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Molecular Pharmacology

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Table of Contents

December 01, 2004; Volume 66,Issue 6

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    Designing Transcription Factor Architectures for Drug Discovery
    Pilar Blancafort, David J. Segal and Carlos F. Barbas
    Molecular Pharmacology December 2004, 66 (6) 1361-1371; DOI: https://doi.org/10.1124/mol.104.002758

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    Oxidative Stress and Mitochondrial Aldehyde Dehydrogenase Activity: A Comparison of Pentaerythritol Tetranitrate with Other Organic Nitrates
    Andreas Daiber, Matthias Oelze, Meike Coldewey, Markus Bachschmid, Philip Wenzel, Karsten Sydow, Maria Wendt, Andrei L. Kleschyov, Dirk Stalleicken, Volker Ullrich, Alexander Mülsch and Thomas Münzel
    Molecular Pharmacology December 2004, 66 (6) 1372-1382; DOI: https://doi.org/10.1124/mol.104.002600
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    Critical Role of Reactive Oxygen Species and Mitochondrial Membrane Potential in Korean Mistletoe Lectin-Induced Apoptosis in Human Hepatocarcinoma Cells
    Won-Ho Kim, Won Bong Park, Bin Gao and Myeong Ho Jung
    Molecular Pharmacology December 2004, 66 (6) 1383-1396; DOI: https://doi.org/10.1124/mol.104.001347
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    Analysis of ATP-Binding Cassette Transporter Expression in Drug-Selected Cell Lines by a Microarray Dedicated to Multidrug Resistance
    Jean-Philippe Annereau, Gergely Szakács, Charles J. Tucker, Angela Arciello, Carol Cardarelli, Jennifer Collins, Sherry Grissom, Barry R. Zeeberg, William Reinhold, John N. Weinstein, Yves Pommier, Richard S. Paules and Michael M. Gottesman
    Molecular Pharmacology December 2004, 66 (6) 1397-1405; DOI: https://doi.org/10.1124/mol.104.005009
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    Ligand Binding and Kinetics of Folate Receptor Recycling in Vivo: Impact on Receptor-Mediated Drug Delivery
    Chrystal M. Paulos, Joseph A. Reddy, Christopher P. Leamon, Mary Jo Turk and Philip S. Low
    Molecular Pharmacology December 2004, 66 (6) 1406-1414; DOI: https://doi.org/10.1124/mol.104.003723
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    Doxorubicin Inhibits DNMT1, Resulting in Conditional Apoptosis
    Tomoki Yokochi and Keith D. Robertson
    Molecular Pharmacology December 2004, 66 (6) 1415-1420; DOI: https://doi.org/10.1124/mol.104.002634
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    Low-Affinity Neurotensin Receptor (NTS2) Signaling: Internalization-Dependent Activation of Extracellular Signal-Regulated Kinases 1/2
    Louis Gendron, Amélie Perron, Marcel Daniel Payet, Nicole Gallo-Payet, Philippe Sarret and Alain Beaudet
    Molecular Pharmacology December 2004, 66 (6) 1421-1430; DOI: https://doi.org/10.1124/mol.104.002303
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    Viral Macrophage Inflammatory Protein-II and Fractalkine (CX3CL1) Chimeras Identify Molecular Determinants of Affinity, Efficacy, and Selectivity at CX3CR1
    Christopher N. Davis, Violetta Zujovic and Jeffrey K. Harrison
    Molecular Pharmacology December 2004, 66 (6) 1431-1439; DOI: https://doi.org/10.1124/mol.104.003277
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    Overlapping Transcriptional Programs Regulated by the Nuclear Receptors Peroxisome Proliferator-Activated Receptor α, Retinoid X Receptor, and Liver X Receptor in Mouse Liver
    Steven P. Anderson, Corrie Dunn, Ashley Laughter, Lawrence Yoon, Cynthia Swanson, Thomas M. Stulnig, Knut R. Steffensen, Roshantha A.S. Chandraratna, Jan-Åke Gustafsson and J. Christopher Corton
    Molecular Pharmacology December 2004, 66 (6) 1440-1452; DOI: https://doi.org/10.1124/mol.104.005496
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    Single-Cell Imaging of Intracellular Ca2+ and Phospholipase C Activity Reveals That RGS 2, 3, and 4 Differentially Regulate Signaling via the Gαq/11-Linked Muscarinic M3 Receptor
    Stephen C. Tovey and Gary B. Willars
    Molecular Pharmacology December 2004, 66 (6) 1453-1464; DOI: https://doi.org/10.1124/mol.104.005827
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    Induction of Cyclooxygenase-2 Overexpression in Human Gastric Epithelial Cells by Helicobacter pylori Involves TLR2/TLR9 and c-Src-Dependent Nuclear Factor-κB Activation
    Ya Jen Chang, Ming Shiang Wu, Jaw Town Lin, Bor Shyang Sheu, Tatsushi Muta, Hiroyasu Inoue and Ching-Chow Chen
    Molecular Pharmacology December 2004, 66 (6) 1465-1477; DOI: https://doi.org/10.1124/mol.104.005199
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    Evidence That Mitogen-Activated Protein Kinase Phosphatase-1 Induction by Proteasome Inhibitors Plays an Antiapoptotic Role
    George W. Small, Yue Y. Shi, Natalie A. Edmund, Sivagurunathan Somasundaram, Dominic T. Moore and Robert Z. Orlowski
    Molecular Pharmacology December 2004, 66 (6) 1478-1490; DOI: https://doi.org/10.1124/mol.104.003400
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    Certain 1,4-Disubstituted Aromatic Piperidines and Piperazines with Extreme Selectivity for the Dopamine D4 Receptor Interact with a Common Receptor Microdomain
    Sandhya Kortagere, Peter Gmeiner, Harel Weinstein and John A. Schetz
    Molecular Pharmacology December 2004, 66 (6) 1491-1499; DOI: https://doi.org/10.1124/mol.104.001321
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    Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked Dopamine Receptor in Rat Brain
    Xuechu Zhen, Satindra Goswami, Syed Amir Abdali, Mara Gil, Kalindi Bakshi and Eitan Friedman
    Molecular Pharmacology December 2004, 66 (6) 1500-1507; DOI: https://doi.org/10.1124/mol.104.002279
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    Gαz Inhibits Serum Response Factor-Dependent Transcription by Inhibiting Rho Signaling
    Parmesh Dutt, Aron B. Jaffe, Keith D. Merdek, Alan Hall and Deniz Toksoz
    Molecular Pharmacology December 2004, 66 (6) 1508-1516; DOI: https://doi.org/10.1124/mol.104.002949
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    Multiple Actions of Propofol on αβγ and αβδ GABAA Receptors
    Hua-Jun Feng and Robert L. Macdonald
    Molecular Pharmacology December 2004, 66 (6) 1517-1524; DOI: https://doi.org/10.1124/mol.104.003426
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    Selective Modulation of Ligand-Gated P2X Purinoceptor Channels by Acute Hypoxia Is Mediated by Reactive Oxygen Species
    H. S. Mason, S. Bourke and P. J. Kemp
    Molecular Pharmacology December 2004, 66 (6) 1525-1535; DOI: https://doi.org/10.1124/mol.104.000851
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    Impaired CREB-1 Phosphorylation in Antifolate-Resistant Cell Lines with Down-Regulation of the Reduced Folate Carrier Gene
    Lilah Rothem, Michal Stark and Yehuda G. Assaraf
    Molecular Pharmacology December 2004, 66 (6) 1536-1543; DOI: https://doi.org/10.1124/mol.104.004135
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    Signaling and Ligand Binding by Recombinant Neuromedin U Receptors: Evidence for Dual Coupling to Gαq/11 and Gαi and an Irreversible Ligand-Receptor Interaction
    Paul J. Brighton, Philip G. Szekeres, Alan Wise and Gary B. Willars
    Molecular Pharmacology December 2004, 66 (6) 1544-1556; DOI: https://doi.org/10.1124/mol.104.002337
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    A Novel Computational Approach for the Prediction of Networked Transcription Factors of Aryl Hydrocarbon-Receptor-Regulated Genes
    Alexander Kel, Susanne Reymann, Volker Matys, Paul Nettesheim, Edgar Wingender and Jürgen Borlak
    Molecular Pharmacology December 2004, 66 (6) 1557-1572; DOI: https://doi.org/10.1124/mol.104.001677
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    Mechanisms of Agonist Action at D2 Dopamine Receptors
    David J. Roberts, Hong Lin and Philip G. Strange
    Molecular Pharmacology December 2004, 66 (6) 1573-1579; DOI: https://doi.org/10.1124/mol.104.004077
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    Differential Expression of μ-Opioid Receptor Gene in CXBK and B6 Mice by Sp1
    Po-Wei Lee, Sally Wu and Yu-May Lee
    Molecular Pharmacology December 2004, 66 (6) 1580-1584; DOI: https://doi.org/10.1124/mol.66.6.1580
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    Protocols for Regulation and Study of Diphosphoinositol Polyphosphates
    S. T. Safrany
    Molecular Pharmacology December 2004, 66 (6) 1585-1591; DOI: https://doi.org/10.1124/mol.104.002667
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    Protein Kinase C Activation Enhances Morphine-Induced Rapid Desensitization of μ-Opioid Receptors in Mature Rat Locus Ceruleus Neurons
    Christopher P. Bailey, Eamonn Kelly and Graeme Henderson
    Molecular Pharmacology December 2004, 66 (6) 1592-1598; DOI: https://doi.org/10.1124/mol.104.004747
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    Suppression of Pathogenicity of Porphyromonas gingivalis by Newly Developed Gingipain Inhibitors
    Tomoko Kadowaki, Atsuyo Baba, Naoko Abe, Ryosuke Takii, Munetaka Hashimoto, Takayuki Tsukuba, Shinji Okazaki, Yoshimitsu Suda, Tetsuji Asao and Kenji Yamamoto
    Molecular Pharmacology December 2004, 66 (6) 1599-1606; DOI: https://doi.org/10.1124/mol.104.004366
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    Enhancement of Cardiac L-Type Ca2+ Currents in Transgenic Mice with Cardiac-Specific Overexpression of CYP2J2
    Yong-Fu Xiao, Qingen Ke, John M. Seubert, J. Alyce Bradbury, Joan Graves, Laura M. DeGraff, John R. Falck, Kris Krausz, Harry V. Gelboin, James P. Morgan and Darryl C. Zeldin
    Molecular Pharmacology December 2004, 66 (6) 1607-1616; DOI: https://doi.org/10.1124/mol.104.004150
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    Using Molecular Tools to Dissect the Role of Gαs in Sensitization of AC1
    Timothy A. Vortherms, Chau H. Nguyen, Catherine H. Berlot and Val J. Watts
    Molecular Pharmacology December 2004, 66 (6) 1617-1624; DOI: https://doi.org/10.1124/mol.104.000166
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    Alterations in Receptor Expression or Agonist Concentration Change the Pathways Gastrin-Releasing Peptide Receptor Uses to Regulate Extracellular Signal-Regulated Kinase
    Pei-Wen Chen and Glenn S. Kroog
    Molecular Pharmacology December 2004, 66 (6) 1625-1634; DOI: https://doi.org/10.1124/mol.104.001206
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    Preferential Interaction between the Dopamine D2 Receptor and Arrestin2 in Neostriatal Neurons
    Tara A. Macey, Vsevolod V. Gurevich and Kim A. Neve
    Molecular Pharmacology December 2004, 66 (6) 1635-1642; DOI: https://doi.org/10.1124/mol.104.001495
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    Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells
    Burkhard Hinz, Robert Ramer, Karin Eichele, Ulrike Weinzierl and Kay Brune
    Molecular Pharmacology December 2004, 66 (6) 1643-1651; DOI: https://doi.org/10.1124/mol.104.002618
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    State-Dependent Mibefradil Block of Na+ Channels
    Megan M. McNulty and Dorothy A. Hanck
    Molecular Pharmacology December 2004, 66 (6) 1652-1661; DOI: https://doi.org/10.1124/mol.66.6.1652
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    2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Suppressor of Cytokine Signaling 2 in Murine B Cells
    Darrell R. Boverhof, Elaine Tam, Allison S. Harney, Robert B. Crawford, Norbert E. Kaminski and Timothy R. Zacharewski
    Molecular Pharmacology December 2004, 66 (6) 1662-1670; DOI: https://doi.org/10.1124/mol.104.002915
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    Specificity of the Dihydroceramide Desaturase Inhibitor N-[(1R,2S)-2-Hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11) in Primary Cultured Cerebellar Neurons
    Gemma Triola, Gemma Fabrias, Mihaela Dragusin, Lars Niederhausen, Roland Broere, Amadeu Llebaria and Gerhild van Echten-Deckert
    Molecular Pharmacology December 2004, 66 (6) 1671-1678; DOI: https://doi.org/10.1124/mol.104.003681
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    Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes
    Susan J. Smith, Lenora B. Cieslinski, Robert Newton, Louise E. Donnelly, Peter S. Fenwick, Andrew G. Nicholson, Peter J. Barnes, Mary S. Barnette and Mark A. Giembycz
    Molecular Pharmacology December 2004, 66 (6) 1679-1689; DOI: https://doi.org/10.1124/mol.104.002246
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    The Human Sulfotransferase SULT1A1 Gene Is Regulated in a Synergistic Manner by Sp1 and GA Binding Protein
    Nadine Hempel, Hongbing Wang, Edward L. LeCluyse, Michael E. McManus and Masahiko Negishi
    Molecular Pharmacology December 2004, 66 (6) 1690-1701; DOI: https://doi.org/10.1124/mol.104.003350
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    Tibolone Is Metabolized by the 3α/3β-Hydroxysteroid Dehydrogenase Activities of the Four Human Isozymes of the Aldo-Keto Reductase 1C Subfamily: Inversion of Stereospecificity with a Δ5(10)-3-Ketosteroid
    Stephan Steckelbroeck, Yi Jin, Busola Oyesanmi, Helenius J. Kloosterboer and Trevor M. Penning
    Molecular Pharmacology December 2004, 66 (6) 1702-1711; DOI: https://doi.org/10.1124/mol.104.004515
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    Long-Term Exposure to Nicotine Modulates the Level and Activity of Acetylcholine Receptors in White Blood Cells of Smokers and Model Mice
    Anne Cormier, Yoav Paas, Roland Zini, Jean-Paul Tillement, Gilbert Lagrue, Jean-Pierre Changeux and Régis Grailhe
    Molecular Pharmacology December 2004, 66 (6) 1712-1718; DOI: https://doi.org/10.1124/mol.104.000463
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    Transcriptional Regulation of the Human μ-Opioid Receptor Gene by Interleukin-6
    Christine Börner, Jürgen Kraus, Helmut Schröder, Hermann Ammer and Volker Höllt
    Molecular Pharmacology December 2004, 66 (6) 1719-1726; DOI: https://doi.org/10.1124/mol.104.003806
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    A Retinoic Acid Receptor β/γ-Selective Prodrug (tazarotene) Plus a Retinoid X Receptor Ligand Induces Extracellular Signal-Regulated Kinase Activation, Retinoblastoma Hypophosphorylation, G0 Arrest, and Cell Differentiation
    Andrew Yen, Robert Fenning, Roshantha Chandraratna, Patricia Walker and Susi Varvayanis
    Molecular Pharmacology December 2004, 66 (6) 1727-1737; DOI: https://doi.org/10.1124/mol.104.003475
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    Divergent Effects of the Purinoceptor Antagonists Suramin and Pyridoxal-5′-phosphate-6-(2′-naphthylazo-6′-nitro-4′,8′-disulfonate) (PPNDS) on α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
    Erika Suzuki, Markus Kessler, Kyle Montgomery and Amy C. Arai
    Molecular Pharmacology December 2004, 66 (6) 1738-1747; DOI: https://doi.org/10.1124/mol.104.003038
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Molecular Pharmacology: 66 (6)
Molecular Pharmacology
Vol. 66, Issue 6
1 Dec 2004
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