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Molecular Pharmacology

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Table of Contents

January 01, 2006; Volume 69,Issue 1

Perspective

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    The α1D-Adrenergic Receptor: Cinderella or Ugly Stepsister
    Angela M. Finch and Robert M. Graham
    Molecular Pharmacology January 2006, 69 (1) 1-4; DOI: https://doi.org/10.1124/mol.105.020230

Accelerated Communication

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    EP4 Prostanoid Receptor Coupling to a Pertussis Toxin-Sensitive Inhibitory G Protein
    Hiromichi Fujino and John W. Regan
    Molecular Pharmacology January 2006, 69 (1) 5-10; DOI: https://doi.org/10.1124/mol.105.017749

Articles

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    Binding Site Flexibility: Molecular Simulation of Partial and Full Agonists within a Glutamate Receptor
    Yalini Arinaminpathy, Mark S. P. Sansom and Philip C. Biggin
    Molecular Pharmacology January 2006, 69 (1) 11-18; DOI: https://doi.org/10.1124/mol.105.016691
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    Signaling via the Angiotensin-Converting Enzyme Results in the Phosphorylation of the Nonmuscle Myosin Heavy Chain IIA
    Karin Kohlstedt, Roland Kellner, Rudi Busse and Ingrid Fleming
    Molecular Pharmacology January 2006, 69 (1) 19-26; DOI: https://doi.org/10.1124/mol.105.016733
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    Determinants of Zinc Potentiation on the α4 Subunit of Neuronal Nicotinic Receptors
    Bernard Hsiao, Karla B. Mihalak, Sarah E. Repicky, Drew Everhart, Ana H. Mederos, Arun Malhotra and Charles W. Luetje
    Molecular Pharmacology January 2006, 69 (1) 27-36; DOI: https://doi.org/10.1124/mol.105.015164
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    Peripheral Benzodiazepine Receptor: Characterization in Human T-Lymphoma Jurkat Cells
    Barbara Costa, Alessandra Salvetti, Leonardo Rossi, Francesca Spinetti, Annalisa Lena, Beatrice Chelli, Mariarosa Rechichi, Eleonora Da Pozzo, Vittorio Gremigni and Claudia Martini
    Molecular Pharmacology January 2006, 69 (1) 37-44; DOI: https://doi.org/10.1124/mol.105.015289
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    Heterodimers of α1B- and α1D-Adrenergic Receptors Form a Single Functional Entity
    Chris Hague, Sarah E. Lee, Zhongjian Chen, Steven C. Prinster, Randy A. Hall and Kenneth P. Minneman
    Molecular Pharmacology January 2006, 69 (1) 45-55; DOI: https://doi.org/10.1124/mol.105.014985
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    Intestinal and Hepatic CYP3A4 Catalyze Hydroxylation of 1α,25-Dihydroxyvitamin D3: Implications for Drug-Induced Osteomalacia
    Yang Xu, Takanori Hashizume, Margaret C. Shuhart, Connie L. Davis, Wendel L. Nelson, Toshiyuki Sakaki, Thomas F. Kalhorn, Paul B. Watkins, Erin G. Schuetz and Kenneth E. Thummel
    Molecular Pharmacology January 2006, 69 (1) 56-65; DOI: https://doi.org/10.1124/mol.105.017392
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    Regulation of CXCR4-Mediated Nuclear Translocation of Extracellular Signal-Related Kinases 1 and 2
    Ming Zhao, Richard G. DiScipio, Antonia G. Wimmer and Ingrid U. Schraufstatter
    Molecular Pharmacology January 2006, 69 (1) 66-75; DOI: https://doi.org/10.1124/mol.105.016923
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    Mefenamic Acid Shows Neuroprotective Effects and Improves Cognitive Impairment in in Vitro and in Vivo Alzheimer's Disease Models
    Yuyoung Joo, Hye-Sun Kim, Ran-Sook Woo, Cheol Hyoung Park, Ki-Young Shin, Jean-Pyo Lee, Keun-A Chang, Seonghan Kim and Yoo-Hun Suh
    Molecular Pharmacology January 2006, 69 (1) 76-84; DOI: https://doi.org/10.1124/mol.105.015206
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    Activation of Extracellular Signal-Regulated Kinase Signaling by Epidermal Growth Factor Mediates c-Jun Activation and p300 Recruitment in Keratin 16 Gene Expression
    Ying-Nai Wang, Yun-Ju Chen and Wen-Chang Chang
    Molecular Pharmacology January 2006, 69 (1) 85-98; DOI: https://doi.org/10.1124/mol.105.016220
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    Regulation and Binding of Pregnane X Receptor by Nuclear Receptor Corepressor Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT)
    David R. Johnson, Chia-Wei Li, Liuh-Yow Chen, Jagadish C. Ghosh and J. Don Chen
    Molecular Pharmacology January 2006, 69 (1) 99-108; DOI: https://doi.org/10.1124/mol.105.013375
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    Characterization of Agonist-Induced Motilin Receptor Trafficking and Its Implications for Tachyphylaxis
    Vahideh Lamian, Adam Rich, Zhengping Ma, James Li, Ramakrishna Seethala, David Gordon and Yves Dubaquie
    Molecular Pharmacology January 2006, 69 (1) 109-118; DOI: https://doi.org/10.1124/mol.105.017111
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    Revisiting the Postulated “Unitary Glutamate Receptor”: Electrophysiological and Pharmacological Analysis in Two Heterologous Expression Systems Fails to Detect Evidence for Its Existence
    Carsten Schmidt, Markus Werner and Michael Hollmann
    Molecular Pharmacology January 2006, 69 (1) 119-129; DOI: https://doi.org/10.1124/mol.105.016840
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    Mutation P732L in Human DNA Topoisomerase IIβ Abolishes DNA Cleavage in the Presence of Calcium and Confers Drug Resistance
    Chrysoula Leontiou, Jeremy H. Lakey, Robert Lightowlers, Rozalind M. Turnbull and Caroline A. Austin
    Molecular Pharmacology January 2006, 69 (1) 130-139; DOI: https://doi.org/10.1124/mol.105.015933
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    Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries
    Nathalie Tijet, Paul C. Boutros, Ivy D. Moffat, Allan B. Okey, Jouko Tuomisto and Raimo Pohjanvirta
    Molecular Pharmacology January 2006, 69 (1) 140-153; DOI: https://doi.org/10.1124/mol.105.018705
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    The Blockage of Survivin and Securin Expression Increases the Cytochalasin B-Induced Cell Death and Growth Inhibition in Human Cancer Cells
    Jui-I Chao and Huei-Fang Liu
    Molecular Pharmacology January 2006, 69 (1) 154-164; DOI: https://doi.org/10.1124/mol.105.015503
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    Activation and Inhibition of Kidney CLC-K Chloride Channels by Fenamates
    Antonella Liantonio, Alessandra Picollo, Elena Babini, Giuseppe Carbonara, Giuseppe Fracchiolla, Fulvio Loiodice, Vincenzo Tortorella, Michael Pusch and Diana Conte Camerino
    Molecular Pharmacology January 2006, 69 (1) 165-173; DOI: https://doi.org/10.1124/mol.105.017384
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    Altered Expression of Gq/11α Protein Shapes mGlu1 and mGlu5 Receptor-Mediated Single Cell Inositol 1,4,5-Trisphosphate and Ca2+ Signaling
    Peter J. Atkinson, Kenneth W. Young, Steven J. Ennion, James N. C. Kew, Stefan R. Nahorski and R. A. John Challiss
    Molecular Pharmacology January 2006, 69 (1) 174-184; DOI: https://doi.org/10.1124/mol.105.014258
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    Structural Determinants of Pharmacological Specificity Between D1 and D2 Dopamine Receptors
    Hongxiang Lan, Curtiss J. DuRand, Martha M. Teeter and Kim A. Neve
    Molecular Pharmacology January 2006, 69 (1) 185-194; DOI: https://doi.org/10.1124/mol.105.017244
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    Curcumin (Diferuloylmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IκBα Kinase and Akt Activation
    Sita Aggarwal, Haruyo Ichikawa, Yasunari Takada, Santosh K. Sandur, Shishir Shishodia and Bharat B. Aggarwal
    Molecular Pharmacology January 2006, 69 (1) 195-206; DOI: https://doi.org/10.1124/mol.105.017400
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    Activation of Adenylyl Cyclase by Endogenous Gs-Coupled Receptors in Human Embryonic Kidney 293 Cells Is Attenuated by 5-HT7 Receptor Expression
    Kjetil Wessel Andressen, Jens Henrik Norum, Finn Olav Levy and Kurt A. Krobert
    Molecular Pharmacology January 2006, 69 (1) 207-215; DOI: https://doi.org/10.1124/mol.105.015396
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    RETRACTION: The Histone Deacetylase Inhibitor LAQ824 Induces Human Leukemia Cell Death through a Process Involving XIAP Down-Regulation, Oxidative Injury, and the Acid Sphingomyelinase-Dependent Generation of Ceramide
    Roberto R. Rosato, Sonia C. Maggio, Jorge A. Almenara, Shawn G. Payne, Peter Atadja, Sarah Spiegel, Paul Dent and Steven Grant
    Molecular Pharmacology January 2006, 69 (1) 216-225; DOI: https://doi.org/10.1124/mol.105.017145
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    Investigation of Cooperativity in the Binding of Ligands to the D2 Dopamine Receptor
    Meritxell Vivo, Hong Lin and Philip G. Strange
    Molecular Pharmacology January 2006, 69 (1) 226-235; DOI: https://doi.org/10.1124/mol.105.012443
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    Probing the Molecular Mechanism of Interaction between 4-n-Butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the Muscarinic M1 Receptor: Direct Pharmacological Evidence That AC-42 Is an Allosteric Agonist
    Christopher J. Langmead, Victoria A. H. Fry, Ian T. Forbes, Clive L. Branch, Arthur Christopoulos, Martyn D. Wood and Hugh J. Herdon
    Molecular Pharmacology January 2006, 69 (1) 236-246; DOI: https://doi.org/10.1124/mol.105.017814
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    2-Aminoethoxydiphenyl Borate as a Prototype Drug for a Group of Structurally Related Calcium Channel Blockers in Human Platelets
    Yuliya Dobrydneva, Christopher J. Abelt, Beth Dovel, Celina M. Thadigiri, Roy L. Williams and Peter F. Blackmore
    Molecular Pharmacology January 2006, 69 (1) 247-256; DOI: https://doi.org/10.1124/mol.105.015701
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    Aryl Hydrocarbon Receptor Activation Inhibits Regenerative Growth
    Lijoy K. Mathew, Eric A. Andreasen and Robert L. Tanguay
    Molecular Pharmacology January 2006, 69 (1) 257-265; DOI: https://doi.org/10.1124/mol.105.018044
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    Activation of Human ether-a-go-go-Related Gene Potassium Channels by the Diphenylurea 1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)
    Rie Schultz Hansen, Thomas Goldin Diness, Torsten Christ, Joachim Demnitz, Ursula Ravens, Søren-Peter Olesen and Morten Grunnet
    Molecular Pharmacology January 2006, 69 (1) 266-277; DOI: https://doi.org/10.1124/mol.105.015859
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    A Novel Drug Binding Site on Voltage-Gated Sodium Channels in Rat Brain
    Dieter R. Riddall, Michael J. Leach and John Garthwaite
    Molecular Pharmacology January 2006, 69 (1) 278-287; DOI: https://doi.org/10.1124/mol.105.015966
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    RETRACTION: Flavopiridol and Histone Deacetylase Inhibitors Promote Mitochondrial Injury and Cell Death in Human Leukemia Cells That Overexpress Bcl-2
    Girija Dasmahapatra, Jorge A. Almenara and Steven Grant
    Molecular Pharmacology January 2006, 69 (1) 288-298; DOI: https://doi.org/10.1124/mol.105.016154
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    Synaptic Expression of Glutamate Receptor after Encoding of Fear Memory in the Rat Amygdala
    Shiu-Hwa Yeh, Sheng-Chun Mao, Hui-Ching Lin and Po-Wu Gean
    Molecular Pharmacology January 2006, 69 (1) 299-308; DOI: https://doi.org/10.1124/mol.105.017194
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    Identification and Characterization of a Potent, Selective Nonpeptide Agonist of the CC Chemokine Receptor CCR8
    Christopher A. Haskell, Richard Horuk, Meina Liang, Mary Rosser, Laura Dunning, Imadul Islam, Leonor Kremer, Julio Gutiérrez, Gabriel Marquez, Carlos Martinez-A, Mark J. Biscone, Robert W. Doms and Sofia Ribeiro
    Molecular Pharmacology January 2006, 69 (1) 309-316; DOI: https://doi.org/10.1124/mol.105.014779
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    The Impact of Blunted β-Adrenergic Responsiveness on Growth Regulatory Pathways in Hypertension
    Robert Gros, Qingming Ding, Jozef Chorazyczewski, Joseph Andrews, J. Geoffrey Pickering, Robert A. Hegele and Ross D. Feldman
    Molecular Pharmacology January 2006, 69 (1) 317-327; DOI: https://doi.org/10.1124/mol.105.013953
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    The Novel Imidazopyridine 2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) Is a Highly Selective Inhibitor of the Inducible Nitric-Oxide Synthase
    Andreas Strub, Wolf-Rüdiger Ulrich, Christian Hesslinger, Manfrid Eltze, Thomas Fuchß, Jochen Strassner, Susanne Strand, Martin D. Lehner and Rainer Boer
    Molecular Pharmacology January 2006, 69 (1) 328-337; DOI: https://doi.org/10.1124/mol.105.017087
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    Identification of a Potent Inverse Agonist at a Constitutively Active Mutant of Human P2Y12 Receptor
    Zhongren Ding, Soochong Kim and Satya P. Kunapuli
    Molecular Pharmacology January 2006, 69 (1) 338-345; DOI: https://doi.org/10.1124/mol.105.014654
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    A Comparison of the Transportability, and Its Role in Cytotoxicity, of Clofarabine, Cladribine, and Fludarabine by Recombinant Human Nucleoside Transporters Produced in Three Model Expression Systems
    Karen M. King, Vijaya L. Damaraju, Mark F. Vickers, Sylvia Y. Yao, Thach Lang, Tracey E. Tackaberry, Delores A. Mowles, Amy M. L. Ng, James D. Young and Carol E. Cass
    Molecular Pharmacology January 2006, 69 (1) 346-353; DOI: https://doi.org/10.1124/mol.105.015768
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    Pharmacological Profiling of Orthochirus scrobiculosus Toxin 1 Analogs with a Trimmed N-Terminal Domain
    Stéphanie Mouhat, Georgeta Teodorescu, Daniel Homerick, Violeta Visan, Heike Wulff, Yingliang Wu, Stephan Grissmer, Hervé Darbon, Michel De Waard and Jean-Marc Sabatier
    Molecular Pharmacology January 2006, 69 (1) 354-362; DOI: https://doi.org/10.1124/mol.105.017210
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    Constitutive Formation of Oligomeric Complexes between Family B G Protein-Coupled Vasoactive Intestinal Polypeptide and Secretin Receptors
    Kaleeckal G. Harikumar, Maria M. Morfis, Cayle S. Lisenbee, Patrick M. Sexton and Laurence J. Miller
    Molecular Pharmacology January 2006, 69 (1) 363-373; DOI: https://doi.org/10.1124/mol.105.015776
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    Microtubule-Associated Protein 1B-Light Chain 1 Enhances Activation of Rap1 by Exchange Protein Activated by Cyclic AMP but Not Intracellular Targeting
    Gillian Borland, Mona Gupta, Maria M. Magiera, Catherine J. Rundell, Suzanne Fuld and Stephen J. Yarwood
    Molecular Pharmacology January 2006, 69 (1) 374-384; DOI: https://doi.org/10.1124/mol.105.016337
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    Role of p90 Ribosomal S6-Kinase-1 in Oltipraz-Induced Specific Phosphorylation of CCAAT/Enhancer Binding Protein-β for GSTA2 Gene Transactivation
    Seung Jin Lee and Sang Geon Kim
    Molecular Pharmacology January 2006, 69 (1) 385-396; DOI: https://doi.org/10.1124/mol.105.018465
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    The Carboxyl Terminus of the Gα-Subunit Is the Latch for Triggered Activation of Heterotrimeric G Proteins
    Christian Nanoff, Romana Koppensteiner, Qiong Yang, Elisabeth Fuerst, Horst Ahorn and Michael Freissmuth
    Molecular Pharmacology January 2006, 69 (1) 397-405; DOI: https://doi.org/10.1124/mol.105.016725

Erratum

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    Correction to “Different Structural States of the Proteolipid Membrane Are Produced by Ligand Binding to the Human δ-Opioid Receptor as Shown by Plasmon-Waveguide Resonance Spectroscopy”
    Molecular Pharmacology January 2006, 69 (1) 406; DOI: https://doi.org/10.1124/mol.69.1.406
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Molecular Pharmacology: 69 (1)
Molecular Pharmacology
Vol. 69, Issue 1
1 Jan 2006
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  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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