Table of Contents

Articles

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  Identification of Cytoskeletal [¹⁴C]Carboplatin-Binding Proteins Reveals Reduced Expression and Disorganization of Actin and Filamin in Cisplatin-Resistant Cell Lines

  Ding-Wu Shen, Xing-Jie Liang, Mary Ann Gawinowicz and Michael M. Gottesman

  Molecular Pharmacology October 2004, 66 (4) 789-793; DOI: https://doi.org/10.1124/mol.66.4.789
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  P2Y₂ Receptor Activation Regulates the Expression of Acetylcholinesterase and Acetylcholine Receptor Genes at Vertebrate Neuromuscular Junctions

  Edmund K. K. Tung, Roy C. Y. Choi, Nina L. Siow, Joy X. S. Jiang, Karen K. Y. Ling, Joseph Simon, Eric A. Barnard and Karl W. K. Tsim

  Molecular Pharmacology October 2004, 66 (4) 794-806; DOI: https://doi.org/10.1124/mol.104.003269
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  Mutation in Nucleotide-Binding Domains of Sulfonylurea Receptor 2 Evokes Na-ATP-Dependent Activation of ATP-Sensitive K⁺ Channels: Implication for Dimerization of Nucleotide-Binding Domains to Induce Channel Opening

  Mitsuhiko Yamada, Masaru Ishii, Hiroshi Hibino and Yoshihisa Kurachi

  Molecular Pharmacology October 2004, 66 (4) 807-816; DOI: https://doi.org/10.1124/mol.104.002717
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  The Copper Influx Transporter Human Copper Transport Protein 1 Regulates the Uptake of Cisplatin in Human Ovarian Carcinoma Cells

  Alison K. Holzer, Goli Samimi, Kuniyuki Katano, Wiltrud Naerdemann, Xinjian Lin, Roohangiz Safaei and Stephen B. Howell

  Molecular Pharmacology October 2004, 66 (4) 817-823; DOI: https://doi.org/10.1124/mol.104.001198
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  Discovery and Characterization of Novel Small Molecule Inhibitors of Human Cdc25B Dual Specificity Phosphatase

  Marni Brisson, Theresa Nguyen, Andreas Vogt, Jack Yalowich, Angela Giorgianni, Dror Tobi, Ivet Bahar, Corey R. J. Stephenson, Peter Wipf and John S. Lazo

  Molecular Pharmacology October 2004, 66 (4) 824-833; DOI: https://doi.org/10.1124/mol.104.001784
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  Molecular Basis for the Differential Agonist Affinities of Group III Metabotropic Glutamate Receptors

  Erica Rosemond, Minghua Wang, Yi Yao, Laura Storjohann, Thomas Stormann, Edwin C. Johnson and David R. Hampson

  Molecular Pharmacology October 2004, 66 (4) 834-842; DOI: https://doi.org/10.1124/mol.104.002956
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  Cellular Trafficking of Human α_1a-Adrenergic Receptors Is Continuous and Primarily Agonist-Independent

  Daniel P. Morris, R. Reyn Price, Michael P. Smith, Beilei Lei and Debra A. Schwinn

  Molecular Pharmacology October 2004, 66 (4) 843-854; DOI: https://doi.org/10.1124/mol.104.000430
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  Stannin, A Protein That Localizes to the Mitochondria and Sensitizes NIH-3T3 Cells to Trimethyltin and Dimethyltin Toxicity

  Collin E. Davidson, Brian E. Reese, Melvin L. Billingsley and Jong K. Yun

  Molecular Pharmacology October 2004, 66 (4) 855-863; DOI: https://doi.org/10.1124/mol.104.001719
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  Interleukin 2 (IL-2) Variants Engineered for Increased IL-2 Receptor α-Subunit Affinity Exhibit Increased Potency Arising from a Cell Surface Ligand Reservoir Effect

  Balaji M. Rao, Ian Driver, Douglas A. Lauffenburger and K. Dane Wittrup

  Molecular Pharmacology October 2004, 66 (4) 864-869; DOI: https://doi.org/10.1124/mol.66.4.864
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  Activation Loop Phosphorylation Controls Protein Kinase D-Dependent Activation of Nuclear Factor κB

  Peter Storz, Heike Döppler and Alex Toker

  Molecular Pharmacology October 2004, 66 (4) 870-879; DOI: https://doi.org/10.1124/mol.104.000687
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  Mutational Analysis of the Highly Conserved ERY Motif of the Thromboxane A₂ Receptor: Alternative Role in G Protein-Coupled Receptor Signaling

  Valérie Capra, Alessio Veltri, Chiara Foglia, Luca Crimaldi, Aïda Habib, Marco Parenti and G. Enrico Rovati

  Molecular Pharmacology October 2004, 66 (4) 880-889; DOI: https://doi.org/10.1124/mol.104.001487
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  Inhibition of Poly(ADP-Ribose) Glycohydrolase by Gallotannin Selectively Up-Regulates Expression of Proinflammatory Genes

  Elena Rapizzi, Silvia Fossati, Flavio Moroni and Alberto Chiarugi

  Molecular Pharmacology October 2004, 66 (4) 890-898; DOI: https://doi.org/10.1124/mol.104.000968
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  Sodium 4-Phenylbutyrate Protects against Cerebral Ischemic Injury

  Xin Qi, Toru Hosoi, Yasunobu Okuma, Masayuki Kaneko and Yasuyuki Nomura

  Molecular Pharmacology October 2004, 66 (4) 899-908; DOI: https://doi.org/10.1124/mol.104.001339
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  Maitotoxin Induces Biphasic Interleukin-1β Secretion and Membrane Blebbing in Murine Macrophages

  Philip A. Verhoef, Sylvia B. Kertesy, Mark Estacion, William P. Schilling and George R. Dubyak

  Molecular Pharmacology October 2004, 66 (4) 909-920; DOI: https://doi.org/10.1124/mol.66.4.909
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  Raf Kinase Activation of Adenylyl Cyclases: Isoform-Selective Regulation

  Qingming Ding, Robert Gros, Ian D. Gray, Ronald Taussig, Stephen S. G. Ferguson and Ross D. Feldman

  Molecular Pharmacology October 2004, 66 (4) 921-928; DOI: https://doi.org/10.1124/mol.66.4.921
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  Saturation Transfer Difference Nuclear Magnetic Resonance Spectroscopy As a Method for Screening Proteins for Anesthetic Binding

  John H. Streiff, Nenad O. Juranic, Slobodan I. Macura, David O. Warner, Keith A. Jones and William J. Perkins

  Molecular Pharmacology October 2004, 66 (4) 929-935; DOI: https://doi.org/10.1124/mol.66.4.929
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  Superinduction of CYP1A1 in MCF10A Cultures by Cycloheximide, Anisomycin, and Puromycin: A Process Independent of Effects on Protein Translation and Unrelated to Suppression of Aryl Hydrocarbon Receptor Proteolysis by the Proteasome

  Aby Joiakim, Patricia A. Mathieu, Althea A. Elliott and John J. Reiners

  Molecular Pharmacology October 2004, 66 (4) 936-947; DOI: https://doi.org/10.1124/mol.66.4.936
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  Bidirectional Regulation of Ca²⁺/Calmodulin-Dependent Protein Kinase II Activity by Dopamine D₄ Receptors in Prefrontal Cortex

  Zhenglin Gu and Zhen Yan

  Molecular Pharmacology October 2004, 66 (4) 948-955; DOI: https://doi.org/10.1124/mol.104.001404
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  Contribution of Disruption of the Nuclear Factor-κB Pathway to Induction of Apoptosis in Human Leukemia Cells by Histone Deacetylase Inhibitors and Flavopiridol

  Ning Gao, Yun Dai, Mohamed Rahmani, Paul Dent and Steven Grant

  Molecular Pharmacology October 2004, 66 (4) 956-963; DOI: https://doi.org/10.1124/mol.104.002014
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  Ubiquitination and Degradation of Neuronal Nitric-Oxide Synthase in Vitro: Dimer Stabilization Protects the Enzyme from Proteolysis

  Anwar Y. Dunbar, Yasuhiko Kamada, Gary J. Jenkins, Ezra R. Lowe, Scott S. Billecke and Yoichi Osawa

  Molecular Pharmacology October 2004, 66 (4) 964-969; DOI: https://doi.org/10.1124/mol.104.000125
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  Inhibition of Estrogen Receptor α-Mediated Transcription by Antiestrogenic 1,1-Dichloro-2,2,3-triarylcyclopropanes

  Peng Cheng, Beatriz Kanterewicz, Pamela A. Hershberger, Kenneth S. McCarty, Billy W. Day and Mark Nichols

  Molecular Pharmacology October 2004, 66 (4) 970-977; DOI: https://doi.org/10.1124/mol.104.000752
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  The Nicotinic Receptor in the Rat Pineal Gland Is an α3β4 Subtype

  Susan C. Hernandez, Stefano Vicini, Yingxian Xiao, Martha I. Dávila-García, Robert P. Yasuda, Barry B. Wolfe and Kenneth J. Kellar

  Molecular Pharmacology October 2004, 66 (4) 978-987; DOI: https://doi.org/10.1124/mol.104.002345
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  Pentobarbital Differentially Modulates α1β3δ and α1β3γ2L GABA_A Receptor Currents

  Hua-Jun Feng, Matt T. Bianchi and Robert L. Macdonald

  Molecular Pharmacology October 2004, 66 (4) 988-1003; DOI: https://doi.org/10.1124/mol.104.002543
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  Modulation of Multidrug Resistance-Associated Protein 2 (Mrp2) and Mrp3 Expression and Function with Small Interfering RNA in Sandwich-Cultured Rat Hepatocytes

  Xianbin Tian, Maciej J. Zamek-Gliszczynski, Peijin Zhang and Kim L. R. Brouwer

  Molecular Pharmacology October 2004, 66 (4) 1004-1010; DOI: https://doi.org/10.1124/mol.66.4.1004
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  Chronic Nicotine Treatment Leads to Induction of Tyrosine Hydroxylase in Locus Ceruleus Neurons: The Role of Transcriptional Activation

  Baoyong Sun, Xiqun Chen, Lu Xu, Carol Sterling and A. William Tank

  Molecular Pharmacology October 2004, 66 (4) 1011-1021; DOI: https://doi.org/10.1124/mol.104.001974
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  Silencing the Formylpeptide Receptor FPR by Short-Interfering RNA

  Yingying Le, Pablo Iribarren, Ye Zhou, Wanghua Gong, Jinyue Hu, Xia Zhang and Ji Ming Wang

  Molecular Pharmacology October 2004, 66 (4) 1022-1028; DOI: https://doi.org/10.1124/mol.104.001982
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  Critical Role of Lysine 204 in Switch I Region of Gα₁₃ for Regulation of p115RhoGEF and Leukemia-Associated RhoGEF

  Susumu Nakamura, Barry Kreutz, Shihori Tanabe, Nobuchika Suzuki and Tohru Kozasa

  Molecular Pharmacology October 2004, 66 (4) 1029-1034; DOI: https://doi.org/10.1124/mol.104.002287
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  The Antitumor Triazoloacridone C-1305 Is a Topoisomerase II Poison with Unusual Properties

  Krzysztof Lemke, Virginie Poindessous, Andrzej Skladanowski and Annette K. Larsen

  Molecular Pharmacology October 2004, 66 (4) 1035-1042; DOI: https://doi.org/10.1124/mol.104.000703
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  Differential Mechanisms of Nitric Oxide- and Peroxynitrite-Induced Cell Death

  Johanna T. A. Meij, Carole L. Haselton, Kristin L. Hillman, Dhanasekaran Muralikrishnan, Manuchair Ebadi and Lei Yu

  Molecular Pharmacology October 2004, 66 (4) 1043-1053; DOI: https://doi.org/10.1124/mol.104.001354
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  Sulfasalazine Down-Regulates the Expression of the Angiogenic Factors Platelet-Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase and Interleukin-8 in Human Monocytic-Macrophage THP1 and U937 Cells

  Michiel de Bruin, Godefridus J. Peters, Ruud Oerlemans, Yehuda G. Assaraf, Allan J. Masterson, Auke D. Adema, Ben A. C. Dijkmans, Herbert M. Pinedo and Gerrit Jansen

  Molecular Pharmacology October 2004, 66 (4) 1054-1060; DOI: https://doi.org/10.1124/mol.104.000315
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  Alkaloids Indolizidine 235B′, Quinolizidine 1-epi-207I, and the Tricyclic 205B are Potent and Selective Noncompetitive Inhibitors of Nicotinic Acetylcholine Receptors

  Hiroshi Tsuneki, Yueren You, Naoki Toyooka, Syota Kagawa, Soushi Kobayashi, Toshiyasu Sasaoka, Hideo Nemoto, Ikuko Kimura and John A. Dani

  Molecular Pharmacology October 2004, 66 (4) 1061-1069; DOI: https://doi.org/10.1124/mol.104.000729