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Research ArticleORIGINAL ARTICLE

Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4

Shuso Takeda, Yuji Ishii, Megumi Iwanaga, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri and Hideyuki Yamada
Molecular Pharmacology March 2005, 67 (3) 665-672; DOI: https://doi.org/10.1124/mol.104.007641
Shuso Takeda
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Yuji Ishii
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Megumi Iwanaga
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Peter I. Mackenzie
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Kiyoshi Nagata
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Yasushi Yamazoe
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Kazuta Oguri
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Hideyuki Yamada
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Article Information

vol. 67 no. 3 665-672
DOI 
https://doi.org/10.1124/mol.104.007641
PubMed 
15611481

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received September 25, 2004
  • Accepted December 20, 2004
  • Published online February 16, 2005.

Article Versions

  • Earlier version (December 20, 2004 - 14:13).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Shuso Takeda,
  2. Yuji Ishii,
  3. Megumi Iwanaga,
  4. Peter I. Mackenzie,
  5. Kiyoshi Nagata,
  6. Yasushi Yamazoe,
  7. Kazuta Oguri and
  8. Hideyuki Yamada
  1. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan (S.T., Y.I., M.I., H.Y.); Department of Clinical Pharmacology, Flinders Medical Centre and Flinders University, Adelaide, Australia (P.I.M.); Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (K.N., Y.Y.); and School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka, Japan (K.O.)
  1. Address correspondence to:
    Dr. Hideyuki Yamada, Graduate School of Pharmaceutical Sciences, Kyushu University, 3–1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. E-mail: yamada{at}xenoba.phar.kyushu-u.ac.jp
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Molecular Pharmacology: 67 (3)
Molecular Pharmacology
Vol. 67, Issue 3
1 Mar 2005
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Research ArticleORIGINAL ARTICLE

Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4

Shuso Takeda, Yuji Ishii, Megumi Iwanaga, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri and Hideyuki Yamada
Molecular Pharmacology March 1, 2005, 67 (3) 665-672; DOI: https://doi.org/10.1124/mol.104.007641

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Research ArticleORIGINAL ARTICLE

Modulation of UDP-Glucuronosyltransferase Function by Cytochrome P450: Evidence for the Alteration of UGT2B7-Catalyzed Glucuronidation of Morphine by CYP3A4

Shuso Takeda, Yuji Ishii, Megumi Iwanaga, Peter I. Mackenzie, Kiyoshi Nagata, Yasushi Yamazoe, Kazuta Oguri and Hideyuki Yamada
Molecular Pharmacology March 1, 2005, 67 (3) 665-672; DOI: https://doi.org/10.1124/mol.104.007641
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