Design of PAP-1, a Selective Small Molecule Kv1.3 Blocker, for the Suppression of Effector Memory T Cells in Autoimmune Diseases

Pharmaceutical Institute, University of Kiel, Kiel, Germany (A.Sc., K.S.-L., W.H.); and Department of Medical Pharmacology and Toxicology, University of California, Davis, Davis, California (A.Sa., P.A., D.H., H.W.)

Address correspondence to:
Heike Wulff, Department of Medical Pharmacology and Toxicology, Genome and Biomedical Sciences Facility, Room 3502, 451 East Health Sciences Drive, University of California, Davis, Davis, CA 95616. E-mail: hwulff{at}ucdavis.edu.

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2005 to August 2022

	Abstract	Full	Pdf
Aug 2005	27	0	168
Sep 2005	19	0	170
Oct 2005	51	12	127
Nov 2005	58	109	78
Dec 2005	26	66	38
Jan 2006	46	48	65
Feb 2006	25	27	33
Mar 2006	34	26	24
Apr 2006	21	37	41
May 2006	24	31	24
Jun 2006	23	27	35
Jul 2006	27	29	24
Aug 2006	35	33	45
Sep 2006	20	29	22
Oct 2006	30	35	50
Nov 2006	27	69	55
Dec 2006	12	54	43
Jan 2007	28	53	56
Feb 2007	16	78	91
Mar 2007	23	59	52
Apr 2007	17	61	30
May 2007	11	63	46
Jun 2007	20	39	50
Jul 2007	31	39	46
Aug 2007	17	53	39
Sep 2007	16	50	38
Oct 2007	29	64	54
Nov 2007	24	51	39
Dec 2007	11	43	33
Jan 2008	15	40	36
Feb 2008	29	35	28
Mar 2008	27	38	36
Apr 2008	29	37	37
May 2008	31	53	41
Jun 2008	31	54	40
Jul 2008	46	68	45
Aug 2008	42	44	39
Sep 2008	71	50	43
Oct 2008	53	77	71
Nov 2008	47	44	37
Dec 2008	34	33	30
Jan 2009	48	52	41
Feb 2009	27	36	18
Mar 2009	50	42	33
Apr 2009	42	46	47
May 2009	19	33	26
Jun 2009	36	23	29
Jul 2009	25	41	33
Aug 2009	28	26	28
Sep 2009	31	22	29
Oct 2009	58	41	26
Nov 2009	53	45	31
Dec 2009	40	35	26
Jan 2010	32	28	28
Feb 2010	37	22	26
Mar 2010	53	22	42
Apr 2010	47	32	28
May 2010	65	39	21
Jun 2010	44	19	25
Jul 2010	42	14	22
Aug 2010	43	28	20
Sep 2010	32	23	18
Oct 2010	35	34	29
Nov 2010	38	50	35
Dec 2010	37	23	35
Jan 2011	47	32	36
Feb 2011	20	31	33
Mar 2011	37	26	37
Apr 2011	27	17	19
May 2011	25	25	30
Jun 2011	24	23	16
Jul 2011	32	22	34
Aug 2011	41	23	33
Sep 2011	38	32	43
Oct 2011	25	30	25
Nov 2011	44	23	26
Dec 2011	31	17	28
Jan 2012	34	27	40
Feb 2012	52	35	42
Mar 2012	47	49	32
Apr 2012	55	28	24
May 2012	51	24	39
Jun 2012	33	33	41
Jul 2012	48	22	27
Aug 2012	57	25	33
Sep 2012	31	27	27
Oct 2012	69	41	59
Nov 2012	63	44	37
Dec 2012	51	41	41
Jan 2013	73	40	43
Feb 2013	45	29	17
Mar 2013	67	44	34
Apr 2013	68	27	32
May 2013	76	20	26
Jun 2013	56	38	30
Jul 2013	43	13	16
Aug 2013	39	21	16
Sep 2013	44	16	22
Oct 2013	76	25	37
Nov 2013	51	14	20
Dec 2013	59	14	16
Jan 2014	51	15	17
Feb 2014	67	22	25
Mar 2014	63	19	20
Apr 2014	65	24	17
May 2014	69	46	38
Jun 2014	52	38	43
Jul 2014	55	36	34
Aug 2014	33	12	9
Sep 2014	44	20	20
Oct 2014	50	26	22
Nov 2014	35	36	22
Dec 2014	58	24	24
Jan 2015	43	35	21
Feb 2015	37	41	36
Mar 2015	56	35	23
Apr 2015	49	40	26
May 2015	43	31	22
Jun 2015	30	32	13
Jul 2015	52	48	28
Aug 2015	41	20	12
Sep 2015	37	22	148
Oct 2015	45	46	21
Nov 2015	33	26	22
Dec 2015	37	17	15
Jan 2016	48	20	18
Feb 2016	57	23	23
Mar 2016	55	25	40
Apr 2016	33	26	29
May 2016	35	31	29
Jun 2016	32	30	18
Jul 2016	40	33	23
Aug 2016	68	41	26
Sep 2016	44	32	20
Oct 2016	16	204	17
Nov 2016	17	77	25
Dec 2016	1	61	16
Jan 2017	8	89	13
Feb 2017	9	86	18
Mar 2017	12	105	21
Apr 2017	21	120	19
May 2017	16	70	26
Jun 2017	18	70	13
Jul 2017	18	68	30
Aug 2017	14	62	17
Sep 2017	12	82	24
Oct 2017	6	69	19
Nov 2017	14	77	16
Dec 2017	17	52	16
Jan 2018	19	69	19
Feb 2018	26	68	27
Mar 2018	26	76	31
Apr 2018	25	80	12
May 2018	9	69	35
Jun 2018	5	73	25
Jul 2018	3	73	34
Aug 2018	1	54	19
Sep 2018	4	59	26
Oct 2018	7	54	30
Nov 2018	4	79	26
Dec 2018	65	29	27
Jan 2019	97	13	14
Feb 2019	59	11	11
Mar 2019	80	7	12
Apr 2019	54	5	8
May 2019	60	13	14
Jun 2019	68	7	11
Jul 2019	48	5	3
Aug 2019	70	4	3
Sep 2019	124	16	22
Oct 2019	84	10	18
Nov 2019	92	8	10
Dec 2019	81	5	8
Jan 2020	43	7	4
Feb 2020	64	2	1
Mar 2020	58	10	9
Apr 2020	56	7	3
May 2020	45	9	7
Jun 2020	46	2	0
Jul 2020	64	15	10
Aug 2020	45	6	8
Sep 2020	43	9	6
Oct 2020	62	2	4
Nov 2020	41	5	6
Dec 2020	35	13	8
Jan 2021	48	14	9
Feb 2021	62	19	13
Mar 2021	61	20	15
Apr 2021	47	13	10
May 2021	69	12	9
Jun 2021	34	7	1
Jul 2021	24	9	11
Aug 2021	44	12	5
Sep 2021	61	15	6
Oct 2021	50	9	5
Nov 2021	64	6	7
Dec 2021	50	2	3
Jan 2022	71	8	7
Feb 2022	44	8	4
Mar 2022	83	11	8
Apr 2022	62	10	5
May 2022	83	7	5
Jun 2022	81	9	6
Jul 2022	70	4	5
Aug 2022	10	2	1