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Molecular Pharmacology

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Research ArticleArticle

(-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a High-Affinity Electrophilic Ligand, Interacts Covalently with a Cysteine in Helix Six and Activates the CB1 Cannabinoid Receptor

Robert P. Picone, Atmaram D. Khanolkar, Wei Xu, Lionel A. Ayotte, Ganesh A. Thakur, Dow P. Hurst, Mary E. Abood, Patricia H. Reggio, Donna J. Fournier and Alexandros Makriyannis
Molecular Pharmacology December 2005, 68 (6) 1623-1635; DOI: https://doi.org/10.1124/mol.105.014407
Robert P. Picone
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Atmaram D. Khanolkar
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Wei Xu
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Lionel A. Ayotte
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Ganesh A. Thakur
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Dow P. Hurst
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Mary E. Abood
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Patricia H. Reggio
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Donna J. Fournier
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Alexandros Makriyannis
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Article Information

vol. 68 no. 6 1623-1635
DOI 
https://doi.org/10.1124/mol.105.014407
PubMed 
16157695

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 28, 2005
  • Accepted September 12, 2005
  • Published online November 17, 2005.

Article Versions

  • Earlier version (September 12, 2005 - 11:28).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Robert P. Picone,
  2. Atmaram D. Khanolkar,
  3. Wei Xu1,
  4. Lionel A. Ayotte,
  5. Ganesh A. Thakur1,
  6. Dow P. Hurst,
  7. Mary E. Abood,
  8. Patricia H. Reggio,
  9. Donna J. Fournier and
  10. Alexandros Makriyannis1
  1. Center for Drug Discovery (R.P.P., A.D.K., W.X., L.A.A., G.A.T., D.J.F., A.M.), Departments of Pharmaceutical Sciences (R.P.P., A.D.K., W.X., L.A.A., G.A.T., D.J.F., A.M.) and Molecular & Cell Biology (A.M.), University of Connecticut, Storrs, Connecticut; Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina (D.P.H., P.H.R.); and Forbes Norris Amyotrophic Lateral Sclerosis/Muscular Dystrophy Association Research Center, California Pacific Medical Center, San Francisco, California (M.E.A.)
  1. Address correspondence to:
    Alexandros Makriyannis, Center for Drug Discovery, Northeastern University, Boston, MA 02115. E-mail: a.makriyannis{at}neu.edu
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Molecular Pharmacology: 68 (6)
Molecular Pharmacology
Vol. 68, Issue 6
1 Dec 2005
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(-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a High-Affinity Electrophilic Ligand, Interacts Covalently with a Cysteine in Helix Six and Activates the CB1 Cannabinoid Receptor
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Research ArticleArticle

(-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a High-Affinity Electrophilic Ligand, Interacts Covalently with a Cysteine in Helix Six and Activates the CB1 Cannabinoid Receptor

Robert P. Picone, Atmaram D. Khanolkar, Wei Xu, Lionel A. Ayotte, Ganesh A. Thakur, Dow P. Hurst, Mary E. Abood, Patricia H. Reggio, Donna J. Fournier and Alexandros Makriyannis
Molecular Pharmacology December 1, 2005, 68 (6) 1623-1635; DOI: https://doi.org/10.1124/mol.105.014407

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Research ArticleArticle

(-)-7′-Isothiocyanato-11-hydroxy-1′,1′-dimethylheptylhexahydrocannabinol (AM841), a High-Affinity Electrophilic Ligand, Interacts Covalently with a Cysteine in Helix Six and Activates the CB1 Cannabinoid Receptor

Robert P. Picone, Atmaram D. Khanolkar, Wei Xu, Lionel A. Ayotte, Ganesh A. Thakur, Dow P. Hurst, Mary E. Abood, Patricia H. Reggio, Donna J. Fournier and Alexandros Makriyannis
Molecular Pharmacology December 1, 2005, 68 (6) 1623-1635; DOI: https://doi.org/10.1124/mol.105.014407
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