Table of Contents

Articles

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  Binding Site Flexibility: Molecular Simulation of Partial and Full Agonists within a Glutamate Receptor

  Yalini Arinaminpathy, Mark S. P. Sansom and Philip C. Biggin

  Molecular Pharmacology January 2006, 69 (1) 11-18; DOI: https://doi.org/10.1124/mol.105.016691
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  Signaling via the Angiotensin-Converting Enzyme Results in the Phosphorylation of the Nonmuscle Myosin Heavy Chain IIA

  Karin Kohlstedt, Roland Kellner, Rudi Busse and Ingrid Fleming

  Molecular Pharmacology January 2006, 69 (1) 19-26; DOI: https://doi.org/10.1124/mol.105.016733
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  Determinants of Zinc Potentiation on the α4 Subunit of Neuronal Nicotinic Receptors

  Bernard Hsiao, Karla B. Mihalak, Sarah E. Repicky, Drew Everhart, Ana H. Mederos, Arun Malhotra and Charles W. Luetje

  Molecular Pharmacology January 2006, 69 (1) 27-36; DOI: https://doi.org/10.1124/mol.105.015164
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  Peripheral Benzodiazepine Receptor: Characterization in Human T-Lymphoma Jurkat Cells

  Barbara Costa, Alessandra Salvetti, Leonardo Rossi, Francesca Spinetti, Annalisa Lena, Beatrice Chelli, Mariarosa Rechichi, Eleonora Da Pozzo, Vittorio Gremigni and Claudia Martini

  Molecular Pharmacology January 2006, 69 (1) 37-44; DOI: https://doi.org/10.1124/mol.105.015289
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  Heterodimers of α_1B- and α_1D-Adrenergic Receptors Form a Single Functional Entity

  Chris Hague, Sarah E. Lee, Zhongjian Chen, Steven C. Prinster, Randy A. Hall and Kenneth P. Minneman

  Molecular Pharmacology January 2006, 69 (1) 45-55; DOI: https://doi.org/10.1124/mol.105.014985
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  Intestinal and Hepatic CYP3A4 Catalyze Hydroxylation of 1α,25-Dihydroxyvitamin D₃: Implications for Drug-Induced Osteomalacia

  Yang Xu, Takanori Hashizume, Margaret C. Shuhart, Connie L. Davis, Wendel L. Nelson, Toshiyuki Sakaki, Thomas F. Kalhorn, Paul B. Watkins, Erin G. Schuetz and Kenneth E. Thummel

  Molecular Pharmacology January 2006, 69 (1) 56-65; DOI: https://doi.org/10.1124/mol.105.017392
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  Regulation of CXCR4-Mediated Nuclear Translocation of Extracellular Signal-Related Kinases 1 and 2

  Ming Zhao, Richard G. DiScipio, Antonia G. Wimmer and Ingrid U. Schraufstatter

  Molecular Pharmacology January 2006, 69 (1) 66-75; DOI: https://doi.org/10.1124/mol.105.016923
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  Mefenamic Acid Shows Neuroprotective Effects and Improves Cognitive Impairment in in Vitro and in Vivo Alzheimer's Disease Models

  Yuyoung Joo, Hye-Sun Kim, Ran-Sook Woo, Cheol Hyoung Park, Ki-Young Shin, Jean-Pyo Lee, Keun-A Chang, Seonghan Kim and Yoo-Hun Suh

  Molecular Pharmacology January 2006, 69 (1) 76-84; DOI: https://doi.org/10.1124/mol.105.015206
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  Activation of Extracellular Signal-Regulated Kinase Signaling by Epidermal Growth Factor Mediates c-Jun Activation and p300 Recruitment in Keratin 16 Gene Expression

  Ying-Nai Wang, Yun-Ju Chen and Wen-Chang Chang

  Molecular Pharmacology January 2006, 69 (1) 85-98; DOI: https://doi.org/10.1124/mol.105.016220
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  Regulation and Binding of Pregnane X Receptor by Nuclear Receptor Corepressor Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT)

  David R. Johnson, Chia-Wei Li, Liuh-Yow Chen, Jagadish C. Ghosh and J. Don Chen

  Molecular Pharmacology January 2006, 69 (1) 99-108; DOI: https://doi.org/10.1124/mol.105.013375
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  Characterization of Agonist-Induced Motilin Receptor Trafficking and Its Implications for Tachyphylaxis

  Vahideh Lamian, Adam Rich, Zhengping Ma, James Li, Ramakrishna Seethala, David Gordon and Yves Dubaquie

  Molecular Pharmacology January 2006, 69 (1) 109-118; DOI: https://doi.org/10.1124/mol.105.017111
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  Revisiting the Postulated “Unitary Glutamate Receptor”: Electrophysiological and Pharmacological Analysis in Two Heterologous Expression Systems Fails to Detect Evidence for Its Existence

  Carsten Schmidt, Markus Werner and Michael Hollmann

  Molecular Pharmacology January 2006, 69 (1) 119-129; DOI: https://doi.org/10.1124/mol.105.016840
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  Mutation P732L in Human DNA Topoisomerase IIβ Abolishes DNA Cleavage in the Presence of Calcium and Confers Drug Resistance

  Chrysoula Leontiou, Jeremy H. Lakey, Robert Lightowlers, Rozalind M. Turnbull and Caroline A. Austin

  Molecular Pharmacology January 2006, 69 (1) 130-139; DOI: https://doi.org/10.1124/mol.105.015933
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  Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries

  Nathalie Tijet, Paul C. Boutros, Ivy D. Moffat, Allan B. Okey, Jouko Tuomisto and Raimo Pohjanvirta

  Molecular Pharmacology January 2006, 69 (1) 140-153; DOI: https://doi.org/10.1124/mol.105.018705
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  The Blockage of Survivin and Securin Expression Increases the Cytochalasin B-Induced Cell Death and Growth Inhibition in Human Cancer Cells

  Jui-I Chao and Huei-Fang Liu

  Molecular Pharmacology January 2006, 69 (1) 154-164; DOI: https://doi.org/10.1124/mol.105.015503
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  Activation and Inhibition of Kidney CLC-K Chloride Channels by Fenamates

  Antonella Liantonio, Alessandra Picollo, Elena Babini, Giuseppe Carbonara, Giuseppe Fracchiolla, Fulvio Loiodice, Vincenzo Tortorella, Michael Pusch and Diana Conte Camerino

  Molecular Pharmacology January 2006, 69 (1) 165-173; DOI: https://doi.org/10.1124/mol.105.017384
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  Altered Expression of G_q/11α Protein Shapes mGlu1 and mGlu5 Receptor-Mediated Single Cell Inositol 1,4,5-Trisphosphate and Ca²⁺ Signaling

  Peter J. Atkinson, Kenneth W. Young, Steven J. Ennion, James N. C. Kew, Stefan R. Nahorski and R. A. John Challiss

  Molecular Pharmacology January 2006, 69 (1) 174-184; DOI: https://doi.org/10.1124/mol.105.014258
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  Structural Determinants of Pharmacological Specificity Between D₁ and D₂ Dopamine Receptors

  Hongxiang Lan, Curtiss J. DuRand, Martha M. Teeter and Kim A. Neve

  Molecular Pharmacology January 2006, 69 (1) 185-194; DOI: https://doi.org/10.1124/mol.105.017244
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  Curcumin (Diferuloylmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IκBα Kinase and Akt Activation

  Sita Aggarwal, Haruyo Ichikawa, Yasunari Takada, Santosh K. Sandur, Shishir Shishodia and Bharat B. Aggarwal

  Molecular Pharmacology January 2006, 69 (1) 195-206; DOI: https://doi.org/10.1124/mol.105.017400
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  Activation of Adenylyl Cyclase by Endogenous G_s-Coupled Receptors in Human Embryonic Kidney 293 Cells Is Attenuated by 5-HT₇ Receptor Expression

  Kjetil Wessel Andressen, Jens Henrik Norum, Finn Olav Levy and Kurt A. Krobert

  Molecular Pharmacology January 2006, 69 (1) 207-215; DOI: https://doi.org/10.1124/mol.105.015396
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  RETRACTION: The Histone Deacetylase Inhibitor LAQ824 Induces Human Leukemia Cell Death through a Process Involving XIAP Down-Regulation, Oxidative Injury, and the Acid Sphingomyelinase-Dependent Generation of Ceramide

  Roberto R. Rosato, Sonia C. Maggio, Jorge A. Almenara, Shawn G. Payne, Peter Atadja, Sarah Spiegel, Paul Dent and Steven Grant

  Molecular Pharmacology January 2006, 69 (1) 216-225; DOI: https://doi.org/10.1124/mol.105.017145
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  Investigation of Cooperativity in the Binding of Ligands to the D₂ Dopamine Receptor

  Meritxell Vivo, Hong Lin and Philip G. Strange

  Molecular Pharmacology January 2006, 69 (1) 226-235; DOI: https://doi.org/10.1124/mol.105.012443
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  Probing the Molecular Mechanism of Interaction between 4-n-Butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the Muscarinic M₁ Receptor: Direct Pharmacological Evidence That AC-42 Is an Allosteric Agonist

  Christopher J. Langmead, Victoria A. H. Fry, Ian T. Forbes, Clive L. Branch, Arthur Christopoulos, Martyn D. Wood and Hugh J. Herdon

  Molecular Pharmacology January 2006, 69 (1) 236-246; DOI: https://doi.org/10.1124/mol.105.017814
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  2-Aminoethoxydiphenyl Borate as a Prototype Drug for a Group of Structurally Related Calcium Channel Blockers in Human Platelets

  Yuliya Dobrydneva, Christopher J. Abelt, Beth Dovel, Celina M. Thadigiri, Roy L. Williams and Peter F. Blackmore

  Molecular Pharmacology January 2006, 69 (1) 247-256; DOI: https://doi.org/10.1124/mol.105.015701
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  Aryl Hydrocarbon Receptor Activation Inhibits Regenerative Growth

  Lijoy K. Mathew, Eric A. Andreasen and Robert L. Tanguay

  Molecular Pharmacology January 2006, 69 (1) 257-265; DOI: https://doi.org/10.1124/mol.105.018044
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  Activation of Human ether-a-go-go-Related Gene Potassium Channels by the Diphenylurea 1,3-Bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)

  Rie Schultz Hansen, Thomas Goldin Diness, Torsten Christ, Joachim Demnitz, Ursula Ravens, Søren-Peter Olesen and Morten Grunnet

  Molecular Pharmacology January 2006, 69 (1) 266-277; DOI: https://doi.org/10.1124/mol.105.015859
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  A Novel Drug Binding Site on Voltage-Gated Sodium Channels in Rat Brain

  Dieter R. Riddall, Michael J. Leach and John Garthwaite

  Molecular Pharmacology January 2006, 69 (1) 278-287; DOI: https://doi.org/10.1124/mol.105.015966
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  RETRACTION: Flavopiridol and Histone Deacetylase Inhibitors Promote Mitochondrial Injury and Cell Death in Human Leukemia Cells That Overexpress Bcl-2

  Girija Dasmahapatra, Jorge A. Almenara and Steven Grant

  Molecular Pharmacology January 2006, 69 (1) 288-298; DOI: https://doi.org/10.1124/mol.105.016154
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  Synaptic Expression of Glutamate Receptor after Encoding of Fear Memory in the Rat Amygdala

  Shiu-Hwa Yeh, Sheng-Chun Mao, Hui-Ching Lin and Po-Wu Gean

  Molecular Pharmacology January 2006, 69 (1) 299-308; DOI: https://doi.org/10.1124/mol.105.017194
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  Identification and Characterization of a Potent, Selective Nonpeptide Agonist of the CC Chemokine Receptor CCR8

  Christopher A. Haskell, Richard Horuk, Meina Liang, Mary Rosser, Laura Dunning, Imadul Islam, Leonor Kremer, Julio Gutiérrez, Gabriel Marquez, Carlos Martinez-A, Mark J. Biscone, Robert W. Doms and Sofia Ribeiro

  Molecular Pharmacology January 2006, 69 (1) 309-316; DOI: https://doi.org/10.1124/mol.105.014779
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  The Impact of Blunted β-Adrenergic Responsiveness on Growth Regulatory Pathways in Hypertension

  Robert Gros, Qingming Ding, Jozef Chorazyczewski, Joseph Andrews, J. Geoffrey Pickering, Robert A. Hegele and Ross D. Feldman

  Molecular Pharmacology January 2006, 69 (1) 317-327; DOI: https://doi.org/10.1124/mol.105.013953
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  The Novel Imidazopyridine 2-[2-(4-Methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) Is a Highly Selective Inhibitor of the Inducible Nitric-Oxide Synthase

  Andreas Strub, Wolf-Rüdiger Ulrich, Christian Hesslinger, Manfrid Eltze, Thomas Fuchß, Jochen Strassner, Susanne Strand, Martin D. Lehner and Rainer Boer

  Molecular Pharmacology January 2006, 69 (1) 328-337; DOI: https://doi.org/10.1124/mol.105.017087
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  Identification of a Potent Inverse Agonist at a Constitutively Active Mutant of Human P2Y₁₂ Receptor

  Zhongren Ding, Soochong Kim and Satya P. Kunapuli

  Molecular Pharmacology January 2006, 69 (1) 338-345; DOI: https://doi.org/10.1124/mol.105.014654
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  A Comparison of the Transportability, and Its Role in Cytotoxicity, of Clofarabine, Cladribine, and Fludarabine by Recombinant Human Nucleoside Transporters Produced in Three Model Expression Systems

  Karen M. King, Vijaya L. Damaraju, Mark F. Vickers, Sylvia Y. Yao, Thach Lang, Tracey E. Tackaberry, Delores A. Mowles, Amy M. L. Ng, James D. Young and Carol E. Cass

  Molecular Pharmacology January 2006, 69 (1) 346-353; DOI: https://doi.org/10.1124/mol.105.015768
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  Pharmacological Profiling of Orthochirus scrobiculosus Toxin 1 Analogs with a Trimmed N-Terminal Domain

  Stéphanie Mouhat, Georgeta Teodorescu, Daniel Homerick, Violeta Visan, Heike Wulff, Yingliang Wu, Stephan Grissmer, Hervé Darbon, Michel De Waard and Jean-Marc Sabatier

  Molecular Pharmacology January 2006, 69 (1) 354-362; DOI: https://doi.org/10.1124/mol.105.017210
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  Constitutive Formation of Oligomeric Complexes between Family B G Protein-Coupled Vasoactive Intestinal Polypeptide and Secretin Receptors

  Kaleeckal G. Harikumar, Maria M. Morfis, Cayle S. Lisenbee, Patrick M. Sexton and Laurence J. Miller

  Molecular Pharmacology January 2006, 69 (1) 363-373; DOI: https://doi.org/10.1124/mol.105.015776
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  Microtubule-Associated Protein 1B-Light Chain 1 Enhances Activation of Rap1 by Exchange Protein Activated by Cyclic AMP but Not Intracellular Targeting

  Gillian Borland, Mona Gupta, Maria M. Magiera, Catherine J. Rundell, Suzanne Fuld and Stephen J. Yarwood

  Molecular Pharmacology January 2006, 69 (1) 374-384; DOI: https://doi.org/10.1124/mol.105.016337
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  Role of p90 Ribosomal S6-Kinase-1 in Oltipraz-Induced Specific Phosphorylation of CCAAT/Enhancer Binding Protein-β for GSTA2 Gene Transactivation

  Seung Jin Lee and Sang Geon Kim

  Molecular Pharmacology January 2006, 69 (1) 385-396; DOI: https://doi.org/10.1124/mol.105.018465
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  The Carboxyl Terminus of the Gα-Subunit Is the Latch for Triggered Activation of Heterotrimeric G Proteins

  Christian Nanoff, Romana Koppensteiner, Qiong Yang, Elisabeth Fuerst, Horst Ahorn and Michael Freissmuth

  Molecular Pharmacology January 2006, 69 (1) 397-405; DOI: https://doi.org/10.1124/mol.105.016725