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Research ArticleArticle

A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models

Stuart Emanuel, Robert H. Gruninger, Angel Fuentes-Pesquera, Peter J. Connolly, Jennifer A. Seamon, Susan Hazel, Rose Tominovich, Beth Hollister, Cheryl Napier, Michael R. D'Andrea, Michael Reuman, Gilles Bignan, Robert Tuman, Dana Johnson, David Moffatt, Mark Batchelor, Anne Foley, James O'Connell, Rodger Allen, Martin Perry, Linda Jolliffe and Steven A. Middleton
Molecular Pharmacology September 2004, 66 (3) 635-647; DOI: https://doi.org/10.1124/mol.104.000638
Stuart Emanuel
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Robert H. Gruninger
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Angel Fuentes-Pesquera
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Peter J. Connolly
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Jennifer A. Seamon
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Susan Hazel
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Rose Tominovich
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Beth Hollister
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Cheryl Napier
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Michael R. D'Andrea
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Michael Reuman
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Gilles Bignan
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Robert Tuman
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Dana Johnson
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David Moffatt
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Mark Batchelor
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Anne Foley
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James O'Connell
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Rodger Allen
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Martin Perry
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Linda Jolliffe
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Steven A. Middleton
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Article Information

vol. 66 no. 3 635-647
DOI 
https://doi.org/10.1124/mol.104.000638
PubMed 
15322256

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 19, 2004
  • Accepted June 9, 2004
  • Published online August 20, 2004.

Article Versions

  • Earlier version (June 10, 2004 - 09:49).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stuart Emanuel,
  2. Robert H. Gruninger,
  3. Angel Fuentes-Pesquera,
  4. Peter J. Connolly,
  5. Jennifer A. Seamon,
  6. Susan Hazel,
  7. Rose Tominovich,
  8. Beth Hollister,
  9. Cheryl Napier,
  10. Michael R. D'Andrea,
  11. Michael Reuman,
  12. Gilles Bignan,
  13. Robert Tuman,
  14. Dana Johnson,
  15. David Moffatt,
  16. Mark Batchelor,
  17. Anne Foley,
  18. James O'Connell,
  19. Rodger Allen,
  20. Martin Perry,
  21. Linda Jolliffe and
  22. Steven A. Middleton
  1. Cancer Therapeutics Research (S.E., R.H.G., A. F.-P., P.J.C., J.A.S., M.R., G.B., L.J., S.A.M.) and Oncology Research (R.To., M.R.D., R.Tu., D.J.], Johnson & Johnson Pharmaceutical Research and Development, Raritan, New Jersey; Institute of Medical and Veterinary Science, Adelaide, Australia (S.H.); Piedmont Research Center, Morrisville, North Carolina (B.H., C.N.); and Celltech Research, Limited, Slough, United Kingdom (D.M., M.B., A.F., J.O., R.A., M.P.)
  1. Address correspondence to:
    Dr. Stuart Emanuel, Johnson and Johnson Pharmaceutical Research and Development, LLC, 1000 Route 202, Raritan, NJ 08869. E-mail: semanuel{at}prdus.jnj.com
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Molecular Pharmacology: 66 (3)
Molecular Pharmacology
Vol. 66, Issue 3
1 Sep 2004
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Research ArticleArticle

A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models

Stuart Emanuel, Robert H. Gruninger, Angel Fuentes-Pesquera, Peter J. Connolly, Jennifer A. Seamon, Susan Hazel, Rose Tominovich, Beth Hollister, Cheryl Napier, Michael R. D'Andrea, Michael Reuman, Gilles Bignan, Robert Tuman, Dana Johnson, David Moffatt, Mark Batchelor, Anne Foley, James O'Connell, Rodger Allen, Martin Perry, Linda Jolliffe and Steven A. Middleton
Molecular Pharmacology September 1, 2004, 66 (3) 635-647; DOI: https://doi.org/10.1124/mol.104.000638

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Research ArticleArticle

A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models

Stuart Emanuel, Robert H. Gruninger, Angel Fuentes-Pesquera, Peter J. Connolly, Jennifer A. Seamon, Susan Hazel, Rose Tominovich, Beth Hollister, Cheryl Napier, Michael R. D'Andrea, Michael Reuman, Gilles Bignan, Robert Tuman, Dana Johnson, David Moffatt, Mark Batchelor, Anne Foley, James O'Connell, Rodger Allen, Martin Perry, Linda Jolliffe and Steven A. Middleton
Molecular Pharmacology September 1, 2004, 66 (3) 635-647; DOI: https://doi.org/10.1124/mol.104.000638
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