A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Osaka, Japan (M.I., N.M., K.N., K.T., T.K., Y.I.); Division of Molecular Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Higashi-Hiroshima, Japan (K.H., O.H.); and Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Japan (T.S.)

Address correspondence to:
Dr. Masayuki Ii, Pharmacology Research Laboratories I, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, 17-85, Jusohonmachi 2-chome, Yodogawa-ku, Osaka 532-8686, Japan. E-mail: ii_masayuki{at}takeda.co.jp

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