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Molecular Pharmacology

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Table of Contents

April 01, 2005; Volume 67,Issue 4

Perspectives

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    Nuclear Factor-κB Decoys Suppress Endotoxin-Induced Lung Injury
    Delphine Baetz, James Shaw and Lorrie A. Kirshenbaum
    Molecular Pharmacology April 2005, 67 (4) 977-979; DOI: https://doi.org/10.1124/mol.105.011296
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    Fusion Polypeptides That Inhibit Exocytosis: Fusing Aptamer and Cell-Penetrating Peptide Technologies and Pharmacologies
    Lee E. Eiden
    Molecular Pharmacology April 2005, 67 (4) 980-982; DOI: https://doi.org/10.1124/mol.105.011429

Accelerated Communications

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    The Natural Mutation Encoding a C Terminus-Truncated 5-Hydroxytryptamine2B Receptor Is a Gain of Proliferative Functions
    Maud Deraet, Philippe Manivet, Agnes Janoshazi, Jacques Callebert, Silke Guenther, Ludovic Drouet, Jean-Marie Launay and Luc Maroteaux
    Molecular Pharmacology April 2005, 67 (4) 983-991; DOI: https://doi.org/10.1124/mol.104.008268
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    β-Arrestin-Dependent Spontaneous α1a-Adrenoceptor Endocytosis Causes Intracellular Transportation of α-Blockers via Recycling Compartments
    John D. Pediani, Janet F. Colston, Darren Caldwell, Graeme Milligan, Craig J. Daly and John C. McGrath
    Molecular Pharmacology April 2005, 67 (4) 992-1004; DOI: https://doi.org/10.1124/mol.104.008417
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    Benzodiazepines Affect Channel Opening of GABAA Receptors Induced by Either Agonist Binding Site
    Roland Baur and Erwin Sigel
    Molecular Pharmacology April 2005, 67 (4) 1005-1008; DOI: https://doi.org/10.1124/mol.104.008151
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    The New Anticonvulsant Retigabine Favors Voltage-Dependent Opening of the Kv7.2 (KCNQ2) Channel by Binding to Its Activation Gate
    Thomas V. Wuttke, Guiscard Seebohm, Sigrid Bail, Snezana Maljevic and Holger Lerche
    Molecular Pharmacology April 2005, 67 (4) 1009-1017; DOI: https://doi.org/10.1124/mol.104.010793

Original Article

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    Nuclear Factor-κB Decoy Oligodeoxynucleotides Prevent Acute Lung Injury in Mice with Cecal Ligation and Puncture-Induced Sepsis
    Naoyuki Matsuda, Yuichi Hattori, Subrina Jesmin and Satoshi Gando
    Molecular Pharmacology April 2005, 67 (4) 1018-1025; DOI: https://doi.org/10.1124/mol.104.005926
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    The Size of a Single Residue of the Sulfonylurea Receptor Dictates the Effectiveness of KATP Channel Openers
    Christophe Moreau, Fabienne Gally, Heélène Jacquet-Bouix and Michel Vivaudou
    Molecular Pharmacology April 2005, 67 (4) 1026-1033; DOI: https://doi.org/10.1124/mol.104.008698
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    Anuroctoxin, a New Scorpion Toxin of the α-KTx 6 Subfamily, Is Highly Selective for Kv1.3 over IKCa1 Ion Channels of Human T Lymphocytes
    Miklós Bagdáany, Cesar V. F. Batista, Norma A. Valdez-Cruz, Sándor Somodi, Ricardo C. Rodriguez de la Vega, Alexei F. Licea, Zoltáan Varga, Rezső Gáspár, Lourival D. Possani and György Panyi
    Molecular Pharmacology April 2005, 67 (4) 1034-1044; DOI: https://doi.org/10.1124/mol.104.007187
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    Pharmacological Differences between Human and Guinea Pig Histamine H1 Receptors: Asn84 (2.61) as Key Residue within an Additional Binding Pocket in the H1 Receptor
    Martijn Bruysters, Aldo Jongejan, Michel Gillard, Frank van de Manakker, Remko A. Bakker, Pierre Chatelain and Rob Leurs
    Molecular Pharmacology April 2005, 67 (4) 1045-1052; DOI: https://doi.org/10.1124/mol.104.008847
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    Meclofenamic Acid and Diclofenac, Novel Templates of KCNQ2/Q3 Potassium Channel Openers, Depress Cortical Neuron Activity and Exhibit Anticonvulsant Properties
    Asher Peretz, Nurit Degani, Rachel Nachman, Yael Uziyel, Gilad Gibor, Doron Shabat and Bernard Attali
    Molecular Pharmacology April 2005, 67 (4) 1053-1066; DOI: https://doi.org/10.1124/mol.104.007112
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    Molecular Determinants of Substrate/Inhibitor Binding to the Human and Rabbit Renal Organic Cation Transporters hOCT2 and rbOCT2
    Wendy M. Suhre, Sean Ekins, Cheng Chang, Peter W. Swaan and Stephen H. Wright
    Molecular Pharmacology April 2005, 67 (4) 1067-1077; DOI: https://doi.org/10.1124/mol.104.004713
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    Molecular Determinants of the Agonist Binding Domain of a P2X Receptor Channel
    Zonghe Yan, Zhaodong Liang, Melanija Tomić, Tomas Obsil and Stanko S. Stojilkovic
    Molecular Pharmacology April 2005, 67 (4) 1078-1088; DOI: https://doi.org/10.1124/mol.104.010108
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    Phosphatidylinositol-4,5-bisphosphate: Actin Dynamics and the Regulation of ATP-Dependent and -Independent Secretion
    Mary A. Bittner and Ronald W. Holz
    Molecular Pharmacology April 2005, 67 (4) 1089-1098; DOI: https://doi.org/10.1124/mol.104.008474
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    Extracellular Loop 3 (EL3) and EL3-Proximal Transmembrane Helix 7 of the Mammalian Type I and Type II Gonadotropin-Releasing Hormone (GnRH) Receptors Determine Differential Ligand Selectivity to GnRH-I and GnRH-II
    Jian Hua Li, Han Choe, Ai Fen Wang, Kaushik Maiti, Chengbing Wang, Abdus Salam, Sang Young Chun, Won-Kyo Lee, Kyungjin Kim, Hyuk Bang Kwon and Jae Young Seong
    Molecular Pharmacology April 2005, 67 (4) 1099-1110; DOI: https://doi.org/10.1124/mol.104.004887
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    Glycosaminoglycans and Protein Disulfide Isomerase-Mediated Reduction of HIV Env
    Rym Barbouche, Hugues Lortat-Jacob, Ian M. Jones and Emmanuel Fenouillet
    Molecular Pharmacology April 2005, 67 (4) 1111-1118; DOI: https://doi.org/10.1124/mol.104.008276
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    TRPV1b, a Functional Human Vanilloid Receptor Splice Variant
    Gang Lu, Dorian Henderson, Lieju Liu, Peter H. Reinhart and Sidney A. Simon
    Molecular Pharmacology April 2005, 67 (4) 1119-1127; DOI: https://doi.org/10.1124/mol.104.009852
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    Molecular Interactions between Matrilysin and the Matrix Metalloproteinase Inhibitor Doxycycline Investigated by Deuterium Exchange Mass Spectrometry
    Ricardo A. García, Dennis P. Pantazatos, Christopher R. Gessner, Katrina V. Go, Virgil L. Woods and Francisco J. Villarreal
    Molecular Pharmacology April 2005, 67 (4) 1128-1136; DOI: https://doi.org/10.1124/mol.104.006346
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    A Novel Class of Fusion Polypeptides Inhibits Exocytosis
    Kenji Matsushita, Craig N. Morrell and Charles J. Lowenstein
    Molecular Pharmacology April 2005, 67 (4) 1137-1144; DOI: https://doi.org/10.1124/mol.104.004275
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    Src Family Kinase Inhibitors Block Amphiregulin-Mediated Autocrine ErbB Signaling in Normal Human Keratinocytes
    Sanjay Kansra, Stefan W. Stoll, Jessica L. Johnson and James T. Elder
    Molecular Pharmacology April 2005, 67 (4) 1145-1157; DOI: https://doi.org/10.1124/mol.104.004689
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    N-Methyl-D-aspartate and Brain-Derived Neurotrophic Factor Induce Distinct Profiles of Extracellular Signal-Regulated Kinase, Mitogen- and Stress-Activated Kinase, and Ribosomal S6 Kinase Phosphorylation in Cortical Neurons
    S. Rakhit, C. J. Clark, C. T. O'Shaughnessy and B. J. Morris
    Molecular Pharmacology April 2005, 67 (4) 1158-1165; DOI: https://doi.org/10.1124/mol.104.005447
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    Cotreatment with Suberanoylanilide Hydroxamic Acid and 17-Allylamino 17-demethoxygeldanamycin Synergistically Induces Apoptosis in Bcr-Abl+ Cells Sensitive and Resistant to STI571 (Imatinib Mesylate) in Association with Down-Regulation of Bcr-Abl, Abrogation of Signal Transducer and Activator of Transcription 5 Activity, and Bax Conformational Change
    Mohamed Rahmani, Erin Reese, Yun Dai, Cheryl Bauer, Lora B. Kramer, Mei Huang, Richard Jove, Paul Dent and Steven Grant
    Molecular Pharmacology April 2005, 67 (4) 1166-1176; DOI: https://doi.org/10.1124/mol.104.007831
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    Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I2 Pathway in Human Coronary Artery Smooth Muscle Cells
    Alatangaole Damirin, Hideaki Tomura, Mayumi Komachi, Masayuki Tobo, Koichi Sato, Chihiro Mogi, Hiromi Nochi, Koichi Tamoto and Fumikazu Okajima
    Molecular Pharmacology April 2005, 67 (4) 1177-1185; DOI: https://doi.org/10.1124/mol.104.004317
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    Selective Inhibition of Topoisomerase I and Various Steps of Spliceosome Assembly by Diospyrin Derivatives
    Jamal Tazi, Nadia Bakkour, Johann Soret, Latifa Zekri, Banasri Hazra, William Laine, Brigitte Baldeyrou, Amélie Lansiaux and Christian Bailly
    Molecular Pharmacology April 2005, 67 (4) 1186-1194; DOI: https://doi.org/10.1124/mol.104.007633
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    Involvement of Gi/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons
    Eddy H. T. Wu and Yung H. Wong
    Molecular Pharmacology April 2005, 67 (4) 1195-1205; DOI: https://doi.org/10.1124/mol.104.007237
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    Interaction of the Insulin Receptor with the Receptor-Like Protein Tyrosine Phosphatases PTPα and PTPϵ in Living Cells
    Danièle Lacasa, Nicolas Boute and Tarik Issad
    Molecular Pharmacology April 2005, 67 (4) 1206-1213; DOI: https://doi.org/10.1124/mol.104.009514
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    Differential Sensitivity of Kir2 Inward-Rectifier Potassium Channels to a Mitochondrial Uncoupler: Identification of a Regulatory Site
    Anthony Collins, Haoran Wang and Maureen K. Larson
    Molecular Pharmacology April 2005, 67 (4) 1214-1220; DOI: https://doi.org/10.1124/mol.104.008292
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    Developmental Changes of GABA Synaptic Transient in Cerebellar Granule Cells
    Andrea Barberis, Congyi Lu, Stefano Vicini and Jerzy W. Mozrzymas
    Molecular Pharmacology April 2005, 67 (4) 1221-1228; DOI: https://doi.org/10.1124/mol.104.006437
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    β-Arrestin 2-Dependent Angiotensin II Type 1A Receptor-Mediated Pathway of Chemotaxis
    Dacia L. Hunton, William G. Barnes, Jihee Kim, Xiu-Rong Ren, Jonathan D. Violin, Eric Reiter, Graeme Milligan, Dhavalkumar D. Patel and Robert J. Lefkowitz
    Molecular Pharmacology April 2005, 67 (4) 1229-1236; DOI: https://doi.org/10.1124/mol.104.006270
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    Glycogen Synthase Kinase 3 Activity Mediates Neuronal Pentraxin 1 Expression and Cell Death Induced by Potassium Deprivation in Cerebellar Granule Cells
    Marta Enguita, Nuria DeGregorio-Rocasolano, Alba Abad and Ramon Trullas
    Molecular Pharmacology April 2005, 67 (4) 1237-1246; DOI: https://doi.org/10.1124/mol.104.007062
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    Arsenite Inhibition of CYP1A1 Induction by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Independent of Cell Cycle Arrest
    Jessica A. Bonzo, Shujuan Chen, Alema Galijatovic and Robert H. Tukey
    Molecular Pharmacology April 2005, 67 (4) 1247-1256; DOI: https://doi.org/10.1124/mol.104.006130
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    Regulation of Human Hepatic Hydroxysteroid Sulfotransferase Gene Expression by the Peroxisome Proliferator-Activated Receptor α Transcription Factor
    Hai-Lin Fang, Stephen C. Strom, Hongbo Cai, Charles N. Falany, Thomas A. Kocarek and Melissa Runge-Morris
    Molecular Pharmacology April 2005, 67 (4) 1257-1267; DOI: https://doi.org/10.1124/mol.104.005389
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    The CCR5 Receptor-Based Mechanism of Action of 873140, a Potent Allosteric Noncompetitive HIV Entry Inhibitor
    Christian Watson, Stephen Jenkinson, Wieslaw Kazmierski and Terry Kenakin
    Molecular Pharmacology April 2005, 67 (4) 1268-1282; DOI: https://doi.org/10.1124/mol.104.008565
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    Trace Amines Depress GABAB Response in Dopaminergic Neurons by Inhibiting G-βγ-Gated Inwardly Rectifying Potassium Channels
    Mauro Federici, Raffaella Geracitano, Alessandro Tozzi, Patrizia Longone, Silvia Di Angelantonio, C. Peter Bengtson, Giorgio Bernardi and Nicola B. Mercuri
    Molecular Pharmacology April 2005, 67 (4) 1283-1290; DOI: https://doi.org/10.1124/mol.104.007427
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    Residue 33 of Human Equilibrative Nucleoside Transporter 2 Is a Functionally Important Component of Both the Dipyridamole and Nucleoside Binding Sites
    Frank Visser, Jing Zhang, R. Taylor Raborn, Stephen A. Baldwin, James D. Young and Carol E. Cass
    Molecular Pharmacology April 2005, 67 (4) 1291-1298; DOI: https://doi.org/10.1124/mol.104.005884
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    The Xenobiotic-Metabolizing Enzymes Arylamine N-Acetyltransferases in Human Lens Epithelial Cells: Inactivation by Cellular Oxidants and UVB-Induced Oxidative Stress
    Julien Dairou, François Malecaze, Jean-Marie Dupret and Fernando Rodrigues-Lima
    Molecular Pharmacology April 2005, 67 (4) 1299-1306; DOI: https://doi.org/10.1124/mol.104.009738
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    Cross-Resistance to Death Ligand-Induced Apoptosis in Cisplatin-Selected HeLa Cells Associated with Overexpression of DDB2 and Subsequent Induction of cFLIP
    Chun-Ling Sun and Chuck C.-K. Chao
    Molecular Pharmacology April 2005, 67 (4) 1307-1314; DOI: https://doi.org/10.1124/mol.104.008797
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    Elastin Peptides Activate Extracellular Signal-Regulated Kinase 1/2 via a Ras-Independent Mechanism Requiring Both p110γ/Raf-1 and Protein Kinase A/B-Raf Signaling in Human Skin Fibroblasts
    Laurent Duca, Elise Lambert, Romain Debret, Bernard Rothhut, Charlotte Blanchevoye, Frédéric Delacoux, William Hornebeck, Laurent Martiny and Laurent Debelle
    Molecular Pharmacology April 2005, 67 (4) 1315-1324; DOI: https://doi.org/10.1124/mol.104.002725
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    Regulation of the Cyp2a5 Gene Involves an Aryl Hydrocarbon Receptor-Dependent Pathway
    Satu Arpiainen, Françoise Raffalli-Mathieu, Matti A. Lang, Olavi Pelkonen and Jukka Hakkola
    Molecular Pharmacology April 2005, 67 (4) 1325-1333; DOI: https://doi.org/10.1124/mol.104.008078
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    Role of Glycosylation in Trafficking of Mrp2 in Sandwich-Cultured Rat Hepatocytes
    Peijin Zhang, Xianbin Tian, Priyamvada Chandra and Kim L. R. Brouwer
    Molecular Pharmacology April 2005, 67 (4) 1334-1341; DOI: https://doi.org/10.1124/mol.104.004481
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    Peroxisome Proliferator-Activated Receptor γ-Independent Ablation of Cyclin D1 by Thiazolidinediones and Their Derivatives in Breast Cancer Cells
    Jui-Wen Huang, Chung-Wai Shiau, Ya-Ting Yang, Samuel K. Kulp, Kuen-Feng Chen, Robert W. Brueggemeier, Charles L. Shapiro and Ching-Shih Chen
    Molecular Pharmacology April 2005, 67 (4) 1342-1348; DOI: https://doi.org/10.1124/mol.104.007732
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    Cytoplasmic Confinement of Breast Cancer Resistance Protein (BCRP/ABCG2) as a Novel Mechanism of Adaptation to Short-Term Folate Deprivation
    Ilan Ifergan, Gerrit Jansen and Yehuda G. Assaraf
    Molecular Pharmacology April 2005, 67 (4) 1349-1359; DOI: https://doi.org/10.1124/mol.104.008250
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    EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information
    Kevin R. Hayes, Aaron L. Vollrath, Gina M. Zastrow, Brian J. McMillan, Mark Craven, Stevan Jovanovich, David R. Rank, Sharon Penn, Jacqueline A. Walisser, Janardan K. Reddy, Russell S. Thomas and Christopher A. Bradfield
    Molecular Pharmacology April 2005, 67 (4) 1360-1368; DOI: https://doi.org/10.1124/mol.104.009175
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    Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases
    Christine Beeton, Michael W. Pennington, Heike Wulff, Satendra Singh, Daniel Nugent, George Crossley, Ilya Khaytin, Peter A. Calabresi, Chao-Yin Chen, George A. Gutman and K. George Chandy
    Molecular Pharmacology April 2005, 67 (4) 1369-1381; DOI: https://doi.org/10.1124/mol.104.008193

Erratum

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    Correction to “Activation of the melastatin-related cation channel TRMP3 by d-erythro-sphingosine”
    Molecular Pharmacology April 2005, 67 (4) 1382; DOI: https://doi.org/10.1124/mol.67.4.1382
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Molecular Pharmacology: 67 (4)
Molecular Pharmacology
Vol. 67, Issue 4
1 Apr 2005
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