Abstract
Inhibition of the growth of Escherichia coli by levallorphan increased in effectiveness as the medium concentration of Mg++ was decreased. Two molecules of levallorphan were shown to compete with 1 atom of Mg++, presumably on the cell surface. Active transport of Mg++ was altered in the presence of the drug, and this effect could be prevented by high concentrations of Ca++. Reduction of cellular Mg++ content in the presence of levallorphan is suggested to be one possible cause of growth inhibition.
- Copyright ©, 1971, by Academic Press, Inc.
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