 1, 2004, 66 (2) 330-336; DOI: https://doi.org/10.1124/mol.66.2.330

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Research ArticleArticle

Unexpected Mexiletine Responses of a Mutant Cardiac Na⁺ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

Koji Sasaki, Naomasa Makita, Akihiko Sunami, Harumizu Sakurada, Nobumasa Shirai, Hisataka Yokoi, Akinori Kimura, Noritsugu Tohse, Masayasu Hiraoka and Akira Kitabatake

Molecular Pharmacology August 1, 2004, 66 (2) 330-336; DOI: https://doi.org/10.1124/mol.66.2.330

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