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Molecular Pharmacology

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Research ArticleArticle

Atypical Muscarinic Allosteric Modulation: Cooperativity between Modulators and Their Atypical Binding Topology in Muscarinic M2 and M2/M5 Chimeric Receptors

Christian Tränkle, Andreas Dittmann, Uwe Schulz, Oliver Weyand, Stefan Buller, Kirstin Jöhren, Eberhard Heller, Nigel J. M. Birdsall, Ulrike Holzgrabe, John Ellis, Hans Dieter Höltje and Klaus Mohr
Molecular Pharmacology December 2005, 68 (6) 1597-1610; DOI: https://doi.org/10.1124/mol.105.017707
Christian Tränkle
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Andreas Dittmann
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Uwe Schulz
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Oliver Weyand
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Stefan Buller
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Kirstin Jöhren
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Eberhard Heller
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Nigel J. M. Birdsall
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Ulrike Holzgrabe
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John Ellis
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Hans Dieter Höltje
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Klaus Mohr
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Article Information

vol. 68 no. 6 1597-1610
DOI 
https://doi.org/10.1124/mol.105.017707
PubMed 
16157694

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received August 5, 2005
  • Accepted September 9, 2005
  • Published online November 17, 2005.

Article Versions

  • Earlier version (September 12, 2005 - 11:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Christian Tränkle,
  2. Andreas Dittmann,
  3. Uwe Schulz,
  4. Oliver Weyand,
  5. Stefan Buller,
  6. Kirstin Jöhren,
  7. Eberhard Heller,
  8. Nigel J. M. Birdsall,
  9. Ulrike Holzgrabe,
  10. John Ellis,
  11. Hans Dieter Höltje and
  12. Klaus Mohr
  1. Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Bonn, Germany (C.T., A.D., U.S., O.W., S.B., K.M.); Institute of Pharmaceutical & Medicinal Chemistry, Heinrich Heine-University of Düsseldorf, Düsseldorf, Germany (K.J., H.D.H.); Pharmaceutical Chemistry, Institute of Pharmacy, University of Würzburg, Würzburg, Germany (E.H., U.H.); Division of Physical Biochemistry, National Institute for Medical Research, Mill Hill, London, United Kingdom (N.J.M.B.); and Departments of Psychiatry and Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania (J.E.)
  1. Address correspondence to:
    Dr. Christian Tränkle, Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Bonn, Gerhard-Domagk-Str. 3, D-53121 Bonn, Germany. E-mail: traenkle{at}uni-bonn.de
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Molecular Pharmacology: 68 (6)
Molecular Pharmacology
Vol. 68, Issue 6
1 Dec 2005
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Research ArticleArticle

Atypical Muscarinic Allosteric Modulation: Cooperativity between Modulators and Their Atypical Binding Topology in Muscarinic M2 and M2/M5 Chimeric Receptors

Christian Tränkle, Andreas Dittmann, Uwe Schulz, Oliver Weyand, Stefan Buller, Kirstin Jöhren, Eberhard Heller, Nigel J. M. Birdsall, Ulrike Holzgrabe, John Ellis, Hans Dieter Höltje and Klaus Mohr
Molecular Pharmacology December 1, 2005, 68 (6) 1597-1610; DOI: https://doi.org/10.1124/mol.105.017707

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Research ArticleArticle

Atypical Muscarinic Allosteric Modulation: Cooperativity between Modulators and Their Atypical Binding Topology in Muscarinic M2 and M2/M5 Chimeric Receptors

Christian Tränkle, Andreas Dittmann, Uwe Schulz, Oliver Weyand, Stefan Buller, Kirstin Jöhren, Eberhard Heller, Nigel J. M. Birdsall, Ulrike Holzgrabe, John Ellis, Hans Dieter Höltje and Klaus Mohr
Molecular Pharmacology December 1, 2005, 68 (6) 1597-1610; DOI: https://doi.org/10.1124/mol.105.017707
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