Molecular Pharmacology: 66 (3)

September 01, 2004; Volume 66,Issue 3

Perspective

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Arrestin-Independent Internalization of G Protein-Coupled Receptors
Chris J. van Koppen and Karl H. Jakobs

Molecular Pharmacology September 2004, 66 (3) 365-367; DOI: https://doi.org/10.1124/mol.104.003822

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COX-2 Regulates the Insulin-Like Growth Factor I–Induced Potentiation of Zn²⁺-Toxicity in Primary Cortical Culture
Joo-Young Im, Doyeun Kim, Kang-Woo Lee, Jung-Bin Kim, Ja-Kyeong Lee, Dong Sik Kim, Young Ik Lee, Kwon-Soo Ha, Cheol O Joe and Pyung-Lim Han

Molecular Pharmacology September 2004, 66 (3) 368-376;
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Agonist-Induced Internalization of Leukotriene B₄ Receptor 1 Requires G-Protein-Coupled Receptor Kinase 2 but Not Arrestins
Zhangguo Chen, Rémi Gaudreau, Christian Le Gouill, Marek Rola-Pleszczynski and Jana Staňková

Molecular Pharmacology September 2004, 66 (3) 377-386;
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Rapid Regulation of P-Glycoprotein at the Blood-Brain Barrier by Endothelin-1
Anika M. S. Hartz, Björn Bauer, Gert Fricker and David S. Miller

Molecular Pharmacology September 2004, 66 (3) 387-394; DOI: https://doi.org/10.1124/mol.104.001503
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Regulation of the Stability of P-Glycoprotein by Ubiquitination
Zhigang Zhang, Jin-Ying Wu, William N. Hait and Jin-Ming Yang

Molecular Pharmacology September 2004, 66 (3) 395-403; DOI: https://doi.org/10.1124/mol.104.001966
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Antisense Evidence for Nuclear Factor-κB–Dependent Embryopathies Initiated by Phenytoin-Enhanced Oxidative Stress
Julia C. Kennedy, Sylvie Memet and Peter G. Wells

Molecular Pharmacology September 2004, 66 (3) 404-412;
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Pregnane X Receptor Up-Regulation of P-Glycoprotein Expression and Transport Function at the Blood-Brain Barrier
Björn Bauer, Anika M. S. Hartz, Gert Fricker and David S. Miller

Molecular Pharmacology September 2004, 66 (3) 413-419;
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The α7 Nicotinic Acetylcholine Receptor Subunit Exists in Two Isoforms that Contribute to Functional Ligand-Gated Ion Channels
Emily G. Severance, Hongling Zhang, Yolmari Cruz, Sergei Pakhlevaniants, Stephen H. Hadley, Jahanshah Amin, Lynn Wecker, Crystal Reed and Javier Cuevas

Molecular Pharmacology September 2004, 66 (3) 420-429; DOI: https://doi.org/10.1124/mol.104.000059
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Mutation E522K in Human DNA Topoisomerase IIβ Confers Resistance to Methyl N-(4′-(9-acridinylamino)-phenyl)carbamate hydrochloride and Methyl N-(4′-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but Hypersensitivity to Etoposide
Chrysoula Leontiou, Jeremy H. Lakey and Caroline A. Austin

Molecular Pharmacology September 2004, 66 (3) 430-439;
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Enhancement of Fibronectin Fibrillogenesis and Bone Formation by Basic Fibroblast Growth Factor via Protein Kinase C-Dependent Pathway in Rat Osteoblasts
Chih-Hsin Tang, Rong-Sen Yang, Tsang-Hai Huang, Shing-Hwa Liu and Wen-Mei Fu

Molecular Pharmacology September 2004, 66 (3) 440-449;
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Prediction of in Vivo Biliary Clearance from the in Vitro Transcellular Transport of Organic Anions across a Double-Transfected Madin-Darby Canine Kidney II Monolayer Expressing Both Rat Organic Anion Transporting Polypeptide 4 and Multidrug Resistance Associated Protein 2
Makoto Sasaki, Hiroshi Suzuki, Jun Aoki, Kousei Ito, Peter J. Meier and Yuichi Sugiyama

Molecular Pharmacology September 2004, 66 (3) 450-459;
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P-Glycoprotein Mediates Resistance to Histidine Kinase Inhibitors
Sonia Arora, Jin-Ming Yang, Ryutaro Utsumi, Tadashi Okamoto, Takashi Kitayama and William N. Hait

Molecular Pharmacology September 2004, 66 (3) 460-467;
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Activation and Inhibition of Neuronal G Protein-Gated Inwardly Rectifying K⁺ Channels by P2Y Nucleotide Receptors
Alexander K. Filippov, Jose M. Fernández-Fernández, Stephen J. Marsh, Joseph Simon, Eric A. Barnard and David A. Brown

Molecular Pharmacology September 2004, 66 (3) 468-477;
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DNA Damage Induced by Temozolomide Signals to both ATM and ATR: Role of the Mismatch Repair System
Simona Caporali, Sabrina Falcinelli, Giuseppe Starace, Maria Teresa Russo, Enzo Bonmassar, Josef Jiricny and Stefania D'Atri

Molecular Pharmacology September 2004, 66 (3) 478-491;
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3-Morpholinylsydnonimine Inhibits Glutamatergic Transmission in Rat Rostral Ventrolateral Medulla via Peroxynitrite Formation and Adenosine Release
Chiung-Chun Huang, Samuel H. H. Chan and Kuei-Sen Hsu

Molecular Pharmacology September 2004, 66 (3) 492-501; DOI: https://doi.org/10.1124/mol.104.000554
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2,3,7,8-Tetrachlorodibenzo-p-dioxin Blocks Androgen-Dependent Cell Proliferation of LNCaP Cells through Modulation of pRB Phosphorylation
Sonya Barnes-Ellerbe, Karen E. Knudsen and Alvaro Puga

Molecular Pharmacology September 2004, 66 (3) 502-511; DOI: https://doi.org/10.1124/mol.104.000356
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2,3,7,8-Tetrachlorodibenzo-p-dioxin Activation of the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Pathway Causes Developmental Toxicity through a CYP1A-Independent Mechanism in Zebrafish
Sara A. Carney, Richard E. Peterson and Warren Heideman

Molecular Pharmacology September 2004, 66 (3) 512-521;
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Dissociation of [³H]l-Glutamate Uptake from l-Glutamate-Induced [³H]d-Aspartate release by 3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic Acid and 3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic Acid, Two Conformationally Constrained Aspartate and Glutamate Analogs
Marcella Funicello, Paola Conti, Marco De Amici, Carlo De Micheli, Tiziana Mennini and Marco Gobbi

Molecular Pharmacology September 2004, 66 (3) 522-529;
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The Two-Pore-Domain K⁺ Channels TREK-1 and TASK-3 Are Differentially Modulated by Copper and Zinc
Marco Gruss, Alistair Mathie, William R. Lieb and Nicholas P. Franks

Molecular Pharmacology September 2004, 66 (3) 530-537;
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Cholinergic Drugs for Alzheimer's Disease Enhance in Vitro Dopamine Release
Lifen Zhang, Fu-Ming Zhou and John A. Dani

Molecular Pharmacology September 2004, 66 (3) 538-544; DOI: https://doi.org/10.1124/mol.104.000299
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Key Differences in Molecular Complexes of the Cholecystokinin Receptor with Structurally Related Peptide Agonist, Partial Agonist, and Antagonist
Sonnet J. H. Arlander, Maoqing Dong, Xi-Qin Ding, Delia I. Pinon and Laurence J. Miller

Molecular Pharmacology September 2004, 66 (3) 545-552; DOI: https://doi.org/10.1124/mol.104.001396
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Induction of Radiosensitization by Indolocarbazole Derivatives: The Role of DNA Topoisomerase I
Allan Y. Chen, Shyh-Jen Shih, Michael Hsiao, Mace L. Rothenberg and Michelle Prudhomme

Molecular Pharmacology September 2004, 66 (3) 553-560;
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YC-1-Induced Cyclooxygenase-2 Expression Is Mediated by cGMP-Dependent Activations of Ras, Phosphoinositide-3-OH-kinase, Akt, and Nuclear Factor-κB in Human Pulmonary Epithelial Cells
Ming-Shyan Chang, Wen-Sen Lee, Bing-Chang Chen, Joen-Rong Sheu and Chien-Huang Lin

Molecular Pharmacology September 2004, 66 (3) 561-571;
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Effects of Antisense Oligonucleotide-Mediated Depletion of Tumor Necrosis Factor (TNF) Receptor 1-Associated Death Domain Protein on TNF-Induced Gene Expression
Andrew M. Siwkowski, Lisa A. Madge, Seongjoon Koo, Erin L. McMillan, Brett P. Monia, Jordan S. Pober and Brenda F. Baker

Molecular Pharmacology September 2004, 66 (3) 572-579;

Articles

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Low Concentrations of Vinflunine Induce Apoptosis in Human SK-N-SH Neuroblastoma Cells through a Postmitotic G₁ Arrest and a Mitochondrial Pathway
Bertrand Pourroy, Manon Carré, Stéphane Honoré, Véronique Bourgarel-Rey, Anna Kruczynski, Claudette Briand and Diane Braguer

Molecular Pharmacology September 2004, 66 (3) 580-591;
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Nordihydroguaiaretic Acid Does Not Disaggregate β-Amyloid(1–40) Protofibrils but Does Inhibit Growth Arising from Direct Protofibril Association
Melissa A. Moss, Nicholas H. Varvel, Michael R. Nichols, Dana Kim Reed and Terrone L. Rosenberry

Molecular Pharmacology September 2004, 66 (3) 592-600;
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Identification of the P2Y₁₂ Receptor in Nucleotide Inhibition of Exocytosis from Bovine Chromaffin Cells
Steven J. Ennion, Andrew D. Powell and Elizabeth P. Seward

Molecular Pharmacology September 2004, 66 (3) 601-611; DOI: https://doi.org/10.1124/mol.104.000224
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Berberine Inhibits HIF-1α Expression via Enhanced Proteolysis
Shankung Lin, Shiow-Chwen Tsai, Chun-Chung Lee, Bao-Wei Wang, Jer-Young Liou and Kou-Gi Shyu

Molecular Pharmacology September 2004, 66 (3) 612-619;
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Small Interfering RNA-Mediated Suppression of dUTPase Sensitizes Cancer Cell Lines to Thymidylate Synthase Inhibition
Sara E. Koehler and Robert D. Ladner

Molecular Pharmacology September 2004, 66 (3) 620-626;
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DNA Topoisomerase I As One of the Cellular Targets of Certain Tyrphostin Derivatives
Sarit Bendetz-Nezer, Aviv Gazit and Esther Priel

Molecular Pharmacology September 2004, 66 (3) 627-634;
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A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models
Stuart Emanuel, Robert H. Gruninger, Angel Fuentes-Pesquera, Peter J. Connolly, Jennifer A. Seamon, Susan Hazel, Rose Tominovich, Beth Hollister, Cheryl Napier, Michael R. D'Andrea, Michael Reuman, Gilles Bignan, Robert Tuman, Dana Johnson, David Moffatt, Mark Batchelor, Anne Foley, James O'Connell, Rodger Allen, Martin Perry, Linda Jolliffe and Steven A. Middleton

Molecular Pharmacology September 2004, 66 (3) 635-647; DOI: https://doi.org/10.1124/mol.104.000638
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Lidocaine: A Foot in the Door of the Inner Vestibule Prevents Ultra-Slow Inactivation of a Voltage-Gated Sodium Channel
Walter Sandtner, Julia Szendroedi, Touran Zarrabi, Eva Zebedin, Karlheinz Hilber, Ian Glaaser, Harry A. Fozzard, Samuel C. Dudley and Hannes Todt

Molecular Pharmacology September 2004, 66 (3) 648-657;
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Regulation of Nicotinic Acetylcholine Receptor Channel Function by Acetylcholinesterase Inhibitors in Rat Hippocampal CA1 Interneurons
Dmitriy Fayuk and Jerrel L. Yakel

Molecular Pharmacology September 2004, 66 (3) 658-666; DOI: https://doi.org/10.1124/mol.104.000042
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γ-Mangostin Inhibits Inhibitor-κB Kinase Activity and Decreases Lipopolysaccharide-Induced Cyclooxygenase-2 Gene Expression in C6 Rat Glioma Cells
Keigo Nakatani, Tohru Yamakuni, Nobuhiko Kondo, Tsutomu Arakawa, Kenji Oosawa, Susumu Shimura, Hiroyasu Inoue and Yasushi Ohizumi

Molecular Pharmacology September 2004, 66 (3) 667-674; DOI: https://doi.org/10.1124/mol.104.002626
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Enantioselective Effects of Hydroxy Metabolites of Bupropion on Behavior and on Function of Monoamine Transporters and Nicotinic Receptors
M. Imad Damaj, F. Ivy Carroll, J. Brek Eaton, Hernan A. Navarro, Bruce E. Blough, Sadiq Mirza, Ronald J. Lukas and Billy R. Martin

Molecular Pharmacology September 2004, 66 (3) 675-682; DOI: https://doi.org/10.1124/mol.104.001313
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Flavonoids Inhibit Tumor Necrosis Factor-α-Induced Up-Regulation of Intercellular Adhesion Molecule-1 (ICAM-1) in Respiratory Epithelial Cells through Activator Protein-1 and Nuclear Factor-κB: Structure-Activity Relationships
Ching-Chow Chen, Man-Ping Chow, Wei-Chien Huang, Yi-Chu Lin and Ya-Jen Chang

Molecular Pharmacology September 2004, 66 (3) 683-693;
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Role of Liver-Enriched Transcription Factors in the Down-Regulation of Organic Anion Transporting Polypeptide 4 (Oatp4; Oatplb2; Slc21a10) by Lipopolysaccharide
Ning Li and Curtis D. Klaassen

Molecular Pharmacology September 2004, 66 (3) 694-701;
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Diethylstilbestrol Is a Potent Inhibitor of Store-Operated Channels and Capacitative Ca²⁺ Influx
Sergey I. Zakharov, Tarik Smani, Yuliya Dobrydneva, Francisco Monje, Craig Fichandler, Peter F. Blackmore and Victoria M. Bolotina

Molecular Pharmacology September 2004, 66 (3) 702-707;
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The Myosin ATPase Inhibitor 2,3-Butanedione monoxime Dictates Transcriptional Activation of Ion Channels and Ca²⁺-Handling Proteins
Jürgen Borlak and Carolin Zwadlo

Molecular Pharmacology September 2004, 66 (3) 708-717;
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The Role of Membrane and Vesicular Monoamine Transporters in the Neurotoxic and Hypothermic Effects of 1-Methyl-4-(2′-aminophenyl)-1,2,3,6-tetrahydropyridine (2′-NH₂-MPTP)
Adam L. Numis, Erica L. Unger, Douglas L. Sheridan, Angela C. Chisnell and Anne M. Andrews

Molecular Pharmacology September 2004, 66 (3) 718-727;
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Acetaminophen: A Central Analgesic Drug That Involves a Spinal Tropisetron-Sensitive, Non–5-HT₃ Receptor-Mediated Effect
F. Libert, J. Bonnefont, E. Bourinet, E. Doucet, A. Alloui, M. Hamon, J. Nargeot and A. Eschalier

Molecular Pharmacology September 2004, 66 (3) 728-734;
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Evidence for a Novel K⁺ Channel Modulated by α_1A-Adrenoceptors in Cardiac Myocytes
Stéphanie C. M. Choisy, Jules C. Hancox, Lesley A. Arberry, A. Martyn Reynolds, Michael J. Shattock and Andrew F. James

Molecular Pharmacology September 2004, 66 (3) 735-748; DOI: https://doi.org/10.1124/mol.104.000760
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Glutathione Depletion in CYP2E1-Expressing Liver Cells Induces Toxicity Due to the Activation of p38 Mitogen-Activated Protein Kinase and Reduction of Nuclear Factor-κB DNA Binding Activity
Defeng Wu and Arthur Cederbaum

Molecular Pharmacology September 2004, 66 (3) 749-760; DOI: https://doi.org/10.1124/mol.104.002048
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Functional Role of a C-Terminal Gβγ-Binding Domain of Ca_v2.2 Channels
Bin Li, Huijun Zhong, Todd Scheuer and William A. Catterall

Molecular Pharmacology September 2004, 66 (3) 761-769;

Correction

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Correction to “In silico simulation of inhibitor drug effects on nuclear factor--κB pathway dynamics”
Molecular Pharmacology September 2004, 66 (3) 770;
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Correction to “Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers”
Molecular Pharmacology September 2004, 66 (3) 771;
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Correction to “Ca²⁺ regulation of inositol 1,4,5-trisphosphate receptors: can Ca²⁺ function without calmodulin?”
Molecular Pharmacology September 2004, 66 (3) 772;

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