Table of Contents

Articles

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  Oxidative Stress and Mitochondrial Aldehyde Dehydrogenase Activity: A Comparison of Pentaerythritol Tetranitrate with Other Organic Nitrates

  Andreas Daiber, Matthias Oelze, Meike Coldewey, Markus Bachschmid, Philip Wenzel, Karsten Sydow, Maria Wendt, Andrei L. Kleschyov, Dirk Stalleicken, Volker Ullrich, Alexander Mülsch and Thomas Münzel

  Molecular Pharmacology December 2004, 66 (6) 1372-1382; DOI: https://doi.org/10.1124/mol.104.002600
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  Critical Role of Reactive Oxygen Species and Mitochondrial Membrane Potential in Korean Mistletoe Lectin-Induced Apoptosis in Human Hepatocarcinoma Cells

  Won-Ho Kim, Won Bong Park, Bin Gao and Myeong Ho Jung

  Molecular Pharmacology December 2004, 66 (6) 1383-1396; DOI: https://doi.org/10.1124/mol.104.001347
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  Analysis of ATP-Binding Cassette Transporter Expression in Drug-Selected Cell Lines by a Microarray Dedicated to Multidrug Resistance

  Jean-Philippe Annereau, Gergely Szakács, Charles J. Tucker, Angela Arciello, Carol Cardarelli, Jennifer Collins, Sherry Grissom, Barry R. Zeeberg, William Reinhold, John N. Weinstein, Yves Pommier, Richard S. Paules and Michael M. Gottesman

  Molecular Pharmacology December 2004, 66 (6) 1397-1405; DOI: https://doi.org/10.1124/mol.104.005009
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  Ligand Binding and Kinetics of Folate Receptor Recycling in Vivo: Impact on Receptor-Mediated Drug Delivery

  Chrystal M. Paulos, Joseph A. Reddy, Christopher P. Leamon, Mary Jo Turk and Philip S. Low

  Molecular Pharmacology December 2004, 66 (6) 1406-1414; DOI: https://doi.org/10.1124/mol.104.003723
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  Doxorubicin Inhibits DNMT1, Resulting in Conditional Apoptosis

  Tomoki Yokochi and Keith D. Robertson

  Molecular Pharmacology December 2004, 66 (6) 1415-1420; DOI: https://doi.org/10.1124/mol.104.002634
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  Low-Affinity Neurotensin Receptor (NTS2) Signaling: Internalization-Dependent Activation of Extracellular Signal-Regulated Kinases 1/2

  Louis Gendron, Amélie Perron, Marcel Daniel Payet, Nicole Gallo-Payet, Philippe Sarret and Alain Beaudet

  Molecular Pharmacology December 2004, 66 (6) 1421-1430; DOI: https://doi.org/10.1124/mol.104.002303
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  Viral Macrophage Inflammatory Protein-II and Fractalkine (CX3CL1) Chimeras Identify Molecular Determinants of Affinity, Efficacy, and Selectivity at CX3CR1

  Christopher N. Davis, Violetta Zujovic and Jeffrey K. Harrison

  Molecular Pharmacology December 2004, 66 (6) 1431-1439; DOI: https://doi.org/10.1124/mol.104.003277
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  Overlapping Transcriptional Programs Regulated by the Nuclear Receptors Peroxisome Proliferator-Activated Receptor α, Retinoid X Receptor, and Liver X Receptor in Mouse Liver

  Steven P. Anderson, Corrie Dunn, Ashley Laughter, Lawrence Yoon, Cynthia Swanson, Thomas M. Stulnig, Knut R. Steffensen, Roshantha A.S. Chandraratna, Jan-Åke Gustafsson and J. Christopher Corton

  Molecular Pharmacology December 2004, 66 (6) 1440-1452; DOI: https://doi.org/10.1124/mol.104.005496
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  Single-Cell Imaging of Intracellular Ca²⁺ and Phospholipase C Activity Reveals That RGS 2, 3, and 4 Differentially Regulate Signaling via the Gα_q/11-Linked Muscarinic M₃ Receptor

  Stephen C. Tovey and Gary B. Willars

  Molecular Pharmacology December 2004, 66 (6) 1453-1464; DOI: https://doi.org/10.1124/mol.104.005827
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  Induction of Cyclooxygenase-2 Overexpression in Human Gastric Epithelial Cells by Helicobacter pylori Involves TLR2/TLR9 and c-Src-Dependent Nuclear Factor-κB Activation

  Ya Jen Chang, Ming Shiang Wu, Jaw Town Lin, Bor Shyang Sheu, Tatsushi Muta, Hiroyasu Inoue and Ching-Chow Chen

  Molecular Pharmacology December 2004, 66 (6) 1465-1477; DOI: https://doi.org/10.1124/mol.104.005199
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  Evidence That Mitogen-Activated Protein Kinase Phosphatase-1 Induction by Proteasome Inhibitors Plays an Antiapoptotic Role

  George W. Small, Yue Y. Shi, Natalie A. Edmund, Sivagurunathan Somasundaram, Dominic T. Moore and Robert Z. Orlowski

  Molecular Pharmacology December 2004, 66 (6) 1478-1490; DOI: https://doi.org/10.1124/mol.104.003400
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  Certain 1,4-Disubstituted Aromatic Piperidines and Piperazines with Extreme Selectivity for the Dopamine D4 Receptor Interact with a Common Receptor Microdomain

  Sandhya Kortagere, Peter Gmeiner, Harel Weinstein and John A. Schetz

  Molecular Pharmacology December 2004, 66 (6) 1491-1499; DOI: https://doi.org/10.1124/mol.104.001321
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  Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked Dopamine Receptor in Rat Brain

  Xuechu Zhen, Satindra Goswami, Syed Amir Abdali, Mara Gil, Kalindi Bakshi and Eitan Friedman

  Molecular Pharmacology December 2004, 66 (6) 1500-1507; DOI: https://doi.org/10.1124/mol.104.002279
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  Gαz Inhibits Serum Response Factor-Dependent Transcription by Inhibiting Rho Signaling

  Parmesh Dutt, Aron B. Jaffe, Keith D. Merdek, Alan Hall and Deniz Toksoz

  Molecular Pharmacology December 2004, 66 (6) 1508-1516; DOI: https://doi.org/10.1124/mol.104.002949
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  Multiple Actions of Propofol on αβγ and αβδ GABA_A Receptors

  Hua-Jun Feng and Robert L. Macdonald

  Molecular Pharmacology December 2004, 66 (6) 1517-1524; DOI: https://doi.org/10.1124/mol.104.003426
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  Selective Modulation of Ligand-Gated P2X Purinoceptor Channels by Acute Hypoxia Is Mediated by Reactive Oxygen Species

  H. S. Mason, S. Bourke and P. J. Kemp

  Molecular Pharmacology December 2004, 66 (6) 1525-1535; DOI: https://doi.org/10.1124/mol.104.000851
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  Impaired CREB-1 Phosphorylation in Antifolate-Resistant Cell Lines with Down-Regulation of the Reduced Folate Carrier Gene

  Lilah Rothem, Michal Stark and Yehuda G. Assaraf

  Molecular Pharmacology December 2004, 66 (6) 1536-1543; DOI: https://doi.org/10.1124/mol.104.004135
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  Signaling and Ligand Binding by Recombinant Neuromedin U Receptors: Evidence for Dual Coupling to Gα_q/11 and Gα_i and an Irreversible Ligand-Receptor Interaction

  Paul J. Brighton, Philip G. Szekeres, Alan Wise and Gary B. Willars

  Molecular Pharmacology December 2004, 66 (6) 1544-1556; DOI: https://doi.org/10.1124/mol.104.002337
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  A Novel Computational Approach for the Prediction of Networked Transcription Factors of Aryl Hydrocarbon-Receptor-Regulated Genes

  Alexander Kel, Susanne Reymann, Volker Matys, Paul Nettesheim, Edgar Wingender and Jürgen Borlak

  Molecular Pharmacology December 2004, 66 (6) 1557-1572; DOI: https://doi.org/10.1124/mol.104.001677
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  Mechanisms of Agonist Action at D₂ Dopamine Receptors

  David J. Roberts, Hong Lin and Philip G. Strange

  Molecular Pharmacology December 2004, 66 (6) 1573-1579; DOI: https://doi.org/10.1124/mol.104.004077
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  Differential Expression of μ-Opioid Receptor Gene in CXBK and B6 Mice by Sp1

  Po-Wei Lee, Sally Wu and Yu-May Lee

  Molecular Pharmacology December 2004, 66 (6) 1580-1584; DOI: https://doi.org/10.1124/mol.66.6.1580
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  Protocols for Regulation and Study of Diphosphoinositol Polyphosphates

  S. T. Safrany

  Molecular Pharmacology December 2004, 66 (6) 1585-1591; DOI: https://doi.org/10.1124/mol.104.002667
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  Protein Kinase C Activation Enhances Morphine-Induced Rapid Desensitization of μ-Opioid Receptors in Mature Rat Locus Ceruleus Neurons

  Christopher P. Bailey, Eamonn Kelly and Graeme Henderson

  Molecular Pharmacology December 2004, 66 (6) 1592-1598; DOI: https://doi.org/10.1124/mol.104.004747
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  Suppression of Pathogenicity of Porphyromonas gingivalis by Newly Developed Gingipain Inhibitors

  Tomoko Kadowaki, Atsuyo Baba, Naoko Abe, Ryosuke Takii, Munetaka Hashimoto, Takayuki Tsukuba, Shinji Okazaki, Yoshimitsu Suda, Tetsuji Asao and Kenji Yamamoto

  Molecular Pharmacology December 2004, 66 (6) 1599-1606; DOI: https://doi.org/10.1124/mol.104.004366
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  Enhancement of Cardiac L-Type Ca²⁺ Currents in Transgenic Mice with Cardiac-Specific Overexpression of CYP2J2

  Yong-Fu Xiao, Qingen Ke, John M. Seubert, J. Alyce Bradbury, Joan Graves, Laura M. DeGraff, John R. Falck, Kris Krausz, Harry V. Gelboin, James P. Morgan and Darryl C. Zeldin

  Molecular Pharmacology December 2004, 66 (6) 1607-1616; DOI: https://doi.org/10.1124/mol.104.004150
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  Using Molecular Tools to Dissect the Role of Gα_s in Sensitization of AC1

  Timothy A. Vortherms, Chau H. Nguyen, Catherine H. Berlot and Val J. Watts

  Molecular Pharmacology December 2004, 66 (6) 1617-1624; DOI: https://doi.org/10.1124/mol.104.000166
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  Alterations in Receptor Expression or Agonist Concentration Change the Pathways Gastrin-Releasing Peptide Receptor Uses to Regulate Extracellular Signal-Regulated Kinase

  Pei-Wen Chen and Glenn S. Kroog

  Molecular Pharmacology December 2004, 66 (6) 1625-1634; DOI: https://doi.org/10.1124/mol.104.001206
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  Preferential Interaction between the Dopamine D2 Receptor and Arrestin2 in Neostriatal Neurons

  Tara A. Macey, Vsevolod V. Gurevich and Kim A. Neve

  Molecular Pharmacology December 2004, 66 (6) 1635-1642; DOI: https://doi.org/10.1124/mol.104.001495
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  Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells

  Burkhard Hinz, Robert Ramer, Karin Eichele, Ulrike Weinzierl and Kay Brune

  Molecular Pharmacology December 2004, 66 (6) 1643-1651; DOI: https://doi.org/10.1124/mol.104.002618
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  State-Dependent Mibefradil Block of Na⁺ Channels

  Megan M. McNulty and Dorothy A. Hanck

  Molecular Pharmacology December 2004, 66 (6) 1652-1661; DOI: https://doi.org/10.1124/mol.66.6.1652
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  2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Suppressor of Cytokine Signaling 2 in Murine B Cells

  Darrell R. Boverhof, Elaine Tam, Allison S. Harney, Robert B. Crawford, Norbert E. Kaminski and Timothy R. Zacharewski

  Molecular Pharmacology December 2004, 66 (6) 1662-1670; DOI: https://doi.org/10.1124/mol.104.002915
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  Specificity of the Dihydroceramide Desaturase Inhibitor N-[(1R,2S)-2-Hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in Primary Cultured Cerebellar Neurons

  Gemma Triola, Gemma Fabrias, Mihaela Dragusin, Lars Niederhausen, Roland Broere, Amadeu Llebaria and Gerhild van Echten-Deckert

  Molecular Pharmacology December 2004, 66 (6) 1671-1678; DOI: https://doi.org/10.1124/mol.104.003681
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  Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8⁺ T-Lymphocytes

  Susan J. Smith, Lenora B. Cieslinski, Robert Newton, Louise E. Donnelly, Peter S. Fenwick, Andrew G. Nicholson, Peter J. Barnes, Mary S. Barnette and Mark A. Giembycz

  Molecular Pharmacology December 2004, 66 (6) 1679-1689; DOI: https://doi.org/10.1124/mol.104.002246
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  The Human Sulfotransferase SULT1A1 Gene Is Regulated in a Synergistic Manner by Sp1 and GA Binding Protein

  Nadine Hempel, Hongbing Wang, Edward L. LeCluyse, Michael E. McManus and Masahiko Negishi

  Molecular Pharmacology December 2004, 66 (6) 1690-1701; DOI: https://doi.org/10.1124/mol.104.003350
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  Tibolone Is Metabolized by the 3α/3β-Hydroxysteroid Dehydrogenase Activities of the Four Human Isozymes of the Aldo-Keto Reductase 1C Subfamily: Inversion of Stereospecificity with a Δ⁵⁽¹⁰⁾-3-Ketosteroid

  Stephan Steckelbroeck, Yi Jin, Busola Oyesanmi, Helenius J. Kloosterboer and Trevor M. Penning

  Molecular Pharmacology December 2004, 66 (6) 1702-1711; DOI: https://doi.org/10.1124/mol.104.004515
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  Long-Term Exposure to Nicotine Modulates the Level and Activity of Acetylcholine Receptors in White Blood Cells of Smokers and Model Mice

  Anne Cormier, Yoav Paas, Roland Zini, Jean-Paul Tillement, Gilbert Lagrue, Jean-Pierre Changeux and Régis Grailhe

  Molecular Pharmacology December 2004, 66 (6) 1712-1718; DOI: https://doi.org/10.1124/mol.104.000463
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  Transcriptional Regulation of the Human μ-Opioid Receptor Gene by Interleukin-6

  Christine Börner, Jürgen Kraus, Helmut Schröder, Hermann Ammer and Volker Höllt

  Molecular Pharmacology December 2004, 66 (6) 1719-1726; DOI: https://doi.org/10.1124/mol.104.003806
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  A Retinoic Acid Receptor β/γ-Selective Prodrug (tazarotene) Plus a Retinoid X Receptor Ligand Induces Extracellular Signal-Regulated Kinase Activation, Retinoblastoma Hypophosphorylation, G₀ Arrest, and Cell Differentiation

  Andrew Yen, Robert Fenning, Roshantha Chandraratna, Patricia Walker and Susi Varvayanis

  Molecular Pharmacology December 2004, 66 (6) 1727-1737; DOI: https://doi.org/10.1124/mol.104.003475
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  Divergent Effects of the Purinoceptor Antagonists Suramin and Pyridoxal-5′-phosphate-6-(2′-naphthylazo-6′-nitro-4′,8′-disulfonate) (PPNDS) on α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors

  Erika Suzuki, Markus Kessler, Kyle Montgomery and Amy C. Arai

  Molecular Pharmacology December 2004, 66 (6) 1738-1747; DOI: https://doi.org/10.1124/mol.104.003038