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Research ArticleArticle

Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the Interaction of Synaptophysin I with VAMP2

Dario Bonanomi, Maria Pennuto, Michela Rigoni, Ornella Rossetto, Cesare Montecucco and Flavia Valtorta
Molecular Pharmacology June 2005, 67 (6) 1901-1908; DOI: https://doi.org/10.1124/mol.104.005678
Dario Bonanomi
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Maria Pennuto
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Michela Rigoni
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Ornella Rossetto
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Cesare Montecucco
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Flavia Valtorta
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Abstract

The application of the snake neurotoxin taipoxin to hippocampal neurons in culture induced Ca2+-dependent synaptic vesicle (SV) exocytosis, with swelling of nerve terminals and redistribution of SV proteins to the axolemma. Using digital imaging videomicroscopy to measure fluorescence resonance energy transfer in live neurons, we also found that taipoxin modulates the machinery for neurosecretion by causing dissociation of the SV proteins synaptobrevin 2 and synaptophysin I at a stage preceding taipoxin-induced facilitation of SV fusion. These early effects of the toxin are followed by severe impairment of SV exo-endocytosis, which might underlie the prevention of neurotransmitter release reported after intoxication by taipoxin.

  • Received July 30, 2004.
  • Accepted February 3, 2005.
  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 67 (6)
Molecular Pharmacology
Vol. 67, Issue 6
1 Jun 2005
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Research ArticleArticle

Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the Interaction of Synaptophysin I with VAMP2

Dario Bonanomi, Maria Pennuto, Michela Rigoni, Ornella Rossetto, Cesare Montecucco and Flavia Valtorta
Molecular Pharmacology June 1, 2005, 67 (6) 1901-1908; DOI: https://doi.org/10.1124/mol.104.005678

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Research ArticleArticle

Taipoxin Induces Synaptic Vesicle Exocytosis and Disrupts the Interaction of Synaptophysin I with VAMP2

Dario Bonanomi, Maria Pennuto, Michela Rigoni, Ornella Rossetto, Cesare Montecucco and Flavia Valtorta
Molecular Pharmacology June 1, 2005, 67 (6) 1901-1908; DOI: https://doi.org/10.1124/mol.104.005678
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