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Research ArticleArticle

Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

Matthew Perry, Phillip J. Stansfeld, Joanne Leaney, Claire Wood, Marcel J. de Groot, Derek Leishman, Michael J. Sutcliffe and John S. Mitcheson
Molecular Pharmacology February 2006, 69 (2) 509-519; DOI: https://doi.org/10.1124/mol.105.016741
Matthew Perry
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Phillip J. Stansfeld
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Joanne Leaney
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Claire Wood
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Marcel J. de Groot
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Derek Leishman
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Michael J. Sutcliffe
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John S. Mitcheson
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Article Information

vol. 69 no. 2 509-519
DOI 
https://doi.org/10.1124/mol.105.016741
PubMed 
16291873

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received July 14, 2005
  • Accepted November 16, 2005
  • Published online January 17, 2006.

Article Versions

  • Earlier version (November 16, 2005 - 11:17).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Matthew Perry,
  2. Phillip J. Stansfeld,
  3. Joanne Leaney,
  4. Claire Wood,
  5. Marcel J. de Groot,
  6. Derek Leishman,
  7. Michael J. Sutcliffe and
  8. John S. Mitcheson
  1. Department of Cell Physiology and Pharmacology, Maurice Shock Medical Sciences Building, University of Leicester, Leicester, United Kingdom (M.P., J.S.M.); Pfizer Global Research & Development, Pfizer Limited, Sandwich, Kent, United Kingdom (J.L., C.W., M.J.d.G., D.L.); and Department of Biochemistry, University of Leicester, Leicester, United Kingdom (P.J.S., M.J.S.)
  1. Address correspondence to:
    John Mitcheson, University of Leicester, Department of Cell Physiology and Pharmacology, Maurice Shock Medical Sciences Building, University Road, Leicester, LE1 9HN, United Kingdom. E-mail: jm109{at}le.ac.uk
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Molecular Pharmacology: 69 (2)
Molecular Pharmacology
Vol. 69, Issue 2
1 Feb 2006
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Research ArticleArticle

Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

Matthew Perry, Phillip J. Stansfeld, Joanne Leaney, Claire Wood, Marcel J. de Groot, Derek Leishman, Michael J. Sutcliffe and John S. Mitcheson
Molecular Pharmacology February 1, 2006, 69 (2) 509-519; DOI: https://doi.org/10.1124/mol.105.016741

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Research ArticleArticle

Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

Matthew Perry, Phillip J. Stansfeld, Joanne Leaney, Claire Wood, Marcel J. de Groot, Derek Leishman, Michael J. Sutcliffe and John S. Mitcheson
Molecular Pharmacology February 1, 2006, 69 (2) 509-519; DOI: https://doi.org/10.1124/mol.105.016741
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