Table of Contents

ORIGINAL ARTICLE

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  Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein

  Seung Joon Baek, Jong-Sik Kim, Scott M. Moore, Seong-Ho Lee, Jeanelle Martinez and Thomas E. Eling

  Molecular Pharmacology February 2005, 67 (2) 356-364; DOI: https://doi.org/10.1124/mol.104.005108
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  P-Glycoprotein Substrate Binding Domains Are Located at the Transmembrane Domain/Transmembrane Domain Interfaces: A Combined Photoaffinity Labeling-Protein Homology Modeling Approach

  Karin Pleban, Stephan Kopp, Edina Csaszar, Michael Peer, Thomas Hrebicek, Andreas Rizzi, Gerhard F. Ecker and Peter Chiba

  Molecular Pharmacology February 2005, 67 (2) 365-374; DOI: https://doi.org/10.1124/mol.104.006973
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  Helix I of β-Arrestin Is Involved in Postendocytic Trafficking but Is Not Required for Membrane Translocation, Receptor Binding, and Internalization

  Diem T. Dinh, Hongwei Qian, Ruth Seeber, Esther Lim, Kevin Pfleger, Karin A. Eidne and Walter G. Thomas

  Molecular Pharmacology February 2005, 67 (2) 375-382; DOI: https://doi.org/10.1124/mol.104.004721
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  E-Ring 8-Isoprostanes Are Agonists at EP₂- and EP₄-Prostanoid Receptors on Human Airway Smooth Muscle Cells and Regulate the Release of Colony-Stimulating Factors by Activating cAMP-Dependent Protein Kinase

  Deborah L. Clarke, Maria G. Belvisi, Elizabeth Hardaker, Robert Newton and Mark A. Giembycz

  Molecular Pharmacology February 2005, 67 (2) 383-393; DOI: https://doi.org/10.1124/mol.104.006486
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  Examination of Human Tissue Cytosols for Expression of Sulfotransferase Isoform 1A2 (SULT1A2) Using a SULT1A2-Specific Antibody

  Susan Nowell, Bridgett Green, Yong Ming Tang, Rick Wiese and Fred F. Kadlubar

  Molecular Pharmacology February 2005, 67 (2) 394-399; DOI: https://doi.org/10.1124/mol.104.006171
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  Adenosine A_2A Receptor and Dopamine D₃ Receptor Interactions: Evidence of Functional A_2A/D₃ Heteromeric Complexes

  Maria Torvinen, Daniel Marcellino, Meritxell Canals, Luigi F. Agnati, Carmen Lluis, Rafael Franco and Kjell Fuxe

  Molecular Pharmacology February 2005, 67 (2) 400-407; DOI: https://doi.org/10.1124/mol.104.003376
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  Expression of Deoxynucleotide Carrier Is Not Associated with the Mitochondrial DNA Depletion Caused by Anti-HIV Dideoxynucleoside Analogs and Mitochondrial dNTP Uptake

  Wing Lam, ChinShing Chen, Shuolun Ruan, Chung-Hang Leung and Yung-Chi Cheng

  Molecular Pharmacology February 2005, 67 (2) 408-416; DOI: https://doi.org/10.1124/mol.104.007120
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  Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells

  Helen A. Seow, Michael F. Belcourt, Philip G. Penketh, William F. Hodnick, Maria Tomasz, Sara Rockwell and Alan C. Sartorelli

  Molecular Pharmacology February 2005, 67 (2) 417-423; DOI: https://doi.org/10.1124/mol.104.004929
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  A Multifunctional Aromatic Residue in the External Pore Vestibule of Na⁺ Channels Contributes to the Local Anesthetic Receptor

  Suk Ying Tsang, Robert G. Tsushima, Gordon F. Tomaselli, Ronald A. Li and Peter H. Backx

  Molecular Pharmacology February 2005, 67 (2) 424-434; DOI: https://doi.org/10.1124/mol.67.2.424
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  Proteasomal Degradation of Human CYP1B1: Effect of the Asn453Ser Polymorphism on the Post-Translational Regulation of CYP1B1 Expression

  Silvio Bandiera, Simone Weidlich, Volker Harth, Peter Broede, Yun Ko and Thomas Friedberg

  Molecular Pharmacology February 2005, 67 (2) 435-443; DOI: https://doi.org/10.1124/mol.104.006056
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  2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Insulin-Like Growth Factor Binding Protein-1 Gene Expression and Counteracts the Negative Effect of Insulin

  A. Marchand, C. Tomkiewicz, J.-P. Marchandeau, E. Boitier, R. Barouki and M. Garlatti

  Molecular Pharmacology February 2005, 67 (2) 444-452; DOI: https://doi.org/10.1124/mol.104.004010
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  Characterization of Binding of Folates and Antifolates to Brush-Border Membrane Vesicles Isolated from Human Kidney

  Vijaya L. Damaraju, Katherine F. Hamilton, Michelle L. Seth-Smith, Carol E. Cass and Michael B. Sawyer

  Molecular Pharmacology February 2005, 67 (2) 453-459; DOI: https://doi.org/10.1124/mol.104.004978
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  Evidence for Negative Binding Cooperativity within CCR5-CCR2b Heterodimers

  Laïla El-Asmar, Jean-Yves Springael, Sébastien Ballet, Eneko Urizar Andrieu, Gilbert Vassart and Marc Parmentier

  Molecular Pharmacology February 2005, 67 (2) 460-469; DOI: https://doi.org/10.1124/mol.104.003624
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  Picrotoxin Accelerates Relaxation of GABA_C Receptors

  Haohua Qian, Yi Pan, Yujie Zhu and Parham Khalili

  Molecular Pharmacology February 2005, 67 (2) 470-479; DOI: https://doi.org/10.1124/mol.104.003996
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  Kv2.1 Channel Activation and Inactivation Is Influenced by Physical Interactions of Both Syntaxin 1A and the Syntaxin 1A/Soluble N-Ethylmaleimide-Sensitive Factor-25 (t-SNARE) Complex with the C Terminus of the Channel

  Sharon Tsuk, Izhak Michaelevski, Geoffrey N. Bentley, Rolf H. Joho, Dodo Chikvashvili and Ilana Lotan

  Molecular Pharmacology February 2005, 67 (2) 480-488; DOI: https://doi.org/10.1124/mol.104.005314
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  Receptor-Independent Activation of GABAergic Neurotransmission and Receptor-Dependent Nontranscriptional Activation of Phosphatidylinositol 3-kinase/Protein Kinase Akt Pathway in Short-Term Cardiovascular Actions of Dexamethasone at the Nucleus Tractus Solitarii of the Rat

  Ling-Lin Wang, Chen-Chun Ou and Julie Y.H. Chan

  Molecular Pharmacology February 2005, 67 (2) 489-498; DOI: https://doi.org/10.1124/mol.104.005595
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  Steroidogenic Factor-1 Interacts with cAMP Response Element-Binding Protein to Mediate cAMP Stimulation of CYP1B1 via a Far Upstream Enhancer

  Wenchao Zheng and Colin R. Jefcoate

  Molecular Pharmacology February 2005, 67 (2) 499-512; DOI: https://doi.org/10.1124/mol.104.005504
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  Identification of Amino Acid Residues in the Insect Sodium Channel Critical for Pyrethroid Binding

  Jianguo Tan, Zhiqi Liu, Ruiwu Wang, Zachary Y. Huang, Andrew C. Chen, Michael Gurevitz and Ke Dong

  Molecular Pharmacology February 2005, 67 (2) 513-522; DOI: https://doi.org/10.1124/mol.104.006205
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  Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

  Smitha Antony, Glenda Kohlhagen, Keli Agama, Muthusamy Jayaraman, Shousong Cao, Farukh A. Durrani, Youcef M. Rustum, Mark Cushman and Yves Pommier

  Molecular Pharmacology February 2005, 67 (2) 523-530; DOI: https://doi.org/10.1124/mol.104.003889
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  Membrane Structure Modulation, Protein Kinase Cα Activation, and Anticancer Activity of Minerval

  Jordi Martínez, Oliver Vögler, Jesús Casas, Francisca Barceló, Regina Alemany, Jesús Prades, Tünde Nagy, Carmela Baamonde, Philip G. Kasprzyk, Silvia Terés, Carlos Saus and Pablo V. Escribá

  Molecular Pharmacology February 2005, 67 (2) 531-540; DOI: https://doi.org/10.1124/mol.104.000778
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  Inhibition of L-Type Ca_v1.2 Ca²⁺ Channels by 2,(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) Maleimide (Gö6983)

  A. Welling, F. Hofmann and J. W. Wegener

  Molecular Pharmacology February 2005, 67 (2) 541-544; DOI: https://doi.org/10.1124/mol.104.006049
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  Transport of Bile Acids, Sulfated Steroids, Estradiol 17-β-d-Glucuronide, and Leukotriene C4 by Human Multidrug Resistance Protein 8 (ABCC11)

  Zhe-Sheng Chen, Yanping Guo, Martin G. Belinsky, Elena Kotova and Gary D. Kruh

  Molecular Pharmacology February 2005, 67 (2) 545-557; DOI: https://doi.org/10.1124/mol.104.007138
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  Negative Regulation of TRPC3 Channels by Protein Kinase C-Mediated Phosphorylation of Serine 712

  Mohamed Trebak, Nadine Hempel, Barbara J. Wedel, Jeremy T. Smyth, Gary St. J. Bird and James W. Putney

  Molecular Pharmacology February 2005, 67 (2) 558-563; DOI: https://doi.org/10.1124/mol.104.007252
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  Isoform-Specific Regulation of Adenylyl Cyclase Function by Disruption of Membrane Trafficking

  Qingming Ding, Robert Gros, Jozef Chorazyczewski, Stephen S. G. Ferguson and Ross D. Feldman

  Molecular Pharmacology February 2005, 67 (2) 564-571; DOI: https://doi.org/10.1124/mol.104.006817
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  N3-Methyladenine Induces Early Poly(ADP-Ribosylation), Reduction of Nuclear Factor-κB DNA Binding Ability, and Nuclear Up-Regulation of Telomerase Activity

  Lucio Tentori, Olindo Forini, Emanuela Fossile, Alessia Muzi, Matteo Vergati, Ilaria Portarena, Carla Amici, Barry Gold and Grazia Graziani

  Molecular Pharmacology February 2005, 67 (2) 572-581; DOI: https://doi.org/10.1124/mol.104.004937