Molecular Pharmacology: 67 (5)

May 01, 2005; Volume 67,Issue 5

Perspectives

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From Plants to Man: The GPCR “Tree of Life”
Dianne M. Perez

Molecular Pharmacology May 2005, 67 (5) 1383-1384; DOI: https://doi.org/10.1124/mol.105.011890
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Adenosine in Tissue Protection and Tissue Regeneration
Joel Linden

Molecular Pharmacology May 2005, 67 (5) 1385-1387; DOI: https://doi.org/10.1124/mol.105.011783
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Internal PDZ Ligands: Novel Endocytic Recycling Motifs for G Protein-Coupled Receptors
JoAnn Trejo

Molecular Pharmacology May 2005, 67 (5) 1388-1390; DOI: https://doi.org/10.1124/mol.105.011288
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Polyspecific Organic Cation Transport: Insights into the Substrate Binding Site
Gerhard Burckhardt

Molecular Pharmacology May 2005, 67 (5) 1391-1392; DOI: https://doi.org/10.1124/mol.105.012161

Accelerated Communications

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Aspects of Dioxin Toxicity Are Mediated by Interleukin 1-Like Cytokines
Kalyan Pande, Susan M. Moran and Christopher A. Bradfield

Molecular Pharmacology May 2005, 67 (5) 1393-1398; DOI: https://doi.org/10.1124/mol.105.010983
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U937 Cell Necrosis Mediated by Peroxynitrite Is Not Caused by Depletion of ATP and Is Prevented by Arachidonate via an ATP-Dependent Mechanism
Orazio Cantoni, Andrea Guidarelli, Letizia Palomba and Mara Fiorani

Molecular Pharmacology May 2005, 67 (5) 1399-1405; DOI: https://doi.org/10.1124/mol.104.009498

ORIGINAL ARTICLE

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Adenosine A_2A Receptor Stimulation Increases Angiogenesis by Down-Regulating Production of the Antiangiogenic Matrix Protein Thrombospondin 1
Avani Desai, Cassandre Victor-Vega, Swathi Gadangi, M. Carmen Montesinos, Charles C. Chu and Bruce N. Cronstein

Molecular Pharmacology May 2005, 67 (5) 1406-1413; DOI: https://doi.org/10.1124/mol.104.007807
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The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes
Robert Fredriksson and Helgi B. Schiöth

Molecular Pharmacology May 2005, 67 (5) 1414-1425; DOI: https://doi.org/10.1124/mol.104.009001
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Effects of Valproic Acid Derivatives on Inositol Trisphosphate Depletion, Teratogenicity, Glycogen Synthase Kinase-3β Inhibition, and Viral Replication: A Screening Approach for New Bipolar Disorder Drugs Derived from the Valproic Acid Core Structure
B. J. Eickholt, G. J. Towers, W. J. Ryves, D. Eikel, K. Adley, L. M. J. Ylinen, N. H. Chadborn, A. J. Harwood, H. Nau and R. S. B. Williams

Molecular Pharmacology May 2005, 67 (5) 1426-1433; DOI: https://doi.org/10.1124/mol.104.009308
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Palmitoylation of the 5-Hydroxytryptamine_4a Receptor Regulates Receptor Phosphorylation, Desensitization, and β-Arrestin-Mediated Endocytosis
Evgeni Ponimaskin, Aline Dumuis, Florence Gaven, Gaël Barthet, Martin Heine, Konstantin Glebov, Diethelm W. Richter and Martin Oppermann

Molecular Pharmacology May 2005, 67 (5) 1434-1443; DOI: https://doi.org/10.1124/mol.104.008748
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Blockade of Vascular Endothelial Growth Factor Receptor Signal Pathway and Antitumor Activity of ON-III (2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone), a Component from Chinese Herbal Medicine
Xiao-Feng Zhu, Bin-Fen Xie, Jun-Min Zhou, Gong-Kan Feng, Zong-Chao Liu, Xiao-Yi Wei, Feng-Xian Zhang, Mei-Fang Liu and Yi-Xin Zeng

Molecular Pharmacology May 2005, 67 (5) 1444-1450; DOI: https://doi.org/10.1124/mol.104.009894
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Antiangiogenic and Vascular-Targeting Activity of the Microtubule-Destabilizing trans-Resveratrol Derivative 3,5,4′-Trimethoxystilbene
Mirella Belleri, Domenico Ribatti, Stefania Nicoli, Franco Cotelli, Luca Forti, Vanio Vannini, Lucia Anna Stivala and Marco Presta

Molecular Pharmacology May 2005, 67 (5) 1451-1459; DOI: https://doi.org/10.1124/mol.104.009043
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Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for the Degradation of Mammalian Endoplasmic Reticulum P450 Proteins
Mingxiang Liao, Victor G. Zgoda, Bernard P. Murray and Maria Almira Correia

Molecular Pharmacology May 2005, 67 (5) 1460-1469; DOI: https://doi.org/10.1124/mol.104.009654
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Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-d-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling
Philip E. Chen, Matthew T. Geballe, Phillip J. Stansfeld, Alexander R. Johnston, Hongjie Yuan, Amanda L. Jacob, James P. Snyder, Stephen F. Traynelis and David J. A. Wyllie

Molecular Pharmacology May 2005, 67 (5) 1470-1484; DOI: https://doi.org/10.1124/mol.104.008185
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Modulation of Cellular Response to Cisplatin by a Novel Inhibitor of DNA Polymerase β
F. Boudsocq, P. Benaim, Y. Canitrot, M. Knibiehler, F. Ausseil, J. P. Capp, A. Bieth, C. Long, B. David, I. Shevelev, E. Frierich-Heinecken, U. Hübscher, F. Amalric, G. Massiot, J. S. Hoffmann and C. Cazaux

Molecular Pharmacology May 2005, 67 (5) 1485-1492; DOI: https://doi.org/10.1124/mol.104.001776
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β-Adrenergic Receptor Stimulation Promotes Gαs Internalization through Lipid Rafts: A Study in Living Cells
John A. Allen, Jiang Z. Yu, Robert J. Donati and Mark M. Rasenick

Molecular Pharmacology May 2005, 67 (5) 1493-1504; DOI: https://doi.org/10.1124/mol.104.008342
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Investigations of Calsequestrin as a Target for Anthracyclines: Comparison of Functional Effects of Daunorubicin, Daunorubicinol, and Trifluoperazine
Henry A. Charlier, Richard D. Olson, Carissa M. Thornock, Wendy K. Mercer, David R. Olson, T. Stephen Broyles, Dawn J. Muhlestein, Corianton L. Larson, Barry J. Cusack and Susan E. Shadle

Molecular Pharmacology May 2005, 67 (5) 1505-1512; DOI: https://doi.org/10.1124/mol.104.005728
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Stichodactyla helianthus Peptide, a Pharmacological Tool for Studying Kv3.2 Channels
Lizhen Yan, James Herrington, Ethan Goldberg, Paula M. Dulski, Randal M. Bugianesi, Robert S. Slaughter, Priya Banerjee, Richard M. Brochu, Birgit T. Priest, Gregory J. Kaczorowski, Bernardo Rudy and Maria L. Garcia

Molecular Pharmacology May 2005, 67 (5) 1513-1521; DOI: https://doi.org/10.1124/mol.105.011064
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Isoflurane Induces a Protein Kinase C α-Dependent Increase in Cell-Surface Protein Level and Activity of Glutamate Transporter Type 3
Yueming Huang and Zhiyi Zuo

Molecular Pharmacology May 2005, 67 (5) 1522-1533; DOI: https://doi.org/10.1124/mol.104.007443
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Heparan Sulfate Regulates the Antiangiogenic Activity of Endothelial Monocyte-Activating Polypeptide-II at Acidic pH
Sun-Young Chang, Hyun-Jeong Ko, Tae-Hwe Heo and Chang-Yuil Kang

Molecular Pharmacology May 2005, 67 (5) 1534-1543; DOI: https://doi.org/10.1124/mol.104.008532
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A Synthetic Derivative of the Natural Product Rocaglaol Is a Potent Inhibitor of Cytokine-Mediated Signaling and Shows Neuroprotective Activity in Vitro and in Animal Models of Parkinson's Disease and Traumatic Brain Injury
T. Fahrig, I. Gerlach and E. Horváth

Molecular Pharmacology May 2005, 67 (5) 1544-1555; DOI: https://doi.org/10.1124/mol.104.008177
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Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus nivalis
Jan Balzarini, Kristel Van Laethem, Sigrid Hatse, Matheus Froeyen, Els Van Damme, Anders Bolmstedt, Willy Peumans, Erik De Clercq and Dominique Schols

Molecular Pharmacology May 2005, 67 (5) 1556-1565; DOI: https://doi.org/10.1124/mol.104.005082
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Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction
Guy Eelen, Lieve Verlinden, Natacha Rochel, Frank Claessens, Pierre De Clercq, Maurits Vandewalle, Giuseppe Tocchini-Valentini, Dino Moras, Roger Bouillon and Annemieke Verstuyf

Molecular Pharmacology May 2005, 67 (5) 1566-1573; DOI: https://doi.org/10.1124/mol.104.008730
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A Novel and Efficient Approach to Discriminate between Pre- and Post-Transcription HIV Inhibitors
Dirk Daelemans, Christophe Pannecouque, George N. Pavlakis, Oriana Tabarrini and Erik De Clercq

Molecular Pharmacology May 2005, 67 (5) 1574-1580; DOI: https://doi.org/10.1124/mol.104.010249
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Subtype-Specific Sorting of the ET_A Endothelin Receptor by a Novel Endocytic Recycling Signal for G Protein-Coupled Receptors
Joachim D. Paasche, Toril Attramadal, Kurt Kristiansen, Morten P. Oksvold, Heidi K. Johansen, Henrik S. Huitfeldt, Svein G. Dahl and Håvard Attramadal

Molecular Pharmacology May 2005, 67 (5) 1581-1590; DOI: https://doi.org/10.1124/mol.104.007013
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The General Anesthetic Isoflurane Depresses Synaptic Vesicle Exocytosis
Hugh C. Hemmings, Wayne Yan, Robert I. Westphalen and Timothy A. Ryan

Molecular Pharmacology May 2005, 67 (5) 1591-1599; DOI: https://doi.org/10.1124/mol.104.003210
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Amino Acids Critical for Substrate Affinity of Rat Organic Cation Transporter 1 Line the Substrate Binding Region in a Model Derived from the Tertiary Structure of Lactose Permease
Christian Popp, Valentin Gorboulev, Thomas D. Müller, Dmitry Gorbunov, Natalia Shatskaya and Hermann Koepsell

Molecular Pharmacology May 2005, 67 (5) 1600-1611; DOI: https://doi.org/10.1124/mol.104.008839
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Subtype-Specific Affinity for Corticosterone of Rat Organic Cation Transporters rOCT1 and rOCT2 Depends on Three Amino Acids within the Substrate Binding Region
Valentin Gorboulev, Natalia Shatskaya, Christopher Volk and Hermann Koepsell

Molecular Pharmacology May 2005, 67 (5) 1612-1619; DOI: https://doi.org/10.1124/mol.104.008821
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Mechanism of the Anti-Inflammatory Effect of Thiazolidinediones: Relationship with the Glucocorticoid Pathway
Armando Ialenti, Gianluca Grassia, Paola Di Meglio, Pasquale Maffia, Massimo Di Rosa and Angela Ianaro

Molecular Pharmacology May 2005, 67 (5) 1620-1628; DOI: https://doi.org/10.1124/mol.104.004895
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The Human Organic Anion Transporter 2 Gene Is Transactivated by Hepatocyte Nuclear Factor-4α and Suppressed by Bile Acids
Katrin Popowski, Jyrki J. Eloranta, Michael Saborowski, Michael Fried, Peter J. Meier and Gerd A. Kullak-Ublick

Molecular Pharmacology May 2005, 67 (5) 1629-1638; DOI: https://doi.org/10.1124/mol.104.010223
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Long-Term Nicotine Treatment Decreases Striatal α6* Nicotinic Acetylcholine Receptor Sites and Function in Mice
Albert Lai, Neeraja Parameswaran, Mirium Khwaja, Paul Whiteaker, Jon M. Lindstrom, Hong Fan, J. Michael McIntosh, Sharon R. Grady and Maryka Quik

Molecular Pharmacology May 2005, 67 (5) 1639-1647; DOI: https://doi.org/10.1124/mol.104.006429
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Differential Modulation of Glutamatergic Transmission by 3,5-Dibromo-l-phenylalanine
V. Yarotskyy, A. V. Glushakov, C. Sumners, N. Gravenstein, D. M. Dennis, C. N. Seubert and A. E. Martynyuk

Molecular Pharmacology May 2005, 67 (5) 1648-1654; DOI: https://doi.org/10.1124/mol.104.005983
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Pharmacological Discrimination of Calcitonin Receptor: Receptor Activity-Modifying Protein Complexes
Debbie L. Hay, George Christopoulos, Arthur Christopoulos, David R. Poyner and Patrick M. Sexton

Molecular Pharmacology May 2005, 67 (5) 1655-1665; DOI: https://doi.org/10.1124/mol.104.008615
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Effect of Azelnidipine on Angiotensin II-Mediated Growth-Promoting Signaling in Vascular Smooth Muscle Cells
Jian-Mei Li, Masaru Iwai, Tai-Xing Cui, Li-Juan Min, Masahiro Tsuda, Jun Iwanami, Jun Suzuki, Masaki Mogi and Masatsugu Horiuchi

Molecular Pharmacology May 2005, 67 (5) 1666-1673; DOI: https://doi.org/10.1124/mol.104.008144
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Transcriptional Regulation of Mouse μ Opioid Receptor Gene: Sp3 Isoforms (M1, M2) Function as Repressors in Neuronal Cells to Regulate the μ Opioid Receptor Gene
Hack Sun Choi, Cheol Kyu Hwang, Chun Sung Kim, Kyu Young Song, Ping-Yee Law, Li-Na Wei and Horace H. Loh

Molecular Pharmacology May 2005, 67 (5) 1674-1683; DOI: https://doi.org/10.1124/mol.104.008284
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Cephalostatin 1 Inactivates Bcl-2 by Hyperphosphorylation Independent of M-Phase Arrest and DNA Damage
Irina M. Müller, Verena M. Dirsch, Anita Rudy, Nancy López-Antón, George R. Pettit and Angelika M. Vollmar

Molecular Pharmacology May 2005, 67 (5) 1684-1689; DOI: https://doi.org/10.1124/mol.104.004234
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α2-Adrenergic Agonist Enrichment of Spinophilin at the Cell Surface Involves βγ Subunits of G_i Proteins and Is Preferentially Induced by the α_2A-Subtype
Ashley E. Brady, Qin Wang, Patrick B. Allen, Mark Rizzo, Paul Greengard and Lee E. Limbird

Molecular Pharmacology May 2005, 67 (5) 1690-1696; DOI: https://doi.org/10.1124/mol.104.005215
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Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Enhances Heterodimer Formation: A Mechanism for Receptor Cross-Talk?
Christopher S. Kearn, Katherine Blake-Palmer, Emma Daniel, Ken Mackie and Michelle Glass

Molecular Pharmacology May 2005, 67 (5) 1697-1704; DOI: https://doi.org/10.1124/mol.104.006882
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Potentiation of P2Y Receptors by Physiological Elevations of Extracellular K⁺ via a Mechanism Independent of Ca²⁺ Influx
Samantha J. Pitt, Juan Martinez-Pinna, Eric A. Barnard and Martyn P. Mahaut-Smith

Molecular Pharmacology May 2005, 67 (5) 1705-1713; DOI: https://doi.org/10.1124/mol.104.009902
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The Met852 Residue Is a Key Organizer of the Ligand-Binding Cavity of the Human Mineralocorticoid Receptor
Jérôme Fagart, Cendrine Seguin, Grégory Maurice Pinon and Marie-Edith Rafestin-Oblin

Molecular Pharmacology May 2005, 67 (5) 1714-1722; DOI: https://doi.org/10.1124/mol.104.010710
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The Effect of Hydroxylamine on K_ATP Channels in Vascular Smooth Muscle and Underlying Mechanisms
Guanghua Tang, Lingyun Wu and Rui Wang

Molecular Pharmacology May 2005, 67 (5) 1723-1731; DOI: https://doi.org/10.1124/mol.104.008953
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Identification and Characterization of a Functional TATA Box Polymorphism of the UDP Glucuronosyltransferase 1A7 Gene
Tim O. Lankisch, Arndt Vogel, Stefan Eilermann, Anette Fiebeler, Britta Krone, Ayse Barut, Michael P. Manns and Christian P. Strassburg

Molecular Pharmacology May 2005, 67 (5) 1732-1739; DOI: https://doi.org/10.1124/mol.104.007146
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Constitutive Activation and Environmental Chemical Induction of the Aryl Hydrocarbon Receptor/Transcription Factor in Activated Human B Lymphocytes
Lenka L. Allan and David H. Sherr

Molecular Pharmacology May 2005, 67 (5) 1740-1750; DOI: https://doi.org/10.1124/mol.104.009100
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The Aminosteroid Phospholipase C Antagonist U-73122 (1-[6-[[17-β-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) Potently Inhibits Human 5-Lipoxygenase in Vivo and in Vitro
Christian Feißt, Dana Albert, Dieter Steinhilber and Oliver Werz

Molecular Pharmacology May 2005, 67 (5) 1751-1757; DOI: https://doi.org/10.1124/mol.105.011007
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The Breast Cancer Resistance Protein (BCRP/ABCG2) Affects Pharmacokinetics, Hepatobiliary Excretion, and Milk Secretion of the Antibiotic Nitrofurantoin
Gracia Merino, Johan W. Jonker, Els Wagenaar, Antonius E. van Herwaarden and Alfred H. Schinkel

Molecular Pharmacology May 2005, 67 (5) 1758-1764; DOI: https://doi.org/10.1124/mol.104.010439
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Sex-Dependent Expression and Activity of the ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (BCRP/ABCG2) in Liver
Gracia Merino, Antonius E. van Herwaarden, Els Wagenaar, Johan W. Jonker and Alfred H. Schinkel

Molecular Pharmacology May 2005, 67 (5) 1765-1771; DOI: https://doi.org/10.1124/mol.105.011080
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A Natural CYP2B6 TATA Box Polymorphism (–82T→ C) Leading to Enhanced Transcription and Relocation of the Transcriptional Start Site
Jörg Zukunft, Thomas Lang, Tanja Richter, Karen I. Hirsch-Ernst, Andreas K. Nussler, Kathrin Klein, Matthias Schwab, Michel Eichelbaum and Ulrich M. Zanger

Molecular Pharmacology May 2005, 67 (5) 1772-1782; DOI: https://doi.org/10.1124/mol.104.008086
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Developmental Regulation of β-Carboline-Induced Inhibition of Glycine-Evoked Responses Depends on Glycine Receptor β Subunit Expression
Jean-Marie Mangin, Laurent Nguyen, Catherine Gougnard, Grégory Hans, Bernard Rogister, Shibeshih Belachew, Gustave Moonen, Pascal Legendre and Jean-Michel Rigo

Molecular Pharmacology May 2005, 67 (5) 1783-1796; DOI: https://doi.org/10.1124/mol.104.007435
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Phenylglycine and Sulfonamide Correctors of Defective ΔF508 and G551D Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Gating
Nicoletta Pedemonte, N. D. Sonawane, Alessandro Taddei, Jie Hu, Olga Zegarra-Moran, Yat Fan Suen, Lori I. Robins, Christopher W. Dicus, Dan Willenbring, Michael H. Nantz, Mark J. Kurth, Luis J. V. Galietta and A. S. Verkman

Molecular Pharmacology May 2005, 67 (5) 1797-1807; DOI: https://doi.org/10.1124/mol.105.010959
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Expression of the Retinoic Acid-Metabolizing Enzyme CYP26A1 Limits Programmed Cell Death
Makoto Osanai and Martin Petkovich

Molecular Pharmacology May 2005, 67 (5) 1808-1817; DOI: https://doi.org/10.1124/mol.104.005769

Erratum

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Correction to “TRPV1b, a Functional Human Vanilloid Receptor Splice Variant”
Molecular Pharmacology May 2005, 67 (5) 1818; DOI: https://doi.org/10.1124/mol.67.5.1818

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