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Molecular Pharmacology

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Table of Contents

May 01, 2005; Volume 67,Issue 5

Perspectives

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    From Plants to Man: The GPCR “Tree of Life”
    Dianne M. Perez
    Molecular Pharmacology May 2005, 67 (5) 1383-1384; DOI: https://doi.org/10.1124/mol.105.011890
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    Adenosine in Tissue Protection and Tissue Regeneration
    Joel Linden
    Molecular Pharmacology May 2005, 67 (5) 1385-1387; DOI: https://doi.org/10.1124/mol.105.011783
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    Internal PDZ Ligands: Novel Endocytic Recycling Motifs for G Protein-Coupled Receptors
    JoAnn Trejo
    Molecular Pharmacology May 2005, 67 (5) 1388-1390; DOI: https://doi.org/10.1124/mol.105.011288
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    Polyspecific Organic Cation Transport: Insights into the Substrate Binding Site
    Gerhard Burckhardt
    Molecular Pharmacology May 2005, 67 (5) 1391-1392; DOI: https://doi.org/10.1124/mol.105.012161

Accelerated Communications

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    Aspects of Dioxin Toxicity Are Mediated by Interleukin 1-Like Cytokines
    Kalyan Pande, Susan M. Moran and Christopher A. Bradfield
    Molecular Pharmacology May 2005, 67 (5) 1393-1398; DOI: https://doi.org/10.1124/mol.105.010983
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    U937 Cell Necrosis Mediated by Peroxynitrite Is Not Caused by Depletion of ATP and Is Prevented by Arachidonate via an ATP-Dependent Mechanism
    Orazio Cantoni, Andrea Guidarelli, Letizia Palomba and Mara Fiorani
    Molecular Pharmacology May 2005, 67 (5) 1399-1405; DOI: https://doi.org/10.1124/mol.104.009498

ORIGINAL ARTICLE

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    Adenosine A2A Receptor Stimulation Increases Angiogenesis by Down-Regulating Production of the Antiangiogenic Matrix Protein Thrombospondin 1
    Avani Desai, Cassandre Victor-Vega, Swathi Gadangi, M. Carmen Montesinos, Charles C. Chu and Bruce N. Cronstein
    Molecular Pharmacology May 2005, 67 (5) 1406-1413; DOI: https://doi.org/10.1124/mol.104.007807
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    The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes
    Robert Fredriksson and Helgi B. Schiöth
    Molecular Pharmacology May 2005, 67 (5) 1414-1425; DOI: https://doi.org/10.1124/mol.104.009001
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    Effects of Valproic Acid Derivatives on Inositol Trisphosphate Depletion, Teratogenicity, Glycogen Synthase Kinase-3β Inhibition, and Viral Replication: A Screening Approach for New Bipolar Disorder Drugs Derived from the Valproic Acid Core Structure
    B. J. Eickholt, G. J. Towers, W. J. Ryves, D. Eikel, K. Adley, L. M. J. Ylinen, N. H. Chadborn, A. J. Harwood, H. Nau and R. S. B. Williams
    Molecular Pharmacology May 2005, 67 (5) 1426-1433; DOI: https://doi.org/10.1124/mol.104.009308
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    Palmitoylation of the 5-Hydroxytryptamine4a Receptor Regulates Receptor Phosphorylation, Desensitization, and β-Arrestin-Mediated Endocytosis
    Evgeni Ponimaskin, Aline Dumuis, Florence Gaven, Gaël Barthet, Martin Heine, Konstantin Glebov, Diethelm W. Richter and Martin Oppermann
    Molecular Pharmacology May 2005, 67 (5) 1434-1443; DOI: https://doi.org/10.1124/mol.104.008748
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    Blockade of Vascular Endothelial Growth Factor Receptor Signal Pathway and Antitumor Activity of ON-III (2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone), a Component from Chinese Herbal Medicine
    Xiao-Feng Zhu, Bin-Fen Xie, Jun-Min Zhou, Gong-Kan Feng, Zong-Chao Liu, Xiao-Yi Wei, Feng-Xian Zhang, Mei-Fang Liu and Yi-Xin Zeng
    Molecular Pharmacology May 2005, 67 (5) 1444-1450; DOI: https://doi.org/10.1124/mol.104.009894
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    Antiangiogenic and Vascular-Targeting Activity of the Microtubule-Destabilizing trans-Resveratrol Derivative 3,5,4′-Trimethoxystilbene
    Mirella Belleri, Domenico Ribatti, Stefania Nicoli, Franco Cotelli, Luca Forti, Vanio Vannini, Lucia Anna Stivala and Marco Presta
    Molecular Pharmacology May 2005, 67 (5) 1451-1459; DOI: https://doi.org/10.1124/mol.104.009043
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    Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for the Degradation of Mammalian Endoplasmic Reticulum P450 Proteins
    Mingxiang Liao, Victor G. Zgoda, Bernard P. Murray and Maria Almira Correia
    Molecular Pharmacology May 2005, 67 (5) 1460-1469; DOI: https://doi.org/10.1124/mol.104.009654
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    Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-d-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling
    Philip E. Chen, Matthew T. Geballe, Phillip J. Stansfeld, Alexander R. Johnston, Hongjie Yuan, Amanda L. Jacob, James P. Snyder, Stephen F. Traynelis and David J. A. Wyllie
    Molecular Pharmacology May 2005, 67 (5) 1470-1484; DOI: https://doi.org/10.1124/mol.104.008185
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    Modulation of Cellular Response to Cisplatin by a Novel Inhibitor of DNA Polymerase β
    F. Boudsocq, P. Benaim, Y. Canitrot, M. Knibiehler, F. Ausseil, J. P. Capp, A. Bieth, C. Long, B. David, I. Shevelev, E. Frierich-Heinecken, U. Hübscher, F. Amalric, G. Massiot, J. S. Hoffmann and C. Cazaux
    Molecular Pharmacology May 2005, 67 (5) 1485-1492; DOI: https://doi.org/10.1124/mol.104.001776
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    β-Adrenergic Receptor Stimulation Promotes Gαs Internalization through Lipid Rafts: A Study in Living Cells
    John A. Allen, Jiang Z. Yu, Robert J. Donati and Mark M. Rasenick
    Molecular Pharmacology May 2005, 67 (5) 1493-1504; DOI: https://doi.org/10.1124/mol.104.008342
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    Investigations of Calsequestrin as a Target for Anthracyclines: Comparison of Functional Effects of Daunorubicin, Daunorubicinol, and Trifluoperazine
    Henry A. Charlier, Richard D. Olson, Carissa M. Thornock, Wendy K. Mercer, David R. Olson, T. Stephen Broyles, Dawn J. Muhlestein, Corianton L. Larson, Barry J. Cusack and Susan E. Shadle
    Molecular Pharmacology May 2005, 67 (5) 1505-1512; DOI: https://doi.org/10.1124/mol.104.005728
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    Stichodactyla helianthus Peptide, a Pharmacological Tool for Studying Kv3.2 Channels
    Lizhen Yan, James Herrington, Ethan Goldberg, Paula M. Dulski, Randal M. Bugianesi, Robert S. Slaughter, Priya Banerjee, Richard M. Brochu, Birgit T. Priest, Gregory J. Kaczorowski, Bernardo Rudy and Maria L. Garcia
    Molecular Pharmacology May 2005, 67 (5) 1513-1521; DOI: https://doi.org/10.1124/mol.105.011064
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    Isoflurane Induces a Protein Kinase C α-Dependent Increase in Cell-Surface Protein Level and Activity of Glutamate Transporter Type 3
    Yueming Huang and Zhiyi Zuo
    Molecular Pharmacology May 2005, 67 (5) 1522-1533; DOI: https://doi.org/10.1124/mol.104.007443
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    Heparan Sulfate Regulates the Antiangiogenic Activity of Endothelial Monocyte-Activating Polypeptide-II at Acidic pH
    Sun-Young Chang, Hyun-Jeong Ko, Tae-Hwe Heo and Chang-Yuil Kang
    Molecular Pharmacology May 2005, 67 (5) 1534-1543; DOI: https://doi.org/10.1124/mol.104.008532
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    A Synthetic Derivative of the Natural Product Rocaglaol Is a Potent Inhibitor of Cytokine-Mediated Signaling and Shows Neuroprotective Activity in Vitro and in Animal Models of Parkinson's Disease and Traumatic Brain Injury
    T. Fahrig, I. Gerlach and E. Horváth
    Molecular Pharmacology May 2005, 67 (5) 1544-1555; DOI: https://doi.org/10.1124/mol.104.008177
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    Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus nivalis
    Jan Balzarini, Kristel Van Laethem, Sigrid Hatse, Matheus Froeyen, Els Van Damme, Anders Bolmstedt, Willy Peumans, Erik De Clercq and Dominique Schols
    Molecular Pharmacology May 2005, 67 (5) 1556-1565; DOI: https://doi.org/10.1124/mol.104.005082
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    Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction
    Guy Eelen, Lieve Verlinden, Natacha Rochel, Frank Claessens, Pierre De Clercq, Maurits Vandewalle, Giuseppe Tocchini-Valentini, Dino Moras, Roger Bouillon and Annemieke Verstuyf
    Molecular Pharmacology May 2005, 67 (5) 1566-1573; DOI: https://doi.org/10.1124/mol.104.008730
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    A Novel and Efficient Approach to Discriminate between Pre- and Post-Transcription HIV Inhibitors
    Dirk Daelemans, Christophe Pannecouque, George N. Pavlakis, Oriana Tabarrini and Erik De Clercq
    Molecular Pharmacology May 2005, 67 (5) 1574-1580; DOI: https://doi.org/10.1124/mol.104.010249
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    Subtype-Specific Sorting of the ETA Endothelin Receptor by a Novel Endocytic Recycling Signal for G Protein-Coupled Receptors
    Joachim D. Paasche, Toril Attramadal, Kurt Kristiansen, Morten P. Oksvold, Heidi K. Johansen, Henrik S. Huitfeldt, Svein G. Dahl and Håvard Attramadal
    Molecular Pharmacology May 2005, 67 (5) 1581-1590; DOI: https://doi.org/10.1124/mol.104.007013
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    The General Anesthetic Isoflurane Depresses Synaptic Vesicle Exocytosis
    Hugh C. Hemmings, Wayne Yan, Robert I. Westphalen and Timothy A. Ryan
    Molecular Pharmacology May 2005, 67 (5) 1591-1599; DOI: https://doi.org/10.1124/mol.104.003210
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    Amino Acids Critical for Substrate Affinity of Rat Organic Cation Transporter 1 Line the Substrate Binding Region in a Model Derived from the Tertiary Structure of Lactose Permease
    Christian Popp, Valentin Gorboulev, Thomas D. Müller, Dmitry Gorbunov, Natalia Shatskaya and Hermann Koepsell
    Molecular Pharmacology May 2005, 67 (5) 1600-1611; DOI: https://doi.org/10.1124/mol.104.008839
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    Subtype-Specific Affinity for Corticosterone of Rat Organic Cation Transporters rOCT1 and rOCT2 Depends on Three Amino Acids within the Substrate Binding Region
    Valentin Gorboulev, Natalia Shatskaya, Christopher Volk and Hermann Koepsell
    Molecular Pharmacology May 2005, 67 (5) 1612-1619; DOI: https://doi.org/10.1124/mol.104.008821
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    Mechanism of the Anti-Inflammatory Effect of Thiazolidinediones: Relationship with the Glucocorticoid Pathway
    Armando Ialenti, Gianluca Grassia, Paola Di Meglio, Pasquale Maffia, Massimo Di Rosa and Angela Ianaro
    Molecular Pharmacology May 2005, 67 (5) 1620-1628; DOI: https://doi.org/10.1124/mol.104.004895
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    The Human Organic Anion Transporter 2 Gene Is Transactivated by Hepatocyte Nuclear Factor-4α and Suppressed by Bile Acids
    Katrin Popowski, Jyrki J. Eloranta, Michael Saborowski, Michael Fried, Peter J. Meier and Gerd A. Kullak-Ublick
    Molecular Pharmacology May 2005, 67 (5) 1629-1638; DOI: https://doi.org/10.1124/mol.104.010223
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    Long-Term Nicotine Treatment Decreases Striatal α6* Nicotinic Acetylcholine Receptor Sites and Function in Mice
    Albert Lai, Neeraja Parameswaran, Mirium Khwaja, Paul Whiteaker, Jon M. Lindstrom, Hong Fan, J. Michael McIntosh, Sharon R. Grady and Maryka Quik
    Molecular Pharmacology May 2005, 67 (5) 1639-1647; DOI: https://doi.org/10.1124/mol.104.006429
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    Differential Modulation of Glutamatergic Transmission by 3,5-Dibromo-l-phenylalanine
    V. Yarotskyy, A. V. Glushakov, C. Sumners, N. Gravenstein, D. M. Dennis, C. N. Seubert and A. E. Martynyuk
    Molecular Pharmacology May 2005, 67 (5) 1648-1654; DOI: https://doi.org/10.1124/mol.104.005983
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    Pharmacological Discrimination of Calcitonin Receptor: Receptor Activity-Modifying Protein Complexes
    Debbie L. Hay, George Christopoulos, Arthur Christopoulos, David R. Poyner and Patrick M. Sexton
    Molecular Pharmacology May 2005, 67 (5) 1655-1665; DOI: https://doi.org/10.1124/mol.104.008615
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    Effect of Azelnidipine on Angiotensin II-Mediated Growth-Promoting Signaling in Vascular Smooth Muscle Cells
    Jian-Mei Li, Masaru Iwai, Tai-Xing Cui, Li-Juan Min, Masahiro Tsuda, Jun Iwanami, Jun Suzuki, Masaki Mogi and Masatsugu Horiuchi
    Molecular Pharmacology May 2005, 67 (5) 1666-1673; DOI: https://doi.org/10.1124/mol.104.008144
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    Transcriptional Regulation of Mouse μ Opioid Receptor Gene: Sp3 Isoforms (M1, M2) Function as Repressors in Neuronal Cells to Regulate the μ Opioid Receptor Gene
    Hack Sun Choi, Cheol Kyu Hwang, Chun Sung Kim, Kyu Young Song, Ping-Yee Law, Li-Na Wei and Horace H. Loh
    Molecular Pharmacology May 2005, 67 (5) 1674-1683; DOI: https://doi.org/10.1124/mol.104.008284
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    Cephalostatin 1 Inactivates Bcl-2 by Hyperphosphorylation Independent of M-Phase Arrest and DNA Damage
    Irina M. Müller, Verena M. Dirsch, Anita Rudy, Nancy López-Antón, George R. Pettit and Angelika M. Vollmar
    Molecular Pharmacology May 2005, 67 (5) 1684-1689; DOI: https://doi.org/10.1124/mol.104.004234
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    α2-Adrenergic Agonist Enrichment of Spinophilin at the Cell Surface Involves βγ Subunits of Gi Proteins and Is Preferentially Induced by the α2A-Subtype
    Ashley E. Brady, Qin Wang, Patrick B. Allen, Mark Rizzo, Paul Greengard and Lee E. Limbird
    Molecular Pharmacology May 2005, 67 (5) 1690-1696; DOI: https://doi.org/10.1124/mol.104.005215
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    Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Enhances Heterodimer Formation: A Mechanism for Receptor Cross-Talk?
    Christopher S. Kearn, Katherine Blake-Palmer, Emma Daniel, Ken Mackie and Michelle Glass
    Molecular Pharmacology May 2005, 67 (5) 1697-1704; DOI: https://doi.org/10.1124/mol.104.006882
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    Potentiation of P2Y Receptors by Physiological Elevations of Extracellular K+ via a Mechanism Independent of Ca2+ Influx
    Samantha J. Pitt, Juan Martinez-Pinna, Eric A. Barnard and Martyn P. Mahaut-Smith
    Molecular Pharmacology May 2005, 67 (5) 1705-1713; DOI: https://doi.org/10.1124/mol.104.009902
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    The Met852 Residue Is a Key Organizer of the Ligand-Binding Cavity of the Human Mineralocorticoid Receptor
    Jérôme Fagart, Cendrine Seguin, Grégory Maurice Pinon and Marie-Edith Rafestin-Oblin
    Molecular Pharmacology May 2005, 67 (5) 1714-1722; DOI: https://doi.org/10.1124/mol.104.010710
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    The Effect of Hydroxylamine on KATP Channels in Vascular Smooth Muscle and Underlying Mechanisms
    Guanghua Tang, Lingyun Wu and Rui Wang
    Molecular Pharmacology May 2005, 67 (5) 1723-1731; DOI: https://doi.org/10.1124/mol.104.008953
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    Identification and Characterization of a Functional TATA Box Polymorphism of the UDP Glucuronosyltransferase 1A7 Gene
    Tim O. Lankisch, Arndt Vogel, Stefan Eilermann, Anette Fiebeler, Britta Krone, Ayse Barut, Michael P. Manns and Christian P. Strassburg
    Molecular Pharmacology May 2005, 67 (5) 1732-1739; DOI: https://doi.org/10.1124/mol.104.007146
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    Constitutive Activation and Environmental Chemical Induction of the Aryl Hydrocarbon Receptor/Transcription Factor in Activated Human B Lymphocytes
    Lenka L. Allan and David H. Sherr
    Molecular Pharmacology May 2005, 67 (5) 1740-1750; DOI: https://doi.org/10.1124/mol.104.009100
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    The Aminosteroid Phospholipase C Antagonist U-73122 (1-[6-[[17-β-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) Potently Inhibits Human 5-Lipoxygenase in Vivo and in Vitro
    Christian Feißt, Dana Albert, Dieter Steinhilber and Oliver Werz
    Molecular Pharmacology May 2005, 67 (5) 1751-1757; DOI: https://doi.org/10.1124/mol.105.011007
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    The Breast Cancer Resistance Protein (BCRP/ABCG2) Affects Pharmacokinetics, Hepatobiliary Excretion, and Milk Secretion of the Antibiotic Nitrofurantoin
    Gracia Merino, Johan W. Jonker, Els Wagenaar, Antonius E. van Herwaarden and Alfred H. Schinkel
    Molecular Pharmacology May 2005, 67 (5) 1758-1764; DOI: https://doi.org/10.1124/mol.104.010439
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    Sex-Dependent Expression and Activity of the ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (BCRP/ABCG2) in Liver
    Gracia Merino, Antonius E. van Herwaarden, Els Wagenaar, Johan W. Jonker and Alfred H. Schinkel
    Molecular Pharmacology May 2005, 67 (5) 1765-1771; DOI: https://doi.org/10.1124/mol.105.011080
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    A Natural CYP2B6 TATA Box Polymorphism (–82T→ C) Leading to Enhanced Transcription and Relocation of the Transcriptional Start Site
    Jörg Zukunft, Thomas Lang, Tanja Richter, Karen I. Hirsch-Ernst, Andreas K. Nussler, Kathrin Klein, Matthias Schwab, Michel Eichelbaum and Ulrich M. Zanger
    Molecular Pharmacology May 2005, 67 (5) 1772-1782; DOI: https://doi.org/10.1124/mol.104.008086
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    Developmental Regulation of β-Carboline-Induced Inhibition of Glycine-Evoked Responses Depends on Glycine Receptor β Subunit Expression
    Jean-Marie Mangin, Laurent Nguyen, Catherine Gougnard, Grégory Hans, Bernard Rogister, Shibeshih Belachew, Gustave Moonen, Pascal Legendre and Jean-Michel Rigo
    Molecular Pharmacology May 2005, 67 (5) 1783-1796; DOI: https://doi.org/10.1124/mol.104.007435
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    Phenylglycine and Sulfonamide Correctors of Defective ΔF508 and G551D Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Gating
    Nicoletta Pedemonte, N. D. Sonawane, Alessandro Taddei, Jie Hu, Olga Zegarra-Moran, Yat Fan Suen, Lori I. Robins, Christopher W. Dicus, Dan Willenbring, Michael H. Nantz, Mark J. Kurth, Luis J. V. Galietta and A. S. Verkman
    Molecular Pharmacology May 2005, 67 (5) 1797-1807; DOI: https://doi.org/10.1124/mol.105.010959
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    Expression of the Retinoic Acid-Metabolizing Enzyme CYP26A1 Limits Programmed Cell Death
    Makoto Osanai and Martin Petkovich
    Molecular Pharmacology May 2005, 67 (5) 1808-1817; DOI: https://doi.org/10.1124/mol.104.005769

Erratum

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    Correction to “TRPV1b, a Functional Human Vanilloid Receptor Splice Variant”
    Molecular Pharmacology May 2005, 67 (5) 1818; DOI: https://doi.org/10.1124/mol.67.5.1818
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Molecular Pharmacology: 67 (5)
Molecular Pharmacology
Vol. 67, Issue 5
1 May 2005
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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