Table of Contents

Articles

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  Transcriptional Response to Corticotropin-Releasing Factor in AtT-20 Cells

  Pieter J. Peeters, Hinrich W. Göhlmann, Ilse Van den Wyngaert, Sigrid M. Swagemakers, Luc Bijnens, Stefan U. Kass and Thomas Steckler

  Molecular Pharmacology November 2004, 66 (5) 1083-1092; DOI: https://doi.org/10.1124/mol.104.000950
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  A Common Antitussive Drug, Clobutinol, Precipitates the Long QT Syndrome 2

  Chloé Bellocq, Ronald Wilders, Jean-Jacques Schott, Bénédicte Louérat-Oriou, Pierre Boisseau, Hervé Le Marec, Denis Escande and Isabelle Baró

  Molecular Pharmacology November 2004, 66 (5) 1093-1102; DOI: https://doi.org/10.1124/mol.104.001065
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  Mapping of Maurotoxin Binding Sites on hKv1.2, hKv1.3, and hIKCa1 Channels

  Violeta Visan, Ziad Fajloun, Jean-Marc Sabatier and Stephan Grissmer

  Molecular Pharmacology November 2004, 66 (5) 1103-1112; DOI: https://doi.org/10.1124/mol.104.002774
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  An Investigation of the Neuroprotective Effects of Tetracycline Derivatives in Experimental Models of Retinal Cell Death

  Darryl C. Baptiste, Andrew T. E. Hartwick, Christine A. B. Jollimore, William H. Baldridge, Gail M. Seigel and Melanie E. M. Kelly

  Molecular Pharmacology November 2004, 66 (5) 1113-1122; DOI: https://doi.org/10.1124/mol.104.001081
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  Multiple Interactions between Transmembrane Helices Generate the Oligomeric α_1b-Adrenoceptor

  Juan J. Carrillo, Juan F. López-Giménez and Graeme Milligan

  Molecular Pharmacology November 2004, 66 (5) 1123-1137; DOI: https://doi.org/10.1124/mol.104.001586
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  Biological Activity of the G-Quadruplex Ligand RHPS4 (3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) Is Associated with Telomere Capping Alteration

  Carlo Leonetti, Sarah Amodei, Carmen D'Angelo, Angela Rizzo, Barbara Benassi, Anna Antonelli, Raffaella Elli, Malcolm F. G. Stevens, Maurizio D'Incalci, Gabriella Zupi and Annamaria Biroccio

  Molecular Pharmacology November 2004, 66 (5) 1138-1146; DOI: https://doi.org/10.1124/mol.104.001537
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  Specific Inhibition of Nuclear Factor-κB–Dependent Inflammatory Responses by Cell Type-Specific Mechanisms upon A_2A Adenosine Receptor Gene Transfer

  William A. Sands, Anthony F. Martin, Elaine W. Strong and Timothy M. Palmer

  Molecular Pharmacology November 2004, 66 (5) 1147-1159; DOI: https://doi.org/10.1124/mol.104.001107
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  Targeting Ischemic Stroke with a Novel Opener of ATP-Sensitive Potassium Channels in the Brain

  Hai Wang, Ying-li Zhang, Xing-Chun Tang, Hua-Song Feng and Gang Hu

  Molecular Pharmacology November 2004, 66 (5) 1160-1168; DOI: https://doi.org/10.1124/mol.104.003178
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  A Three-Dimensional Model for the Substrate Binding Domain of the Multidrug ATP Binding Cassette Transporter LmrA

  Gerhard F. Ecker, Karin Pleban, Stephan Kopp, Edina Csaszar, Gerrit J. Poelarends, Monique Putman, Dominik Kaiser, Wil N. Konings and Peter Chiba

  Molecular Pharmacology November 2004, 66 (5) 1169-1179; DOI: https://doi.org/10.1124/mol.104.001420
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  The Catecholamine Release-Inhibitory “Catestatin” Fragment of Chromogranin A: Naturally Occurring Human Variants with Different Potencies for Multiple Chromaffin Cell Nicotinic Cholinergic Responses

  Sushil K. Mahata, Manjula Mahata, Gen Wen, William B. Wong, Nitish R. Mahapatra, Bruce A. Hamilton and Daniel T. O'Connor

  Molecular Pharmacology November 2004, 66 (5) 1180-1191; DOI: https://doi.org/10.1124/mol.104.002139
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  A Model of Inverse Agonist Action at Thyrotropin-Releasing Hormone Receptor Type 1: Role of a Conserved Tryptophan in Helix 6

  Xinping Lu, Wei Huang, Sharon Worthington, Piotr Drabik, Roman Osman and Marvin C. Gershengorn

  Molecular Pharmacology November 2004, 66 (5) 1192-1200; DOI: https://doi.org/10.1124/mol.104.000349
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  The Low-Potency, Voltage-Dependent HERG Blocker Propafenone—Molecular Determinants and Drug Trapping

  Harry J. Witchel, Christopher E. Dempsey, Richard B. Sessions, Matthew Perry, James T. Milnes, Jules C. Hancox and John S. Mitcheson

  Molecular Pharmacology November 2004, 66 (5) 1201-1212; DOI: https://doi.org/10.1124/mol.104.001743
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  A Novel Nonpeptide Ligand for Formyl Peptide Receptor-Like 1

  Masakatsu Nanamori, Xiyuan Cheng, Jianghua Mei, Hairong Sang, Yunxia Xuan, Caihong Zhou, Ming-Wei Wang and Richard D. Ye

  Molecular Pharmacology November 2004, 66 (5) 1213-1222; DOI: https://doi.org/10.1124/mol.104.004309
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  5β-Reduced Neuroactive Steroids Are Novel Voltage-Dependent Blockers of T-Type Ca²⁺ Channels in Rat Sensory Neurons in Vitro and Potent Peripheral Analgesics in Vivo

  Slobodan M. Todorovic, Sriyani Pathirathna, Barbara C. Brimelow, Miljen M. Jagodic, Seong-Hoon Ko, Xin Jiang, Kent R. Nilsson, Charles F. Zorumski, Douglas F. Covey and Vesna Jevtovic-Todorovic

  Molecular Pharmacology November 2004, 66 (5) 1223-1235; DOI: https://doi.org/10.1124/mol.104.002402
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  Molecular Determinants of Frequency Dependence and Ca²⁺ Potentiation of Verapamil Block in the Pore Region of Ca_v1.2

  Nejmi Dilmac, Nathan Hilliard and Gregory H. Hockerman

  Molecular Pharmacology November 2004, 66 (5) 1236-1247; DOI: https://doi.org/10.1124/mol.104.000893
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  Molecular Dissection of the Butyrate Action Revealed the Involvement of Mitogen-Activated Protein Kinase in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis

  Makoto Sugita, Hiroyasu Kongo and Yoshiki Shiba

  Molecular Pharmacology November 2004, 66 (5) 1248-1259; DOI: https://doi.org/10.1124/mol.104.001008
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  RNA Interference Suggests a Primary Role for Monoacylglycerol Lipase in the Degradation of the Endocannabinoid 2-Arachidonoylglycerol

  Thien P. Dinh, Satish Kathuria and Daniele Piomelli

  Molecular Pharmacology November 2004, 66 (5) 1260-1264; DOI: https://doi.org/10.1124/mol.104.002071
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  Cloning, Up-Regulation, and Mitogenic Role of Porcine P2Y₂ Receptor in Coronary Artery Smooth Muscle Cells

  Jianzhong Shen, Cheikh I. Seye, Meifang Wang, Gary A. Weisman, Peter A. Wilden and Michael Sturek

  Molecular Pharmacology November 2004, 66 (5) 1265-1274; DOI: https://doi.org/10.1124/mol.104.002642
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  Long-Term Administration of Δ⁹-Tetrahydrocannabinol Desensitizes CB₁-, Adenosine A₁-, and GABA_B-Mediated Inhibition of Adenylyl Cyclase in Mouse Cerebellum

  Dana E. Selley, Michael P. Cassidy, Billy R. Martin and Laura J. Sim-Selley

  Molecular Pharmacology November 2004, 66 (5) 1275-1284; DOI: https://doi.org/10.1124/mol.104.000604
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  Role of mPKCI, a Novel μ-Opioid Receptor Interactive Protein, in Receptor Desensitization, Phosphorylation, and Morphine-Induced Analgesia

  Wei Guang, Hongyan Wang, Tao Su, I. Bernard Weinstein and Jia Bei Wang

  Molecular Pharmacology November 2004, 66 (5) 1285-1292; DOI: https://doi.org/10.1124/mol.66.5.1285
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  His452Tyr Polymorphism in the Human 5-HT_2A Receptor Destabilizes the Signaling Conformation

  Lisa A. Hazelwood and Elaine Sanders-Bush

  Molecular Pharmacology November 2004, 66 (5) 1293-1300; DOI: https://doi.org/10.1124/mol.66.5.1293
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  p53 Elevation in Relation to Levels and Cytotoxicity of Mono- and Bifunctional Melphalan-DNA Adducts

  Katherine A. Gould, Cally Nixon and Michael J. Tilby

  Molecular Pharmacology November 2004, 66 (5) 1301-1309; DOI: https://doi.org/10.1124/mol.104.000596
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  Kinin B₁ Receptors Stimulate Nitric Oxide Production in Endothelial Cells: Signaling Pathways Activated by Angiotensin I-Converting Enzyme Inhibitors and Peptide Ligands

  Tatjana Ignjatovic, Sinisa Stanisavljevic, Viktor Brovkovych, Randal A. Skidgel and Ervin G. Erdos

  Molecular Pharmacology November 2004, 66 (5) 1310-1316; DOI: https://doi.org/10.1124/mol.104.001990
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  RNF4 Is a Coactivator for Nuclear Factor Y on GTP Cyclohydrolase I Proximal Promoter

  Sheng-Ming Wu, Wen-Chih Kuo, Wuh-Liang Hwu, Kuo-Yuan Hwa, Roberto Mantovani and Yu-May Lee

  Molecular Pharmacology November 2004, 66 (5) 1317-1324; DOI: https://doi.org/10.1124/mol.66.5.1317
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  Reciprocal Signaling between the Transcriptional Co-Factor Eya2 and Specific Members of the Gαi Family

  Alan C. Embry, Jennifer L. Glick, Maurine E. Linder and Patrick J. Casey

  Molecular Pharmacology November 2004, 66 (5) 1325-1331; DOI: https://doi.org/10.1124/mol.104.004093
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  Modulation of Cellular Cholesterol Alters P-Glycoprotein Activity in Multidrug-Resistant Cells

  Joachim Troost, Heike Lindenmaier, Walter Emil Haefeli and Johanna Weiss

  Molecular Pharmacology November 2004, 66 (5) 1332-1339; DOI: https://doi.org/10.1124/mol.104.002329
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  The Involvement of PTEN in Sleep Deprivation-Induced Memory Impairment in Rats

  Chun-Lin Su, Chun-Hung Chen, Hsin-Yi Lu and Po-Wu Gean

  Molecular Pharmacology November 2004, 66 (5) 1340-1348; DOI: https://doi.org/10.1124/mol.104.001156
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  Protein Thiol Modification by 15-deoxy-Δ^12,14-Prostaglandin J₂ Addition in Mesangial Cells: Role in the Inhibition of Pro-inflammatory Genes

  Francisco J. Sánchez-Gómez, Eva Cernuda-Morollón, Konstantinos Stamatakis and Dolores Pérez-Sala

  Molecular Pharmacology November 2004, 66 (5) 1349-1358; DOI: https://doi.org/10.1124/mol.104.002824
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  Correction to “Maitotoxin induces biphasic interleukin-1β secretion and membrane blebbing in murine macrophages”

  Molecular Pharmacology November 2004, 66 (5) 1359; DOI: https://doi.org/10.1124/mol.66.5.1359