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Molecular Pharmacology

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OtherPerspective

Can a GDP-Liganded G-Protein Be Active?

Thomas Wieland and Martin C. Michel
Molecular Pharmacology September 2005, 68 (3) 559-562; DOI: https://doi.org/10.1124/mol.105.016071
Thomas Wieland
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Abstract

The replacement of GDP bound to the α-subunit of a G-protein by GTP is generally considered a crucial step in the activation of effectors by a G-protein. New data by Uğur et al. (2005) (p. 720) raise the possibility that for the heterotrimeric G-protein Gs, GDP-liganded Gs is able to activate the effector adenylyl cyclase as potently and effectively as when Gs is in its GTP bound form. We summarize here the evidence that GTP is necessary for effector activation by G-proteins and discuss potential implications and limitations of data to the contrary.

  • Received June 23, 2005.
  • Accepted June 24, 2005.
  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 68 (3)
Molecular Pharmacology
Vol. 68, Issue 3
1 Sep 2005
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OtherPerspective

Can a GDP-Liganded G-Protein Be Active?

Thomas Wieland and Martin C. Michel
Molecular Pharmacology September 1, 2005, 68 (3) 559-562; DOI: https://doi.org/10.1124/mol.105.016071

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OtherPerspective

Can a GDP-Liganded G-Protein Be Active?

Thomas Wieland and Martin C. Michel
Molecular Pharmacology September 1, 2005, 68 (3) 559-562; DOI: https://doi.org/10.1124/mol.105.016071
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