Research ArticleArticle
Intestinal and Hepatic CYP3A4 Catalyze Hydroxylation of 1α,25-Dihydroxyvitamin D3: Implications for Drug-Induced Osteomalacia
Yang Xu, Takanori Hashizume, Margaret C. Shuhart, Connie L. Davis, Wendel L. Nelson, Toshiyuki Sakaki, Thomas F. Kalhorn, Paul B. Watkins, Erin G. Schuetz and Kenneth E. Thummel
Molecular Pharmacology January 2006, 69 (1) 56-65; DOI: https://doi.org/10.1124/mol.105.017392
Yang Xu
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)
Takanori Hashizume
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)
Margaret C. Shuhart
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)
Connie L. Davis
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)
Wendel L. Nelson
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)
Toshiyuki Sakaki
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)
Thomas F. Kalhorn
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)
Paul B. Watkins
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)
Erin G. Schuetz
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)
Kenneth E. Thummel
Department of Pharmaceutics (Y.X., T.H., K.E.T.), Divisions of Gastroenterology (M.C.S.) and Nephrology (C.L.D.), Department of Medicine, and Department of Medicinal Chemistry (W.L.N., T.F.K.), University of Washington, Seattle, Washington; Biotechnology Research Center, Toyama Prefectural University, Izumi-gun, Toyama, Japan (T.S.); Division of Hepatology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina (P.B.W.); and St. Jude Children's Research Hospital, Memphis, Tennessee (E.G.S.)

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Research ArticleArticle
Intestinal and Hepatic CYP3A4 Catalyze Hydroxylation of 1α,25-Dihydroxyvitamin D3: Implications for Drug-Induced Osteomalacia
Yang Xu, Takanori Hashizume, Margaret C. Shuhart, Connie L. Davis, Wendel L. Nelson, Toshiyuki Sakaki, Thomas F. Kalhorn, Paul B. Watkins, Erin G. Schuetz and Kenneth E. Thummel
Molecular Pharmacology January 1, 2006, 69 (1) 56-65; DOI: https://doi.org/10.1124/mol.105.017392
Research ArticleArticle
Intestinal and Hepatic CYP3A4 Catalyze Hydroxylation of 1α,25-Dihydroxyvitamin D3: Implications for Drug-Induced Osteomalacia
Yang Xu, Takanori Hashizume, Margaret C. Shuhart, Connie L. Davis, Wendel L. Nelson, Toshiyuki Sakaki, Thomas F. Kalhorn, Paul B. Watkins, Erin G. Schuetz and Kenneth E. Thummel
Molecular Pharmacology January 1, 2006, 69 (1) 56-65; DOI: https://doi.org/10.1124/mol.105.017392
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