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Molecular Pharmacology

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Table of Contents

March 01, 2006; Volume 69,Issue 3

Perspectives

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    Novel Features of G Protein-Coupled Receptor Kinase 4
    Kim A. Neve
    Molecular Pharmacology March 2006, 69 (3) 673-676; DOI: https://doi.org/10.1124/mol.105.021535
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    Endothelial Nitric-Oxide Synthase Reveals a New Face in G Protein Signaling
    Matthew L. Bilodeau and Heidi E. Hamm
    Molecular Pharmacology March 2006, 69 (3) 677-679; DOI: https://doi.org/10.1124/mol.105.022038

Articles

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    Partial Agonism, Neutral Antagonism, and Inverse Agonism at the Human Wild-Type and Constitutively Active Cholecystokinin-2 Receptors
    Magali Foucaud, Irina G. Tikhonova, Ingrid Langer, Chantal Escrieut, Marlène Dufresne, Cathy Seva, Bernard Maigret and Daniel Fourmy
    Molecular Pharmacology March 2006, 69 (3) 680-690; DOI: https://doi.org/10.1124/mol.105.019992
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    Molecular Mechanisms of Cannabinoid Protection from Neuronal Excitotoxicity
    Sun Hee Kim, Seok Joon Won, Xiao Ou Mao, Kunlin Jin and David A. Greenberg
    Molecular Pharmacology March 2006, 69 (3) 691-696; DOI: https://doi.org/10.1124/mol.105.016428
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    Heme Deficiency Is Associated with Senescence and Causes Suppression of N-Methyl-d-aspartate Receptor Subunits Expression in Primary Cortical Neurons
    Tatyana Chernova, Pierluigi Nicotera and Andrew G. Smith
    Molecular Pharmacology March 2006, 69 (3) 697-705; DOI: https://doi.org/10.1124/mol.105.016675
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    Ethanol Induces Apoptotic Death of Developing β-Endorphin Neurons via Suppression of Cyclic Adenosine Monophosphate Production and Activation of Transforming Growth Factor-β1-Linked Apoptotic Signaling
    Cui Ping Chen, Peter Kuhn, Kirti Chaturvedi, Nadka Boyadjieva and Dipak K. Sarkar
    Molecular Pharmacology March 2006, 69 (3) 706-717; DOI: https://doi.org/10.1124/mol.105.017004
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    1,4-Diazabicyclo[2.2.2]octane Derivatives: A Novel Class of Voltage-Gated Potassium Channel Blockers
    Earl Gordon, Jaime-Lee Cohen, Robert Engel and Geoffrey W. Abbott
    Molecular Pharmacology March 2006, 69 (3) 718-726; DOI: https://doi.org/10.1124/mol.105.018663
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    A Membrane-Permeable Peptide Containing the Last 21 Residues of the GαS Carboxyl Terminus Inhibits GS-Coupled Receptor Signaling in Intact Cells: Correlations between Peptide Structure and Biological Activity
    Anna Maria D'Ursi, Laura Giusti, Stefania Albrizio, Francesca Porchia, Cinzia Esposito, Gabriella Caliendo, Claudia Gargini, Ettore Novellino, Antonio Lucacchini, Paolo Rovero and Maria Rosa Mazzoni
    Molecular Pharmacology March 2006, 69 (3) 727-736; DOI: https://doi.org/10.1124/mol.105.017715
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    Differential Gene Expression as a Potential Classifier of 2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole-Sensitive and -Insensitive Cell Lines
    Anders Wallqvist, John Connelly, Edward A. Sausville, David G. Covell and Anne Monks
    Molecular Pharmacology March 2006, 69 (3) 737-748; DOI: https://doi.org/10.1124/mol.105.017061
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    Anti-Inflammatory Mechanisms of Phenanthroindolizidine Alkaloids
    Cheng-Wei Yang, Wei-Liang Chen, Pei-Lin Wu, Huan-Yi Tseng and Shiow-Ju Lee
    Molecular Pharmacology March 2006, 69 (3) 749-758; DOI: https://doi.org/10.1124/mol.105.017764
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    The D1 Dopamine Receptor Is Constitutively Phosphorylated by G Protein-Coupled Receptor Kinase 4
    Michele L. Rankin, Paul S. Marinec, David M. Cabrera, Zheng Wang, Pedro A. Jose and David R. Sibley
    Molecular Pharmacology March 2006, 69 (3) 759-769; DOI: https://doi.org/10.1124/mol.105.019901
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    The Teratogenic Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Modified by a Locus on Mouse Chromosome 3
    Tami L. Thomae, Emily A. Stevens, Adam L. Liss, Norman R. Drinkwater and Christopher A. Bradfield
    Molecular Pharmacology March 2006, 69 (3) 770-775; DOI: https://doi.org/10.1124/mol.105.019760
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    Identification of Zebrafish ARNT1 Homologs: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Developing Zebrafish Requires ARNT1
    Amy L. Prasch, Robert L. Tanguay, Vatsal Mehta, Warren Heideman and Richard E. Peterson
    Molecular Pharmacology March 2006, 69 (3) 776-787; DOI: https://doi.org/10.1124/mol.105.016873
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    How Batrachotoxin Modifies the Sodium Channel Permeation Pathway: Computer Modeling and Site-Directed Mutagenesis
    Sho-Ya Wang, Jane Mitchell, Denis B. Tikhonov, Boris S. Zhorov and Ging Kuo Wang
    Molecular Pharmacology March 2006, 69 (3) 788-795; DOI: https://doi.org/10.1124/mol.105.018200
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    Novel Targeting of Cyclooxygenase-2 (COX-2) Pre-mRNA Using Antisense Morpholino Oligonucleotides Directed to the 3′ Acceptor and 5′ Donor Splice Sites of Exon 4: Suppression of COX-2 Activity in Human Amnion-Derived WISH and Myometrial Cells
    Alison J. Tyson-Capper and G. Nicholas Europe-Finner
    Molecular Pharmacology March 2006, 69 (3) 796-804; DOI: https://doi.org/10.1124/mol.105.020529
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    Loss of Synaptic D1 Dopamine/N-Methyl-d-aspartate Glutamate Receptor Complexes in l-DOPA-Induced Dyskinesia in the Rat
    Chiara Fiorentini, Maria Cristina Rizzetti, Chiara Busi, Sandra Bontempi, Ginetta Collo, PierFranco Spano and Cristina Missale
    Molecular Pharmacology March 2006, 69 (3) 805-812; DOI: https://doi.org/10.1124/mol.105.016667
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    Activation of Dopamine D4 Receptors Induces Synaptic Translocation of Ca2+/Calmodulin-Dependent Protein Kinase II in Cultured Prefrontal Cortical Neurons
    Zhenglin Gu, Qian Jiang, Eunice Y. Yuen and Zhen Yan
    Molecular Pharmacology March 2006, 69 (3) 813-822; DOI: https://doi.org/10.1124/mol.105.018853
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    Block of Peripheral Nerve Sodium Channels Selectively Inhibits Features of Neuropathic Pain in Rats
    Richard M. Brochu, Ivy E. Dick, Jason W. Tarpley, Erin McGowan, David Gunner, James Herrington, Pengcheng P. Shao, Dong Ok, Chunshi Li, William H. Parsons, Gary L. Stump, Christopher P. Regan, Joseph J. Lynch, Kathryn A. Lyons, Owen B. McManus, Samantha Clark, Zahid Ali, Gregory J. Kaczorowski, William J. Martin and Birgit T. Priest
    Molecular Pharmacology March 2006, 69 (3) 823-832; DOI: https://doi.org/10.1124/mol.105.018127
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    Insulin-Like Growth Factor Binding Protein-2: Contributions of the C-Terminal Domain to Insulin-Like Growth Factor-1 Binding
    Megan M. Kibbey, Mark J. Jameson, Erin M. Eaton and Steven A. Rosenzweig
    Molecular Pharmacology March 2006, 69 (3) 833-845; DOI: https://doi.org/10.1124/mol.105.016998
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    Presynaptic Mechanism Underlying cAMP-Induced Synaptic Potentiation in Medial Prefrontal Cortex Pyramidal Neurons
    Chiung-Chun Huang and Kuei-Sen Hsu
    Molecular Pharmacology March 2006, 69 (3) 846-856; DOI: https://doi.org/10.1124/mol.105.018093
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    The Amino Terminus and the Third Extracellular Loop of CX3CR1 Contain Determinants Critical for Distinct Receptor Functions
    Yiming Chen, Simone R. Green, Felicidad Almazan and Oswald Quehenberger
    Molecular Pharmacology March 2006, 69 (3) 857-865; DOI: https://doi.org/10.1124/mol.105.015909
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    Involvement of cAMP/cAMP-Dependent Protein Kinase Signaling Pathway in Regulation of Na+,K+-ATPase upon Activation of Opioid Receptors by Morphine
    Zhao-Qiu Wu, Mu Li, Jie Chen, Zhi-Qiang Chi and Jing-Gen Liu
    Molecular Pharmacology March 2006, 69 (3) 866-876; DOI: https://doi.org/10.1124/mol.105.016501
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    Regions in the G Protein γ Subunit Important for Interaction with Receptors and Effectors
    Chang-Seon Myung, William K. Lim, Joseph M. DeFilippo, Hiroshi Yasuda, Richard R. Neubig and James C. Garrison
    Molecular Pharmacology March 2006, 69 (3) 877-887; DOI: https://doi.org/10.1124/mol.105.018994
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    Chemokine-Directed Trafficking of Receptor Stimulus to Different G Proteins: Selective Inducible and Constitutive Signaling by Human Herpesvirus 6-Encoded Chemokine Receptor U51
    Carlos P. Fitzsimons, Ursula A. Gompels, Dennis Verzijl, Henry F. Vischer, Claire Mattick, Rob Leurs and Martine J. Smit
    Molecular Pharmacology March 2006, 69 (3) 888-898; DOI: https://doi.org/10.1124/mol.105.015222
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    Mouse β-TC6 Insulinoma Cells: High Expression of Functional α3β4 Nicotinic Receptors Mediating Membrane Potential, Intracellular Calcium, and Insulin Release
    Masahiro Ohtani, Takami Oka, Maryna Badyuk, Yingxian Xiao, Kenneth J. Kellar and John W. Daly
    Molecular Pharmacology March 2006, 69 (3) 899-907; DOI: https://doi.org/10.1124/mol.105.014902
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    Inactivation of the Pure Antiestrogen Fulvestrant and Other Synthetic Estrogen Molecules by UDP-Glucuronosyltransferase 1A Enzymes Expressed in Breast Tissue
    Sarah Chouinard, Mélanie Tessier, Gabrielle Vernouillet, Sylvain Gauthier, Fernand Labrie, Olivier Barbier and Alain Bélanger
    Molecular Pharmacology March 2006, 69 (3) 908-920; DOI: https://doi.org/10.1124/mol.105.015891
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    Evidence for a Multivalent Interaction of Symmetrical, N-Linked, Lidocaine Dimers with Voltage-Gated Na+ Channels
    J. A. M. Smith, S. M. Amagasu, J. Hembrador, S. Axt, R. Chang, T. Church, C. Gee, J. R. Jacobsen, T. Jenkins, E. Kaufman, N. Mai and R. G. Vickery
    Molecular Pharmacology March 2006, 69 (3) 921-931; DOI: https://doi.org/10.1124/mol.105.019257
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    Angiotensin II Up-Regulates the Leukemia-Associated Rho Guanine Nucleotide Exchange Factor (RhoGEF), a Regulator of G Protein Signaling Domain-Containing RhoGEF, in Vascular Smooth Muscle Cells
    Zhekang Ying, Liming Jin, Trenis Palmer and R. Clinton Webb
    Molecular Pharmacology March 2006, 69 (3) 932-940; DOI: https://doi.org/10.1124/mol.105.017830
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    Glabridin Suppresses Intercellular Adhesion Molecule-1 Expression in Tumor Necrosis Factor-α-Stimulated Human Umbilical Vein Endothelial Cells by Blocking Sphingosine Kinase Pathway: Implications of Akt, Extracellular Signal-Regulated Kinase, and Nuclear Factor-κB/Rel Signaling Pathways
    Jong Soon Kang, Yeo Dae Yoon, Mi Hwa Han, Sang-Bae Han, Kiho Lee, Ki Hoon Lee, Song-Kyu Park and Hwan Mook Kim
    Molecular Pharmacology March 2006, 69 (3) 941-949; DOI: https://doi.org/10.1124/mol.105.017442
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    Ester Derivatives of Tournefolic Acid B Attenuate N-Methyl-d-aspartate-Mediated Excitotoxicity in Rat Cortical Neurons
    Chuen-Neu Wang, Hsien-Chia Pan, Yun-Lian Lin, Chih-Wen Chi and Young-Ji Shiao
    Molecular Pharmacology March 2006, 69 (3) 950-959; DOI: https://doi.org/10.1124/mol.105.018770
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    The Role of Rho-Associated Kinase in Differential Regulation by Statins of Interleukin-1β- and Lipopolysaccharide-Mediated Nuclear Factor κB Activation and Inducible Nitric-Oxide Synthase Gene Expression in Vascular Smooth Muscle Cells
    Chun-Yu Wei, Kuo-Chin Huang, Yin-Hsiang Chou, Pe-Fang Hsieh, Kuei-Hui Lin and Wan-Wan Lin
    Molecular Pharmacology March 2006, 69 (3) 960-967; DOI: https://doi.org/10.1124/mol.105.017368
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    Increased Divalent Metal Transporter 1 Expression Might Be Associated with the Neurotoxicity of l-DOPA
    Yan-Zhong Chang, Ya Ke, Jun-Rong Du, Georges M. Halpern, Kwok-Ping Ho, Li Zhu, Xiao-Song Gu, You-Jia Xu, Qin Wang, Lian-Zhi Li, Chen-Yuen Wang and Zhong-Ming Qian
    Molecular Pharmacology March 2006, 69 (3) 968-974; DOI: https://doi.org/10.1124/mol.105.017756
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    Novel Mechanisms of G Protein-Dependent Regulation of Endothelial Nitric-Oxide Synthase
    Alexandra V. Andreeva, Rita Vaiskunaite, Mikhail A. Kutuzov, Jasmina Profirovic, Randal A. Skidgel and Tatyana Voyno-Yasenetskaya
    Molecular Pharmacology March 2006, 69 (3) 975-982; DOI: https://doi.org/10.1124/mol.105.018846
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    Nitric Oxide-Dependent Reduction in Soluble Guanylate Cyclase Functionality Accounts for Early Lipopolysaccharide-Induced Changes in Vascular Reactivity
    Daniel Fernandes, José Eduardo da Silva-Santos, Danielle Duma, Christina Gaspar Villela, Christina Barja-Fidalgo and Jamil Assreuy
    Molecular Pharmacology March 2006, 69 (3) 983-990; DOI: https://doi.org/10.1124/mol.105.015479
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    Δ9-Tetrahydrocannabinol and Endogenous Cannabinoid Anandamide Directly Potentiate the Function of Glycine Receptors
    Nadia Hejazi, Chunyi Zhou, Murat Oz, Hui Sun, Jiang Hong Ye and Li Zhang
    Molecular Pharmacology March 2006, 69 (3) 991-997; DOI: https://doi.org/10.1124/mol.105.019174
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    Corticotropin-Releasing Hormone Induces Vascular Endothelial Growth Factor Release from Human Mast Cells via the cAMP/Protein Kinase A/p38 Mitogen-Activated Protein Kinase Pathway
    Jing Cao, Curtis L. Cetrulo and Theoharis C. Theoharides
    Molecular Pharmacology March 2006, 69 (3) 998-1006; DOI: https://doi.org/10.1124/mol.105.019539
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    Electrophysiological Characterization of Benzofuroindole-Induced Potentiation of Large-Conductance Ca2+-Activated K+ Channels
    Tal Soo Ha, Hyun-Ho Lim, Ga Eun Lee, Yong-Chul Kim and Chul-Seung Park
    Molecular Pharmacology March 2006, 69 (3) 1007-1014; DOI: https://doi.org/10.1124/mol.105.016170
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    Phosphorylation-Dependent Desensitization by Anandamide of Vanilloid Receptor-1 (TRPV1) Function in Rat Skeletal Muscle Arterioles and in Chinese Hamster Ovary Cells Expressing TRPV1
    Erzsébet Lizanecz, Zsolt Bagi, Enikő T. Pásztor, Zoltán Papp, István Édes, Noémi Kedei, Peter M. Blumberg and Attila Tóth
    Molecular Pharmacology March 2006, 69 (3) 1015-1023; DOI: https://doi.org/10.1124/mol.105.015644
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    Zinc and Mercuric Ions Distinguish TRESK from the Other Two-Pore-Domain K+ Channels
    Gábor Czirják and Péter Enyedi
    Molecular Pharmacology March 2006, 69 (3) 1024-1032; DOI: https://doi.org/10.1124/mol.105.018556
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    Involvement of Nrf2, p38, B-Raf, and Nuclear Factor-κB, but Not Phosphatidylinositol 3-Kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols
    Catherine K. Andreadi, Lynne M. Howells, Paul A. Atherfold and Margaret M. Manson
    Molecular Pharmacology March 2006, 69 (3) 1033-1040; DOI: https://doi.org/10.1124/mol.105.018374
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    Janus Kinase-Signal Transducer and Activator of Transcription Mediates Phosphatidic Acid-Induced Interleukin (IL)-1β and IL-6 Production
    ChuHee Lee, Hyung-Kyu Lim, Joon Sakong, Yun-Sik Lee, Jae-Ryong Kim and Suk-Hwan Baek
    Molecular Pharmacology March 2006, 69 (3) 1041-1047; DOI: https://doi.org/10.1124/mol.105.018481
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    Opposing Functions of Spinal M2, M3, and M4 Receptor Subtypes in Regulation of GABAergic Inputs to Dorsal Horn Neurons Revealed by Muscarinic Receptor Knockout Mice
    Hong-Mei Zhang, Shao-Rui Chen, Minoru Matsui, Dinesh Gautam, Jürgen Wess and Hui-Lin Pan
    Molecular Pharmacology March 2006, 69 (3) 1048-1055; DOI: https://doi.org/10.1124/mol.105.018069
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    Hydralazine Inhibits Rapid Acrolein-Induced Protein Oligomerization: Role of Aldehyde Scavenging and Adduct Trapping in Cross-Link Blocking and Cytoprotection
    Philip C. Burcham and Simon M. Pyke
    Molecular Pharmacology March 2006, 69 (3) 1056-1065; DOI: https://doi.org/10.1124/mol.105.018168
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    Lysophosphatidylserine Stimulates L2071 Mouse Fibroblast Chemotactic Migration via a Process Involving Pertussis Toxin-Sensitive Trimeric G-Proteins
    Kyoung Sun Park, Ha-Young Lee, Mi-Kyoung Kim, Eun Ha Shin, Seong Ho Jo, Sang Doo Kim, Dong-Soon Im and Yoe-Sik Bae
    Molecular Pharmacology March 2006, 69 (3) 1066-1073; DOI: https://doi.org/10.1124/mol.105.018960

Retraction

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    Notice of Retraction
    Molecular Pharmacology March 2006, 69 (3) 1074; DOI: https://doi.org/10.1124/mol.69.3.1074
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Molecular Pharmacology: 69 (3)
Molecular Pharmacology
Vol. 69, Issue 3
1 Mar 2006
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  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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