Meclofenamic Acid and Diclofenac, Novel Templates of KCNQ2/Q3 Potassium Channel Openers, Depress Cortical Neuron Activity and Exhibit Anticonvulsant Properties

Department of Physiology and Pharmacology, Sackler Faculty of Medical Sciences (A.P., N.D., R.N., Y.U., G.G., B.A.) and School of Chemistry, Faculty of Exact Sciences (D.S.), Tel Aviv University, Tel Aviv, Israel

Address correspondence to:
Dr. Bernard Attali, Department of Physiology and Pharmacology, Sackler Medical School, Tel Aviv University, Tel Aviv 69978, Israel. E-mail: battali{at}post.tau.ac.il

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: December 2004 to April 2021

	Abstract	Full	Pdf
Dec 2004	37	0	74
Jan 2005	32	0	63
Feb 2005	29	0	44
Mar 2005	104	58	101
Apr 2005	40	87	52
May 2005	46	92	44
Jun 2005	44	90	42
Jul 2005	29	66	34
Aug 2005	23	62	30
Sep 2005	16	48	20
Oct 2005	19	33	14
Nov 2005	45	68	28
Dec 2005	18	33	10
Jan 2006	29	19	20
Feb 2006	29	16	6
Mar 2006	36	17	17
Apr 2006	15	37	22
May 2006	29	48	28
Jun 2006	32	50	35
Jul 2006	27	34	15
Aug 2006	15	39	25
Sep 2006	15	37	19
Oct 2006	24	59	34
Nov 2006	21	62	42
Dec 2006	15	35	20
Jan 2007	14	33	23
Feb 2007	20	40	29
Mar 2007	18	43	33
Apr 2007	20	45	30
May 2007	24	53	32
Jun 2007	22	46	19
Jul 2007	17	29	19
Aug 2007	26	47	23
Sep 2007	23	28	13
Oct 2007	18	47	39
Nov 2007	17	43	18
Dec 2007	15	32	15
Jan 2008	8	46	43
Feb 2008	13	27	6
Mar 2008	16	36	21
Apr 2008	19	46	32
May 2008	23	32	30
Jun 2008	35	50	29
Jul 2008	28	32	22
Aug 2008	29	49	19
Sep 2008	38	31	41
Oct 2008	23	26	21
Nov 2008	30	35	25
Dec 2008	21	28	14
Jan 2009	23	26	17
Feb 2009	21	17	16
Mar 2009	29	35	20
Apr 2009	29	30	20
May 2009	20	29	19
Jun 2009	11	25	10
Jul 2009	23	18	12
Aug 2009	16	29	19
Sep 2009	21	26	28
Oct 2009	26	19	15
Nov 2009	22	17	14
Dec 2009	15	13	11
Jan 2010	13	22	7
Feb 2010	22	15	15
Mar 2010	18	19	16
Apr 2010	25	31	22
May 2010	33	48	21
Jun 2010	22	31	22
Jul 2010	48	24	23
Aug 2010	35	23	16
Sep 2010	32	32	15
Oct 2010	12	49	26
Nov 2010	12	32	7
Dec 2010	14	26	16
Jan 2011	19	22	16
Feb 2011	20	30	28
Mar 2011	28	37	21
Apr 2011	24	27	25
May 2011	23	19	18
Jun 2011	23	22	20
Jul 2011	18	16	10
Aug 2011	34	9	17
Sep 2011	29	28	15
Oct 2011	19	13	13
Nov 2011	33	29	17
Dec 2011	22	32	21
Jan 2012	21	20	17
Feb 2012	15	16	16
Mar 2012	29	21	28
Apr 2012	36	22	25
May 2012	33	28	35
Jun 2012	16	25	27
Jul 2012	17	31	23
Aug 2012	22	26	21
Sep 2012	27	27	24
Oct 2012	28	38	29
Nov 2012	16	35	33
Dec 2012	17	29	21
Jan 2013	37	32	21
Feb 2013	32	21	28
Mar 2013	33	24	24
Apr 2013	27	42	35
May 2013	20	26	27
Jun 2013	20	21	22
Jul 2013	25	22	19
Aug 2013	18	26	16
Sep 2013	6	13	22
Oct 2013	15	22	20
Nov 2013	14	10	11
Dec 2013	13	20	16
Jan 2014	21	22	15
Feb 2014	20	27	14
Mar 2014	44	21	50
Apr 2014	33	30	29
May 2014	34	24	28
Jun 2014	25	18	38
Jul 2014	21	27	8
Aug 2014	16	23	13
Sep 2014	12	26	22
Oct 2014	24	23	22
Nov 2014	28	35	19
Dec 2014	20	18	9
Jan 2015	19	30	14
Feb 2015	9	22	9
Mar 2015	18	43	10
Apr 2015	18	17	10
May 2015	28	34	17
Jun 2015	15	21	9
Jul 2015	20	57	24
Aug 2015	14	17	8
Sep 2015	15	18	8
Oct 2015	30	29	19
Nov 2015	18	26	3
Dec 2015	20	16	3
Jan 2016	33	42	21
Feb 2016	63	31	23
Mar 2016	35	27	16
Apr 2016	18	16	17
May 2016	37	29	22
Jun 2016	14	26	11
Jul 2016	23	17	16
Aug 2016	23	28	16
Sep 2016	20	16	8
Oct 2016	13	32	12
Nov 2016	9	34	7
Dec 2016	4	23	9
Jan 2017	4	43	9
Feb 2017	3	24	9
Mar 2017	4	27	8
Apr 2017	6	28	13
May 2017	7	39	23
Jun 2017	1	31	18
Jul 2017	6	22	14
Aug 2017	1	25	11
Sep 2017	5	24	11
Oct 2017	6	29	20
Nov 2017	3	38	19
Dec 2017	6	30	17
Jan 2018	4	36	24
Feb 2018	1	21	12
Mar 2018	1	36	23
Apr 2018	0	29	15
May 2018	0	33	18
Jun 2018	2	52	18
Jul 2018	0	23	16
Aug 2018	0	15	9
Sep 2018	0	18	17
Oct 2018	1	61	23
Nov 2018	3	20	17
Dec 2018	46	9	5
Jan 2019	31	6	8
Feb 2019	40	5	3
Mar 2019	38	4	8
Apr 2019	47	5	13
May 2019	22	2	2
Jun 2019	22	3	16
Jul 2019	32	5	9
Aug 2019	26	17	16
Sep 2019	36	13	11
Oct 2019	36	5	14
Nov 2019	42	5	10
Dec 2019	36	4	7
Jan 2020	39	6	0
Feb 2020	23	1	0
Mar 2020	22	5	0
Apr 2020	26	0	1
May 2020	24	2	4
Jun 2020	28	4	4
Jul 2020	21	1	1
Aug 2020	17	3	3
Sep 2020	13	0	2
Oct 2020	19	4	1
Nov 2020	16	6	9
Dec 2020	32	2	4
Jan 2021	39	24	8
Feb 2021	32	9	19
Mar 2021	31	8	2
Apr 2021	8	2	2