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Research ArticleORIGINAL ARTICLE

Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

Smitha Antony, Glenda Kohlhagen, Keli Agama, Muthusamy Jayaraman, Shousong Cao, Farukh A. Durrani, Youcef M. Rustum, Mark Cushman and Yves Pommier
Molecular Pharmacology February 2005, 67 (2) 523-530; DOI: https://doi.org/10.1124/mol.104.003889
Smitha Antony
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Glenda Kohlhagen
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Keli Agama
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Muthusamy Jayaraman
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Shousong Cao
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Farukh A. Durrani
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Youcef M. Rustum
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Mark Cushman
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Yves Pommier
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Article Information

vol. 67 no. 2 523-530
DOI 
https://doi.org/10.1124/mol.104.003889
PubMed 
15531731

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received June 14, 2004
  • Accepted November 5, 2004
  • Published online January 19, 2005.

Article Versions

  • Earlier version (November 5, 2004 - 12:42).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Smitha Antony,
  2. Glenda Kohlhagen,
  3. Keli Agama,
  4. Muthusamy Jayaraman,
  5. Shousong Cao,
  6. Farukh A. Durrani,
  7. Youcef M. Rustum,
  8. Mark Cushman and
  9. Yves Pommier
  1. Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (S.A., G.K., K.A., Y.P.); Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana (M.J., M.C.); and Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York (S.C., F.D., Y.M.R.)
  1. Address correspondence to:
    Dr. Yves Pommier, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 37 Convent Dr., Bldg 37, Rm 5068, National Institutes of Health, Bethesda, MD 20892-4255. E-mail: pommier{at}nih.gov
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Molecular Pharmacology: 67 (2)
Molecular Pharmacology
Vol. 67, Issue 2
1 Feb 2005
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Research ArticleORIGINAL ARTICLE

Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

Smitha Antony, Glenda Kohlhagen, Keli Agama, Muthusamy Jayaraman, Shousong Cao, Farukh A. Durrani, Youcef M. Rustum, Mark Cushman and Yves Pommier
Molecular Pharmacology February 1, 2005, 67 (2) 523-530; DOI: https://doi.org/10.1124/mol.104.003889

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Research ArticleORIGINAL ARTICLE

Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

Smitha Antony, Glenda Kohlhagen, Keli Agama, Muthusamy Jayaraman, Shousong Cao, Farukh A. Durrani, Youcef M. Rustum, Mark Cushman and Yves Pommier
Molecular Pharmacology February 1, 2005, 67 (2) 523-530; DOI: https://doi.org/10.1124/mol.104.003889
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