Table of Contents

Articles

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  Reversing Hypoxic Cell Chemoresistance in Vitro Using Genetic and Small Molecule Approaches Targeting Hypoxia Inducible Factor-1

  Louisa M. Brown, Rachel L. Cowen, Camille Debray, Amanda Eustace, Janine T. Erler, Freda C. D. Sheppard, Catriona A. Parker, Ian J. Stratford and Kaye J. Williams

  Molecular Pharmacology February 2006, 69 (2) 411-418; DOI: https://doi.org/10.1124/mol.105.015743
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  Four Novel Tarantula Toxins as Selective Modulators of Voltage-Gated Sodium Channel Subtypes

  Frank Bosmans, Lachlan Rash, Shunyi Zhu, Sylvie Diochot, Michel Lazdunski, Pierre Escoubas and Jan Tytgat

  Molecular Pharmacology February 2006, 69 (2) 419-429; DOI: https://doi.org/10.1124/mol.105.015941
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  Activation and Potentiation of Interferon-γ Signaling by 3,3′-Diindolylmethane in MCF-7 Breast Cancer Cells

  Jacques E. Riby, Ling Xue, Urmi Chatterji, Erik L. Bjeldanes, Gary L. Firestone and Leonard F. Bjeldanes

  Molecular Pharmacology February 2006, 69 (2) 430-439; DOI: https://doi.org/10.1124/mol.105.017053
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  Gene Transfer of Pro-opiomelanocortin Prohormone Suppressed the Growth and Metastasis of Melanoma: Involvement of α-Melanocyte-Stimulating Hormone-Mediated Inhibition of the Nuclear Factor κB/Cyclooxygenase-2 Pathway

  Guei-Sheung Liu, Li-Fen Liu, Che-Jen Lin, Jui-Cheng Tseng, Ming-Ju Chuang, Hing-Chung Lam, Jenn-Kuen Lee, Lin-Cheng Yang, Julie Hwa Yu Chan, Shen-Long Howng and Ming-Hong Tai

  Molecular Pharmacology February 2006, 69 (2) 440-451; DOI: https://doi.org/10.1124/mol.105.015404
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  Probing the Reorganization of the Nicotinic Acetylcholine Receptor during Desensitization by Time-Resolved Covalent Labeling Using [³H]AC5, a Photoactivatable Agonist

  Alexandre Mourot, Jordi Rodrigo, Florence Kotzyba-Hibert, Sonia Bertrand, Daniel Bertrand and Maurice Goeldner

  Molecular Pharmacology February 2006, 69 (2) 452-461; DOI: https://doi.org/10.1124/mol.105.017566
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  Rapid Modulation of P-Glycoprotein-Mediated Transport at the Blood-Brain Barrier by Tumor Necrosis Factor-α and Lipopolysaccharide

  Anika M. S. Hartz, Björn Bauer, Gert Fricker and David S. Miller

  Molecular Pharmacology February 2006, 69 (2) 462-470; DOI: https://doi.org/10.1124/mol.105.017954
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  The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Cell Proliferation and Increases Markers of Adipocyte Maturation in Cultured Mouse 3T3 F442A Preadipocytes

  Magali Gary-Bobo, Ghizlane Elachouri, Bernard Scatton, Gérard Le Fur, Florence Oury-Donat and Mohammed Bensaid

  Molecular Pharmacology February 2006, 69 (2) 471-478; DOI: https://doi.org/10.1124/mol.105.015040
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  Interactions between the Mas-Related Receptors MrgD and MrgE Alter Signalling and Trafficking of MrgD

  Sandra Milasta, John Pediani, Shirley Appelbe, Steven Trim, Michael Wyatt, Peter Cox, Mark Fidock and Graeme Milligan

  Molecular Pharmacology February 2006, 69 (2) 479-491; DOI: https://doi.org/10.1124/mol.105.018788
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  Specific Modulation of Airway Epithelial Tight Junctions by Apical Application of an Occludin Peptide

  Ruth S. Everett, Miriam K. Vanhook, Nadia Barozzi, Istvan Toth and Larry G. Johnson

  Molecular Pharmacology February 2006, 69 (2) 492-500; DOI: https://doi.org/10.1124/mol.105.017251
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  A Glutathione S-Transferase π-Activated Prodrug Causes Kinase Activation Concurrent with S-Glutathionylation of Proteins

  Danyelle M. Townsend, Victoria J. Findlay, Farit Fazilev, Molly Ogle, Jacob Fraser, Joseph E. Saavedra, Xinhua Ji, Larry K. Keefer and Kenneth D. Tew

  Molecular Pharmacology February 2006, 69 (2) 501-508; DOI: https://doi.org/10.1124/mol.105.018523
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  Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

  Matthew Perry, Phillip J. Stansfeld, Joanne Leaney, Claire Wood, Marcel J. de Groot, Derek Leishman, Michael J. Sutcliffe and John S. Mitcheson

  Molecular Pharmacology February 2006, 69 (2) 509-519; DOI: https://doi.org/10.1124/mol.105.016741
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  Positive Inter-Regulation between β-Catenin/T Cell Factor-4 Signaling and Endothelin-1 Signaling Potentiates Proliferation and Survival of Prostate Cancer Cells

  Ping Sun, Hui Xiong, Tae Hoon Kim, Bing Ren and Zhuohua Zhang

  Molecular Pharmacology February 2006, 69 (2) 520-531; DOI: https://doi.org/10.1124/mol.105.019620
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  Hydroxylated Xestospongins Block Inositol-1,4,5-trisphosphate-Induced Ca²⁺ Release and Sensitize Ca²⁺-Induced Ca²⁺ Release Mediated by Ryanodine Receptors

  Tram Anh Ta, Wei Feng, Tadeusz F. Molinski and Isaac N. Pessah

  Molecular Pharmacology February 2006, 69 (2) 532-538; DOI: https://doi.org/10.1124/mol.105.019125
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  Chemokine Stromal Cell-Derived Factor 1α Induces Proliferation and Growth Hormone Release in GH4C1 Rat Pituitary Adenoma Cell Line through Multiple Intracellular Signals

  Tullio Florio, Silvia Casagrande, Fabrizio Diana, Adriana Bajetto, Carola Porcile, Gianluigi Zona, Stefano Thellung, Sara Arena, Alessandra Pattarozzi, Alessandro Corsaro, Renato Spaziante, Mauro Robello and Gennaro Schettini

  Molecular Pharmacology February 2006, 69 (2) 539-546; DOI: https://doi.org/10.1124/mol.105.015255
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  Novel and Specific Inhibitors of a Poxvirus Type I Topoisomerase

  Alexis Bond, Zachary Reichert and James T. Stivers

  Molecular Pharmacology February 2006, 69 (2) 547-557; DOI: https://doi.org/10.1124/mol.105.019067
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  Constraining the Expression of Nicotinic Acetylcholine Receptors by Using Pentameric Constructs

  Paul J. Groot-Kormelink, Steven Broadbent, Marco Beato and Lucia G. Sivilotti

  Molecular Pharmacology February 2006, 69 (2) 558-563; DOI: https://doi.org/10.1124/mol.105.019356
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  High-Affinity, Slowly Desensitizing GABA_A Receptors Mediate Tonic Inhibition in Hippocampal Dentate Granule Cells

  Zakaria Mtchedlishvili and Jaideep Kapur

  Molecular Pharmacology February 2006, 69 (2) 564-575; DOI: https://doi.org/10.1124/mol.105.016683
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  Functional Properties of Internalization-Deficient P2X₄ Receptors Reveal a Novel Mechanism of Ligand-Gated Channel Facilitation by Ivermectin

  Estelle Toulmé, Florentina Soto, Maurice Garret and Eric Boué-Grabot

  Molecular Pharmacology February 2006, 69 (2) 576-587; DOI: https://doi.org/10.1124/mol.105.018812
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  CD38 Expression Is Insensitive to Steroid Action in Cells Treated with Tumor Necrosis Factor-α and Interferon-γ by a Mechanism Involving the Up-Regulation of the Glucocorticoid Receptor β Isoform

  Omar Tliba, John A. Cidlowski and Yassine Amrani

  Molecular Pharmacology February 2006, 69 (2) 588-596; DOI: https://doi.org/10.1124/mol.105.019679
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  Characterization of SIS3, a Novel Specific Inhibitor of Smad3, and Its Effect on Transforming Growth Factor-β1-Induced Extracellular Matrix Expression

  Masatoshi Jinnin, Hironobu Ihn and Kunihiko Tamaki

  Molecular Pharmacology February 2006, 69 (2) 597-607; DOI: https://doi.org/10.1124/mol.105.017483
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  A Direct Interaction between the N Terminus of Adenylyl Cyclase AC8 and the Catalytic Subunit of Protein Phosphatase 2A

  Andrew J. Crossthwaite, Antonio Ciruela, Timothy F. Rayner and Dermot M. F. Cooper

  Molecular Pharmacology February 2006, 69 (2) 608-617; DOI: https://doi.org/10.1124/mol.105.018275
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  Indirect Modulation by α7 Nicotinic Acetylcholine Receptors of Noradrenaline Release in Rat Hippocampal Slices: Interaction with Glutamate and GABA Systems and Effect of Nicotine Withdrawal

  Jacques Barik and Susan Wonnacott

  Molecular Pharmacology February 2006, 69 (2) 618-628; DOI: https://doi.org/10.1124/mol.105.018184
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  Acquired Cadmium Resistance in Metallothionein-I/II(–/–) Knockout Cells: Role of the T-Type Calcium Channel Cacnα_1G in Cadmium Uptake

  Elaine M. Leslie, Jie Liu, Curtis D. Klaassen and Michael P. Waalkes

  Molecular Pharmacology February 2006, 69 (2) 629-639; DOI: https://doi.org/10.1124/mol.105.014241
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  Pharmacological Properties of GABA_A Receptors Containing γ1 Subunits

  S. Khom, I. Baburin, E. N. Timin, A. Hohaus, W. Sieghart and S. Hering

  Molecular Pharmacology February 2006, 69 (2) 640-649; DOI: https://doi.org/10.1124/mol.105.017236
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  Deficiency of Glutathione Transferase Zeta Causes Oxidative Stress and Activation of Antioxidant Response Pathways

  Anneke C. Blackburn, Klaus I. Matthaei, Cindy Lim, Matthew C. Taylor, Jean Y. Cappello, John D. Hayes, M. W. Anders and Philip G. Board

  Molecular Pharmacology February 2006, 69 (2) 650-657; DOI: https://doi.org/10.1124/mol.105.018911
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  Mechanism of Action of a Novel Human ether-a-go-go-Related Gene Channel Activator

  Oscar Casis, Søren-Peter Olesen and Michael C. Sanguinetti

  Molecular Pharmacology February 2006, 69 (2) 658-665; DOI: https://doi.org/10.1124/mol.105.019943
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  Biological Consequences of Trinuclear Platinum Complexes: Comparison of [{trans-PtCl(NH₃)₂}₂μ-(trans-Pt(NH₃)₂(H₂N(CH₂)₆-NH₂)₂)]⁴⁺ (BBR 3464) with Its Noncovalent Congeners

  Amanda L. Harris, John J. Ryan and Nicholas Farrell

  Molecular Pharmacology February 2006, 69 (2) 666-672; DOI: https://doi.org/10.1124/mol.105.018762