Table of Contents

Original Article

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  Nuclear Factor-κB Decoy Oligodeoxynucleotides Prevent Acute Lung Injury in Mice with Cecal Ligation and Puncture-Induced Sepsis

  Naoyuki Matsuda, Yuichi Hattori, Subrina Jesmin and Satoshi Gando

  Molecular Pharmacology April 2005, 67 (4) 1018-1025; DOI: https://doi.org/10.1124/mol.104.005926
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  The Size of a Single Residue of the Sulfonylurea Receptor Dictates the Effectiveness of K_ATP Channel Openers

  Christophe Moreau, Fabienne Gally, Heélène Jacquet-Bouix and Michel Vivaudou

  Molecular Pharmacology April 2005, 67 (4) 1026-1033; DOI: https://doi.org/10.1124/mol.104.008698
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  Anuroctoxin, a New Scorpion Toxin of the α-KTx 6 Subfamily, Is Highly Selective for Kv1.3 over IKCa1 Ion Channels of Human T Lymphocytes

  Miklós Bagdáany, Cesar V. F. Batista, Norma A. Valdez-Cruz, Sándor Somodi, Ricardo C. Rodriguez de la Vega, Alexei F. Licea, Zoltáan Varga, Rezső Gáspár, Lourival D. Possani and György Panyi

  Molecular Pharmacology April 2005, 67 (4) 1034-1044; DOI: https://doi.org/10.1124/mol.104.007187
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  Pharmacological Differences between Human and Guinea Pig Histamine H₁ Receptors: Asn⁸⁴ (2.61) as Key Residue within an Additional Binding Pocket in the H₁ Receptor

  Martijn Bruysters, Aldo Jongejan, Michel Gillard, Frank van de Manakker, Remko A. Bakker, Pierre Chatelain and Rob Leurs

  Molecular Pharmacology April 2005, 67 (4) 1045-1052; DOI: https://doi.org/10.1124/mol.104.008847
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  Meclofenamic Acid and Diclofenac, Novel Templates of KCNQ2/Q3 Potassium Channel Openers, Depress Cortical Neuron Activity and Exhibit Anticonvulsant Properties

  Asher Peretz, Nurit Degani, Rachel Nachman, Yael Uziyel, Gilad Gibor, Doron Shabat and Bernard Attali

  Molecular Pharmacology April 2005, 67 (4) 1053-1066; DOI: https://doi.org/10.1124/mol.104.007112
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  Molecular Determinants of Substrate/Inhibitor Binding to the Human and Rabbit Renal Organic Cation Transporters hOCT2 and rbOCT2

  Wendy M. Suhre, Sean Ekins, Cheng Chang, Peter W. Swaan and Stephen H. Wright

  Molecular Pharmacology April 2005, 67 (4) 1067-1077; DOI: https://doi.org/10.1124/mol.104.004713
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  Molecular Determinants of the Agonist Binding Domain of a P2X Receptor Channel

  Zonghe Yan, Zhaodong Liang, Melanija Tomić, Tomas Obsil and Stanko S. Stojilkovic

  Molecular Pharmacology April 2005, 67 (4) 1078-1088; DOI: https://doi.org/10.1124/mol.104.010108
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  Phosphatidylinositol-4,5-bisphosphate: Actin Dynamics and the Regulation of ATP-Dependent and -Independent Secretion

  Mary A. Bittner and Ronald W. Holz

  Molecular Pharmacology April 2005, 67 (4) 1089-1098; DOI: https://doi.org/10.1124/mol.104.008474
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  Extracellular Loop 3 (EL3) and EL3-Proximal Transmembrane Helix 7 of the Mammalian Type I and Type II Gonadotropin-Releasing Hormone (GnRH) Receptors Determine Differential Ligand Selectivity to GnRH-I and GnRH-II

  Jian Hua Li, Han Choe, Ai Fen Wang, Kaushik Maiti, Chengbing Wang, Abdus Salam, Sang Young Chun, Won-Kyo Lee, Kyungjin Kim, Hyuk Bang Kwon and Jae Young Seong

  Molecular Pharmacology April 2005, 67 (4) 1099-1110; DOI: https://doi.org/10.1124/mol.104.004887
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  Glycosaminoglycans and Protein Disulfide Isomerase-Mediated Reduction of HIV Env

  Rym Barbouche, Hugues Lortat-Jacob, Ian M. Jones and Emmanuel Fenouillet

  Molecular Pharmacology April 2005, 67 (4) 1111-1118; DOI: https://doi.org/10.1124/mol.104.008276
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  TRPV1b, a Functional Human Vanilloid Receptor Splice Variant

  Gang Lu, Dorian Henderson, Lieju Liu, Peter H. Reinhart and Sidney A. Simon

  Molecular Pharmacology April 2005, 67 (4) 1119-1127; DOI: https://doi.org/10.1124/mol.104.009852
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  Molecular Interactions between Matrilysin and the Matrix Metalloproteinase Inhibitor Doxycycline Investigated by Deuterium Exchange Mass Spectrometry

  Ricardo A. García, Dennis P. Pantazatos, Christopher R. Gessner, Katrina V. Go, Virgil L. Woods and Francisco J. Villarreal

  Molecular Pharmacology April 2005, 67 (4) 1128-1136; DOI: https://doi.org/10.1124/mol.104.006346
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  A Novel Class of Fusion Polypeptides Inhibits Exocytosis

  Kenji Matsushita, Craig N. Morrell and Charles J. Lowenstein

  Molecular Pharmacology April 2005, 67 (4) 1137-1144; DOI: https://doi.org/10.1124/mol.104.004275
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  Src Family Kinase Inhibitors Block Amphiregulin-Mediated Autocrine ErbB Signaling in Normal Human Keratinocytes

  Sanjay Kansra, Stefan W. Stoll, Jessica L. Johnson and James T. Elder

  Molecular Pharmacology April 2005, 67 (4) 1145-1157; DOI: https://doi.org/10.1124/mol.104.004689
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  N-Methyl-D-aspartate and Brain-Derived Neurotrophic Factor Induce Distinct Profiles of Extracellular Signal-Regulated Kinase, Mitogen- and Stress-Activated Kinase, and Ribosomal S6 Kinase Phosphorylation in Cortical Neurons

  S. Rakhit, C. J. Clark, C. T. O'Shaughnessy and B. J. Morris

  Molecular Pharmacology April 2005, 67 (4) 1158-1165; DOI: https://doi.org/10.1124/mol.104.005447
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  Cotreatment with Suberanoylanilide Hydroxamic Acid and 17-Allylamino 17-demethoxygeldanamycin Synergistically Induces Apoptosis in Bcr-Abl⁺ Cells Sensitive and Resistant to STI571 (Imatinib Mesylate) in Association with Down-Regulation of Bcr-Abl, Abrogation of Signal Transducer and Activator of Transcription 5 Activity, and Bax Conformational Change

  Mohamed Rahmani, Erin Reese, Yun Dai, Cheryl Bauer, Lora B. Kramer, Mei Huang, Richard Jove, Paul Dent and Steven Grant

  Molecular Pharmacology April 2005, 67 (4) 1166-1176; DOI: https://doi.org/10.1124/mol.104.007831
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  Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I₂ Pathway in Human Coronary Artery Smooth Muscle Cells

  Alatangaole Damirin, Hideaki Tomura, Mayumi Komachi, Masayuki Tobo, Koichi Sato, Chihiro Mogi, Hiromi Nochi, Koichi Tamoto and Fumikazu Okajima

  Molecular Pharmacology April 2005, 67 (4) 1177-1185; DOI: https://doi.org/10.1124/mol.104.004317
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  Selective Inhibition of Topoisomerase I and Various Steps of Spliceosome Assembly by Diospyrin Derivatives

  Jamal Tazi, Nadia Bakkour, Johann Soret, Latifa Zekri, Banasri Hazra, William Laine, Brigitte Baldeyrou, Amélie Lansiaux and Christian Bailly

  Molecular Pharmacology April 2005, 67 (4) 1186-1194; DOI: https://doi.org/10.1124/mol.104.007633
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  Involvement of G_i/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons

  Eddy H. T. Wu and Yung H. Wong

  Molecular Pharmacology April 2005, 67 (4) 1195-1205; DOI: https://doi.org/10.1124/mol.104.007237
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  Interaction of the Insulin Receptor with the Receptor-Like Protein Tyrosine Phosphatases PTPα and PTPϵ in Living Cells

  Danièle Lacasa, Nicolas Boute and Tarik Issad

  Molecular Pharmacology April 2005, 67 (4) 1206-1213; DOI: https://doi.org/10.1124/mol.104.009514
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  Differential Sensitivity of K_ir2 Inward-Rectifier Potassium Channels to a Mitochondrial Uncoupler: Identification of a Regulatory Site

  Anthony Collins, Haoran Wang and Maureen K. Larson

  Molecular Pharmacology April 2005, 67 (4) 1214-1220; DOI: https://doi.org/10.1124/mol.104.008292
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  Developmental Changes of GABA Synaptic Transient in Cerebellar Granule Cells

  Andrea Barberis, Congyi Lu, Stefano Vicini and Jerzy W. Mozrzymas

  Molecular Pharmacology April 2005, 67 (4) 1221-1228; DOI: https://doi.org/10.1124/mol.104.006437
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  β-Arrestin 2-Dependent Angiotensin II Type 1A Receptor-Mediated Pathway of Chemotaxis

  Dacia L. Hunton, William G. Barnes, Jihee Kim, Xiu-Rong Ren, Jonathan D. Violin, Eric Reiter, Graeme Milligan, Dhavalkumar D. Patel and Robert J. Lefkowitz

  Molecular Pharmacology April 2005, 67 (4) 1229-1236; DOI: https://doi.org/10.1124/mol.104.006270
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  Glycogen Synthase Kinase 3 Activity Mediates Neuronal Pentraxin 1 Expression and Cell Death Induced by Potassium Deprivation in Cerebellar Granule Cells

  Marta Enguita, Nuria DeGregorio-Rocasolano, Alba Abad and Ramon Trullas

  Molecular Pharmacology April 2005, 67 (4) 1237-1246; DOI: https://doi.org/10.1124/mol.104.007062
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  Arsenite Inhibition of CYP1A1 Induction by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Independent of Cell Cycle Arrest

  Jessica A. Bonzo, Shujuan Chen, Alema Galijatovic and Robert H. Tukey

  Molecular Pharmacology April 2005, 67 (4) 1247-1256; DOI: https://doi.org/10.1124/mol.104.006130
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  Regulation of Human Hepatic Hydroxysteroid Sulfotransferase Gene Expression by the Peroxisome Proliferator-Activated Receptor α Transcription Factor

  Hai-Lin Fang, Stephen C. Strom, Hongbo Cai, Charles N. Falany, Thomas A. Kocarek and Melissa Runge-Morris

  Molecular Pharmacology April 2005, 67 (4) 1257-1267; DOI: https://doi.org/10.1124/mol.104.005389
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  The CCR5 Receptor-Based Mechanism of Action of 873140, a Potent Allosteric Noncompetitive HIV Entry Inhibitor

  Christian Watson, Stephen Jenkinson, Wieslaw Kazmierski and Terry Kenakin

  Molecular Pharmacology April 2005, 67 (4) 1268-1282; DOI: https://doi.org/10.1124/mol.104.008565
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  Trace Amines Depress GABA_B Response in Dopaminergic Neurons by Inhibiting G-βγ-Gated Inwardly Rectifying Potassium Channels

  Mauro Federici, Raffaella Geracitano, Alessandro Tozzi, Patrizia Longone, Silvia Di Angelantonio, C. Peter Bengtson, Giorgio Bernardi and Nicola B. Mercuri

  Molecular Pharmacology April 2005, 67 (4) 1283-1290; DOI: https://doi.org/10.1124/mol.104.007427
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  Residue 33 of Human Equilibrative Nucleoside Transporter 2 Is a Functionally Important Component of Both the Dipyridamole and Nucleoside Binding Sites

  Frank Visser, Jing Zhang, R. Taylor Raborn, Stephen A. Baldwin, James D. Young and Carol E. Cass

  Molecular Pharmacology April 2005, 67 (4) 1291-1298; DOI: https://doi.org/10.1124/mol.104.005884
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  The Xenobiotic-Metabolizing Enzymes Arylamine N-Acetyltransferases in Human Lens Epithelial Cells: Inactivation by Cellular Oxidants and UVB-Induced Oxidative Stress

  Julien Dairou, François Malecaze, Jean-Marie Dupret and Fernando Rodrigues-Lima

  Molecular Pharmacology April 2005, 67 (4) 1299-1306; DOI: https://doi.org/10.1124/mol.104.009738
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  Cross-Resistance to Death Ligand-Induced Apoptosis in Cisplatin-Selected HeLa Cells Associated with Overexpression of DDB2 and Subsequent Induction of cFLIP

  Chun-Ling Sun and Chuck C.-K. Chao

  Molecular Pharmacology April 2005, 67 (4) 1307-1314; DOI: https://doi.org/10.1124/mol.104.008797
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  Elastin Peptides Activate Extracellular Signal-Regulated Kinase 1/2 via a Ras-Independent Mechanism Requiring Both p110γ/Raf-1 and Protein Kinase A/B-Raf Signaling in Human Skin Fibroblasts

  Laurent Duca, Elise Lambert, Romain Debret, Bernard Rothhut, Charlotte Blanchevoye, Frédéric Delacoux, William Hornebeck, Laurent Martiny and Laurent Debelle

  Molecular Pharmacology April 2005, 67 (4) 1315-1324; DOI: https://doi.org/10.1124/mol.104.002725
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  Regulation of the Cyp2a5 Gene Involves an Aryl Hydrocarbon Receptor-Dependent Pathway

  Satu Arpiainen, Françoise Raffalli-Mathieu, Matti A. Lang, Olavi Pelkonen and Jukka Hakkola

  Molecular Pharmacology April 2005, 67 (4) 1325-1333; DOI: https://doi.org/10.1124/mol.104.008078
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  Role of Glycosylation in Trafficking of Mrp2 in Sandwich-Cultured Rat Hepatocytes

  Peijin Zhang, Xianbin Tian, Priyamvada Chandra and Kim L. R. Brouwer

  Molecular Pharmacology April 2005, 67 (4) 1334-1341; DOI: https://doi.org/10.1124/mol.104.004481
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  Peroxisome Proliferator-Activated Receptor γ-Independent Ablation of Cyclin D1 by Thiazolidinediones and Their Derivatives in Breast Cancer Cells

  Jui-Wen Huang, Chung-Wai Shiau, Ya-Ting Yang, Samuel K. Kulp, Kuen-Feng Chen, Robert W. Brueggemeier, Charles L. Shapiro and Ching-Shih Chen

  Molecular Pharmacology April 2005, 67 (4) 1342-1348; DOI: https://doi.org/10.1124/mol.104.007732
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  Cytoplasmic Confinement of Breast Cancer Resistance Protein (BCRP/ABCG2) as a Novel Mechanism of Adaptation to Short-Term Folate Deprivation

  Ilan Ifergan, Gerrit Jansen and Yehuda G. Assaraf

  Molecular Pharmacology April 2005, 67 (4) 1349-1359; DOI: https://doi.org/10.1124/mol.104.008250
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  EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information

  Kevin R. Hayes, Aaron L. Vollrath, Gina M. Zastrow, Brian J. McMillan, Mark Craven, Stevan Jovanovich, David R. Rank, Sharon Penn, Jacqueline A. Walisser, Janardan K. Reddy, Russell S. Thomas and Christopher A. Bradfield

  Molecular Pharmacology April 2005, 67 (4) 1360-1368; DOI: https://doi.org/10.1124/mol.104.009175
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  Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases

  Christine Beeton, Michael W. Pennington, Heike Wulff, Satendra Singh, Daniel Nugent, George Crossley, Ilya Khaytin, Peter A. Calabresi, Chao-Yin Chen, George A. Gutman and K. George Chandy

  Molecular Pharmacology April 2005, 67 (4) 1369-1381; DOI: https://doi.org/10.1124/mol.104.008193