Table of Contents

Articles

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  Decursin Inhibits Induction of Inflammatory Mediators by Blocking Nuclear Factor-κB Activation in Macrophages

  Jung-Hee Kim, Ji-Hye Jeong, Sung-Tak Jeon, Ho Kim, Jiyeon Ock, Kyoungho Suk, Sang-In Kim, Kyung-Sik Song and Won-ha Lee

  Molecular Pharmacology June 2006, 69 (6) 1783-1790; DOI: https://doi.org/10.1124/mol.105.021048
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  IκB Kinase-2-Independent and -Dependent Inflammation in Airway Disease Models: Relevance of IKK-2 Inhibition to the Clinic

  Mark A. Birrell, Sissie Wong, Elizabeth L. Hardaker, Matthew C. Catley, Kerryn McCluskie, Michael Collins, Saleem Haj-Yahia and Maria G. Belvisi

  Molecular Pharmacology June 2006, 69 (6) 1791-1800; DOI: https://doi.org/10.1124/mol.105.019521
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  Development of a Novel Nitro-Derivative of Noscapine for the Potential Treatment of Drug-Resistant Ovarian Cancer and T-Cell Lymphoma

  Ritu Aneja, Surya N. Vangapandu, Manu Lopus, Ramesh Chandra, Dulal Panda and Harish C. Joshi

  Molecular Pharmacology June 2006, 69 (6) 1801-1809; DOI: https://doi.org/10.1124/mol.105.021899
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  Short- and Long-Term Regulation of Adenylyl Cyclase Activity by δ-Opioid Receptor Are Mediated by Gα_i2 in Neuroblastoma N₂A Cells

  Lei Zhang, Joan Tetrault, Wei Wang, Horace H. Loh and Ping-Yee Law

  Molecular Pharmacology June 2006, 69 (6) 1810-1819; DOI: https://doi.org/10.1124/mol.105.021352
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  Suppression and Regression of Choroidal Neovascularization by Systemic Administration of an α₅β₁ Integrin Antagonist

  Naoyasu Umeda, Shu Kachi, Hideo Akiyama, Grit Zahn, Doerte Vossmeyer, Roland Stragies and Peter A. Campochiaro

  Molecular Pharmacology June 2006, 69 (6) 1820-1828; DOI: https://doi.org/10.1124/mol.105.020941
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  Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Reduces Vascular Endothelial Growth Factor Expression in Allergen-Induced Airway Inflammation

  Kyung Sun Lee, So Ri Kim, Seoung Ju Park, Ho Kyung Lee, Hee Sun Park, Kyung Hoon Min, Sun Mi Jin and Yong Chul Lee

  Molecular Pharmacology June 2006, 69 (6) 1829-1839; DOI: https://doi.org/10.1124/mol.106.022228
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  A Novel Vitamin D Derivative Activates Bone Morphogenetic Protein Signaling in MCF10 Breast Epithelial Cells

  Hong Jin Lee, Andrew Wislocki, Catherine Goodman, Yan Ji, Rongrong Ge, Hubert Maehr, Milan Uskokovic, Michael Reiss and Nanjoo Suh

  Molecular Pharmacology June 2006, 69 (6) 1840-1848; DOI: https://doi.org/10.1124/mol.105.022079
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  Determination of Binding Site Residues Responsible for the Subunit Selectivity of Novel Marine-Derived Compounds on Kainate Receptors

  James M. Sanders, Olli T. Pentikäinen, Luca Settimo, Ulla Pentikäinen, Muneo Shoji, Makoto Sasaki, Ryuichi Sakai, Mark S. Johnson and Geoffrey T. Swanson

  Molecular Pharmacology June 2006, 69 (6) 1849-1860; DOI: https://doi.org/10.1124/mol.106.022772
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  Antieosinophilic Activity of Orazipone

  Hannu Kankaanranta, Pinja Ilmarinen, Xianzhi Zhang, Erkki Nissinen and Eeva Moilanen

  Molecular Pharmacology June 2006, 69 (6) 1861-1870; DOI: https://doi.org/10.1124/mol.105.021170
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  Novel Compound 2-Methyl-2H-pyrazole-3-carboxylic Acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) Prevents 2,3,7,8-TCDD-Induced Toxicity by Antagonizing the Aryl Hydrocarbon Receptor

  Sun-Hee Kim, Ellen C. Henry, Dong-Kyu Kim, Yun-Hee Kim, Kum Joo Shin, Myoung Sook Han, Taehoon G. Lee, Jong-Ku Kang, Thomas A. Gasiewicz, Sung Ho Ryu and Pann-Ghill Suh

  Molecular Pharmacology June 2006, 69 (6) 1871-1878; DOI: https://doi.org/10.1124/mol.105.021832
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  Induction of Apoptosis in Renal Cell Carcinoma by Reactive Oxygen Species: Involvement of Extracellular Signal-Regulated Kinase 1/2, p38δ/γ, Cyclooxygenase-2 Down-Regulation, and Translocation of Apoptosis-Inducing Factor

  Monica Ambrose, Aideen Ryan, Gerald C. O'Sullivan, Colum Dunne and Orla P. Barry

  Molecular Pharmacology June 2006, 69 (6) 1879-1890; DOI: https://doi.org/10.1124/mol.105.020875
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  Mutations Distal to the Substrate Site Can Affect Varicella Zoster Virus Thymidine Kinase Activity: Implications for Drug Design

  Kamel El Omari, Sandra Liekens, Louise E. Bird, Jan Balzarini and David K. Stammers

  Molecular Pharmacology June 2006, 69 (6) 1891-1896; DOI: https://doi.org/10.1124/mol.106.023002
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  Endoplasmic Reticulum-Associated Degradation of Cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: Further Characterization of Cellular Participants and Structural Determinants

  Mingxiang Liao, Saadia Faouzi, Andrey Karyakin and Maria Almira Correia

  Molecular Pharmacology June 2006, 69 (6) 1897-1904; DOI: https://doi.org/10.1124/mol.105.021816
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  The Two-State Dimer Receptor Model: A General Model for Receptor Dimers

  Rafael Franco, Vicent Casadó, Josefa Mallol, Carla Ferrada, Sergi Ferré, Kjell Fuxe, Antoni Cortés, Francisco Ciruela, Carmen Lluis and Enric I. Canela

  Molecular Pharmacology June 2006, 69 (6) 1905-1912; DOI: https://doi.org/10.1124/mol.105.020685
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  Transactivation of Rat Apical Sodium-Dependent Bile Acid Transporter and Increased Bile Acid Transport by 1α,25-Dihydroxyvitamin D₃ via the Vitamin D Receptor

  Xianghai Chen, Frank Chen, Shanjun Liu, Hartmut Glaeser, Paul A. Dawson, Alan F. Hofmann, Richard B. Kim, Benjamin L. Shneider and K. Sandy Pang

  Molecular Pharmacology June 2006, 69 (6) 1913-1923; DOI: https://doi.org/10.1124/mol.105.020792
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  A Common Regulatory Region Functions Bidirectionally in Transcriptional Activation of the Human CYP1A1 and CYP1A2 Genes

  Rika Ueda, Hiromi Iketaki, Kiyoshi Nagata, Shioko Kimura, Frank J. Gonzalez, Kazutomi Kusano, Tsutomu Yoshimura and Yasushi Yamazoe

  Molecular Pharmacology June 2006, 69 (6) 1924-1930; DOI: https://doi.org/10.1124/mol.105.021220
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  Phoneutria nigriventer Toxin 1: A Novel, State-Dependent Inhibitor of Neuronal Sodium Channels That Interacts with μ Conotoxin Binding Sites

  Nicole Martin-Moutot, Pascal Mansuelle, Gisèle Alcaraz, Raquel Gouvêa Dos Santos, Marta N. Cordeiro, Maria Elena De Lima, Michael Seagar and Catherine Van Renterghem

  Molecular Pharmacology June 2006, 69 (6) 1931-1937; DOI: https://doi.org/10.1124/mol.105.021147
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  Suppression of the Phosphorylation of Receptor Tyrosine Phosphatase-α on the Src-Independent Site Tyrosine 789 by Reactive Oxygen Species

  Qin Hao, Stacey A. Rutherford, Brad Low and Hua Tang

  Molecular Pharmacology June 2006, 69 (6) 1938-1944; DOI: https://doi.org/10.1124/mol.105.020115
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  2-Fluoro-3-(4-nitro-phenyl)deschloroepibatidine Is a Novel Potent Competitive Antagonist of Human Neuronal α4β2 nAChRs

  Galya R. Abdrakhmanova, M. Imad Damaj, F. Ivy Carroll and Billy R. Martin

  Molecular Pharmacology June 2006, 69 (6) 1945-1952; DOI: https://doi.org/10.1124/mol.105.021782
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  A Constitutively Active Hypoxia-Inducible Factor-1α/VP16 Hybrid Factor Activates Expression of the Human B-Type Natriuretic Peptide Gene

  Yuxia Luo, Canwen Jiang, Adam J. Belanger, Geoffrey Y. Akita, Samuel C. Wadsworth, Richard J. Gregory and Karen A. Vincent

  Molecular Pharmacology June 2006, 69 (6) 1953-1962; DOI: https://doi.org/10.1124/mol.105.017905
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  T-Type Calcium Channels Are Inhibited by Fluoxetine and Its Metabolite Norfluoxetine

  Achraf Traboulsie, Jean Chemin, Elodie Kupfer, Joël Nargeot and Philippe Lory

  Molecular Pharmacology June 2006, 69 (6) 1963-1968; DOI: https://doi.org/10.1124/mol.105.020842
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  Desensitization of NO/cGMP Signaling in Smooth Muscle: Blood Vessels Versus Airways

  Florian Mullershausen, Alexander Lange, Evanthia Mergia, Andreas Friebe and Doris Koesling

  Molecular Pharmacology June 2006, 69 (6) 1969-1974; DOI: https://doi.org/10.1124/mol.105.020909
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  Potentiation of Native and Recombinant P2X7-Mediated Calcium Signaling by Arachidonic Acid in Cultured Cortical Astrocytes and Human Embryonic Kidney 293 Cells

  Susanna Alloisio, Rita Aiello, Stefano Ferroni and Mario Nobile

  Molecular Pharmacology June 2006, 69 (6) 1975-1983; DOI: https://doi.org/10.1124/mol.105.020164
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  Distinct Receptor Activity-Modifying Protein Domains Differentially Modulate Interaction with Calcitonin Receptors

  Madhara Udawela, George Christopoulos, Nanda Tilakaratne, Arthur Christopoulos, Anthony Albiston and Patrick M. Sexton

  Molecular Pharmacology June 2006, 69 (6) 1984-1989; DOI: https://doi.org/10.1124/mol.105.021915
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  The Interaction of an Impermeant Cation with the Sheep Cardiac RyR Channel Alters Ryanoid Association

  Bhavna Tanna, William Welch, Luc Ruest, John L. Sutko and Alan J. Williams

  Molecular Pharmacology June 2006, 69 (6) 1990-1997; DOI: https://doi.org/10.1124/mol.105.021659
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  Neurochemical Characterization of a Neuroprotective Compound from Parawixia bistriata Spider Venom That Inhibits Synaptosomal Uptake of GABA and Glycine

  Renê Oliveira Beleboni, Renato Guizzo, Andréia Cristina Karklin Fontana, Andrea Baldocchi Pizzo, Ruither Oliveira Gomes Carolino, Leonardo Gobbo-Neto, Norberto Peporine Lopes, Joaquim Coutinho-Netto and Wagner Ferreira dos Santos

  Molecular Pharmacology June 2006, 69 (6) 1998-2006; DOI: https://doi.org/10.1124/mol.105.017319
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  Recombinant Enzymes Overexpressed in Bacteria Show Broad Catalytic Specificity of Human Cytochrome P450 2W1 and Limited Activity of Human Cytochrome P450 2S1

  Zhong-Liu Wu, Christal D. Sohl, Tsutomu Shimada and F. Peter Guengerich

  Molecular Pharmacology June 2006, 69 (6) 2007-2014; DOI: https://doi.org/10.1124/mol.106.023648
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  Dual Potentiating and Inhibitory Actions of a Benz[e]indene Neurosteroid Analog on Recombinant α1β2γ2 GABA_A Receptors

  Ping Li, Douglas F. Covey, Joe Henry Steinbach and Gustav Akk

  Molecular Pharmacology June 2006, 69 (6) 2015-2026; DOI: https://doi.org/10.1124/mol.106.022590
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  In Vitro and in Vivo Nuclear Factor-κB Inhibitory Effects of the Cell-Penetrating Penetratin Peptide

  Tamás Letoha, Erzsébet Kusz, Gábor Pápai, Annamária Szabolcs, József Kaszaki, Ilona Varga, Tamás Takács, Botond Penke and Ernő Duda

  Molecular Pharmacology June 2006, 69 (6) 2027-2036; DOI: https://doi.org/10.1124/mol.105.019653
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  Modulation by LL-37 of the Responses of Salivary Glands to Purinergic Agonists

  Stéphanie Pochet, Séverine Tandel, Stéphanie Querriére, Marie Tre-Hardy, Mikel Garcia-Marcos, Manuela De Lorenzi, Michel Vandenbranden, Aida Marino, Michel Devleeschouwer and Jean-Paul Dehaye

  Molecular Pharmacology June 2006, 69 (6) 2037-2046; DOI: https://doi.org/10.1124/mol.105.021444
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  Ultrasound Stimulates Cyclooxygenase-2 Expression and Increases Bone Formation through Integrin, Focal Adhesion Kinase, Phosphatidylinositol 3-Kinase, and Akt Pathway in Osteoblasts

  Chih-Hsin Tang, Rong-Sen Yang, Tsang-Hai Huang, Dah-Yuu Lu, Woei-Jer Chuang, Tur-Fu Huang and Wen-Mei Fu

  Molecular Pharmacology June 2006, 69 (6) 2047-2057; DOI: https://doi.org/10.1124/mol.105.022160
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  The Suramin Analog 4,4′,4″,4″′-(Carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic Acid (NF110) Potently Blocks P2X₃ Receptors: Subtype Selectivity Is Determined by Location of Sulfonic Acid Groups

  Ralf Hausmann, Jürgen Rettinger, Zoltan Gerevich, Sabine Meis, Matthias U. Kassack, Peter Illes, Günter Lambrecht and Günther Schmalzing

  Molecular Pharmacology June 2006, 69 (6) 2058-2067; DOI: https://doi.org/10.1124/mol.106.022665
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  Gα_12/13- and Rho-Dependent Activation of Phospholipase C-ϵ by Lysophosphatidic Acid and Thrombin Receptors

  Melinda D. Hains, Michele R. Wing, Savitri Maddileti, David P. Siderovski and T. Kendall Harden

  Molecular Pharmacology June 2006, 69 (6) 2068-2075; DOI: https://doi.org/10.1124/mol.105.017921
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  The Aryl Hydrocarbon Receptor Agonist 2,3,7,8-Tetrachlorodibenzo-p-dioxin Alters the Circadian Rhythms, Quiescence, and Expression of Clock Genes in Murine Hematopoietic Stem and Progenitor Cells

  Russell W. Garrett and Thomas A. Gasiewicz

  Molecular Pharmacology June 2006, 69 (6) 2076-2083; DOI: https://doi.org/10.1124/mol.105.021006
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  Sulfotransferase (SULT) 1A1 Polymorphic Variants ^*1, ^*2, and ^*3 Are Associated with Altered Enzymatic Activity, Cellular Phenotype, and Protein Degradation

  Swati Nagar, Susan Walther and Rebecca L. Blanchard

  Molecular Pharmacology June 2006, 69 (6) 2084-2092; DOI: https://doi.org/10.1124/mol.105.019240