Table of Contents

Articles

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  Role of the Outer β-Sheet in Divalent Cation Modulation of α7 Nicotinic Receptors

  James T. McLaughlin, Jie Fu, Adrian D. Sproul and Robert L. Rosenberg

  Molecular Pharmacology July 2006, 70 (1) 16-22; DOI: https://doi.org/10.1124/mol.106.023259
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  High Accumulation of Platinum-DNA Adducts in Strial Marginal Cells of the Cochlea Is an Early Event in Cisplatin but Not Carboplatin Ototoxicity

  Jan Peter Thomas, Juergen Lautermann, Bernd Liedert, Frank Seiler and Juergen Thomale

  Molecular Pharmacology July 2006, 70 (1) 23-29; DOI: https://doi.org/10.1124/mol.106.022244
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  The Phenotypic Differentiation of Locus Ceruleus Noradrenergic Neurons Mediated by Brain-Derived Neurotrophic Factor Is Enhanced by Corticotropin Releasing Factor through the Activation of a cAMP-Dependent Signaling Pathway

  Sabine Traver, Marc Marien, Elodie Martin, Etienne C. Hirsch and Patrick P. Michel

  Molecular Pharmacology July 2006, 70 (1) 30-40; DOI: https://doi.org/10.1124/mol.106.022715
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  Sphingosine and Its Analog, the Immunosuppressant 2-Amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, Interact with the CB₁ Cannabinoid Receptor

  Steven W. Paugh, Michael P. Cassidy, Hengjun He, Sheldon Milstien, Laura J. Sim-Selley, Sarah Spiegel and Dana E. Selley

  Molecular Pharmacology July 2006, 70 (1) 41-50; DOI: https://doi.org/10.1124/mol.105.020552
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  A Cannabinoid Quinone Inhibits Angiogenesis by Targeting Vascular Endothelial Cells

  Natalya M. Kogan, Cristina Blázquez, Luis Álvarez, Ruth Gallily, Michael Schlesinger, Manuel Guzmán and Raphael Mechoulam

  Molecular Pharmacology July 2006, 70 (1) 51-59; DOI: https://doi.org/10.1124/mol.105.021089
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  Identification of Tubulin as the Molecular Target of Proapoptotic Pyrrolo-1,5-benzoxazepines

  Jude M. Mulligan, Lisa M. Greene, Suzanne Cloonan, Margaret M. Mc Gee, Valeria Onnis, Giuseppe Campiani, Caterina Fattorusso, Mark Lawler, D. Clive Williams and Daniela M. Zisterer

  Molecular Pharmacology July 2006, 70 (1) 60-70; DOI: https://doi.org/10.1124/mol.105.021204
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  Receptor Regulation of Gene Expression of Axon Guidance Molecules: Implications for Adaptation

  Amy K. Jassen, Hong Yang, Gregory M. Miller, Elizabeth Calder and Bertha K. Madras

  Molecular Pharmacology July 2006, 70 (1) 71-77; DOI: https://doi.org/10.1124/mol.105.021998
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  Agonist-Induced Cell Surface Trafficking of an Intracellularly Sequestered D1 Dopamine Receptor Homo-Oligomer

  Michael M. C. Kong, Theresa Fan, George Varghese, Brian F. O'Dowd and Susan R. George

  Molecular Pharmacology July 2006, 70 (1) 78-89; DOI: https://doi.org/10.1124/mol.105.021246
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  Phosducin and Phosducin-like Protein Attenuate G-Protein-Coupled Receptor-Mediated Inhibition of Voltage-Gated Calcium Channels in Rat Sympathetic Neurons

  John G. Partridge, Henry L. Puhl and Stephen R. Ikeda

  Molecular Pharmacology July 2006, 70 (1) 90-100; DOI: https://doi.org/10.1124/mol.105.021394
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  Interleukin-2 Suppression by 2-Arachidonyl Glycerol Is Mediated through Peroxisome Proliferator-Activated Receptor γ Independently of Cannabinoid Receptors 1 and 2

  Cheryl E. Rockwell, Natasha T. Snider, Jerry T. Thompson, John P. Vanden Heuvel and Norbert E. Kaminski

  Molecular Pharmacology July 2006, 70 (1) 101-111; DOI: https://doi.org/10.1124/mol.105.019117
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  Resveratrol Suppresses Tumor Necrosis Factor-α-Induced Fractalkine Expression in Endothelial Cells

  Sang-Ok Moon, Won Kim, Mi Jeong Sung, Sik Lee, Kyung Pyo Kang, Duk Hoon Kim, Sang Yong Lee, June-No So and Sung Kwang Park

  Molecular Pharmacology July 2006, 70 (1) 112-119; DOI: https://doi.org/10.1124/mol.106.022392
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  Structure-Function Analysis of Vitamin D 24-Hydroxylase (CYP24A1) by Site-Directed Mutagenesis: Amino Acid Residues Responsible for Species-Based Difference of CYP24A1 between Humans and Rats

  Hiromi Hamamoto, Tatsuya Kusudo, Naoko Urushino, Hiroyuki Masuno, Keiko Yamamoto, Sachiko Yamada, Masaki Kamakura, Miho Ohta, Kuniyo Inouye and Toshiyuki Sakaki

  Molecular Pharmacology July 2006, 70 (1) 120-128; DOI: https://doi.org/10.1124/mol.106.023275
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  Novel α₁-Adrenergic Receptor Signaling Pathways: Secreted Factors and Interactions with the Extracellular Matrix

  Ting Shi, Zhong-Hui Duan, Robert Papay, Elzbieta Pluskota, Robert J. Gaivin, Carol A. de la Motte, Edward F. Plow and Dianne M. Perez

  Molecular Pharmacology July 2006, 70 (1) 129-142; DOI: https://doi.org/10.1124/mol.105.020735
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  Comparative Study of ortho- and meta-Nitrated Inhibitors of Catechol-O-methyltransferase: Interactions with the Active Site and Regioselectivity of O-Methylation

  P. N. Palma, M. L. Rodrigues, M. Archer, M. J. Bonifácio, A. I. Loureiro, D. A. Learmonth, M. A. Carrondo and P. Soares-da-Silva

  Molecular Pharmacology July 2006, 70 (1) 143-153; DOI: https://doi.org/10.1124/mol.106.023119
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  Estrogens Cross-Talk to α_1b-Adrenergic Receptors

  Aliesha González-Arenas, Beatriz Aguilar-Maldonado, S. Eréndira Avendaño-Vázquez and J. Adolfo García-Sáinz

  Molecular Pharmacology July 2006, 70 (1) 154-162; DOI: https://doi.org/10.1124/mol.106.025064
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  Sustained Aryl Hydrocarbon Receptor Activity Attenuates Liver Regeneration

  Kristen A. Mitchell, Courtney A. Lockhart, Gengming Huang and Cornelis J. Elferink

  Molecular Pharmacology July 2006, 70 (1) 163-170; DOI: https://doi.org/10.1124/mol.106.023465
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  ZIP8, Member of the Solute-Carrier-39 (SLC39) Metal-Transporter Family: Characterization of Transporter Properties

  Lei He, Kuppuswami Girijashanker, Timothy P. Dalton, Jodie Reed, Hong Li, Manoocher Soleimani and Daniel W. Nebert

  Molecular Pharmacology July 2006, 70 (1) 171-180; DOI: https://doi.org/10.1124/mol.106.024521
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  Allosteric Interactions with Muscarinic Acetylcholine Receptors: Complex Role of the Conserved Tryptophan M₂⁴²²Trp in a Critical Cluster of Amino Acids for Baseline Affinity, Subtype Selectivity, and Cooperativity

  Stefanie Prilla, Jasmin Schrobang, John Ellis, Hans-Dieter Höltje and Klaus Mohr

  Molecular Pharmacology July 2006, 70 (1) 181-193; DOI: https://doi.org/10.1124/mol.106.023481
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  Analysis of G Protein βγ Dimer Formation in Live Cells Using Multicolor Bimolecular Fluorescence Complementation Demonstrates Preferences of β₁ for Particular γ Subunits

  Stacy M. Mervine, Evan A. Yost, Jonathan L. Sabo, Thomas R. Hynes and Catherine H. Berlot

  Molecular Pharmacology July 2006, 70 (1) 194-205; DOI: https://doi.org/10.1124/mol.106.022616
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  Possible Endogenous Agonist Mechanism for the Activation of Secretin Family G Protein-Coupled Receptors

  Maoqing Dong, Delia I. Pinon, Yan W. Asmann and Laurence J. Miller

  Molecular Pharmacology July 2006, 70 (1) 206-213; DOI: https://doi.org/10.1124/mol.105.021840
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  Relaxin Family Peptide Receptors RXFP1 and RXFP2 Modulate cAMP Signaling by Distinct Mechanisms

  Michelle L. Halls, Ross A. D. Bathgate and Roger J. Summers

  Molecular Pharmacology July 2006, 70 (1) 214-226; DOI: https://doi.org/10.1124/mol.105.021691
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  Untranslated Region-Dependent Exclusive Expression of High-Sensitivity Subforms of α4β2 and α3β2 Nicotinic Acetylcholine Receptors

  Clark A. Briggs, Earl J. Gubbins, Michael J. Marks, C. Brent Putman, Rama Thimmapaya, Michael D. Meyer and Carol S. Surowy

  Molecular Pharmacology July 2006, 70 (1) 227-240; DOI: https://doi.org/10.1124/mol.105.020198
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  Serum Amyloid A Induces Contrary Immune Responses via Formyl Peptide Receptor-Like 1 in Human Monocytes

  Ha Young Lee, Mi-Kyoung Kim, Kyoung Sun Park, Eun Ha Shin, Seong Ho Jo, Sang Doo Kim, Eun Jin Jo, Youl-Nam Lee, Chuhee Lee, Suk-Hwan Baek and Yoe-Sik Bae

  Molecular Pharmacology July 2006, 70 (1) 241-248; DOI: https://doi.org/10.1124/mol.105.022103
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  Soluble Mimics of the Cytoplasmic Face of the Human V1-Vascular Vasopressin Receptor Bind Arrestin2 and Calmodulin

  Nan Wu, Rosemarie Macion-Dazard, Stanley Nithianantham, Zhen Xu, Susan M. Hanson, Sergey A. Vishnivetskiy, Vsevolod V. Gurevich, Marc Thibonnier and Menachem Shoham

  Molecular Pharmacology July 2006, 70 (1) 249-258; DOI: https://doi.org/10.1124/mol.105.018804
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  Structural Determinants of 4-Chloro-m-cresol Required for Activation of Ryanodine Receptor Type 1

  Alan R. Jacobson, Scott T. Moe, P. D. Allen and James D. Fessenden

  Molecular Pharmacology July 2006, 70 (1) 259-266; DOI: https://doi.org/10.1124/mol.106.022491
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  The Promoter Region of the MDR1 Gene Is Largely Invariant, but Different Single Nucleotide Polymorphism Haplotypes Affect MDR1 Promoter Activity Differently in Different Cell Lines

  Baoshuang Wang, Soomun Ngoi, Jingbo Wang, Samuel S. Chong and Caroline G. L. Lee

  Molecular Pharmacology July 2006, 70 (1) 267-276; DOI: https://doi.org/10.1124/mol.105.019810
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  Chemical Inducers of Rodent Glutathione S-Transferases Down-Regulate Human GSTA1 Transcription through a Mechanism Involving Variant Hepatic Nuclear Factor 1-C

  Laura Romero, Lorraine Ng and Gordon M. Kirby

  Molecular Pharmacology July 2006, 70 (1) 277-286; DOI: https://doi.org/10.1124/mol.105.018622
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  Functional Validation of the Genetic Polymorphisms of Human ATP-Binding Cassette (ABC) Transporter ABCG2: Identification of Alleles That Are Defective in Porphyrin Transport

  Ai Tamura, Masato Watanabe, Hikaru Saito, Hiroshi Nakagawa, Toshiaki Kamachi, Ichiro Okura and Toshihisa Ishikawa

  Molecular Pharmacology July 2006, 70 (1) 287-296; DOI: https://doi.org/10.1124/mol.106.023556
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  Specific Rescue of Cystic Fibrosis Transmembrane Conductance Regulator Processing Mutants Using Pharmacological Chaperones

  Ying Wang, M. Claire Bartlett, Tip W. Loo and David M. Clarke

  Molecular Pharmacology July 2006, 70 (1) 297-302; DOI: https://doi.org/10.1124/mol.106.023994
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  The Role of Human Nucleoside Transporters in Cellular Uptake of 4′-Thio-β-d-arabinofuranosylcytosine and β-d-Arabinosylcytosine

  Marilyn L. Clarke, Vijaya L. Damaraju, Jing Zhang, Delores Mowles, Tracey Tackaberry, Thach Lang, Kyla M. Smith, James D. Young, Blake Tomkinson and Carol E. Cass

  Molecular Pharmacology July 2006, 70 (1) 303-310; DOI: https://doi.org/10.1124/mol.105.021543
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  Direct Modulation of Phospholipase D Activity by Gβγ

  A. M. Preininger, L. G. Henage, W. M. Oldham, E. J. Yoon, H. E. Hamm and H. A. Brown

  Molecular Pharmacology July 2006, 70 (1) 311-318; DOI: https://doi.org/10.1124/mol.105.021451
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  Retinoic Acids Increase P2X₂ Receptor Expression through the 5′-Flanking Region of P2rx2 Gene in Rat Phaeochromocytoma PC-12 Cells

  Hidetoshi Tozaki-Saitoh, Schuichi Koizumi, Yoji Sato, Makoto Tsuda, Taku Nagao and Kazuhide Inoue

  Molecular Pharmacology July 2006, 70 (1) 319-328; DOI: https://doi.org/10.1124/mol.105.020511
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  Ketoconazole and Miconazole Are Antagonists of the Human Glucocorticoid Receptor: Consequences on the Expression and Function of the Constitutive Androstane Receptor and the Pregnane X Receptor

  Cedric Duret, Martine Daujat-Chavanieu, Jean-Marc Pascussi, Lydiane Pichard-Garcia, Patrick Balaguer, Jean-Michel Fabre, Marie-José Vilarem, Patrick Maurel and Sabine Gerbal-Chaloin

  Molecular Pharmacology July 2006, 70 (1) 329-339; DOI: https://doi.org/10.1124/mol.105.022046
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  Subtype Specificity of Scorpion β-Toxin Tz1 Interaction with Voltage-Gated Sodium Channels Is Determined by the Pore Loop of Domain 3

  Enrico Leipold, Alfred Hansel, Adolfo Borges and Stefan H. Heinemann

  Molecular Pharmacology July 2006, 70 (1) 340-347; DOI: https://doi.org/10.1124/mol.106.024034
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  Modification and Uptake of a Cisplatin Carbonato Complex by Jurkat Cells

  Corey R. Centerwall, Kirk A. Tacka, Deborah J. Kerwood, Jerry Goodisman, Bonnie B. Toms, Ronald L. Dubowy and James C. Dabrowiak

  Molecular Pharmacology July 2006, 70 (1) 348-355; DOI: https://doi.org/10.1124/mol.106.023184
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  Transfection of Drug-Specific T-Cell Receptors into Hybridoma Cells: Tools to Monitor Drug Interaction with T-Cell Receptors and Evaluate Cross-Reactivity to Related Compounds

  Daphné Anne Schmid, Jan Paul Heribert Depta, Michael Lüthi and Werner Joseph Pichler

  Molecular Pharmacology July 2006, 70 (1) 356-365; DOI: https://doi.org/10.1124/mol.105.021576
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  Inhibition of Human Tyrosyl-DNA Phosphodiesterase by Aminoglycoside Antibiotics and Ribosome Inhibitors

  Zhiyong Liao, Laurent Thibaut, Andrew Jobson and Yves Pommier

  Molecular Pharmacology July 2006, 70 (1) 366-372; DOI: https://doi.org/10.1124/mol.105.021865
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  Experimental and Modeling Studies of Desensitization of P2X₃ Receptors

  Elena Sokolova, Andrei Skorinkin, Igor Moiseev, Andrei Agrachev, Andrea Nistri and Rashid Giniatullin

  Molecular Pharmacology July 2006, 70 (1) 373-382; DOI: https://doi.org/10.1124/mol.106.023564
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  Reducing and Oxidizing Agents Sensitize Heat-Activated Vanilloid Receptor (TRPV1) Current

  Klara Susankova, Karolina Tousova, Ladislav Vyklicky, Jan Teisinger and Viktorie Vlachova

  Molecular Pharmacology July 2006, 70 (1) 383-394; DOI: https://doi.org/10.1124/mol.106.023069
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  Neuroprotective Effects of 17β-Estradiol and Nonfeminizing Estrogens against H₂O₂ Toxicity in Human Neuroblastoma SK-N-SH Cells

  Xiaofei Wang, James A. Dykens, Evelyn Perez, Ran Liu, Shaohua Yang, Douglas F. Covey and James W. Simpkins

  Molecular Pharmacology July 2006, 70 (1) 395-404; DOI: https://doi.org/10.1124/mol.106.022384
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  Potent Modulation of the Voltage-Gated Sodium Channel Na_v1.7 by OD1, a Toxin from the Scorpion Odonthobuthus doriae

  Chantal Maertens, Eva Cuypers, Mehriar Amininasab, Amir Jalali, Hossein Vatanpour and Jan Tytgat

  Molecular Pharmacology July 2006, 70 (1) 405-414; DOI: https://doi.org/10.1124/mol.106.022970
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  Peroxisome Proliferator-Activated Receptor-γ and Retinoic Acid X Receptor α Represses the TGFβ1 Gene via PTEN-Mediated p70 Ribosomal S6 Kinase-1 Inhibition: Role for Zf9 Dephosphorylation

  Seung Jin Lee, Eun Kyoung Yang and Sang Geon Kim

  Molecular Pharmacology July 2006, 70 (1) 415-425; DOI: https://doi.org/10.1124/mol.106.022954
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  A Boronic-Chalcone Derivative Exhibits Potent Anticancer Activity through Inhibition of the Proteasome

  Geetha Achanta, Aneta Modzelewska, Li Feng, Saeed R. Khan and Peng Huang

  Molecular Pharmacology July 2006, 70 (1) 426-433; DOI: https://doi.org/10.1124/mol.105.021311