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Molecular Pharmacology

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Table of Contents

February 01, 2005; Volume 67,Issue 2

Accelerated Communication

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    The mGluR5 Antagonist 6-Methyl-2-(phenylethynyl)pyridine Decreases Ethanol Consumption via a Protein Kinase Cϵ-Dependent Mechanism
    M. Foster Olive, Andrew J. Mcgeehan, Jennifer R. Kinder, Thomas McMahon, Clyde W. Hodge, Patricia H. Janak and Robert O. Messing
    Molecular Pharmacology February 2005, 67 (2) 349-355; DOI: https://doi.org/10.1124/mol.104.003319

ORIGINAL ARTICLE

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    Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein
    Seung Joon Baek, Jong-Sik Kim, Scott M. Moore, Seong-Ho Lee, Jeanelle Martinez and Thomas E. Eling
    Molecular Pharmacology February 2005, 67 (2) 356-364; DOI: https://doi.org/10.1124/mol.104.005108
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    P-Glycoprotein Substrate Binding Domains Are Located at the Transmembrane Domain/Transmembrane Domain Interfaces: A Combined Photoaffinity Labeling-Protein Homology Modeling Approach
    Karin Pleban, Stephan Kopp, Edina Csaszar, Michael Peer, Thomas Hrebicek, Andreas Rizzi, Gerhard F. Ecker and Peter Chiba
    Molecular Pharmacology February 2005, 67 (2) 365-374; DOI: https://doi.org/10.1124/mol.104.006973
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    Helix I of β-Arrestin Is Involved in Postendocytic Trafficking but Is Not Required for Membrane Translocation, Receptor Binding, and Internalization
    Diem T. Dinh, Hongwei Qian, Ruth Seeber, Esther Lim, Kevin Pfleger, Karin A. Eidne and Walter G. Thomas
    Molecular Pharmacology February 2005, 67 (2) 375-382; DOI: https://doi.org/10.1124/mol.104.004721
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    E-Ring 8-Isoprostanes Are Agonists at EP2- and EP4-Prostanoid Receptors on Human Airway Smooth Muscle Cells and Regulate the Release of Colony-Stimulating Factors by Activating cAMP-Dependent Protein Kinase
    Deborah L. Clarke, Maria G. Belvisi, Elizabeth Hardaker, Robert Newton and Mark A. Giembycz
    Molecular Pharmacology February 2005, 67 (2) 383-393; DOI: https://doi.org/10.1124/mol.104.006486
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    Examination of Human Tissue Cytosols for Expression of Sulfotransferase Isoform 1A2 (SULT1A2) Using a SULT1A2-Specific Antibody
    Susan Nowell, Bridgett Green, Yong Ming Tang, Rick Wiese and Fred F. Kadlubar
    Molecular Pharmacology February 2005, 67 (2) 394-399; DOI: https://doi.org/10.1124/mol.104.006171
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    Adenosine A2A Receptor and Dopamine D3 Receptor Interactions: Evidence of Functional A2A/D3 Heteromeric Complexes
    Maria Torvinen, Daniel Marcellino, Meritxell Canals, Luigi F. Agnati, Carmen Lluis, Rafael Franco and Kjell Fuxe
    Molecular Pharmacology February 2005, 67 (2) 400-407; DOI: https://doi.org/10.1124/mol.104.003376
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    Expression of Deoxynucleotide Carrier Is Not Associated with the Mitochondrial DNA Depletion Caused by Anti-HIV Dideoxynucleoside Analogs and Mitochondrial dNTP Uptake
    Wing Lam, ChinShing Chen, Shuolun Ruan, Chung-Hang Leung and Yung-Chi Cheng
    Molecular Pharmacology February 2005, 67 (2) 408-416; DOI: https://doi.org/10.1124/mol.104.007120
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    Nuclear Localization of NADPH:Cytochrome c (P450) Reductase Enhances the Cytotoxicity of Mitomycin C to Chinese Hamster Ovary Cells
    Helen A. Seow, Michael F. Belcourt, Philip G. Penketh, William F. Hodnick, Maria Tomasz, Sara Rockwell and Alan C. Sartorelli
    Molecular Pharmacology February 2005, 67 (2) 417-423; DOI: https://doi.org/10.1124/mol.104.004929
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    A Multifunctional Aromatic Residue in the External Pore Vestibule of Na+ Channels Contributes to the Local Anesthetic Receptor
    Suk Ying Tsang, Robert G. Tsushima, Gordon F. Tomaselli, Ronald A. Li and Peter H. Backx
    Molecular Pharmacology February 2005, 67 (2) 424-434; DOI: https://doi.org/10.1124/mol.67.2.424
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    Proteasomal Degradation of Human CYP1B1: Effect of the Asn453Ser Polymorphism on the Post-Translational Regulation of CYP1B1 Expression
    Silvio Bandiera, Simone Weidlich, Volker Harth, Peter Broede, Yun Ko and Thomas Friedberg
    Molecular Pharmacology February 2005, 67 (2) 435-443; DOI: https://doi.org/10.1124/mol.104.006056
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    2,3,7,8-Tetrachlorodibenzo-p-dioxin Induces Insulin-Like Growth Factor Binding Protein-1 Gene Expression and Counteracts the Negative Effect of Insulin
    A. Marchand, C. Tomkiewicz, J.-P. Marchandeau, E. Boitier, R. Barouki and M. Garlatti
    Molecular Pharmacology February 2005, 67 (2) 444-452; DOI: https://doi.org/10.1124/mol.104.004010
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    Characterization of Binding of Folates and Antifolates to Brush-Border Membrane Vesicles Isolated from Human Kidney
    Vijaya L. Damaraju, Katherine F. Hamilton, Michelle L. Seth-Smith, Carol E. Cass and Michael B. Sawyer
    Molecular Pharmacology February 2005, 67 (2) 453-459; DOI: https://doi.org/10.1124/mol.104.004978
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    Evidence for Negative Binding Cooperativity within CCR5-CCR2b Heterodimers
    Laïla El-Asmar, Jean-Yves Springael, Sébastien Ballet, Eneko Urizar Andrieu, Gilbert Vassart and Marc Parmentier
    Molecular Pharmacology February 2005, 67 (2) 460-469; DOI: https://doi.org/10.1124/mol.104.003624
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    Picrotoxin Accelerates Relaxation of GABAC Receptors
    Haohua Qian, Yi Pan, Yujie Zhu and Parham Khalili
    Molecular Pharmacology February 2005, 67 (2) 470-479; DOI: https://doi.org/10.1124/mol.104.003996
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    Kv2.1 Channel Activation and Inactivation Is Influenced by Physical Interactions of Both Syntaxin 1A and the Syntaxin 1A/Soluble N-Ethylmaleimide-Sensitive Factor-25 (t-SNARE) Complex with the C Terminus of the Channel
    Sharon Tsuk, Izhak Michaelevski, Geoffrey N. Bentley, Rolf H. Joho, Dodo Chikvashvili and Ilana Lotan
    Molecular Pharmacology February 2005, 67 (2) 480-488; DOI: https://doi.org/10.1124/mol.104.005314
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    Receptor-Independent Activation of GABAergic Neurotransmission and Receptor-Dependent Nontranscriptional Activation of Phosphatidylinositol 3-kinase/Protein Kinase Akt Pathway in Short-Term Cardiovascular Actions of Dexamethasone at the Nucleus Tractus Solitarii of the Rat
    Ling-Lin Wang, Chen-Chun Ou and Julie Y.H. Chan
    Molecular Pharmacology February 2005, 67 (2) 489-498; DOI: https://doi.org/10.1124/mol.104.005595
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    Steroidogenic Factor-1 Interacts with cAMP Response Element-Binding Protein to Mediate cAMP Stimulation of CYP1B1 via a Far Upstream Enhancer
    Wenchao Zheng and Colin R. Jefcoate
    Molecular Pharmacology February 2005, 67 (2) 499-512; DOI: https://doi.org/10.1124/mol.104.005504
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    Identification of Amino Acid Residues in the Insect Sodium Channel Critical for Pyrethroid Binding
    Jianguo Tan, Zhiqi Liu, Ruiwu Wang, Zachary Y. Huang, Andrew C. Chen, Michael Gurevitz and Ke Dong
    Molecular Pharmacology February 2005, 67 (2) 513-522; DOI: https://doi.org/10.1124/mol.104.006205
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    Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison
    Smitha Antony, Glenda Kohlhagen, Keli Agama, Muthusamy Jayaraman, Shousong Cao, Farukh A. Durrani, Youcef M. Rustum, Mark Cushman and Yves Pommier
    Molecular Pharmacology February 2005, 67 (2) 523-530; DOI: https://doi.org/10.1124/mol.104.003889
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    Membrane Structure Modulation, Protein Kinase Cα Activation, and Anticancer Activity of Minerval
    Jordi Martínez, Oliver Vögler, Jesús Casas, Francisca Barceló, Regina Alemany, Jesús Prades, Tünde Nagy, Carmela Baamonde, Philip G. Kasprzyk, Silvia Terés, Carlos Saus and Pablo V. Escribá
    Molecular Pharmacology February 2005, 67 (2) 531-540; DOI: https://doi.org/10.1124/mol.104.000778
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    Inhibition of L-Type Cav1.2 Ca2+ Channels by 2,(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-Dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) Maleimide (Gö6983)
    A. Welling, F. Hofmann and J. W. Wegener
    Molecular Pharmacology February 2005, 67 (2) 541-544; DOI: https://doi.org/10.1124/mol.104.006049
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    Transport of Bile Acids, Sulfated Steroids, Estradiol 17-β-d-Glucuronide, and Leukotriene C4 by Human Multidrug Resistance Protein 8 (ABCC11)
    Zhe-Sheng Chen, Yanping Guo, Martin G. Belinsky, Elena Kotova and Gary D. Kruh
    Molecular Pharmacology February 2005, 67 (2) 545-557; DOI: https://doi.org/10.1124/mol.104.007138
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    Negative Regulation of TRPC3 Channels by Protein Kinase C-Mediated Phosphorylation of Serine 712
    Mohamed Trebak, Nadine Hempel, Barbara J. Wedel, Jeremy T. Smyth, Gary St. J. Bird and James W. Putney
    Molecular Pharmacology February 2005, 67 (2) 558-563; DOI: https://doi.org/10.1124/mol.104.007252
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    Isoform-Specific Regulation of Adenylyl Cyclase Function by Disruption of Membrane Trafficking
    Qingming Ding, Robert Gros, Jozef Chorazyczewski, Stephen S. G. Ferguson and Ross D. Feldman
    Molecular Pharmacology February 2005, 67 (2) 564-571; DOI: https://doi.org/10.1124/mol.104.006817
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    N3-Methyladenine Induces Early Poly(ADP-Ribosylation), Reduction of Nuclear Factor-κB DNA Binding Ability, and Nuclear Up-Regulation of Telomerase Activity
    Lucio Tentori, Olindo Forini, Emanuela Fossile, Alessia Muzi, Matteo Vergati, Ilaria Portarena, Carla Amici, Barry Gold and Grazia Graziani
    Molecular Pharmacology February 2005, 67 (2) 572-581; DOI: https://doi.org/10.1124/mol.104.004937
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Molecular Pharmacology: 67 (2)
Molecular Pharmacology
Vol. 67, Issue 2
1 Feb 2005
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  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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