Table of Contents

Articles

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  Partial Agonism, Neutral Antagonism, and Inverse Agonism at the Human Wild-Type and Constitutively Active Cholecystokinin-2 Receptors

  Magali Foucaud, Irina G. Tikhonova, Ingrid Langer, Chantal Escrieut, Marlène Dufresne, Cathy Seva, Bernard Maigret and Daniel Fourmy

  Molecular Pharmacology March 2006, 69 (3) 680-690; DOI: https://doi.org/10.1124/mol.105.019992
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  Molecular Mechanisms of Cannabinoid Protection from Neuronal Excitotoxicity

  Sun Hee Kim, Seok Joon Won, Xiao Ou Mao, Kunlin Jin and David A. Greenberg

  Molecular Pharmacology March 2006, 69 (3) 691-696; DOI: https://doi.org/10.1124/mol.105.016428
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  Heme Deficiency Is Associated with Senescence and Causes Suppression of N-Methyl-d-aspartate Receptor Subunits Expression in Primary Cortical Neurons

  Tatyana Chernova, Pierluigi Nicotera and Andrew G. Smith

  Molecular Pharmacology March 2006, 69 (3) 697-705; DOI: https://doi.org/10.1124/mol.105.016675
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  Ethanol Induces Apoptotic Death of Developing β-Endorphin Neurons via Suppression of Cyclic Adenosine Monophosphate Production and Activation of Transforming Growth Factor-β1-Linked Apoptotic Signaling

  Cui Ping Chen, Peter Kuhn, Kirti Chaturvedi, Nadka Boyadjieva and Dipak K. Sarkar

  Molecular Pharmacology March 2006, 69 (3) 706-717; DOI: https://doi.org/10.1124/mol.105.017004
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  1,4-Diazabicyclo[2.2.2]octane Derivatives: A Novel Class of Voltage-Gated Potassium Channel Blockers

  Earl Gordon, Jaime-Lee Cohen, Robert Engel and Geoffrey W. Abbott

  Molecular Pharmacology March 2006, 69 (3) 718-726; DOI: https://doi.org/10.1124/mol.105.018663
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  A Membrane-Permeable Peptide Containing the Last 21 Residues of the Gα_S Carboxyl Terminus Inhibits G_S-Coupled Receptor Signaling in Intact Cells: Correlations between Peptide Structure and Biological Activity

  Anna Maria D'Ursi, Laura Giusti, Stefania Albrizio, Francesca Porchia, Cinzia Esposito, Gabriella Caliendo, Claudia Gargini, Ettore Novellino, Antonio Lucacchini, Paolo Rovero and Maria Rosa Mazzoni

  Molecular Pharmacology March 2006, 69 (3) 727-736; DOI: https://doi.org/10.1124/mol.105.017715
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  Differential Gene Expression as a Potential Classifier of 2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole-Sensitive and -Insensitive Cell Lines

  Anders Wallqvist, John Connelly, Edward A. Sausville, David G. Covell and Anne Monks

  Molecular Pharmacology March 2006, 69 (3) 737-748; DOI: https://doi.org/10.1124/mol.105.017061
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  Anti-Inflammatory Mechanisms of Phenanthroindolizidine Alkaloids

  Cheng-Wei Yang, Wei-Liang Chen, Pei-Lin Wu, Huan-Yi Tseng and Shiow-Ju Lee

  Molecular Pharmacology March 2006, 69 (3) 749-758; DOI: https://doi.org/10.1124/mol.105.017764
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  The D₁ Dopamine Receptor Is Constitutively Phosphorylated by G Protein-Coupled Receptor Kinase 4

  Michele L. Rankin, Paul S. Marinec, David M. Cabrera, Zheng Wang, Pedro A. Jose and David R. Sibley

  Molecular Pharmacology March 2006, 69 (3) 759-769; DOI: https://doi.org/10.1124/mol.105.019901
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  The Teratogenic Sensitivity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Modified by a Locus on Mouse Chromosome 3

  Tami L. Thomae, Emily A. Stevens, Adam L. Liss, Norman R. Drinkwater and Christopher A. Bradfield

  Molecular Pharmacology March 2006, 69 (3) 770-775; DOI: https://doi.org/10.1124/mol.105.019760
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  Identification of Zebrafish ARNT1 Homologs: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Developing Zebrafish Requires ARNT1

  Amy L. Prasch, Robert L. Tanguay, Vatsal Mehta, Warren Heideman and Richard E. Peterson

  Molecular Pharmacology March 2006, 69 (3) 776-787; DOI: https://doi.org/10.1124/mol.105.016873
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  How Batrachotoxin Modifies the Sodium Channel Permeation Pathway: Computer Modeling and Site-Directed Mutagenesis

  Sho-Ya Wang, Jane Mitchell, Denis B. Tikhonov, Boris S. Zhorov and Ging Kuo Wang

  Molecular Pharmacology March 2006, 69 (3) 788-795; DOI: https://doi.org/10.1124/mol.105.018200
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  Novel Targeting of Cyclooxygenase-2 (COX-2) Pre-mRNA Using Antisense Morpholino Oligonucleotides Directed to the 3′ Acceptor and 5′ Donor Splice Sites of Exon 4: Suppression of COX-2 Activity in Human Amnion-Derived WISH and Myometrial Cells

  Alison J. Tyson-Capper and G. Nicholas Europe-Finner

  Molecular Pharmacology March 2006, 69 (3) 796-804; DOI: https://doi.org/10.1124/mol.105.020529
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  Loss of Synaptic D1 Dopamine/N-Methyl-d-aspartate Glutamate Receptor Complexes in l-DOPA-Induced Dyskinesia in the Rat

  Chiara Fiorentini, Maria Cristina Rizzetti, Chiara Busi, Sandra Bontempi, Ginetta Collo, PierFranco Spano and Cristina Missale

  Molecular Pharmacology March 2006, 69 (3) 805-812; DOI: https://doi.org/10.1124/mol.105.016667
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  Activation of Dopamine D₄ Receptors Induces Synaptic Translocation of Ca²⁺/Calmodulin-Dependent Protein Kinase II in Cultured Prefrontal Cortical Neurons

  Zhenglin Gu, Qian Jiang, Eunice Y. Yuen and Zhen Yan

  Molecular Pharmacology March 2006, 69 (3) 813-822; DOI: https://doi.org/10.1124/mol.105.018853
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  Block of Peripheral Nerve Sodium Channels Selectively Inhibits Features of Neuropathic Pain in Rats

  Richard M. Brochu, Ivy E. Dick, Jason W. Tarpley, Erin McGowan, David Gunner, James Herrington, Pengcheng P. Shao, Dong Ok, Chunshi Li, William H. Parsons, Gary L. Stump, Christopher P. Regan, Joseph J. Lynch, Kathryn A. Lyons, Owen B. McManus, Samantha Clark, Zahid Ali, Gregory J. Kaczorowski, William J. Martin and Birgit T. Priest

  Molecular Pharmacology March 2006, 69 (3) 823-832; DOI: https://doi.org/10.1124/mol.105.018127
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  Insulin-Like Growth Factor Binding Protein-2: Contributions of the C-Terminal Domain to Insulin-Like Growth Factor-1 Binding

  Megan M. Kibbey, Mark J. Jameson, Erin M. Eaton and Steven A. Rosenzweig

  Molecular Pharmacology March 2006, 69 (3) 833-845; DOI: https://doi.org/10.1124/mol.105.016998
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  Presynaptic Mechanism Underlying cAMP-Induced Synaptic Potentiation in Medial Prefrontal Cortex Pyramidal Neurons

  Chiung-Chun Huang and Kuei-Sen Hsu

  Molecular Pharmacology March 2006, 69 (3) 846-856; DOI: https://doi.org/10.1124/mol.105.018093
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  The Amino Terminus and the Third Extracellular Loop of CX3CR1 Contain Determinants Critical for Distinct Receptor Functions

  Yiming Chen, Simone R. Green, Felicidad Almazan and Oswald Quehenberger

  Molecular Pharmacology March 2006, 69 (3) 857-865; DOI: https://doi.org/10.1124/mol.105.015909
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  Involvement of cAMP/cAMP-Dependent Protein Kinase Signaling Pathway in Regulation of Na⁺,K⁺-ATPase upon Activation of Opioid Receptors by Morphine

  Zhao-Qiu Wu, Mu Li, Jie Chen, Zhi-Qiang Chi and Jing-Gen Liu

  Molecular Pharmacology March 2006, 69 (3) 866-876; DOI: https://doi.org/10.1124/mol.105.016501
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  Regions in the G Protein γ Subunit Important for Interaction with Receptors and Effectors

  Chang-Seon Myung, William K. Lim, Joseph M. DeFilippo, Hiroshi Yasuda, Richard R. Neubig and James C. Garrison

  Molecular Pharmacology March 2006, 69 (3) 877-887; DOI: https://doi.org/10.1124/mol.105.018994
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  Chemokine-Directed Trafficking of Receptor Stimulus to Different G Proteins: Selective Inducible and Constitutive Signaling by Human Herpesvirus 6-Encoded Chemokine Receptor U51

  Carlos P. Fitzsimons, Ursula A. Gompels, Dennis Verzijl, Henry F. Vischer, Claire Mattick, Rob Leurs and Martine J. Smit

  Molecular Pharmacology March 2006, 69 (3) 888-898; DOI: https://doi.org/10.1124/mol.105.015222
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  Mouse β-TC6 Insulinoma Cells: High Expression of Functional α3β4 Nicotinic Receptors Mediating Membrane Potential, Intracellular Calcium, and Insulin Release

  Masahiro Ohtani, Takami Oka, Maryna Badyuk, Yingxian Xiao, Kenneth J. Kellar and John W. Daly

  Molecular Pharmacology March 2006, 69 (3) 899-907; DOI: https://doi.org/10.1124/mol.105.014902
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  Inactivation of the Pure Antiestrogen Fulvestrant and Other Synthetic Estrogen Molecules by UDP-Glucuronosyltransferase 1A Enzymes Expressed in Breast Tissue

  Sarah Chouinard, Mélanie Tessier, Gabrielle Vernouillet, Sylvain Gauthier, Fernand Labrie, Olivier Barbier and Alain Bélanger

  Molecular Pharmacology March 2006, 69 (3) 908-920; DOI: https://doi.org/10.1124/mol.105.015891
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  Evidence for a Multivalent Interaction of Symmetrical, N-Linked, Lidocaine Dimers with Voltage-Gated Na⁺ Channels

  J. A. M. Smith, S. M. Amagasu, J. Hembrador, S. Axt, R. Chang, T. Church, C. Gee, J. R. Jacobsen, T. Jenkins, E. Kaufman, N. Mai and R. G. Vickery

  Molecular Pharmacology March 2006, 69 (3) 921-931; DOI: https://doi.org/10.1124/mol.105.019257
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  Angiotensin II Up-Regulates the Leukemia-Associated Rho Guanine Nucleotide Exchange Factor (RhoGEF), a Regulator of G Protein Signaling Domain-Containing RhoGEF, in Vascular Smooth Muscle Cells

  Zhekang Ying, Liming Jin, Trenis Palmer and R. Clinton Webb

  Molecular Pharmacology March 2006, 69 (3) 932-940; DOI: https://doi.org/10.1124/mol.105.017830
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  Glabridin Suppresses Intercellular Adhesion Molecule-1 Expression in Tumor Necrosis Factor-α-Stimulated Human Umbilical Vein Endothelial Cells by Blocking Sphingosine Kinase Pathway: Implications of Akt, Extracellular Signal-Regulated Kinase, and Nuclear Factor-κB/Rel Signaling Pathways

  Jong Soon Kang, Yeo Dae Yoon, Mi Hwa Han, Sang-Bae Han, Kiho Lee, Ki Hoon Lee, Song-Kyu Park and Hwan Mook Kim

  Molecular Pharmacology March 2006, 69 (3) 941-949; DOI: https://doi.org/10.1124/mol.105.017442
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  Ester Derivatives of Tournefolic Acid B Attenuate N-Methyl-d-aspartate-Mediated Excitotoxicity in Rat Cortical Neurons

  Chuen-Neu Wang, Hsien-Chia Pan, Yun-Lian Lin, Chih-Wen Chi and Young-Ji Shiao

  Molecular Pharmacology March 2006, 69 (3) 950-959; DOI: https://doi.org/10.1124/mol.105.018770
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  The Role of Rho-Associated Kinase in Differential Regulation by Statins of Interleukin-1β- and Lipopolysaccharide-Mediated Nuclear Factor κB Activation and Inducible Nitric-Oxide Synthase Gene Expression in Vascular Smooth Muscle Cells

  Chun-Yu Wei, Kuo-Chin Huang, Yin-Hsiang Chou, Pe-Fang Hsieh, Kuei-Hui Lin and Wan-Wan Lin

  Molecular Pharmacology March 2006, 69 (3) 960-967; DOI: https://doi.org/10.1124/mol.105.017368
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  Increased Divalent Metal Transporter 1 Expression Might Be Associated with the Neurotoxicity of l-DOPA

  Yan-Zhong Chang, Ya Ke, Jun-Rong Du, Georges M. Halpern, Kwok-Ping Ho, Li Zhu, Xiao-Song Gu, You-Jia Xu, Qin Wang, Lian-Zhi Li, Chen-Yuen Wang and Zhong-Ming Qian

  Molecular Pharmacology March 2006, 69 (3) 968-974; DOI: https://doi.org/10.1124/mol.105.017756
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  Novel Mechanisms of G Protein-Dependent Regulation of Endothelial Nitric-Oxide Synthase

  Alexandra V. Andreeva, Rita Vaiskunaite, Mikhail A. Kutuzov, Jasmina Profirovic, Randal A. Skidgel and Tatyana Voyno-Yasenetskaya

  Molecular Pharmacology March 2006, 69 (3) 975-982; DOI: https://doi.org/10.1124/mol.105.018846
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  Nitric Oxide-Dependent Reduction in Soluble Guanylate Cyclase Functionality Accounts for Early Lipopolysaccharide-Induced Changes in Vascular Reactivity

  Daniel Fernandes, José Eduardo da Silva-Santos, Danielle Duma, Christina Gaspar Villela, Christina Barja-Fidalgo and Jamil Assreuy

  Molecular Pharmacology March 2006, 69 (3) 983-990; DOI: https://doi.org/10.1124/mol.105.015479
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  Δ⁹-Tetrahydrocannabinol and Endogenous Cannabinoid Anandamide Directly Potentiate the Function of Glycine Receptors

  Nadia Hejazi, Chunyi Zhou, Murat Oz, Hui Sun, Jiang Hong Ye and Li Zhang

  Molecular Pharmacology March 2006, 69 (3) 991-997; DOI: https://doi.org/10.1124/mol.105.019174
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  Corticotropin-Releasing Hormone Induces Vascular Endothelial Growth Factor Release from Human Mast Cells via the cAMP/Protein Kinase A/p38 Mitogen-Activated Protein Kinase Pathway

  Jing Cao, Curtis L. Cetrulo and Theoharis C. Theoharides

  Molecular Pharmacology March 2006, 69 (3) 998-1006; DOI: https://doi.org/10.1124/mol.105.019539
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  Electrophysiological Characterization of Benzofuroindole-Induced Potentiation of Large-Conductance Ca²⁺-Activated K⁺ Channels

  Tal Soo Ha, Hyun-Ho Lim, Ga Eun Lee, Yong-Chul Kim and Chul-Seung Park

  Molecular Pharmacology March 2006, 69 (3) 1007-1014; DOI: https://doi.org/10.1124/mol.105.016170
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  Phosphorylation-Dependent Desensitization by Anandamide of Vanilloid Receptor-1 (TRPV1) Function in Rat Skeletal Muscle Arterioles and in Chinese Hamster Ovary Cells Expressing TRPV1

  Erzsébet Lizanecz, Zsolt Bagi, Enikő T. Pásztor, Zoltán Papp, István Édes, Noémi Kedei, Peter M. Blumberg and Attila Tóth

  Molecular Pharmacology March 2006, 69 (3) 1015-1023; DOI: https://doi.org/10.1124/mol.105.015644
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  Zinc and Mercuric Ions Distinguish TRESK from the Other Two-Pore-Domain K⁺ Channels

  Gábor Czirják and Péter Enyedi

  Molecular Pharmacology March 2006, 69 (3) 1024-1032; DOI: https://doi.org/10.1124/mol.105.018556
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  Involvement of Nrf2, p38, B-Raf, and Nuclear Factor-κB, but Not Phosphatidylinositol 3-Kinase, in Induction of Hemeoxygenase-1 by Dietary Polyphenols

  Catherine K. Andreadi, Lynne M. Howells, Paul A. Atherfold and Margaret M. Manson

  Molecular Pharmacology March 2006, 69 (3) 1033-1040; DOI: https://doi.org/10.1124/mol.105.018374
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  Janus Kinase-Signal Transducer and Activator of Transcription Mediates Phosphatidic Acid-Induced Interleukin (IL)-1β and IL-6 Production

  ChuHee Lee, Hyung-Kyu Lim, Joon Sakong, Yun-Sik Lee, Jae-Ryong Kim and Suk-Hwan Baek

  Molecular Pharmacology March 2006, 69 (3) 1041-1047; DOI: https://doi.org/10.1124/mol.105.018481
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  Opposing Functions of Spinal M₂, M₃, and M₄ Receptor Subtypes in Regulation of GABAergic Inputs to Dorsal Horn Neurons Revealed by Muscarinic Receptor Knockout Mice

  Hong-Mei Zhang, Shao-Rui Chen, Minoru Matsui, Dinesh Gautam, Jürgen Wess and Hui-Lin Pan

  Molecular Pharmacology March 2006, 69 (3) 1048-1055; DOI: https://doi.org/10.1124/mol.105.018069
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  Hydralazine Inhibits Rapid Acrolein-Induced Protein Oligomerization: Role of Aldehyde Scavenging and Adduct Trapping in Cross-Link Blocking and Cytoprotection

  Philip C. Burcham and Simon M. Pyke

  Molecular Pharmacology March 2006, 69 (3) 1056-1065; DOI: https://doi.org/10.1124/mol.105.018168
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  Lysophosphatidylserine Stimulates L2071 Mouse Fibroblast Chemotactic Migration via a Process Involving Pertussis Toxin-Sensitive Trimeric G-Proteins

  Kyoung Sun Park, Ha-Young Lee, Mi-Kyoung Kim, Eun Ha Shin, Seong Ho Jo, Sang Doo Kim, Dong-Soon Im and Yoe-Sik Bae

  Molecular Pharmacology March 2006, 69 (3) 1066-1073; DOI: https://doi.org/10.1124/mol.105.018960