Table of Contents

Articles

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  Rescue of p53 Blockage by the A_2A Adenosine Receptor via a Novel Interacting Protein, Translin-Associated Protein X

  Chung-Nan Sun, Hsiao-Chun Cheng, Jui-ling Chou, Shen-Yang Lee, Ya-Wen Lin, Hsing-Lin Lai, Hui-Mei Chen and Yijuang Chern

  Molecular Pharmacology August 2006, 70 (2) 454-466; DOI: https://doi.org/10.1124/mol.105.021261
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  Pregabalin Reduces the Release of Synaptic Vesicles from Cultured Hippocampal Neurons

  Kristina D. Micheva, Charles P. Taylor and Stephen J Smith

  Molecular Pharmacology August 2006, 70 (2) 467-476; DOI: https://doi.org/10.1124/mol.106.023309
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  CYP2C76, a Novel Cytochrome P450 in Cynomolgus Monkey, Is a Major CYP2C in Liver, Metabolizing Tolbutamide and Testosterone

  Yasuhiro Uno, Hideki Fujino, Go Kito, Tetsuya Kamataki and Ryoichi Nagata

  Molecular Pharmacology August 2006, 70 (2) 477-486; DOI: https://doi.org/10.1124/mol.106.022673
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  Fluoxetine and Cocaine Induce the Epigenetic Factors MeCP2 and MBD1 in Adult Rat Brain

  Suzanne Cassel, Delphine Carouge, Claire Gensburger, Patrick Anglard, Claude Burgun, Jean-Bernard Dietrich, Dominique Aunis and Jean Zwiller

  Molecular Pharmacology August 2006, 70 (2) 487-492; DOI: https://doi.org/10.1124/mol.106.022301
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  Isoliquiritigenin Selectively Inhibits H₂ Histamine Receptor Signaling

  Dong-Chan Kim, Se-Young Choi, Sun-Hee Kim, Bong-Sik Yun, Ick-Dong Yoo, Nanga. Ravi Prakash Reddy, Ho Sup Yoon and Kyong-Tai Kim

  Molecular Pharmacology August 2006, 70 (2) 493-500; DOI: https://doi.org/10.1124/mol.106.023226
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  5′-O-Tritylated Nucleoside Derivatives: Inhibition of Thymidine Phosphorylase and Angiogenesis

  Sandra Liekens, Annelies Bronckaers, Ana-Isabel Hernández, Eva-María Priego, Elena Casanova, Maria-José Camarasa, Maria-Jesus Pérez-Pérez and Jan Balzarini

  Molecular Pharmacology August 2006, 70 (2) 501-509; DOI: https://doi.org/10.1124/mol.105.021188
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  Lithium Inhibits Ceramide- and Etoposide-Induced Protein Phosphatase 2A Methylation, Bcl-2 Dephosphorylation, Caspase-2 Activation, and Apoptosis

  Chia-Ling Chen, Chiou-Feng Lin, Chi-Wu Chiang, Ming-Shiou Jan and Yee-Shin Lin

  Molecular Pharmacology August 2006, 70 (2) 510-517; DOI: https://doi.org/10.1124/mol.106.024059
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  Transforming Growth Factor-β Receptor Type 1 (TGFβRI) Kinase Activity but Not p38 Activation Is Required for TGFβRI-Induced Myofibroblast Differentiation and Profibrotic Gene Expression

  Ann M. Kapoun, Nicholas J. Gaspar, Ying Wang, Debby Damm, Yu-Wang Liu, Gilbert O'Young, Diana Quon, Andrew Lam, Kimberly Munson, Thomas-Toan Tran, Jing Ying Ma, Alison Murphy, Sundeep Dugar, Sarvajit Chakravarty, Andrew A. Protter, Fu-Qiang Wen, Xiangde Liu, Stephen I. Rennard and Linda Slanec Higgins

  Molecular Pharmacology August 2006, 70 (2) 518-531; DOI: https://doi.org/10.1124/mol.105.021600
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  Mammalian Tolloid Alters Subcellular Localization, Internalization, and Signaling of α_1a-Adrenergic Receptors

  Qi Xu, Ning Xu, Tan Zhang, Hui Zhang, Zijian Li, Feng Yin, Zhizhen Lu, Qide Han and Youyi Zhang

  Molecular Pharmacology August 2006, 70 (2) 532-541; DOI: https://doi.org/10.1124/mol.105.016451
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  Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine

  Kristopher M. Kahlig, Brandon J. Lute, Yuqiang Wei, Claus J. Loland, Ulrik Gether, Jonathan A. Javitch and Aurelio Galli

  Molecular Pharmacology August 2006, 70 (2) 542-548; DOI: https://doi.org/10.1124/mol.106.023952
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  Aryl Hydrocarbon Receptor Activation Produces Heart-Specific Transcriptional and Toxic Responses in Developing Zebrafish

  Sara A. Carney, Jing Chen, C. Geoffrey Burns, Kong M. Xiong, Richard E. Peterson and Warren Heideman

  Molecular Pharmacology August 2006, 70 (2) 549-561; DOI: https://doi.org/10.1124/mol.106.025304
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  Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor

  Liwei Chen, Shen-Shu Sung, M. L. Richard Yip, Harshani R. Lawrence, Yuan Ren, Wayne C. Guida, Said M. Sebti, Nicholas J. Lawrence and Jie Wu

  Molecular Pharmacology August 2006, 70 (2) 562-570; DOI: https://doi.org/10.1124/mol.106.025536
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  Mapping Residues in the Ligand-Binding Domain of the 5-HT₃ Receptor onto d-Tubocurarine Structure

  Dong Yan, Julia K. Meyer and Michael M. White

  Molecular Pharmacology August 2006, 70 (2) 571-578; DOI: https://doi.org/10.1124/mol.106.024075
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  Tamoxifen and Raloxifene Differ in Their Functional Interactions with Aspartate 351 of Estrogen Receptor α

  Guila Dayan, Mathieu Lupien, Anick Auger, Silvia I. Anghel, Walter Rocha, Sébastien Croisetière, John A. Katzenellenbogen and Sylvie Mader

  Molecular Pharmacology August 2006, 70 (2) 579-588; DOI: https://doi.org/10.1124/mol.105.021931
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  OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells

  Adly Yacoub, Margaret A. Park, David Hanna, Young Hong, Clint Mitchell, Aditi P. Pandya, Hisashi Harada, Garth Powis, Ching-Shih Chen, Costas Koumenis, Steven Grant and Paul Dent

  Molecular Pharmacology August 2006, 70 (2) 589-603; DOI: https://doi.org/10.1124/mol.106.025007
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  Oligomerization of Recombinant and Endogenously Expressed Human Histamine H₄ Receptors

  Richard M. van Rijn, Paul L. Chazot, Fiona C. Shenton, Kamonchanok Sansuk, Remko A. Bakker and Rob Leurs

  Molecular Pharmacology August 2006, 70 (2) 604-615; DOI: https://doi.org/10.1124/mol.105.020818
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  A Novel Class of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Interact with a Site Distinct from That of Negative Allosteric Modulators

  Kamondanai Hemstapat, Tomas de Paulis, Yelin Chen, Ashley E. Brady, Vandana K. Grover, David Alagille, Gilles D. Tamagnan and P. Jeffrey Conn

  Molecular Pharmacology August 2006, 70 (2) 616-626; DOI: https://doi.org/10.1124/mol.105.021857
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  Hepatocyte Nuclear Factor (HNF) 1 and HNF4 Mediate Hepatic Multidrug Resistance Protein 2 Up-Regulation during Hepatitis C Virus Gene Expression

  Ishtiaq Qadri, Mieko Iwahashi, Gerd A. Kullak-Ublick and Francis R. Simon

  Molecular Pharmacology August 2006, 70 (2) 627-636; DOI: https://doi.org/10.1124/mol.106.023499
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  Polysaccharide Purified from Ganoderma lucidum Induces Gene Expression Changes in Human Dendritic Cells and Promotes T Helper 1 Immune Response in BALB/c Mice

  Yu-Li Lin, Shiuh-Sheng Lee, Shin-Miao Hou and Bor-Luen Chiang

  Molecular Pharmacology August 2006, 70 (2) 637-644; DOI: https://doi.org/10.1124/mol.106.022327
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  The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 through a Transcriptional Mechanism

  Ning Gao, Lora Kramer, Mohamed Rahmani, Paul Dent and Steven Grant

  Molecular Pharmacology August 2006, 70 (2) 645-655; DOI: https://doi.org/10.1124/mol.106.024505
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  Differences in Kinetics of Xanomeline Binding and Selectivity of Activation of G Proteins at M₁ and M₂ Muscarinic Acetylcholine Receptors

  Jan Jakubík, Esam E. El-Fakahany and Vladimír Dolezal

  Molecular Pharmacology August 2006, 70 (2) 656-666; DOI: https://doi.org/10.1124/mol.106.023762
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  Allosteric Interactions Required for High-Affinity Binding of Dihydropyridine Antagonists to Ca_V1.1 Channels Are Modulated by Calcium in the Pore

  Blaise Z. Peterson and William A. Catterall

  Molecular Pharmacology August 2006, 70 (2) 667-675; DOI: https://doi.org/10.1124/mol.105.020644
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  Agonist-Selective Mechanisms of μ-Opioid Receptor Desensitization in Human Embryonic Kidney 293 Cells

  Elizabeth A. Johnson, Sue Oldfield, Ellen Braksator, Ana Gonzalez-Cuello, Daniel Couch, Kellie J. Hall, Stuart J. Mundell, Chris P. Bailey, Eamonn Kelly and Graeme Henderson

  Molecular Pharmacology August 2006, 70 (2) 676-685; DOI: https://doi.org/10.1124/mol.106.022376
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  Simultaneous Activation of the δ Opioid Receptor (δOR)/Sensory Neuron-Specific Receptor-4 (SNSR-4) Hetero-Oligomer by the Mixed Bivalent Agonist Bovine Adrenal Medulla Peptide 22 Activates SNSR-4 but Inhibits δOR Signaling

  Andreas Breit, Khatuna Gagnidze, Lakshmi A. Devi, Monique Lagacé and Michel Bouvier

  Molecular Pharmacology August 2006, 70 (2) 686-696; DOI: https://doi.org/10.1124/mol.106.022897
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  Validation of the Anti-Inflammatory Properties of Small-Molecule IκB Kinase (IKK)-2 Inhibitors by Comparison with Adenoviral-Mediated Delivery of Dominant-Negative IKK1 and IKK2 in Human Airways Smooth Muscle

  Matthew C. Catley, Maria B. Sukkar, K. Fan Chung, Bruce Jaffee, Sha-Mei Liao, Anthony J. Coyle, El-Bdaoui Haddad, Peter J. Barnes and Robert Newton

  Molecular Pharmacology August 2006, 70 (2) 697-705; DOI: https://doi.org/10.1124/mol.106.023150
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  Mechanisms of Cardiolipin Oxidation by Cytochrome c: Relevance to Pro- and Antiapoptotic Functions of Etoposide

  Yulia Y. Tyurina, Vidisha Kini, Vladimir A. Tyurin, Irina I. Vlasova, Jianfei Jiang, Alexander A. Kapralov, Natalia A. Belikova, Jack C. Yalowich, Igor V. Kurnikov and Valerian E. Kagan

  Molecular Pharmacology August 2006, 70 (2) 706-717; DOI: https://doi.org/10.1124/mol.106.022731
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  State-Dependent Verapamil Block of the Cloned Human Ca_v3.1 T-Type Ca²⁺ Channel

  Benjamin S. Freeze, Megan M. McNulty and Dorothy A. Hanck

  Molecular Pharmacology August 2006, 70 (2) 718-726; DOI: https://doi.org/10.1124/mol.106.023473
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  Cross-Talk between G_s- and G_q-Coupled Pathways in Regulation of Interleukin-4 by A_2B Adenosine Receptors in Human Mast Cells

  Sergey Ryzhov, Anna E. Goldstein, Italo Biaggioni and Igor Feoktistov

  Molecular Pharmacology August 2006, 70 (2) 727-735; DOI: https://doi.org/10.1124/mol.106.022780
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  Interaction Studies of Multiple Binding Sites on M₄ Muscarinic Acetylcholine Receptors

  Alfred A. Lanzafame, Patrick M. Sexton and Arthur Christopoulos

  Molecular Pharmacology August 2006, 70 (2) 736-746; DOI: https://doi.org/10.1124/mol.106.024711
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  Divergent Activities of Human Glutathione Transferases in the Bioactivation of Azathioprine

  Birgitta I. Eklund, My Moberg, Jonas Bergquist and Bengt Mannervik

  Molecular Pharmacology August 2006, 70 (2) 747-754; DOI: https://doi.org/10.1124/mol.106.025288
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  α4β2 Nicotinic Receptors with High and Low Acetylcholine Sensitivity: Pharmacology, Stoichiometry, and Sensitivity to Long-Term Exposure to Nicotine

  Mirko Moroni, Ruud Zwart, Emanuele Sher, Bruce K. Cassels and Isabel Bermudez

  Molecular Pharmacology August 2006, 70 (2) 755-768; DOI: https://doi.org/10.1124/mol.106.023044
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  Capacitative and 1-Oleyl-2-acetyl-sn-glycerol-Activated Ca²⁺ Entry Distinguished Using Adenylyl Cyclase Type 8

  Agnes C. L. Martin and Dermot M. F. Cooper

  Molecular Pharmacology August 2006, 70 (2) 769-777; DOI: https://doi.org/10.1124/mol.106.025213