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Molecular Pharmacology

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Research ArticleOriginal Article

EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information

Kevin R. Hayes, Aaron L. Vollrath, Gina M. Zastrow, Brian J. McMillan, Mark Craven, Stevan Jovanovich, David R. Rank, Sharon Penn, Jacqueline A. Walisser, Janardan K. Reddy, Russell S. Thomas and Christopher A. Bradfield
Molecular Pharmacology April 2005, 67 (4) 1360-1368; DOI: https://doi.org/10.1124/mol.104.009175
Kevin R. Hayes
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Aaron L. Vollrath
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Gina M. Zastrow
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Brian J. McMillan
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Mark Craven
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Stevan Jovanovich
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David R. Rank
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Sharon Penn
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Jacqueline A. Walisser
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Janardan K. Reddy
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Russell S. Thomas
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Christopher A. Bradfield
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Abstract

Transcriptional profiling via microarrays holds great promise for toxicant classification and hazard prediction. Unfortunately, the use of different microarray platforms, protocols, and informatics often hinders the meaningful comparison of transcriptional profiling data across laboratories. One solution to this problem is to provide a low-cost and centralized resource that enables researchers to share toxicogenomic data that has been generated on a common platform. In an effort to create such a resource, we developed a standardized set of microarray reagents and reproducible protocols to simplify the analysis of liver gene expression in the mouse model. This resource, referred to as EDGE, was then used to generate a training set of 117 publicly accessible transcriptional profiles that can be accessed at http://edge.oncology.wisc.edu/. The Web-accessible database was also linked to an informatics suite that allows on-line clustering and K-means analyses as well as Boolean and sequence-based searches of the data. We propose that EDGE can serve as a prototype resource for the sharing of toxicogenomics information and be used to develop algorithms for efficient chemical classification and hazard prediction.

  • Received November 12, 2004.
  • Accepted January 6, 2005.
  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 67 (4)
Molecular Pharmacology
Vol. 67, Issue 4
1 Apr 2005
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Research ArticleOriginal Article

EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information

Kevin R. Hayes, Aaron L. Vollrath, Gina M. Zastrow, Brian J. McMillan, Mark Craven, Stevan Jovanovich, David R. Rank, Sharon Penn, Jacqueline A. Walisser, Janardan K. Reddy, Russell S. Thomas and Christopher A. Bradfield
Molecular Pharmacology April 1, 2005, 67 (4) 1360-1368; DOI: https://doi.org/10.1124/mol.104.009175

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Research ArticleOriginal Article

EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information

Kevin R. Hayes, Aaron L. Vollrath, Gina M. Zastrow, Brian J. McMillan, Mark Craven, Stevan Jovanovich, David R. Rank, Sharon Penn, Jacqueline A. Walisser, Janardan K. Reddy, Russell S. Thomas and Christopher A. Bradfield
Molecular Pharmacology April 1, 2005, 67 (4) 1360-1368; DOI: https://doi.org/10.1124/mol.104.009175
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