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Molecular Pharmacology

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Research ArticleArticle

Altered Expression of Gq/11α Protein Shapes mGlu1 and mGlu5 Receptor-Mediated Single Cell Inositol 1,4,5-Trisphosphate and Ca2+ Signaling

Peter J. Atkinson, Kenneth W. Young, Steven J. Ennion, James N. C. Kew, Stefan R. Nahorski and R. A. John Challiss
Molecular Pharmacology January 2006, 69 (1) 174-184; DOI: https://doi.org/10.1124/mol.105.014258
Peter J. Atkinson
Department of Cell Physiology & Pharmacology, University of Leicester, Leicester, United Kingdom (P.J.A., K.W.Y., S.J.E., S.R.N., R.A.J.C.); and Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom (J.N.C.K.)
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Kenneth W. Young
Department of Cell Physiology & Pharmacology, University of Leicester, Leicester, United Kingdom (P.J.A., K.W.Y., S.J.E., S.R.N., R.A.J.C.); and Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom (J.N.C.K.)
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Steven J. Ennion
Department of Cell Physiology & Pharmacology, University of Leicester, Leicester, United Kingdom (P.J.A., K.W.Y., S.J.E., S.R.N., R.A.J.C.); and Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom (J.N.C.K.)
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James N. C. Kew
Department of Cell Physiology & Pharmacology, University of Leicester, Leicester, United Kingdom (P.J.A., K.W.Y., S.J.E., S.R.N., R.A.J.C.); and Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom (J.N.C.K.)
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Stefan R. Nahorski
Department of Cell Physiology & Pharmacology, University of Leicester, Leicester, United Kingdom (P.J.A., K.W.Y., S.J.E., S.R.N., R.A.J.C.); and Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom (J.N.C.K.)
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R. A. John Challiss
Department of Cell Physiology & Pharmacology, University of Leicester, Leicester, United Kingdom (P.J.A., K.W.Y., S.J.E., S.R.N., R.A.J.C.); and Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom (J.N.C.K.)
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Article Information

vol. 69 no. 1 174-184
DOI 
https://doi.org/10.1124/mol.105.014258
PubMed 
16234485

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received April 26, 2005
  • Accepted October 18, 2005
  • Published online December 28, 2005.

Article Versions

  • Earlier version (October 18, 2005 - 12:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Peter J. Atkinson,
  2. Kenneth W. Young,
  3. Steven J. Ennion,
  4. James N. C. Kew,
  5. Stefan R. Nahorski, and
  6. R. A. John Challiss
  1. Department of Cell Physiology & Pharmacology, University of Leicester, Leicester, United Kingdom (P.J.A., K.W.Y., S.J.E., S.R.N., R.A.J.C.); and Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, United Kingdom (J.N.C.K.)
  1. Address correspondence to:
    Prof. R. A. J. Challiss, Department of Cell Physiology and Pharmacology, University of Leicester, Maurice Shock Medical Sciences Building, University Road, Leicester, LE1 9HN, UK. E-mail: jc36{at}le.ac.uk
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Molecular Pharmacology: 69 (1)
Molecular Pharmacology
Vol. 69, Issue 1
1 Jan 2006
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Research ArticleArticle

Altered Expression of Gq/11α Protein Shapes mGlu1 and mGlu5 Receptor-Mediated Single Cell Inositol 1,4,5-Trisphosphate and Ca2+ Signaling

Peter J. Atkinson, Kenneth W. Young, Steven J. Ennion, James N. C. Kew, Stefan R. Nahorski and R. A. John Challiss
Molecular Pharmacology January 1, 2006, 69 (1) 174-184; DOI: https://doi.org/10.1124/mol.105.014258

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Research ArticleArticle

Altered Expression of Gq/11α Protein Shapes mGlu1 and mGlu5 Receptor-Mediated Single Cell Inositol 1,4,5-Trisphosphate and Ca2+ Signaling

Peter J. Atkinson, Kenneth W. Young, Steven J. Ennion, James N. C. Kew, Stefan R. Nahorski and R. A. John Challiss
Molecular Pharmacology January 1, 2006, 69 (1) 174-184; DOI: https://doi.org/10.1124/mol.105.014258
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