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Molecular Pharmacology

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Table of Contents

April 01, 2006; Volume 69,Issue 4

Perspectives

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    Adenosine Receptors Find a New Partner and Move Out
    Myron L. Toews
    Molecular Pharmacology April 2006, 69 (4) 1075-1078; DOI: https://doi.org/10.1124/mol.106.022699
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    Bring Your Own G Protein
    John D. Hildebrandt
    Molecular Pharmacology April 2006, 69 (4) 1079-1082; DOI: https://doi.org/10.1124/mol.106.022921

Original Article

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    The Ubiquitin-Specific Protease Usp4 Regulates the Cell Surface Level of the A2a Receptor
    Tetyana Milojević, Veronika Reiterer, Eduard Stefan, Vladimir M. Korkhov, Mario M. Dorostkar, Eszter Ducza, Egon Ogris, Stefan Boehm, Michael Freissmuth and Christian Nanoff
    Molecular Pharmacology April 2006, 69 (4) 1083-1094; DOI: https://doi.org/10.1124/mol.105.015818
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    Serine 202 Regulates the Nuclear Translocation of Constitutive Active/Androstane Receptor
    F. Hosseinpour, R. Moore, M. Negishi and T. Sueyoshi
    Molecular Pharmacology April 2006, 69 (4) 1095-1102; DOI: https://doi.org/10.1124/mol.105.019505
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    Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines: CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate
    Shigeyuki Uno, Timothy P. Dalton, Nadine Dragin, Christine P. Curran, Sandrine Derkenne, Marian L. Miller, Howard G. Shertzer, Frank J. Gonzalez and Daniel W. Nebert
    Molecular Pharmacology April 2006, 69 (4) 1103-1114; DOI: https://doi.org/10.1124/mol.105.021501
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    Use of Penetrating Peptides Interacting with PP1/PP2A Proteins As a General Approach for a Drug Phosphatase Technology
    Julien Guergnon, Frédéric Dessauge, Victoria Dominguez, Jean Viallet, Serge Bonnefoy, Victor J. Yuste, Odile Mercereau-Puijalon, Xavier Cayla, Angelita Rebollo, Santos A. Susin, Pierre-Etienne Bost and Alphonse Garcia
    Molecular Pharmacology April 2006, 69 (4) 1115-1124; DOI: https://doi.org/10.1124/mol.105.019364
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    Bafilomycin A1 Inhibits Chloroquine-Induced Death of Cerebellar Granule Neurons
    John J. Shacka, Barbara J. Klocke, Masahiro Shibata, Yasuo Uchiyama, Geeta Datta, Robert E. Schmidt and Kevin A. Roth
    Molecular Pharmacology April 2006, 69 (4) 1125-1136; DOI: https://doi.org/10.1124/mol.105.018408
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    Emergence of Functional δ-Opioid Receptors Induced by Long-Term Treatment with Morphine
    Junyi Ma, Yong Zhang, Alex E. Kalyuzhny and Zhizhong Z. Pan
    Molecular Pharmacology April 2006, 69 (4) 1137-1145; DOI: https://doi.org/10.1124/mol.105.019109
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    A Nonpeptide Antagonist Reveals a Highly Glycosylated State of the Rabbit Kinin B1 Receptor
    Jean-Philippe Fortin, Edward K. Dziadulewicz, Lajos Gera and François Marceau
    Molecular Pharmacology April 2006, 69 (4) 1146-1157; DOI: https://doi.org/10.1124/mol.105.019976
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    2-Cyano-3,12-dioxooleana-1,9(11)-diene-28-oic Acid Disrupts Microtubule Polymerization: A Possible Mechanism Contributing to Apoptosis
    Robin D. Couch, Neil J. Ganem, Ming Zhou, Veljko M. Popov, Tadashi Honda, Timothy D. Veenstra, Michael B. Sporn and Amy C. Anderson
    Molecular Pharmacology April 2006, 69 (4) 1158-1165; DOI: https://doi.org/10.1124/mol.105.018572
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    Kinetics of Penetration Influence the Apparent Potency of Vanilloids on TRPV1
    Jozsef Lazar, Derek C. Braun, Attila Tóth, Yun Wang, Larry V. Pearce, Vladimir A. Pavlyukovets, Peter M. Blumberg, Susan H. Garfield, Stephen Wincovitch, Hyun-Kyung Choi and Jeewoo Lee
    Molecular Pharmacology April 2006, 69 (4) 1166-1173; DOI: https://doi.org/10.1124/mol.105.019158
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    Inhibition of Cardiac Hypertrophy by Triflusal (4-Trifluoromethyl Derivative of Salicylate) and Its Active Metabolite
    Anna Planavila, Ricardo Rodríguez-Calvo, Alberto Fernández de Arriba, Rosa M. Sánchez, Juan C. Laguna, Manuel Merlos and Manuel Vazquez-Carrera
    Molecular Pharmacology April 2006, 69 (4) 1174-1181; DOI: https://doi.org/10.1124/mol.105.016345
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    A Novel Mechanism of Action of Methyl-2-cyano-3,12 Dioxoolean-1,9 Diene-28-oate: Direct Permeabilization of the Inner Mitochondrial Membrane to Inhibit Electron Transport and Induce Apoptosis
    Ismael Samudio, Marina Konopleva, Helene Pelicano, Peng Huang, Olga Frolova, William Bornmann, Yunming Ying, Randall Evans, Rooha Contractor and Michael Andreeff
    Molecular Pharmacology April 2006, 69 (4) 1182-1193; DOI: https://doi.org/10.1124/mol.105.018051
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    Discovery of Naturally Occurring Splice Variants of the Rat Histamine H3 Receptor That Act as Dominant-Negative Isoforms
    Remko A. Bakker, Adrian Flores Lozada, André van Marle, Fiona C. Shenton, Guillaume Drutel, Kaj Karlstedt, Marcel Hoffmann, Minnamaija Lintunen, Yumiko Yamamoto, Richard M. van Rijn, Paul L. Chazot, Pertti Panula and Rob Leurs
    Molecular Pharmacology April 2006, 69 (4) 1194-1206; DOI: https://doi.org/10.1124/mol.105.019299
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    The Microtubule Binding Drug Laulimalide Inhibits Vascular Endothelial Growth Factor-Induced Human Endothelial Cell Migration and Is Synergistic when Combined with Docetaxel (Taxotere)
    Haiyan Lu, Janice Murtagh and Edward L. Schwartz
    Molecular Pharmacology April 2006, 69 (4) 1207-1215; DOI: https://doi.org/10.1124/mol.105.019075
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    Antimony-Based Antileishmanial Compounds Prolong the Cardiac Action Potential by an Increase in Cardiac Calcium Currents
    Yuri A. Kuryshev, Lu Wang, Barbara A. Wible, Xiaoping Wan and Eckhard Ficker
    Molecular Pharmacology April 2006, 69 (4) 1216-1225; DOI: https://doi.org/10.1124/mol.105.019281
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    Pseudolarix Acid B, a New Tubulin-Binding Agent, Inhibits Angiogenesis by Interacting with a Novel Binding Site on Tubulin
    Yun-Guang Tong, Xiong-Wen Zhang, Mei-Yu Geng, Jian-Ming Yue, Xian-Liang Xin, Fang Tian, Xu Shen, Lin-Jiang Tong, Mei-Hong Li, Chao Zhang, Wei-Hong Li, Li-Ping Lin and Jian Ding
    Molecular Pharmacology April 2006, 69 (4) 1226-1233; DOI: https://doi.org/10.1124/mol.105.020537
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    Insulin Secretion Is Controlled by mGlu5 Metabotropic Glutamate Receptors
    Marianna Storto, Loredana Capobianco, Giuseppe Battaglia, Gemma Molinaro, Roberto Gradini, Barbara Riozzi, Alessandra Di Mambro, Kathryn J. Mitchell, Valeria Bruno, Maria P. Vairetti, Guy A. Rutter and Ferdinando Nicoletti
    Molecular Pharmacology April 2006, 69 (4) 1234-1241; DOI: https://doi.org/10.1124/mol.105.018390
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    Dissection of an Allosteric Mechanism on the Serotonin Transporter: A Cross-Species Study
    Henrik Amtoft Neubauer, Carsten Gram Hansen and Ove Wiborg
    Molecular Pharmacology April 2006, 69 (4) 1242-1250; DOI: https://doi.org/10.1124/mol.105.018507
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    Subunit Dependencies of N-Methyl-d-aspartate (NMDA) Receptor-Induced α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Internalization
    C. M. Tigaret, A. Thalhammer, G. F. Rast, C. G. Specht, Y. P. Auberson, M. G. Stewart and R. Schoepfer
    Molecular Pharmacology April 2006, 69 (4) 1251-1259; DOI: https://doi.org/10.1124/mol.105.018580
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    Biochemistry and Pharmacology of Novel Anthranilic Acid Derivatives Activating Heme-Oxidized Soluble Guanylyl Cyclase
    Ursula Schindler, Hartmut Strobel, Karl Schönafinger, Wolfgang Linz, Matthias Löhn, Piero A. Martorana, Hartmut Rütten, Peter W. Schindler, Andreas E. Busch, Michael Sohn, Andrea Töpfer, Astrid Pistorius, Christoph Jannek and Alexander Mülsch
    Molecular Pharmacology April 2006, 69 (4) 1260-1268; DOI: https://doi.org/10.1124/mol.105.018747
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    The 73-kDa Heat Shock Cognate Protein Is a CXCR4 Binding Protein that Regulates the Receptor Endocytosis and the Receptor-Mediated Chemotaxis
    Yun Ding, Mika Li, Jinwu Zhang, Ningli Li, Zongqin Xia, Yaer Hu, Sunxin Wang and Guo-Huang Fan
    Molecular Pharmacology April 2006, 69 (4) 1269-1279; DOI: https://doi.org/10.1124/mol.105.020271
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    Endogenous Regulator of G-Protein Signaling Proteins Regulate the Kinetics of Gαq/11-Mediated Modulation of Ion Channels in Central Nervous System Neurons
    Michael A. Clark and Nevin A. Lambert
    Molecular Pharmacology April 2006, 69 (4) 1280-1287; DOI: https://doi.org/10.1124/mol.105.019059
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    A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling
    Masayuki Ii, Naoko Matsunaga, Kaoru Hazeki, Kazuyo Nakamura, Katsunori Takashima, Tsukasa Seya, Osamu Hazeki, Tomoyuki Kitazaki and Yuji Iizawa
    Molecular Pharmacology April 2006, 69 (4) 1288-1295; DOI: https://doi.org/10.1124/mol.105.019695

Articles

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    Probing N-Methyl-d-aspartate Receptor Desensitization with the Substituted-Cysteine Accessibility Method
    Christopher G. Thomas, Johannes J. Krupp, Elena E. Bagley, Reginald Bauzon, Stephen F. Heinemann, Bryce Vissel and Gary L. Westbrook
    Molecular Pharmacology April 2006, 69 (4) 1296-1303; DOI: https://doi.org/10.1124/mol.105.017350
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    Valproic Acid Increases Conservative Homologous Recombination Frequency and Reactive Oxygen Species Formation: A Potential Mechanism for Valproic Acid-Induced Neural Tube Defects
    Ericka N. Defoort, Perry M. Kim and Louise M. Winn
    Molecular Pharmacology April 2006, 69 (4) 1304-1310; DOI: https://doi.org/10.1124/mol.105.017855
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    Tumor Necrosis Factor-α Prevents Desensitization of Gαs-Coupled Receptors by Regulating GRK2 Association with the Plasma Membrane
    Nguyen D. Khoa, Michael Postow, Jennifer Danielsson and Bruce N. Cronstein
    Molecular Pharmacology April 2006, 69 (4) 1311-1319; DOI: https://doi.org/10.1124/mol.105.016857
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    3,3′-Diindolylmethane Is a Novel Topoisomerase IIα Catalytic Inhibitor That Induces S-Phase Retardation and Mitotic Delay in Human Hepatoma HepG2 Cells
    Yixuan Gong, Gary L. Firestone and Leonard F. Bjeldanes
    Molecular Pharmacology April 2006, 69 (4) 1320-1327; DOI: https://doi.org/10.1124/mol.105.018978
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    Bradycardic and Proarrhythmic Properties of Sinus Node Inhibitors
    Juliane Stieber, Karen Wieland, Georg Stöckl, Andreas Ludwig and Franz Hofmann
    Molecular Pharmacology April 2006, 69 (4) 1328-1337; DOI: https://doi.org/10.1124/mol.105.020701
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    Transcriptional Regulation of the Human NRIP1/RIP140 Gene by Estrogen Is Modulated by Dioxin Signalling
    Patrick Augereau, Eric Badia, Maryse Fuentes, Fanja Rabenoelina, Marine Corniou, Danièle Derocq, Patrick Balaguer and Vincent Cavailles
    Molecular Pharmacology April 2006, 69 (4) 1338-1346; DOI: https://doi.org/10.1124/mol.105.017376
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    Reactive Oxygen Species Generation Is Involved in Epidermal Growth Factor Receptor Transactivation through the Transient Oxidization of Src Homology 2-Containing Tyrosine Phosphatase in Endothelin-1 Signaling Pathway in Rat Cardiac Fibroblasts
    Cheng-Hsien Chen, Tzu-Hurng Cheng, Heng Lin, Neng-Lang Shih, Yen-Ling Chen, Yee-Shiuan Chen, Ching-Feng Cheng, Wei-Shiung Lian, Tzu-Ching Meng, Wen-Ta Chiu and Jin-Jer Chen
    Molecular Pharmacology April 2006, 69 (4) 1347-1355; DOI: https://doi.org/10.1124/mol.105.017558
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    Interaction of d-Tubocurarine with Potassium Channels: Molecular Modeling and Ligand Binding
    Alexei Rossokhin, Georgeta Teodorescu, Stephan Grissmer and Boris S. Zhorov
    Molecular Pharmacology April 2006, 69 (4) 1356-1365; DOI: https://doi.org/10.1124/mol.105.017970
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    Long-Term Exposure to the Atypical Antipsychotic Olanzapine Differently Up-Regulates Extracellular Signal-Regulated Kinases 1 and 2 Phosphorylation in Subcellular Compartments of Rat Prefrontal Cortex
    Fabio Fumagalli, Angelisa Frasca, Maria Spartà, Filippo Drago, Giorgio Racagni and Marco Andrea Riva
    Molecular Pharmacology April 2006, 69 (4) 1366-1372; DOI: https://doi.org/10.1124/mol.105.019828
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    Iodinated N-Acylvanillamines: Potential “Multiple-Target” Anti-Inflammatory Agents Acting via the Inhibition of T-Cell Activation and Antagonism at Vanilloid TRPV1 Channels
    Nieves Márquez, Luciano De Petrocellis, Francisco J. Caballero, Antonio Macho, Aniello Schiano-Moriello, Alberto Minassi, Giovanni Appendino, Eduardo Muñoz and Vincenzo Di Marzo
    Molecular Pharmacology April 2006, 69 (4) 1373-1382; DOI: https://doi.org/10.1124/mol.105.019786
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    Identification by Functional Cloning from a Retroviral cDNA Library of cDNAs for Ribosomal Protein L36 and the 10-kDa Heat Shock Protein that Confer Cisplatin Resistance
    Ding-Wu Shen, Xing-Jie Liang, Toshihiro Suzuki and Michael M. Gottesman
    Molecular Pharmacology April 2006, 69 (4) 1383-1388; DOI: https://doi.org/10.1124/mol.105.017525
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    Modulation of Uridine Phosphorylase Gene Expression by Tumor Necrosis Factor-α Enhances the Antiproliferative Activity of the Capecitabine Intermediate 5′-Deoxy-5-fluorouridine in Breast Cancer Cells
    Laxiang Wan, Deliang Cao, Jianmin Zeng, Ruilan Yan and Giuseppe Pizzorno
    Molecular Pharmacology April 2006, 69 (4) 1389-1395; DOI: https://doi.org/10.1124/mol.105.018515
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    Identification and Characterization of Compounds That Potentiate NT-3-Mediated Trk Receptor Activity
    Martin A. Lewis, Lisa Hunihan, Diana Franco, Barbara Robertson, Jane Palmer, Denis R. St. Laurent, Balu N. Balasubramanian, Yi Li and Ryan S. Westphal
    Molecular Pharmacology April 2006, 69 (4) 1396-1404; DOI: https://doi.org/10.1124/mol.105.020255
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    A Molecular Mechanism for the Anti-Inflammatory Effect of Taurine-Conjugated 5-Aminosalicylic Acid in Inflamed Colon
    Heejung Kim, Hyunchu Jeon, Hyesik Kong, Youngwook Yang, Boim Choi, Young Mi Kim, Len Neckers and Yunjin Jung
    Molecular Pharmacology April 2006, 69 (4) 1405-1412; DOI: https://doi.org/10.1124/mol.105.020578
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    A Pyrazole Derivative Potently Inhibits Lymphocyte Ca2+ Influx and Cytokine Production by Facilitating Transient Receptor Potential Melastatin 4 Channel Activity
    Ryuichi Takezawa, Henrique Cheng, Andreas Beck, Jun Ishikawa, Pierre Launay, Hirokazu Kubota, Jean-Pierre Kinet, Andrea Fleig, Toshimitsu Yamada and Reinhold Penner
    Molecular Pharmacology April 2006, 69 (4) 1413-1420; DOI: https://doi.org/10.1124/mol.105.021154
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    Adenylyl Cyclase Superactivation Induced by Long-Term Treatment with Opioid Agonist Is Dependent on Receptor Localized within Lipid Rafts and Is Independent of Receptor Internalization
    Hui Zhao, Horace H. Loh and P. Y. Law
    Molecular Pharmacology April 2006, 69 (4) 1421-1432; DOI: https://doi.org/10.1124/mol.105.020024
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    The G12 Family of G Proteins as a Reporter of Thromboxane A2 Receptor Activity
    Li Zhang, Cherisse DiLizio, David Kim, Emer M. Smyth and David R. Manning
    Molecular Pharmacology April 2006, 69 (4) 1433-1440; DOI: https://doi.org/10.1124/mol.105.019703
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    On the Mechanism of Interaction of Potent Surmountable and Insurmountable Antagonists with the Prostaglandin D2 Receptor CRTH2
    Jesper Mosolff Mathiesen, Arthur Christopoulos, Trond Ulven, Julia F. Royer, Mercedes Campillo, Akos Heinemann, Leonardo Pardo and Evi Kostenis
    Molecular Pharmacology April 2006, 69 (4) 1441-1453; DOI: https://doi.org/10.1124/mol.105.017681
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    Preferential Inhibition of the Magnesium-Dependent Strand Transfer Reaction of HIV-1 Integrase by α-Hydroxytropolones
    Elena A. Semenova, Allison A. Johnson, Christophe Marchand, David A. Davis, Robert Yarchoan and Yves Pommier
    Molecular Pharmacology April 2006, 69 (4) 1454-1460; DOI: https://doi.org/10.1124/mol.105.020321
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    The Anti-Yellow Fever Virus Activity of Ribavirin Is Independent of Error-Prone Replication
    Pieter Leyssen, Erik De Clercq and Johan Neyts
    Molecular Pharmacology April 2006, 69 (4) 1461-1467; DOI: https://doi.org/10.1124/mol.105.020057
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    The Contribution of TWIK-Related Acid-Sensitive K+-Containing Channels to the Function of Dorsal Lateral Geniculate Thalamocortical Relay Neurons
    Sven G. Meuth, M. Isabel Aller, Thomas Munsch, Thekla Schuhmacher, Thomas Seidenbecher, Patrick Meuth, Christoph Kleinschnitz, Hans-Christian Pape, Heinz Wiendl, William Wisden and Thomas Budde
    Molecular Pharmacology April 2006, 69 (4) 1468-1476; DOI: https://doi.org/10.1124/mol.105.020594
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    Merbarone Induces Activation of Caspase-Activated DNase and Excision of Chromosomal DNA Loops from the Nuclear Matrix
    Yoko Otake, Alice Mims and Daniel J. Fernandes
    Molecular Pharmacology April 2006, 69 (4) 1477-1485; DOI: https://doi.org/10.1124/mol.105.018036
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    Cannabinoid Receptor Type 2 Agonists Induce Transcription of the μ-Opioid Receptor Gene in Jurkat T Cells
    Christine Börner, Volker Höllt and Jürgen Kraus
    Molecular Pharmacology April 2006, 69 (4) 1486-1491; DOI: https://doi.org/10.1124/mol.105.018325
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    Implication of the Phosphatidylinositol-3 Kinase/Protein Kinase B Signaling Pathway in the Neuroprotective Effect of Estradiol in the Striatum of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mice
    Myreille D'Astous, Pablo Mendez, Marc Morissette, Luis Miguel Garcia-Segura and Thérèse Di Paolo
    Molecular Pharmacology April 2006, 69 (4) 1492-1498; DOI: https://doi.org/10.1124/mol.105.018671
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    Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediates Resistance to Mitoxantrone via Glutathione-Dependent Drug Efflux
    Charles S. Morrow, Christina Peklak-Scott, Bimjhana Bishwokarma, Timothy E. Kute, Pamela K. Smitherman and Alan J. Townsend
    Molecular Pharmacology April 2006, 69 (4) 1499-1505; DOI: https://doi.org/10.1124/mol.105.017988
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Molecular Pharmacology: 69 (4)
Molecular Pharmacology
Vol. 69, Issue 4
1 Apr 2006
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