Table of Contents

ORIGINAL ARTICLE

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  The Aryl Hydrocarbon Receptor Predisposes Hepatocytes to Fas-Mediated Apoptosis

  Kyung-Tae Park, Kristen A. Mitchell, Gengming Huang and Cornelis J. Elferink

  Molecular Pharmacology March 2005, 67 (3) 612-622; DOI: https://doi.org/10.1124/mol.104.005223
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  In Vivo Mechanisms of Tissue-Selective Drug Toxicity: Effects of Liver-Specific Knockout of the NADPH-Cytochrome P450 Reductase Gene on Acetaminophen Toxicity in Kidney, Lung, and Nasal Mucosa

  Jun Gu, Huadong Cui, Melissa Behr, Li Zhang, Qing-Yu Zhang, Weizhu Yang, Jack A. Hinson and Xinxin Ding

  Molecular Pharmacology March 2005, 67 (3) 623-630; DOI: https://doi.org/10.1124/mol.104.007898
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  RGS2 Is a Mediator of Nitric Oxide Action on Blood Pressure and Vasoconstrictor Signaling

  Xiaoguang Sun, Kevin M. Kaltenbronn, Thomas H. Steinberg and Kendall J. Blumer

  Molecular Pharmacology March 2005, 67 (3) 631-639; DOI: https://doi.org/10.1124/mol.104.007724
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  Structural Determinants of Arylacetic Acid Nonsteroidal Anti-Inflammatory Drugs Necessary for Binding and Activation of the Prostaglandin D₂ Receptor CRTH2

  Aaron N. Hata, Terry P. Lybrand, Lawrence J. Marnett and Richard M. Breyer

  Molecular Pharmacology March 2005, 67 (3) 640-647; DOI: https://doi.org/10.1124/mol.104.007971
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  Transfected β3- but Not β2-Adrenergic Receptors Regulate Cystic Fibrosis Transmembrane Conductance Regulator Activity via a New Pathway Involving the Mitogen-Activated Protein Kinases Extracellular Signal-Regulated Kinases

  Amal Robay, Gilles Toumaniantz, Véronique Leblais and Chantal Gauthier

  Molecular Pharmacology March 2005, 67 (3) 648-654; DOI: https://doi.org/10.1124/mol.104.002097
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  Role of the C Terminus in Neuropeptide Y Y Receptor Desensitization and Internalization

  Nicholas D. Holliday, Chi-Wing Lam, Iain R. Tough and Helen M. Cox

  Molecular Pharmacology March 2005, 67 (3) 655-664; DOI: https://doi.org/10.1124/mol.104.006114
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  Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4

  Shuso Takeda, Yuji Ishii, Megumi Iwanaga, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri and Hideyuki Yamada

  Molecular Pharmacology March 2005, 67 (3) 665-672; DOI: https://doi.org/10.1124/mol.104.007641
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  Urinary Trypsin Inhibitor Protects against Systemic Inflammation Induced by Lipopolysaccharide

  Ken-Ichiro Inoue, Hirohisa Takano, Akinori Shimada, Rie Yanagisawa, Miho Sakurai, Shin Yoshino, Hiroyuki Sato and Toshikazu Yoshikawa

  Molecular Pharmacology March 2005, 67 (3) 673-680; DOI: https://doi.org/10.1124/mol.104.005967
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  Constitutive Expression of Peroxisome Proliferator-Activated Receptor α-Regulated Genes in Dwarf Mice

  Anja J. Stauber, Holly Brown-Borg, Jie Liu, Michael P. Waalkes, Ashley Laughter, Rebecca A. Staben, Jaqueline C. Coley, Cynthia Swanson, Kenneth A. Voss, John J. Kopchick and J. Christopher Corton

  Molecular Pharmacology March 2005, 67 (3) 681-694; DOI: https://doi.org/10.1124/mol.104.007278
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  Functional Characterization of Gαo Signaling through G Protein-Regulated Inducer of Neurite Outgrowth 1

  Hiroko Nakata and Tohru Kozasa

  Molecular Pharmacology March 2005, 67 (3) 695-702; DOI: https://doi.org/10.1124/mol.104.003913
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  Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2

  Anne Frandsen, Darryl S. Pickering, Bente Vestergaard, Christina Kasper, Bettina Bryde Nielsen, Jeremy R. Greenwood, Giuseppe Campiani, Caterina Fattorusso, Michael Gajhede, Arne Schousboe and Jette Sandholm Kastrup

  Molecular Pharmacology March 2005, 67 (3) 703-713; DOI: https://doi.org/10.1124/mol.104.002931
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  The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse

  Garet P. Lahvis, Robert W. Pyzalski, Edward Glover, Henry C. Pitot, Matthew K. McElwee and Christopher A. Bradfield

  Molecular Pharmacology March 2005, 67 (3) 714-720; DOI: https://doi.org/10.1124/mol.104.008888
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  Differential Regulation and Relocalization of the Platelet P2Y Receptors after Activation: A Way to Avoid Loss of Hemostatic Properties?

  Anthony Baurand, Anita Eckly, Béatrice Hechler, Gilles Kauffenstein, Jean-Luc Galzi, Jean-Pierre Cazenave, Catherine Léon and Christian Gachet

  Molecular Pharmacology March 2005, 67 (3) 721-733; DOI: https://doi.org/10.1124/mol.104.004846
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  PDZK1 Directly Regulates the Function of Organic Cation/Carnitine Transporter OCTN2

  Yukio Kato, Yoshimichi Sai, Kazuhiro Yoshida, Chizuru Watanabe, Tadayoshi Hirata and Akira Tsuji

  Molecular Pharmacology March 2005, 67 (3) 734-743; DOI: https://doi.org/10.1124/mol.104.002212
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  The Nongenotropic Synthetic Ligand 4-Estren-3α17β-diol Is a High-Affinity Genotropic Androgen Receptor Agonist

  V. Krishnan, H. A. Bullock, B. C. Yaden, M. Liu, R. J. Barr, C. Montrose-Rafizadeh, K. Chen, J. A. Dodge and H. U. Bryant

  Molecular Pharmacology March 2005, 67 (3) 744-748; DOI: https://doi.org/10.1124/mol.104.005272
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  A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator

  Masuo Kondoh, Akane Masuyama, Azusa Takahashi, Nagayoshi Asano, Hiroyuki Mizuguchi, Naoya Koizumi, Makiko Fujii, Takao Hayakawa, Yasuhiko Horiguchi and Yoshiteru Watanbe

  Molecular Pharmacology March 2005, 67 (3) 749-756; DOI: https://doi.org/10.1124/mol.104.008375
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  Macrophage Inflammatory Protein 2 Inhibits β-Amyloid Peptide (1-42)-Mediated Hippocampal Neuronal Apoptosis through Activation of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Signaling Pathways

  Kurt Watson and Guo-Huang Fan

  Molecular Pharmacology March 2005, 67 (3) 757-765; DOI: https://doi.org/10.1124/mol.104.004812
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  Organotin Compounds Promote Adipocyte Differentiation as Agonists of the Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor Pathway

  Tomohiko Kanayama, Naoki Kobayashi, Satoru Mamiya, Tsuyoshi Nakanishi and Jun-ichi Nishikawa

  Molecular Pharmacology March 2005, 67 (3) 766-774; DOI: https://doi.org/10.1124/mol.104.008409
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  Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABA_A Receptors

  Patrick S. Mangan, Chengsan Sun, Mackenzie Carpenter, Howard P. Goodkin, Werner Sieghart and Jaideep Kapur

  Molecular Pharmacology March 2005, 67 (3) 775-788; DOI: https://doi.org/10.1124/mol.104.007385
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  Regulation of Serum Response Factor-Dependent Gene Expression by Proteasome Inhibitors

  Nathan Sandbo, Yimin Qin, Sebastien Taurin, D. Kyle Hogarth, Barry Kreutz and Nickolai O. Dulin

  Molecular Pharmacology March 2005, 67 (3) 789-797; DOI: https://doi.org/10.1124/mol.104.006874
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  Activation of the Melastatin-Related Cation Channel TRPM3 by d-erythro-Sphingosine

  Christian Grimm, Robert Kraft, Günter Schultz and Christian Harteneck

  Molecular Pharmacology March 2005, 67 (3) 798-805; DOI: https://doi.org/10.1124/mol.104.006734
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  Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium

  Chih-Hung Hsu, Jieh-Yuan Liou, Ginger E. Dutschman and Yung-Chi Cheng

  Molecular Pharmacology March 2005, 67 (3) 806-814; DOI: https://doi.org/10.1124/mol.104.006098
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  Identification of Endogenous Glucocorticoid Repressed Genes Differentially Regulated by a Glucocorticoid Receptor Mutant Able to Separate between Nuclear Factor-κB and Activator Protein-1 Repression

  Lars-Göran Bladh, Johan Lidén, Karin Dahlman-Wright, Mark Reimers, Stefan Nilsson and Sam Okret

  Molecular Pharmacology March 2005, 67 (3) 815-826; DOI: https://doi.org/10.1124/mol.104.005801
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  Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K⁺ Channel

  Jiesheng Kang, Xiao-Liang Chen, Hongge Wang, Junzhi Ji, Hsien Cheng, Josephine Incardona, William Reynolds, Fabrice Viviani, Michel Tabart and David Rampe

  Molecular Pharmacology March 2005, 67 (3) 827-836; DOI: https://doi.org/10.1124/mol.104.006577
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  Residues Met89 and Ser160 in the Human Equilibrative Nucleoside Transporter 1 Affect Its Affinity for Adenosine, Guanosine, S⁶-(4-Nitrobenzyl)-mercaptopurine Riboside, and Dipyridamole

  Christopher J. Endres and Jashvant D. Unadkat

  Molecular Pharmacology March 2005, 67 (3) 837-844; DOI: https://doi.org/10.1124/mol.104.008102
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  Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting Protein 1

  Junko Sugatani, Shinichi Nishitani, Kasumi Yamakawa, Kouichi Yoshinari, Tatsuya Sueyoshi, Masahiko Negishi and Masao Miwa

  Molecular Pharmacology March 2005, 67 (3) 845-855; DOI: https://doi.org/10.1124/mol.104.007161
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  Modulation of Voltage-Gated Potassium Channels in Human T Lymphocytes by Extracellular Glutamate

  Cornelia Poulopoulou, Ioannis Markakis, Panagiota Davaki, Chryssoula Nikolaou, Alexandros Poulopoulos, Euclides Raptis and Dimitrios Vassilopoulos

  Molecular Pharmacology March 2005, 67 (3) 856-867; DOI: https://doi.org/10.1124/mol.67.3.856
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  The Role of N-Linked Glycosylation in Protein Folding, Membrane Targeting, and Substrate Binding of Human Organic Anion Transporter hOAT4

  Fanfan Zhou, Wen Xu, Mei Hong, Zui Pan, Patrick J. Sinko, Jianjie Ma and Guofeng You

  Molecular Pharmacology March 2005, 67 (3) 868-876; DOI: https://doi.org/10.1124/mol.104.007583
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  DNA Damage Effects of a Polyamide-CBI Conjugate in SV40 Virions

  Brian J. Philips, Aileen Y. Chang, Peter B. Dervan and Terry A. Beerman

  Molecular Pharmacology March 2005, 67 (3) 877-882; DOI: https://doi.org/10.1124/mol.104.006254
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  Optimized Targeting of Polyethylene Glycol-Stabilized Anti-Intercellular Adhesion Molecule 1 Oligonucleotide/Lipid Particles to Liver Sinusoidal Endothelial Cells

  Martin Bartsch, Alida H. Weeke-Klimp, Henriëtte W. M. Morselt, Andrea Kimpfler, Sigridur A. Ásgeirsdóttir, Rolf Schubert, Dirk K. F. Meijer, Gerrit L. Scherphof and Jan A. A. M. Kamps

  Molecular Pharmacology March 2005, 67 (3) 883-890; DOI: https://doi.org/10.1124/mol.104.004523
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  Inadequacy of the Janus Kinase 2/Signal Transducer and Activator of Transcription Signal Transduction Pathway to Mediate Episodic Growth Hormone-Dependent Regulation of Hepatic CYP2C11

  Ashish S. Verma, Ravindra N. Dhir and Bernard H. Shapiro

  Molecular Pharmacology March 2005, 67 (3) 891-901; DOI: https://doi.org/10.1124/mol.104.005454
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  Differential Sensitivities of the Human ATP-Binding Cassette Transporters ABCG2 and P-Glycoprotein to Cyclosporin A

  Karin F. K. Ejendal and Christine A. Hrycyna

  Molecular Pharmacology March 2005, 67 (3) 902-911; DOI: https://doi.org/10.1124/mol.104.001701
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  Two α₁-Adrenergic Receptor Subtypes Regulating the Vasopressor Response Have Differential Roles in Blood Pressure Regulation

  Chihiro Hosoda, Taka-aki Koshimizu, Akito Tanoue, Yoshihisa Nasa, Ryo Oikawa, Takashi Tomabechi, Shinya Fukuda, Hitomi Shinoura, Sayuri Oshikawa, Satoshi Takeo, Tadaichi Kitamura, Susanna Cotecchia and Gozoh Tsujimoto

  Molecular Pharmacology March 2005, 67 (3) 912-922; DOI: https://doi.org/10.1124/mol.104.007500
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  Role of Breast Cancer Resistance Protein (Bcrp1/Abcg2) in the Extrusion of Glucuronide and Sulfate Conjugates from Enterocytes to Intestinal Lumen

  Yasuhisa Adachi, Hiroshi Suzuki, Alfred H. Schinkel and Yuichi Sugiyama

  Molecular Pharmacology March 2005, 67 (3) 923-928; DOI: https://doi.org/10.1124/mol.104.007393
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  Digitalis-Induced Signaling by Na⁺/K⁺-ATPase in Human Breast Cancer Cells

  Peter Kometiani, Lijun Liu and Amir Askari

  Molecular Pharmacology March 2005, 67 (3) 929-936; DOI: https://doi.org/10.1124/mol.104.007302
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  Biochemical and Proteomics Approaches to Characterize Topoisomerase IIα Cysteines and DNA as Targets Responsible for Cisplatin-Induced Inhibition of Topoisomerase IIα

  Brian B. Hasinoff, Xing Wu, Oleg V. Krokhin, Werner Ens, Kenneth G. Standing, John L. Nitiss, Tejomoortula Sivaram, Angela Giorgianni, Shaohua Yang, Yu Jiang and Jack C. Yalowich

  Molecular Pharmacology March 2005, 67 (3) 937-947; DOI: https://doi.org/10.1124/mol.104.004416
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  The Hypolipidemic Natural Product Guggulsterone Is a Promiscuous Steroid Receptor Ligand

  Thomas P. Burris, Chahrzad Montrose, Keith A. Houck, Harold E. Osborne, Wayne P. Bocchinfuso, Benjamin C. Yaden, Christine C. Cheng, Richard W. Zink, Robert J. Barr, Christoper D. Hepler, Venkatesh Krishnan, Heather A. Bullock, Lorri L. Burris, Rachelle J. Galvin, Kelli Bramlett and Keith R. Stayrook

  Molecular Pharmacology March 2005, 67 (3) 948-954; DOI: https://doi.org/10.1124/mol.104.007054
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  Evidence for the Functional Expression and Pharmacological Characterization of Adenine Receptors in Native Cells and Tissues

  Simone Gorzalka, Sauro Vittori, Rosaria Volpini, Gloria Cristalli, Ivar von Kügelgen and Christa E. Müller

  Molecular Pharmacology March 2005, 67 (3) 955-964; DOI: https://doi.org/10.1124/mol.104.006601
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  Neuropeptide FF (NPFF) Analogs Functionally Antagonize Opioid Activities in NPFF₂ Receptor-Transfected SH-SY5Y Neuroblastoma Cells

  Catherine Mollereau, Honoré Mazarguil, Jean-Marie Zajac and Michel Roumy

  Molecular Pharmacology March 2005, 67 (3) 965-975; DOI: https://doi.org/10.1124/mol.104.004614