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Research ArticleArticle

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes

Susan J. Smith, Lenora B. Cieslinski, Robert Newton, Louise E. Donnelly, Peter S. Fenwick, Andrew G. Nicholson, Peter J. Barnes, Mary S. Barnette and Mark A. Giembycz
Molecular Pharmacology December 2004, 66 (6) 1679-1689; DOI: https://doi.org/10.1124/mol.104.002246
Susan J. Smith
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Lenora B. Cieslinski
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Robert Newton
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Louise E. Donnelly
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Peter S. Fenwick
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Andrew G. Nicholson
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Peter J. Barnes
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Mary S. Barnette
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Mark A. Giembycz
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Article Information

vol. 66 no. 6 1679-1689
DOI 
https://doi.org/10.1124/mol.104.002246
PubMed 
15371556

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received May 5, 2004
  • Accepted September 14, 2004
  • Published online November 23, 2004.

Article Versions

  • Earlier version (September 15, 2004 - 12:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Susan J. Smith,
  2. Lenora B. Cieslinski,
  3. Robert Newton,
  4. Louise E. Donnelly,
  5. Peter S. Fenwick,
  6. Andrew G. Nicholson,
  7. Peter J. Barnes,
  8. Mary S. Barnette and
  9. Mark A. Giembycz
  1. Thoracic Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom (S.J.S., L.E.D., P.S.F., P.J.B.); Respiratory, Inflammation and Respiratory Pathogens Center for Excellence in Drug Discovery, GlaxoSmithKline, King of Prussia, Pennsylvania (L.B.C., M.S.B.); Department of Histopathology, Royal Brompton Hospital, London, United Kingdom (A.G.N.); and Departments of Cell Biology and Anatomy (R.N.) and Pharmacology and Therapeutics (M.A.G.), Respiratory Research Group, University of Calgary, Calgary, Alberta, Canada
  1. Address correspondence to:
    Dr. Mark A. Giembycz, Department of Pharmacology and Therapeutics, Respiratory Research Group, University of Calgary, 3330 Hospital Dr. NW, Calgary, AB, Canada T2N 4N1. E-mail: giembycz{at}ucalgary.ca
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Molecular Pharmacology: 66 (6)
Molecular Pharmacology
Vol. 66, Issue 6
1 Dec 2004
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Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes
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Research ArticleArticle

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes

Susan J. Smith, Lenora B. Cieslinski, Robert Newton, Louise E. Donnelly, Peter S. Fenwick, Andrew G. Nicholson, Peter J. Barnes, Mary S. Barnette and Mark A. Giembycz
Molecular Pharmacology December 1, 2004, 66 (6) 1679-1689; DOI: https://doi.org/10.1124/mol.104.002246

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Research ArticleArticle

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes

Susan J. Smith, Lenora B. Cieslinski, Robert Newton, Louise E. Donnelly, Peter S. Fenwick, Andrew G. Nicholson, Peter J. Barnes, Mary S. Barnette and Mark A. Giembycz
Molecular Pharmacology December 1, 2004, 66 (6) 1679-1689; DOI: https://doi.org/10.1124/mol.104.002246
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