Table of Contents

Articles

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  Molecular Determinants in the Second Intracellular Loop of the 5-Hydroxytryptamine-1A Receptor for G-Protein Coupling

  Neena Kushwaha, Shannon C. Harwood, Ariel M. Wilson, Miles Berger, Laurence H. Tecott, Bryan L. Roth and Paul R. Albert

  Molecular Pharmacology May 2006, 69 (5) 1518-1526; DOI: https://doi.org/10.1124/mol.105.019844
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  Potent Inhibition of Platelet-Derived Growth Factor-Induced Responses in Vascular Smooth Muscle Cells by BMS-354825 (Dasatinib)

  Zhengming Chen, Francis Y. Lee, Kapil N. Bhalla and Jie Wu

  Molecular Pharmacology May 2006, 69 (5) 1527-1533; DOI: https://doi.org/10.1124/mol.105.020172
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  Liver Deformation in Ahr-Null Mice: Evidence for Aberrant Hepatic Perfusion In Early Development

  Eric B. Harstad, Christopher A. Guite, Tami L. Thomae and Christopher A. Bradfield

  Molecular Pharmacology May 2006, 69 (5) 1534-1541; DOI: https://doi.org/10.1124/mol.105.020107
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  Electrophysiological Characterization and Modeling of the Structure Activity Relationship of the Human Concentrative Nucleoside Transporter 3 (hCNT3)

  Huankai Hu, Christopher J. Endres, Cheng Chang, Nagavedi S. Umapathy, Eun-Woo Lee, You-Jun Fei, Shirou Itagaki, Peter W. Swaan, Vadivel Ganapathy and Jashvant D. Unadkat

  Molecular Pharmacology May 2006, 69 (5) 1542-1553; DOI: https://doi.org/10.1124/mol.105.018945
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  trans-Stilbene Oxide Induces Expression of Genes Involved in Metabolism and Transport in Mouse Liver via CAR and Nrf2 Transcription Factors

  A. L. Slitt, N. J. Cherrington, M. Z. Dieter, L. M. Aleksunes, G. L. Scheffer, W. Huang, D. D. Moore and C. D. Klaassen

  Molecular Pharmacology May 2006, 69 (5) 1554-1563; DOI: https://doi.org/10.1124/mol.105.014571
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  Peroxisome Proliferator-Activated Receptor γ-Independent Repression of Prostate-Specific Antigen Expression by Thiazolidinediones in Prostate Cancer Cells

  Chih-Cheng Yang, Chia-Yu Ku, Shuo Wei, Chung-Wai Shiau, Chang-Shi Chen, Joseph J. Pinzone, Mathew D. Ringel and Ching-Shih Chen

  Molecular Pharmacology May 2006, 69 (5) 1564-1570; DOI: https://doi.org/10.1124/mol.105.018333
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  Differential Regulation of the Cell-Surface Targeting and Function of β- and α₁-Adrenergic Receptors by Rab1 GTPase in Cardiac Myocytes

  Catalin M. Filipeanu, Fuguo Zhou, Erin K. Fugetta and Guangyu Wu

  Molecular Pharmacology May 2006, 69 (5) 1571-1578; DOI: https://doi.org/10.1124/mol.105.019984
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  Celecoxib Inhibits Interleukin-12 αβ and β₂ Folding and Secretion by a Novel COX2-Independent Mechanism Involving Chaperones of the Endoplasmic Reticulum

  Iraide Alloza, Andy Baxter, Qian Chen, Rune Matthiesen and Koen Vandenbroeck

  Molecular Pharmacology May 2006, 69 (5) 1579-1587; DOI: https://doi.org/10.1124/mol.105.020669
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  Carboxyl-Terminal Splicing Enhances Physical Interactions between the Cytoplasmic Tails of Purinergic P2X Receptors

  Taka-aki Koshimizu, Karla Kretschmannova, Mu-Lan He, Susumu Ueno, Akito Tanoue, Nobuyuki Yanagihara, Stanko S. Stojilkovic and Gozoh Tsujimoto

  Molecular Pharmacology May 2006, 69 (5) 1588-1598; DOI: https://doi.org/10.1124/mol.105.019802
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  Dioxin Induces an Estrogen-Like, Estrogen Receptor-Dependent Gene Expression Response in the Murine Uterus

  Darrell R. Boverhof, Joshua C. Kwekel, Daryl G. Humes, Lyle D. Burgoon and Timothy R. Zacharewski

  Molecular Pharmacology May 2006, 69 (5) 1599-1606; DOI: https://doi.org/10.1124/mol.105.019638
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  Apurinic/Apyrimidinic Endonuclease-1 Protein Level Is Associated with the Cytotoxicity of l-Configuration Deoxycytidine Analogs (Troxacitabine and β-l-2′,3′-Dideoxy-2′,3′-didehydro-5-fluorocytidine) but Not d-Configuration Deoxycytidine Analogs (Gemcitabine and β-d-Arabinofuranosylcytosine)

  Wing Lam, Shin-Young Park, Chung-Hang Leung and Yung-Chi Cheng

  Molecular Pharmacology May 2006, 69 (5) 1607-1614; DOI: https://doi.org/10.1124/mol.105.021527
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  Raloxifene-Induced Myeloma Cell Apoptosis: A Study of Nuclear Factor-κB Inhibition and Gene Expression Signature

  Sabine Olivier, Pierre Close, Emilie Castermans, Laurence de Leval, Sebastien Tabruyn, Alain Chariot, Michel Malaise, Marie-Paule Merville, Vincent Bours and Nathalie Franchimont

  Molecular Pharmacology May 2006, 69 (5) 1615-1623; DOI: https://doi.org/10.1124/mol.105.020479
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  Cytosolic Entry of Bisphosphonate Drugs Requires Acidification of Vesicles after Fluid-Phase Endocytosis

  Keith Thompson, Michael J. Rogers, Fraser P. Coxon and Julie C. Crockett

  Molecular Pharmacology May 2006, 69 (5) 1624-1632; DOI: https://doi.org/10.1124/mol.105.020776
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  Iron Released by Sodium Nitroprusside Contributes to Heme Oxygenase-1 Induction via the cAMP-Protein Kinase A-Mitogen-Activated Protein Kinase Pathway in RAW 264.7 Cells

  Hye Jung Kim, Irina Tsoy, Min Kyu Park, Young Soo Lee, Jae Heun Lee, Han Geuk Seo and Ki Churl Chang

  Molecular Pharmacology May 2006, 69 (5) 1633-1640; DOI: https://doi.org/10.1124/mol.105.020487
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  Identification of Various Allosteric Interaction Sites on M₁ Muscarinic Receptor Using ¹²⁵I-Met35-Oxidized Muscarinic Toxin 7

  Carole Fruchart-Gaillard, Gilles Mourier, Catherine Marquer, André Ménez and Denis Servent

  Molecular Pharmacology May 2006, 69 (5) 1641-1651; DOI: https://doi.org/10.1124/mol.105.020883
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  Allosteric Modulation of Binding Properties between Units of Chemokine Receptor Homo- and Hetero-Oligomers

  Jean-Yves Springael, Phu Nguyen Le Minh, Eneko Urizar, Sabine Costagliola, Gilbert Vassart and Marc Parmentier

  Molecular Pharmacology May 2006, 69 (5) 1652-1661; DOI: https://doi.org/10.1124/mol.105.019414
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  Induction of AKR1C2 by Phase II Inducers: Identification of a Distal Consensus Antioxidant Response Element Regulated by NRF2

  Huan Lou, Shouying Du, Qing Ji and Andrew Stolz

  Molecular Pharmacology May 2006, 69 (5) 1662-1672; DOI: https://doi.org/10.1124/mol.105.019794
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  Species Diversity and Peptide Toxins Blocking Selectivity of Ether-à-go-go-Related Gene Subfamily K⁺ Channels in the Central Nervous System

  Rita Restano-Cassulini, Yuliya V. Korolkova, Sylvie Diochot, Georgina Gurrola, Leonardo Guasti, Lourival D. Possani, Michel Lazdunski, Eugene V. Grishin, Annarosa Arcangeli and Enzo Wanke

  Molecular Pharmacology May 2006, 69 (5) 1673-1683; DOI: https://doi.org/10.1124/mol.105.019729
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  Short- and Long-Term Amiodarone Treatments Regulate Ca_v3.2 Low-Voltage-Activated T-type Ca²⁺ Channel through Distinct Mechanisms

  Noboru Yamashita, Toshihiko Kaku, Tomoko Uchino, Shojiro Isomoto, Hironobu Yoshimatsu and Katsushige Ono

  Molecular Pharmacology May 2006, 69 (5) 1684-1691; DOI: https://doi.org/10.1124/mol.105.021253
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  An Uncharged Region within the N Terminus of the P2X₆ Receptor Inhibits Its Assembly and Exit from the Endoplasmic Reticulum

  Susan J. Ormond, Nelson P. Barrera, Omar S. Qureshi, Robert M. Henderson, J. Michael Edwardson and Ruth D. Murrell-Lagnado

  Molecular Pharmacology May 2006, 69 (5) 1692-1700; DOI: https://doi.org/10.1124/mol.105.020404
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  Mechanisms Underlying Lipopolysaccharide-Induced Kinin B₁ Receptor Up-Regulation in the Pig Iris Sphincter in Vitro

  Mariem El Sayah, Rodrigo Medeiros, Elizabeth S. Fernandes, Maria M. Campos and João B. Calixto

  Molecular Pharmacology May 2006, 69 (5) 1701-1708; DOI: https://doi.org/10.1124/mol.105.021097
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  Molecular Determinants of hERG Channel Block

  Kaichiro Kamiya, Ryoko Niwa, John S. Mitcheson and Michael C. Sanguinetti

  Molecular Pharmacology May 2006, 69 (5) 1709-1716; DOI: https://doi.org/10.1124/mol.105.020990
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  Opposite Effects of Wortmannin and 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one Hydrochloride on Toll-Like Receptor-Mediated Nitric Oxide Production: Negative Regulation of Nuclear Factor-κB by Phosphoinositide 3-Kinase

  Kaoru Hazeki, Sachiko Kinoshita, Takayo Matsumura, Kiyomi Nigorikawa, Hiroshi Kubo and Osamu Hazeki

  Molecular Pharmacology May 2006, 69 (5) 1717-1724; DOI: https://doi.org/10.1124/mol.105.021162
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  Angiotensin-Converting Enzyme (ACE) Dimerization Is the Initial Step in the ACE Inhibitor-Induced ACE Signaling Cascade in Endothelial Cells

  Karin Kohlstedt, Cynthia Gershome, Matthias Friedrich, Werner Muller-Esterl, François Alhenc-Gelas, Rudi Busse and Ingrid Fleming

  Molecular Pharmacology May 2006, 69 (5) 1725-1732; DOI: https://doi.org/10.1124/mol.105.020636
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  Flubendiamide, a Novel Ca²⁺ Channel Modulator, Reveals Evidence for Functional Cooperation between Ca²⁺ Pumps and Ca²⁺ Release

  Takao Masaki, Noriaki Yasokawa, Masanori Tohnishi, Tetsuyoshi Nishimatsu, Kenji Tsubata, Kazuyoshi Inoue, Kazuhiko Motoba and Takashi Hirooka

  Molecular Pharmacology May 2006, 69 (5) 1733-1739; DOI: https://doi.org/10.1124/mol.105.020339
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  19nor-1,25-Dihydroxyvitamin D₂ Specifically Induces CYP3A9 in Rat Intestine More Strongly than 1,25-Dihydroxyvitamin D₃ in Vivo and in Vitro

  Claudia Zierold, Jamie A. Mings and Hector F. Deluca

  Molecular Pharmacology May 2006, 69 (5) 1740-1747; DOI: https://doi.org/10.1124/mol.105.019851
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  Human REV1 Modulates the Cytotoxicity and Mutagenicity of Cisplatin in Human Ovarian Carcinoma Cells

  Xinjian Lin, Tsuyoshi Okuda, Julie Trang and Stephen B. Howell

  Molecular Pharmacology May 2006, 69 (5) 1748-1754; DOI: https://doi.org/10.1124/mol.105.020446
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  Halothane Directly Modifies Na⁺ and K⁺ Channel Activities in Cultured Human Alveolar Epithelial Cells

  Antoine Roch, Vadim Shlyonsky, Arnaud Goolaerts, Frédérique Mies and Sarah Sariban-Sohraby

  Molecular Pharmacology May 2006, 69 (5) 1755-1762; DOI: https://doi.org/10.1124/mol.105.021485
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  Dexamethasone-Induced Ras Protein 1 Negatively Regulates Protein Kinase C δ: Implications for Adenylyl Cyclase 2 Signaling

  Chau H. Nguyen and Val J. Watts

  Molecular Pharmacology May 2006, 69 (5) 1763-1771; DOI: https://doi.org/10.1124/mol.105.019133