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Research ArticleArticle

Prediction of in Vivo Biliary Clearance from the in Vitro Transcellular Transport of Organic Anions across a Double-Transfected Madin-Darby Canine Kidney II Monolayer Expressing Both Rat Organic Anion Transporting Polypeptide 4 and Multidrug Resistance Associated Protein 2

Makoto Sasaki, Hiroshi Suzuki, Jun Aoki, Kousei Ito, Peter J. Meier and Yuichi Sugiyama
Molecular Pharmacology September 2004, 66 (3) 450-459;

Article Information

vol. 66 no. 3 450-459
PubMed 
15322236
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received December 8, 2003
  • Accepted June 10, 2004
  • Published online August 20, 2004.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Makoto Sasaki,
  2. Hiroshi Suzuki,
  3. Jun Aoki,
  4. Kousei Ito,
  5. Peter J. Meier and
  6. Yuichi Sugiyama
  1. Department of Biopharmaceutics, School of Pharmaceutical Sciences, the University of Tokyo, Japan (M.S., H.S., J.A., Y.S.); Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Japan (K.I.); and Division of Clinical Pharmacology and Toxicoligy, Department of Medicine, University Hospital, Zurich, Switzerland (P.M.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Professor and Chair, Department of Biopharmaceutics, School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp.
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Research ArticleArticle

Prediction of in Vivo Biliary Clearance from the in Vitro Transcellular Transport of Organic Anions across a Double-Transfected Madin-Darby Canine Kidney II Monolayer Expressing Both Rat Organic Anion Transporting Polypeptide 4 and Multidrug Resistance Associated Protein 2

Makoto Sasaki, Hiroshi Suzuki, Jun Aoki, Kousei Ito, Peter J. Meier and Yuichi Sugiyama
Molecular Pharmacology September 1, 2004, 66 (3) 450-459;
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