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Research ArticleArticle

A Retinoic Acid Receptor β/γ-Selective Prodrug (tazarotene) Plus a Retinoid X Receptor Ligand Induces Extracellular Signal-Regulated Kinase Activation, Retinoblastoma Hypophosphorylation, G0 Arrest, and Cell Differentiation

Andrew Yen, Robert Fenning, Roshantha Chandraratna, Patricia Walker and Susi Varvayanis
Molecular Pharmacology December 2004, 66 (6) 1727-1737; DOI: https://doi.org/10.1124/mol.104.003475
Andrew Yen
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Robert Fenning
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Roshantha Chandraratna
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Patricia Walker
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Susi Varvayanis
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Article Information

vol. 66 no. 6 1727-1737
DOI 
https://doi.org/10.1124/mol.104.003475
PubMed 
15383624

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received June 14, 2004
  • Accepted September 20, 2004
  • Published online November 23, 2004.

Article Versions

  • Earlier version (September 21, 2004 - 12:51).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Andrew Yen,
  2. Robert Fenning,
  3. Roshantha Chandraratna,
  4. Patricia Walker and
  5. Susi Varvayanis
  1. Department of Biomedical Sciences, Cornell University, Ithaca, New York (A.Y., R.F., S.V.); and Allergan, Inc., Irvine, California (P.W., R.C.)
  1. Address correspondence to:
    Dr. Andrew Yen, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853. E-mail: ay13{at}cornell.edu
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Molecular Pharmacology: 66 (6)
Molecular Pharmacology
Vol. 66, Issue 6
1 Dec 2004
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Research ArticleArticle

A Retinoic Acid Receptor β/γ-Selective Prodrug (tazarotene) Plus a Retinoid X Receptor Ligand Induces Extracellular Signal-Regulated Kinase Activation, Retinoblastoma Hypophosphorylation, G0 Arrest, and Cell Differentiation

Andrew Yen, Robert Fenning, Roshantha Chandraratna, Patricia Walker and Susi Varvayanis
Molecular Pharmacology December 1, 2004, 66 (6) 1727-1737; DOI: https://doi.org/10.1124/mol.104.003475

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Research ArticleArticle

A Retinoic Acid Receptor β/γ-Selective Prodrug (tazarotene) Plus a Retinoid X Receptor Ligand Induces Extracellular Signal-Regulated Kinase Activation, Retinoblastoma Hypophosphorylation, G0 Arrest, and Cell Differentiation

Andrew Yen, Robert Fenning, Roshantha Chandraratna, Patricia Walker and Susi Varvayanis
Molecular Pharmacology December 1, 2004, 66 (6) 1727-1737; DOI: https://doi.org/10.1124/mol.104.003475
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