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Molecular Pharmacology

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Table of Contents

March 01, 2005; Volume 67,Issue 3

Perspectives

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    An Orphan Receptor Adopted by a Family of Transmitters
    Olivier Civelli
    Molecular Pharmacology March 2005, 67 (3) 583-584; DOI: https://doi.org/10.1124/mol.104.010348
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    Activators of Cation Channels: Potential in Treatment of Channelopathies
    Guiscard Seebohm
    Molecular Pharmacology March 2005, 67 (3) 585-588; DOI: https://doi.org/10.1124/mol.104.010173

Accelerated Communications

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    Deorphanization of GPRC6A: A Promiscuous l-α-Amino Acid Receptor with Preference for Basic Amino Acids
    Petrine Wellendorph, Kasper B. Hansen, Anders Balsgaard, Jeremy R. Greenwood, Jan Egebjerg and Hans Bräuner-Osborne
    Molecular Pharmacology March 2005, 67 (3) 589-597; DOI: https://doi.org/10.1124/mol.104.007559
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    Dexamethasone Up-Regulates the Inhibitory Adaptor Protein Dok-1 and Suppresses Downstream Activation of the Mitogen-Activated Protein Kinase Pathway in Antigen-Stimulated RBL-2H3 Mast Cells
    Takaaki Hiragun, Ze Peng and Michael A. Beaven
    Molecular Pharmacology March 2005, 67 (3) 598-603; DOI: https://doi.org/10.1124/mol.104.008607
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    RSK4 and PAK5 Are Novel Candidate Genes in Diabetic Rat Kidney and Brain
    Monika Niehof and Jürgen Borlak
    Molecular Pharmacology March 2005, 67 (3) 604-611; DOI: https://doi.org/10.1124/mol.104.008672

ORIGINAL ARTICLE

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    The Aryl Hydrocarbon Receptor Predisposes Hepatocytes to Fas-Mediated Apoptosis
    Kyung-Tae Park, Kristen A. Mitchell, Gengming Huang and Cornelis J. Elferink
    Molecular Pharmacology March 2005, 67 (3) 612-622; DOI: https://doi.org/10.1124/mol.104.005223
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    In Vivo Mechanisms of Tissue-Selective Drug Toxicity: Effects of Liver-Specific Knockout of the NADPH-Cytochrome P450 Reductase Gene on Acetaminophen Toxicity in Kidney, Lung, and Nasal Mucosa
    Jun Gu, Huadong Cui, Melissa Behr, Li Zhang, Qing-Yu Zhang, Weizhu Yang, Jack A. Hinson and Xinxin Ding
    Molecular Pharmacology March 2005, 67 (3) 623-630; DOI: https://doi.org/10.1124/mol.104.007898
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    RGS2 Is a Mediator of Nitric Oxide Action on Blood Pressure and Vasoconstrictor Signaling
    Xiaoguang Sun, Kevin M. Kaltenbronn, Thomas H. Steinberg and Kendall J. Blumer
    Molecular Pharmacology March 2005, 67 (3) 631-639; DOI: https://doi.org/10.1124/mol.104.007724
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    Structural Determinants of Arylacetic Acid Nonsteroidal Anti-Inflammatory Drugs Necessary for Binding and Activation of the Prostaglandin D2 Receptor CRTH2
    Aaron N. Hata, Terry P. Lybrand, Lawrence J. Marnett and Richard M. Breyer
    Molecular Pharmacology March 2005, 67 (3) 640-647; DOI: https://doi.org/10.1124/mol.104.007971
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    Transfected β3- but Not β2-Adrenergic Receptors Regulate Cystic Fibrosis Transmembrane Conductance Regulator Activity via a New Pathway Involving the Mitogen-Activated Protein Kinases Extracellular Signal-Regulated Kinases
    Amal Robay, Gilles Toumaniantz, Véronique Leblais and Chantal Gauthier
    Molecular Pharmacology March 2005, 67 (3) 648-654; DOI: https://doi.org/10.1124/mol.104.002097
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    Role of the C Terminus in Neuropeptide Y Y Receptor Desensitization and Internalization
    Nicholas D. Holliday, Chi-Wing Lam, Iain R. Tough and Helen M. Cox
    Molecular Pharmacology March 2005, 67 (3) 655-664; DOI: https://doi.org/10.1124/mol.104.006114
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    Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4
    Shuso Takeda, Yuji Ishii, Megumi Iwanaga, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri and Hideyuki Yamada
    Molecular Pharmacology March 2005, 67 (3) 665-672; DOI: https://doi.org/10.1124/mol.104.007641
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    Urinary Trypsin Inhibitor Protects against Systemic Inflammation Induced by Lipopolysaccharide
    Ken-Ichiro Inoue, Hirohisa Takano, Akinori Shimada, Rie Yanagisawa, Miho Sakurai, Shin Yoshino, Hiroyuki Sato and Toshikazu Yoshikawa
    Molecular Pharmacology March 2005, 67 (3) 673-680; DOI: https://doi.org/10.1124/mol.104.005967
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    Constitutive Expression of Peroxisome Proliferator-Activated Receptor α-Regulated Genes in Dwarf Mice
    Anja J. Stauber, Holly Brown-Borg, Jie Liu, Michael P. Waalkes, Ashley Laughter, Rebecca A. Staben, Jaqueline C. Coley, Cynthia Swanson, Kenneth A. Voss, John J. Kopchick and J. Christopher Corton
    Molecular Pharmacology March 2005, 67 (3) 681-694; DOI: https://doi.org/10.1124/mol.104.007278
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    Functional Characterization of Gαo Signaling through G Protein-Regulated Inducer of Neurite Outgrowth 1
    Hiroko Nakata and Tohru Kozasa
    Molecular Pharmacology March 2005, 67 (3) 695-702; DOI: https://doi.org/10.1124/mol.104.003913
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    Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2
    Anne Frandsen, Darryl S. Pickering, Bente Vestergaard, Christina Kasper, Bettina Bryde Nielsen, Jeremy R. Greenwood, Giuseppe Campiani, Caterina Fattorusso, Michael Gajhede, Arne Schousboe and Jette Sandholm Kastrup
    Molecular Pharmacology March 2005, 67 (3) 703-713; DOI: https://doi.org/10.1124/mol.104.002931
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    The Aryl Hydrocarbon Receptor Is Required for Developmental Closure of the Ductus Venosus in the Neonatal Mouse
    Garet P. Lahvis, Robert W. Pyzalski, Edward Glover, Henry C. Pitot, Matthew K. McElwee and Christopher A. Bradfield
    Molecular Pharmacology March 2005, 67 (3) 714-720; DOI: https://doi.org/10.1124/mol.104.008888
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    Differential Regulation and Relocalization of the Platelet P2Y Receptors after Activation: A Way to Avoid Loss of Hemostatic Properties?
    Anthony Baurand, Anita Eckly, Béatrice Hechler, Gilles Kauffenstein, Jean-Luc Galzi, Jean-Pierre Cazenave, Catherine Léon and Christian Gachet
    Molecular Pharmacology March 2005, 67 (3) 721-733; DOI: https://doi.org/10.1124/mol.104.004846
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    PDZK1 Directly Regulates the Function of Organic Cation/Carnitine Transporter OCTN2
    Yukio Kato, Yoshimichi Sai, Kazuhiro Yoshida, Chizuru Watanabe, Tadayoshi Hirata and Akira Tsuji
    Molecular Pharmacology March 2005, 67 (3) 734-743; DOI: https://doi.org/10.1124/mol.104.002212
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    The Nongenotropic Synthetic Ligand 4-Estren-3α17β-diol Is a High-Affinity Genotropic Androgen Receptor Agonist
    V. Krishnan, H. A. Bullock, B. C. Yaden, M. Liu, R. J. Barr, C. Montrose-Rafizadeh, K. Chen, J. A. Dodge and H. U. Bryant
    Molecular Pharmacology March 2005, 67 (3) 744-748; DOI: https://doi.org/10.1124/mol.104.005272
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    A Novel Strategy for the Enhancement of Drug Absorption Using a Claudin Modulator
    Masuo Kondoh, Akane Masuyama, Azusa Takahashi, Nagayoshi Asano, Hiroyuki Mizuguchi, Naoya Koizumi, Makiko Fujii, Takao Hayakawa, Yasuhiko Horiguchi and Yoshiteru Watanbe
    Molecular Pharmacology March 2005, 67 (3) 749-756; DOI: https://doi.org/10.1124/mol.104.008375
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    Macrophage Inflammatory Protein 2 Inhibits β-Amyloid Peptide (1-42)-Mediated Hippocampal Neuronal Apoptosis through Activation of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Signaling Pathways
    Kurt Watson and Guo-Huang Fan
    Molecular Pharmacology March 2005, 67 (3) 757-765; DOI: https://doi.org/10.1124/mol.104.004812
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    Organotin Compounds Promote Adipocyte Differentiation as Agonists of the Peroxisome Proliferator-Activated Receptor γ/Retinoid X Receptor Pathway
    Tomohiko Kanayama, Naoki Kobayashi, Satoru Mamiya, Tsuyoshi Nakanishi and Jun-ichi Nishikawa
    Molecular Pharmacology March 2005, 67 (3) 766-774; DOI: https://doi.org/10.1124/mol.104.008409
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    Cultured Hippocampal Pyramidal Neurons Express Two Kinds of GABAA Receptors
    Patrick S. Mangan, Chengsan Sun, Mackenzie Carpenter, Howard P. Goodkin, Werner Sieghart and Jaideep Kapur
    Molecular Pharmacology March 2005, 67 (3) 775-788; DOI: https://doi.org/10.1124/mol.104.007385
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    Regulation of Serum Response Factor-Dependent Gene Expression by Proteasome Inhibitors
    Nathan Sandbo, Yimin Qin, Sebastien Taurin, D. Kyle Hogarth, Barry Kreutz and Nickolai O. Dulin
    Molecular Pharmacology March 2005, 67 (3) 789-797; DOI: https://doi.org/10.1124/mol.104.006874
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    Activation of the Melastatin-Related Cation Channel TRPM3 by d-erythro-Sphingosine
    Christian Grimm, Robert Kraft, Günter Schultz and Christian Harteneck
    Molecular Pharmacology March 2005, 67 (3) 798-805; DOI: https://doi.org/10.1124/mol.104.006734
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    Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium
    Chih-Hung Hsu, Jieh-Yuan Liou, Ginger E. Dutschman and Yung-Chi Cheng
    Molecular Pharmacology March 2005, 67 (3) 806-814; DOI: https://doi.org/10.1124/mol.104.006098
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    Identification of Endogenous Glucocorticoid Repressed Genes Differentially Regulated by a Glucocorticoid Receptor Mutant Able to Separate between Nuclear Factor-κB and Activator Protein-1 Repression
    Lars-Göran Bladh, Johan Lidén, Karin Dahlman-Wright, Mark Reimers, Stefan Nilsson and Sam Okret
    Molecular Pharmacology March 2005, 67 (3) 815-826; DOI: https://doi.org/10.1124/mol.104.005801
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    Discovery of a Small Molecule Activator of the Human Ether-a-go-go-Related Gene (HERG) Cardiac K+ Channel
    Jiesheng Kang, Xiao-Liang Chen, Hongge Wang, Junzhi Ji, Hsien Cheng, Josephine Incardona, William Reynolds, Fabrice Viviani, Michel Tabart and David Rampe
    Molecular Pharmacology March 2005, 67 (3) 827-836; DOI: https://doi.org/10.1124/mol.104.006577
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    Residues Met89 and Ser160 in the Human Equilibrative Nucleoside Transporter 1 Affect Its Affinity for Adenosine, Guanosine, S6-(4-Nitrobenzyl)-mercaptopurine Riboside, and Dipyridamole
    Christopher J. Endres and Jashvant D. Unadkat
    Molecular Pharmacology March 2005, 67 (3) 837-844; DOI: https://doi.org/10.1124/mol.104.008102
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    Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting Protein 1
    Junko Sugatani, Shinichi Nishitani, Kasumi Yamakawa, Kouichi Yoshinari, Tatsuya Sueyoshi, Masahiko Negishi and Masao Miwa
    Molecular Pharmacology March 2005, 67 (3) 845-855; DOI: https://doi.org/10.1124/mol.104.007161
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    Modulation of Voltage-Gated Potassium Channels in Human T Lymphocytes by Extracellular Glutamate
    Cornelia Poulopoulou, Ioannis Markakis, Panagiota Davaki, Chryssoula Nikolaou, Alexandros Poulopoulos, Euclides Raptis and Dimitrios Vassilopoulos
    Molecular Pharmacology March 2005, 67 (3) 856-867; DOI: https://doi.org/10.1124/mol.67.3.856
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    The Role of N-Linked Glycosylation in Protein Folding, Membrane Targeting, and Substrate Binding of Human Organic Anion Transporter hOAT4
    Fanfan Zhou, Wen Xu, Mei Hong, Zui Pan, Patrick J. Sinko, Jianjie Ma and Guofeng You
    Molecular Pharmacology March 2005, 67 (3) 868-876; DOI: https://doi.org/10.1124/mol.104.007583
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    DNA Damage Effects of a Polyamide-CBI Conjugate in SV40 Virions
    Brian J. Philips, Aileen Y. Chang, Peter B. Dervan and Terry A. Beerman
    Molecular Pharmacology March 2005, 67 (3) 877-882; DOI: https://doi.org/10.1124/mol.104.006254
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    Optimized Targeting of Polyethylene Glycol-Stabilized Anti-Intercellular Adhesion Molecule 1 Oligonucleotide/Lipid Particles to Liver Sinusoidal Endothelial Cells
    Martin Bartsch, Alida H. Weeke-Klimp, Henriëtte W. M. Morselt, Andrea Kimpfler, Sigridur A. Ásgeirsdóttir, Rolf Schubert, Dirk K. F. Meijer, Gerrit L. Scherphof and Jan A. A. M. Kamps
    Molecular Pharmacology March 2005, 67 (3) 883-890; DOI: https://doi.org/10.1124/mol.104.004523
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    Inadequacy of the Janus Kinase 2/Signal Transducer and Activator of Transcription Signal Transduction Pathway to Mediate Episodic Growth Hormone-Dependent Regulation of Hepatic CYP2C11
    Ashish S. Verma, Ravindra N. Dhir and Bernard H. Shapiro
    Molecular Pharmacology March 2005, 67 (3) 891-901; DOI: https://doi.org/10.1124/mol.104.005454
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    Differential Sensitivities of the Human ATP-Binding Cassette Transporters ABCG2 and P-Glycoprotein to Cyclosporin A
    Karin F. K. Ejendal and Christine A. Hrycyna
    Molecular Pharmacology March 2005, 67 (3) 902-911; DOI: https://doi.org/10.1124/mol.104.001701
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    Two α1-Adrenergic Receptor Subtypes Regulating the Vasopressor Response Have Differential Roles in Blood Pressure Regulation
    Chihiro Hosoda, Taka-aki Koshimizu, Akito Tanoue, Yoshihisa Nasa, Ryo Oikawa, Takashi Tomabechi, Shinya Fukuda, Hitomi Shinoura, Sayuri Oshikawa, Satoshi Takeo, Tadaichi Kitamura, Susanna Cotecchia and Gozoh Tsujimoto
    Molecular Pharmacology March 2005, 67 (3) 912-922; DOI: https://doi.org/10.1124/mol.104.007500
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    Role of Breast Cancer Resistance Protein (Bcrp1/Abcg2) in the Extrusion of Glucuronide and Sulfate Conjugates from Enterocytes to Intestinal Lumen
    Yasuhisa Adachi, Hiroshi Suzuki, Alfred H. Schinkel and Yuichi Sugiyama
    Molecular Pharmacology March 2005, 67 (3) 923-928; DOI: https://doi.org/10.1124/mol.104.007393
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    Digitalis-Induced Signaling by Na+/K+-ATPase in Human Breast Cancer Cells
    Peter Kometiani, Lijun Liu and Amir Askari
    Molecular Pharmacology March 2005, 67 (3) 929-936; DOI: https://doi.org/10.1124/mol.104.007302
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    Biochemical and Proteomics Approaches to Characterize Topoisomerase IIα Cysteines and DNA as Targets Responsible for Cisplatin-Induced Inhibition of Topoisomerase IIα
    Brian B. Hasinoff, Xing Wu, Oleg V. Krokhin, Werner Ens, Kenneth G. Standing, John L. Nitiss, Tejomoortula Sivaram, Angela Giorgianni, Shaohua Yang, Yu Jiang and Jack C. Yalowich
    Molecular Pharmacology March 2005, 67 (3) 937-947; DOI: https://doi.org/10.1124/mol.104.004416
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    The Hypolipidemic Natural Product Guggulsterone Is a Promiscuous Steroid Receptor Ligand
    Thomas P. Burris, Chahrzad Montrose, Keith A. Houck, Harold E. Osborne, Wayne P. Bocchinfuso, Benjamin C. Yaden, Christine C. Cheng, Richard W. Zink, Robert J. Barr, Christoper D. Hepler, Venkatesh Krishnan, Heather A. Bullock, Lorri L. Burris, Rachelle J. Galvin, Kelli Bramlett and Keith R. Stayrook
    Molecular Pharmacology March 2005, 67 (3) 948-954; DOI: https://doi.org/10.1124/mol.104.007054
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    Evidence for the Functional Expression and Pharmacological Characterization of Adenine Receptors in Native Cells and Tissues
    Simone Gorzalka, Sauro Vittori, Rosaria Volpini, Gloria Cristalli, Ivar von Kügelgen and Christa E. Müller
    Molecular Pharmacology March 2005, 67 (3) 955-964; DOI: https://doi.org/10.1124/mol.104.006601
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    Neuropeptide FF (NPFF) Analogs Functionally Antagonize Opioid Activities in NPFF2 Receptor-Transfected SH-SY5Y Neuroblastoma Cells
    Catherine Mollereau, Honoré Mazarguil, Jean-Marie Zajac and Michel Roumy
    Molecular Pharmacology March 2005, 67 (3) 965-975; DOI: https://doi.org/10.1124/mol.104.004614
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Molecular Pharmacology: 67 (3)
Molecular Pharmacology
Vol. 67, Issue 3
1 Mar 2005
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  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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