Table of Contents

Articles

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  Editor's Note

  Paul A. Insel

  Molecular Pharmacology December 2005, 68 (6) 1505; DOI: https://doi.org/10.1124/mol.68.6.1505
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  Tweaking Agonist Efficacy at N-Methyl-d-aspartate Receptors by Site-Directed Mutagenesis

  Kasper B. Hansen, Rasmus P. Clausen, Esben J. Bjerrum, Christian Bechmann, Jeremy R. Greenwood, Caspar Christensen, Jesper L. Kristensen, Jan Egebjerg and Hans Bräuner-Osborne

  Molecular Pharmacology December 2005, 68 (6) 1510-1523; DOI: https://doi.org/10.1124/mol.105.014795
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  Proton Activation Does Not Alter Antagonist Interaction with the Capsaicin-Binding Pocket of TRPV1

  Narender R. Gavva, Rami Tamir, Lana Klionsky, Mark H. Norman, Jean-Claude Louis, Kenneth D. Wild and James J. S. Treanor

  Molecular Pharmacology December 2005, 68 (6) 1524-1533; DOI: https://doi.org/10.1124/mol.105.015727
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  Stereospecific Induction of Nuclear Factor-κB Activation by Isochamaejasmin

  Qinghai Tian, Jing Li, Xin Xie, Meiling Sun, Hairong Sang, Caihong Zhou, Tianying An, Lihong Hu, Richard D. Ye and Ming-Wei Wang

  Molecular Pharmacology December 2005, 68 (6) 1534-1542; DOI: https://doi.org/10.1124/mol.105.014720
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  Vascular Targeting of Ocular Neovascularization with a Vascular Endothelial Growth Factor₁₂₁/Gelonin Chimeric Protein

  Hideo Akiyama, Khalid A. Mohamedali, Raquel Lima e Silva, Shu Kachi, JiKui Shen, Christina Hatara, Naoyasu Umeda, Sean F. Hackett, Sadia Aslam, Melissa Krause, Hong Lai, Michael G. Rosenblum and Peter A. Campochiaro

  Molecular Pharmacology December 2005, 68 (6) 1543-1550; DOI: https://doi.org/10.1124/mol.105.015628
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  Pharmacodynamics of the G-Quadruplex-Stabilizing Telomerase Inhibitor 3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate (RHPS4) in Vitro: Activity in Human Tumor Cells Correlates with Telomere Length and Can Be Enhanced, or Antagonized, with Cytotoxic Agents

  Jennifer C. Cookson, Fangping Dai, Victoria Smith, Robert A. Heald, Charles A. Laughton, Malcolm F. G. Stevens and Angelika M. Burger

  Molecular Pharmacology December 2005, 68 (6) 1551-1558; DOI: https://doi.org/10.1124/mol.105.013300
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  DNA Structural Similarity in the 2:1 Complexes of the Antitumor Drugs Trabectedin (Yondelis) and Chromomycin A₃ with an Oligonucleotide Sequence Containing Two Adjacent TGG Binding Sites on Opposing Strands

  Esther Marco and Federico Gago

  Molecular Pharmacology December 2005, 68 (6) 1559-1567; DOI: https://doi.org/10.1124/mol.105.015685
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  Involvement of IL-10 in Peroxisome Proliferator-Activated Receptor γ-Mediated Anti-Inflammatory Response in Asthma

  So Ri Kim, Kyung Sun Lee, Hee Sun Park, Seoung Ju Park, Kyung Hoon Min, Sun Mi Jin and Yong Chul Lee

  Molecular Pharmacology December 2005, 68 (6) 1568-1575; DOI: https://doi.org/10.1124/mol.105.017160
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  N-Substituted 4-Aminobenzamides (Procainamide Analogs): An Assessment of Multiple Cellular Effects Concerning Ion Trapping

  Guillaume Morissette, Emmanuel Moreau, René C.-Gaudreault and François Marceau

  Molecular Pharmacology December 2005, 68 (6) 1576-1589; DOI: https://doi.org/10.1124/mol.105.016527
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  Retinoid X Receptor α Regulates the Expression of Glutathione S-transferase Genes and Modulates Acetaminophen-Glutathione Conjugation in Mouse Liver

  Guoli Dai, Nathan Chou, Lin He, Maxwell A. Gyamfi, Alphonse J. Mendy, Angela L. Slitt, Curtis D. Klaassen and Yu-Jui Y. Wan

  Molecular Pharmacology December 2005, 68 (6) 1590-1596; DOI: https://doi.org/10.1124/mol.105.013680
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  Atypical Muscarinic Allosteric Modulation: Cooperativity between Modulators and Their Atypical Binding Topology in Muscarinic M₂ and M₂/M₅ Chimeric Receptors

  Christian Tränkle, Andreas Dittmann, Uwe Schulz, Oliver Weyand, Stefan Buller, Kirstin Jöhren, Eberhard Heller, Nigel J. M. Birdsall, Ulrike Holzgrabe, John Ellis, Hans Dieter Höltje and Klaus Mohr

  Molecular Pharmacology December 2005, 68 (6) 1597-1610; DOI: https://doi.org/10.1124/mol.105.017707
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  Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium Channels

  Gregory M. Lipkind and Harry A. Fozzard

  Molecular Pharmacology December 2005, 68 (6) 1611-1622; DOI: https://doi.org/10.1124/mol.105.014803
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  (-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a High-Affinity Electrophilic Ligand, Interacts Covalently with a Cysteine in Helix Six and Activates the CB1 Cannabinoid Receptor

  Robert P. Picone, Atmaram D. Khanolkar, Wei Xu, Lionel A. Ayotte, Ganesh A. Thakur, Dow P. Hurst, Mary E. Abood, Patricia H. Reggio, Donna J. Fournier and Alexandros Makriyannis

  Molecular Pharmacology December 2005, 68 (6) 1623-1635; DOI: https://doi.org/10.1124/mol.105.014407
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  Gemcitabine-Induced Activation of Checkpoint Signaling Pathways That Affect Tumor Cell Survival

  Larry M. Karnitz, Karen S. Flatten, Jill M. Wagner, David Loegering, Jennifer S. Hackbarth, Sonnet J. H. Arlander, Benjamin T. Vroman, M. Bijoy Thomas, Yong-Un Baek, Kevin M. Hopkins, Howard B. Lieberman, Junjie Chen, William A. Cliby and Scott H. Kaufmann

  Molecular Pharmacology December 2005, 68 (6) 1636-1644; DOI: https://doi.org/10.1124/mol.105.012716
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  Evidence for a Secondary State of the Human β3-Adrenoceptor

  Jillian G. Baker

  Molecular Pharmacology December 2005, 68 (6) 1645-1655; DOI: https://doi.org/10.1124/mol.105.015461
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  Nicotinic Cholinergic Receptors in the Rat Retina: Simple and Mixed Heteromeric Subtypes

  Andrea M. Marritt, Brandon C. Cox, Robert P. Yasuda, J. Michael McIntosh, Yingxian Xiao, Barry B. Wolfe and Kenneth J. Kellar

  Molecular Pharmacology December 2005, 68 (6) 1656-1668; DOI: https://doi.org/10.1124/mol.105.012369
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  Mutations of a Conserved Lysine Residue in the N-Terminal Domain of α7 Nicotinic Receptors Affect Gating and Binding of Nicotinic Agonists

  Manuel Criado, José Mulet, José A. Bernal, Susana Gerber, Salvador Sala and Francisco Sala

  Molecular Pharmacology December 2005, 68 (6) 1669-1677; DOI: https://doi.org/10.1124/mol.105.015446
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  Intracellular cAMP and Calcium Signaling by Serotonin in Mouse Cumulus-Oocyte Complexes

  Pascal Amireault and François Dubé

  Molecular Pharmacology December 2005, 68 (6) 1678-1687; DOI: https://doi.org/10.1124/mol.104.010124
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  Induction of δ Opioid Receptor Function by Up-Regulation of Membrane Receptors in Mouse Primary Afferent Neurons

  Wendy Walwyn, Nigel T. Maidment, Matthew Sanders, Christopher J. Evans, Brigitte L. Kieffer and Tim G. Hales

  Molecular Pharmacology December 2005, 68 (6) 1688-1698; DOI: https://doi.org/10.1124/mol.105.014829
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  Activation of the Unfolded Protein Response Is Necessary and Sufficient for Reducing Topoisomerase IIα Protein Levels and Decreasing Sensitivity to Topoisomerase-Targeted Drugs

  Miranda D. Gray, Melissa Mann, John L. Nitiss and Linda M. Hendershot

  Molecular Pharmacology December 2005, 68 (6) 1699-1707; DOI: https://doi.org/10.1124/mol.105.014753
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  Effects of Drugs with Muscle-Related Side Effects and Affinity for Calsequestrin on the Calcium Regulatory Function of Sarcoplasmic Reticulum Microsomes

  EunJung Kim, Maggie Tam, William F. Siems and ChulHee Kang

  Molecular Pharmacology December 2005, 68 (6) 1708-1715; DOI: https://doi.org/10.1124/mol.105.016253
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  Sulfated Polymannuroguluronate, a Novel Anti-AIDS Drug Candidate, Inhibits T Cell Apoptosis by Combating Oxidative Damage of Mitochondria

  Benchun Miao, Jing Li, Xueyan Fu, Li Gan, Xianliang Xin and Meiyu Geng

  Molecular Pharmacology December 2005, 68 (6) 1716-1727; DOI: https://doi.org/10.1124/mol.105.015412
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  Identification and Selective Inhibition of the Channel Mode of the Neuronal GABA Transporter 1

  Stephan Krause and Wolfgang Schwarz

  Molecular Pharmacology December 2005, 68 (6) 1728-1735; DOI: https://doi.org/10.1124/mol.105.013870
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  Antihypertensive 1,4-Dihydropyridines as Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator Channel Gating Defect Caused by Cystic Fibrosis Mutations

  Nicoletta Pedemonte, Tullia Diena, Emanuela Caci, Erika Nieddu, Mauro Mazzei, Roberto Ravazzolo, Olga Zegarra-Moran and Luis J. V. Galietta

  Molecular Pharmacology December 2005, 68 (6) 1736-1746; DOI: https://doi.org/10.1124/mol.105.015149
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  A Novel Group of Genes Regulates Susceptibility to Antineoplastic Drugs in Highly Tumorigenic Breast Cancer Cells

  Julia C. Mallory, Gerard Crudden, Amelia Oliva, Christopher Saunders, Arnold Stromberg and Rolf J. Craven

  Molecular Pharmacology December 2005, 68 (6) 1747-1756; DOI: https://doi.org/10.1124/mol.105.016519
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  Direct Stimulation of K_ATP Channels by Exogenous and Endogenous Hydrogen Sulfide in Vascular Smooth Muscle Cells

  Guanghua Tang, Lingyun Wu, Wenbin Liang and Rui Wang

  Molecular Pharmacology December 2005, 68 (6) 1757-1764; DOI: https://doi.org/10.1124/mol.105.017467
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  Long-Lasting Impairment of Associative Learning Is Correlated with a Dysfunction of N-Methyl-d-aspartate-Extracellular Signaling-Regulated Kinase Signaling in Mice after Withdrawal from Repeated Administration of Phencyclidine

  Takeshi Enomoto, Yukihiro Noda, Akihiro Mouri, Eun-Joo Shin, Dayong Wang, Rina Murai, Kazuo Hotta, Hiroshi Furukawa, Atsumi Nitta, Hyoung-Chun Kim and Toshitaka Nabeshima

  Molecular Pharmacology December 2005, 68 (6) 1765-1774; DOI: https://doi.org/10.1124/mol.105.011304
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  Characterization of the First Potent and Selective PDE9 Inhibitor Using a cGMP Reporter Cell Line

  Frank Wunder, Adrian Tersteegen, Annegret Rebmann, Christina Erb, Thomas Fahrig and Martin Hendrix

  Molecular Pharmacology December 2005, 68 (6) 1775-1781; DOI: https://doi.org/10.1124/mol.105.017608
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  1,1-Bis(3′-indolyl)-1-(p-substitutedphenyl)methanes Are Peroxisome Proliferator-Activated Receptor γ Agonists but Decrease HCT-116 Colon Cancer Cell Survival through Receptor-Independent Activation of Early Growth Response-1 and Nonsteroidal Anti-Inflammatory Drug-Activated Gene-1

  Sudhakar Chintharlapalli, Sabitha Papineni, Seung Joon Baek, Shengxi Liu and Stephen Safe

  Molecular Pharmacology December 2005, 68 (6) 1782-1792; DOI: https://doi.org/10.1124/mol.105.017046
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  A Close Structural Analog of 2-Methyl-6-(phenylethynyl)-pyridine Acts as a Neutral Allosteric Site Ligand on Metabotropic Glutamate Receptor Subtype 5 and Blocks the Effects of Multiple Allosteric Modulators

  Alice L. Rodriguez, Yi Nong, Nishant K. Sekaran, David Alagille, Gilles D. Tamagnan and P. Jeffrey Conn

  Molecular Pharmacology December 2005, 68 (6) 1793-1802; DOI: https://doi.org/10.1124/mol.105.016139
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  Inhibition of the Catalytic Activity of Hypoxia-Inducible Factor-1α-Prolyl-Hydroxylase 2 by a MYND-Type Zinc Finger

  Kyung-Ok Choi, Taekyong Lee, Naery Lee, Ji-Hyun Kim, Eun Gyeong Yang, Jung Min Yoon, Jin Hwan Kim, Tae Gyu Lee and Hyunsung Park

  Molecular Pharmacology December 2005, 68 (6) 1803-1809; DOI: https://doi.org/10.1124/mol.105.015271
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  Redox Regulation of Cdc25B by Cell-Active Quinolinediones

  Marni Brisson, Theresa Nguyen, Peter Wipf, Beomjun Joo, Billy W. Day, John S. Skoko, Emanuel M. Schreiber, Caleb Foster, Pallavi Bansal and John S. Lazo

  Molecular Pharmacology December 2005, 68 (6) 1810-1820; DOI: https://doi.org/10.1124/mol.105.016360
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  A Key Serine for the GTPase-Activating Protein Function of Regulator of G Protein Signaling Proteins Is Not a General Target for 14-3-3 Interactions

  Richard J. Ward and Graeme Milligan

  Molecular Pharmacology December 2005, 68 (6) 1821-1830; DOI: https://doi.org/10.1124/mol.105.015073
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  Apoptosis Induced by a New Member of Saponin Family Is Mediated through Caspase-8-Dependent Cleavage of Bcl-2

  Jianbei Zhu, Lei Xiong, Biao Yu and Jiarui Wu

  Molecular Pharmacology December 2005, 68 (6) 1831-1838; DOI: https://doi.org/10.1124/mol.105.015826
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  Nicotine Acts as a Pharmacological Chaperone to Up-Regulate Human α4β2 Acetylcholine Receptors

  A. Kuryatov, J. Luo, J. Cooper and J. Lindstrom

  Molecular Pharmacology December 2005, 68 (6) 1839-1851; DOI: https://doi.org/10.1124/mol.105.012419
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  Opposite Effects of Histone Deacetylase Inhibitors on Glucocorticoid and Estrogen Signaling in Human Endometrial Ishikawa Cells

  Walter Rocha, Rocio Sanchez, Julie Deschênes, Anick Auger, Elise Hébert, John H. White and Sylvie Mader

  Molecular Pharmacology December 2005, 68 (6) 1852-1862; DOI: https://doi.org/10.1124/mol.105.014514
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  An α7 Nicotinic Acetylcholine Receptor Gain-of-Function Mutant That Retains Pharmacological Fidelity

  Andon N. Placzek, Francesca Grassi, Edwin M Meyer and Roger L. Papke

  Molecular Pharmacology December 2005, 68 (6) 1863-1876; DOI: https://doi.org/10.1124/mol.105.016402