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Molecular Pharmacology

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Table of Contents

August 01, 2006; Volume 70,Issue 2

Perspectives

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    OSU-03012 in the Treatment of Glioblastoma
    James A. McCubrey, Michelle M. LaHair and Richard A. Franklin
    Molecular Pharmacology August 2006, 70 (2) 437-439; DOI: https://doi.org/10.1124/mol.106.026252
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    Chromatin Remodeling: A Novel Mechanism of Psychotropic Drug Action
    Samuel S. Newton and Ronald S. Duman
    Molecular Pharmacology August 2006, 70 (2) 440-443; DOI: https://doi.org/10.1124/mol.106.027078
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    Pharmacology Meets Vesicular Trafficking at a Central Nervous System Synapse: Pregabalin Effects on Synaptic Vesicle Cycling in Hippocampal Neurons
    Ronald W. Holz
    Molecular Pharmacology August 2006, 70 (2) 444-446; DOI: https://doi.org/10.1124/mol.106.026914
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    A Tail of Two Signals: The C Terminus of the A2A-Adenosine Receptor Recruits Alternative Signaling Pathways
    Ingrid Gsandtner and Michael Freissmuth
    Molecular Pharmacology August 2006, 70 (2) 447-449; DOI: https://doi.org/10.1124/mol.106.026757

Accelerated Communication

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    Cimetidine Induces Interleukin-18 Production through H2-Agonist Activity in Monocytes
    Hideo Kohka Takahashi, Takeshi Watanabe, Akira Yokoyama, Hiromi Iwagaki, Tadashi Yoshino, Noriaki Tanaka and Masahiro Nishibori
    Molecular Pharmacology August 2006, 70 (2) 450-453; DOI: https://doi.org/10.1124/mol.106.025890

Articles

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    Rescue of p53 Blockage by the A2A Adenosine Receptor via a Novel Interacting Protein, Translin-Associated Protein X
    Chung-Nan Sun, Hsiao-Chun Cheng, Jui-ling Chou, Shen-Yang Lee, Ya-Wen Lin, Hsing-Lin Lai, Hui-Mei Chen and Yijuang Chern
    Molecular Pharmacology August 2006, 70 (2) 454-466; DOI: https://doi.org/10.1124/mol.105.021261
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    Pregabalin Reduces the Release of Synaptic Vesicles from Cultured Hippocampal Neurons
    Kristina D. Micheva, Charles P. Taylor and Stephen J Smith
    Molecular Pharmacology August 2006, 70 (2) 467-476; DOI: https://doi.org/10.1124/mol.106.023309
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    CYP2C76, a Novel Cytochrome P450 in Cynomolgus Monkey, Is a Major CYP2C in Liver, Metabolizing Tolbutamide and Testosterone
    Yasuhiro Uno, Hideki Fujino, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
    Molecular Pharmacology August 2006, 70 (2) 477-486; DOI: https://doi.org/10.1124/mol.106.022673
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    Fluoxetine and Cocaine Induce the Epigenetic Factors MeCP2 and MBD1 in Adult Rat Brain
    Suzanne Cassel, Delphine Carouge, Claire Gensburger, Patrick Anglard, Claude Burgun, Jean-Bernard Dietrich, Dominique Aunis and Jean Zwiller
    Molecular Pharmacology August 2006, 70 (2) 487-492; DOI: https://doi.org/10.1124/mol.106.022301
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    Isoliquiritigenin Selectively Inhibits H2 Histamine Receptor Signaling
    Dong-Chan Kim, Se-Young Choi, Sun-Hee Kim, Bong-Sik Yun, Ick-Dong Yoo, Nanga. Ravi Prakash Reddy, Ho Sup Yoon and Kyong-Tai Kim
    Molecular Pharmacology August 2006, 70 (2) 493-500; DOI: https://doi.org/10.1124/mol.106.023226
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    5′-O-Tritylated Nucleoside Derivatives: Inhibition of Thymidine Phosphorylase and Angiogenesis
    Sandra Liekens, Annelies Bronckaers, Ana-Isabel Hernández, Eva-María Priego, Elena Casanova, Maria-José Camarasa, Maria-Jesus Pérez-Pérez and Jan Balzarini
    Molecular Pharmacology August 2006, 70 (2) 501-509; DOI: https://doi.org/10.1124/mol.105.021188
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    Lithium Inhibits Ceramide- and Etoposide-Induced Protein Phosphatase 2A Methylation, Bcl-2 Dephosphorylation, Caspase-2 Activation, and Apoptosis
    Chia-Ling Chen, Chiou-Feng Lin, Chi-Wu Chiang, Ming-Shiou Jan and Yee-Shin Lin
    Molecular Pharmacology August 2006, 70 (2) 510-517; DOI: https://doi.org/10.1124/mol.106.024059
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    Transforming Growth Factor-β Receptor Type 1 (TGFβRI) Kinase Activity but Not p38 Activation Is Required for TGFβRI-Induced Myofibroblast Differentiation and Profibrotic Gene Expression
    Ann M. Kapoun, Nicholas J. Gaspar, Ying Wang, Debby Damm, Yu-Wang Liu, Gilbert O'Young, Diana Quon, Andrew Lam, Kimberly Munson, Thomas-Toan Tran, Jing Ying Ma, Alison Murphy, Sundeep Dugar, Sarvajit Chakravarty, Andrew A. Protter, Fu-Qiang Wen, Xiangde Liu, Stephen I. Rennard and Linda Slanec Higgins
    Molecular Pharmacology August 2006, 70 (2) 518-531; DOI: https://doi.org/10.1124/mol.105.021600
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    Mammalian Tolloid Alters Subcellular Localization, Internalization, and Signaling of α1a-Adrenergic Receptors
    Qi Xu, Ning Xu, Tan Zhang, Hui Zhang, Zijian Li, Feng Yin, Zhizhen Lu, Qide Han and Youyi Zhang
    Molecular Pharmacology August 2006, 70 (2) 532-541; DOI: https://doi.org/10.1124/mol.105.016451
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    Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine
    Kristopher M. Kahlig, Brandon J. Lute, Yuqiang Wei, Claus J. Loland, Ulrik Gether, Jonathan A. Javitch and Aurelio Galli
    Molecular Pharmacology August 2006, 70 (2) 542-548; DOI: https://doi.org/10.1124/mol.106.023952
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    Aryl Hydrocarbon Receptor Activation Produces Heart-Specific Transcriptional and Toxic Responses in Developing Zebrafish
    Sara A. Carney, Jing Chen, C. Geoffrey Burns, Kong M. Xiong, Richard E. Peterson and Warren Heideman
    Molecular Pharmacology August 2006, 70 (2) 549-561; DOI: https://doi.org/10.1124/mol.106.025304
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    Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor
    Liwei Chen, Shen-Shu Sung, M. L. Richard Yip, Harshani R. Lawrence, Yuan Ren, Wayne C. Guida, Said M. Sebti, Nicholas J. Lawrence and Jie Wu
    Molecular Pharmacology August 2006, 70 (2) 562-570; DOI: https://doi.org/10.1124/mol.106.025536
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    Mapping Residues in the Ligand-Binding Domain of the 5-HT3 Receptor onto d-Tubocurarine Structure
    Dong Yan, Julia K. Meyer and Michael M. White
    Molecular Pharmacology August 2006, 70 (2) 571-578; DOI: https://doi.org/10.1124/mol.106.024075
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    Tamoxifen and Raloxifene Differ in Their Functional Interactions with Aspartate 351 of Estrogen Receptor α
    Guila Dayan, Mathieu Lupien, Anick Auger, Silvia I. Anghel, Walter Rocha, Sébastien Croisetière, John A. Katzenellenbogen and Sylvie Mader
    Molecular Pharmacology August 2006, 70 (2) 579-588; DOI: https://doi.org/10.1124/mol.105.021931
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    OSU-03012 Promotes Caspase-Independent but PERK-, Cathepsin B-, BID-, and AIF-Dependent Killing of Transformed Cells
    Adly Yacoub, Margaret A. Park, David Hanna, Young Hong, Clint Mitchell, Aditi P. Pandya, Hisashi Harada, Garth Powis, Ching-Shih Chen, Costas Koumenis, Steven Grant and Paul Dent
    Molecular Pharmacology August 2006, 70 (2) 589-603; DOI: https://doi.org/10.1124/mol.106.025007
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    Oligomerization of Recombinant and Endogenously Expressed Human Histamine H4 Receptors
    Richard M. van Rijn, Paul L. Chazot, Fiona C. Shenton, Kamonchanok Sansuk, Remko A. Bakker and Rob Leurs
    Molecular Pharmacology August 2006, 70 (2) 604-615; DOI: https://doi.org/10.1124/mol.105.020818
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    A Novel Class of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 1 Interact with a Site Distinct from That of Negative Allosteric Modulators
    Kamondanai Hemstapat, Tomas de Paulis, Yelin Chen, Ashley E. Brady, Vandana K. Grover, David Alagille, Gilles D. Tamagnan and P. Jeffrey Conn
    Molecular Pharmacology August 2006, 70 (2) 616-626; DOI: https://doi.org/10.1124/mol.105.021857
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    Hepatocyte Nuclear Factor (HNF) 1 and HNF4 Mediate Hepatic Multidrug Resistance Protein 2 Up-Regulation during Hepatitis C Virus Gene Expression
    Ishtiaq Qadri, Mieko Iwahashi, Gerd A. Kullak-Ublick and Francis R. Simon
    Molecular Pharmacology August 2006, 70 (2) 627-636; DOI: https://doi.org/10.1124/mol.106.023499
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    Polysaccharide Purified from Ganoderma lucidum Induces Gene Expression Changes in Human Dendritic Cells and Promotes T Helper 1 Immune Response in BALB/c Mice
    Yu-Li Lin, Shiuh-Sheng Lee, Shin-Miao Hou and Bor-Luen Chiang
    Molecular Pharmacology August 2006, 70 (2) 637-644; DOI: https://doi.org/10.1124/mol.106.022327
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    The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 through a Transcriptional Mechanism
    Ning Gao, Lora Kramer, Mohamed Rahmani, Paul Dent and Steven Grant
    Molecular Pharmacology August 2006, 70 (2) 645-655; DOI: https://doi.org/10.1124/mol.106.024505
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    Differences in Kinetics of Xanomeline Binding and Selectivity of Activation of G Proteins at M1 and M2 Muscarinic Acetylcholine Receptors
    Jan Jakubík, Esam E. El-Fakahany and Vladimír Dolezal
    Molecular Pharmacology August 2006, 70 (2) 656-666; DOI: https://doi.org/10.1124/mol.106.023762
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    Allosteric Interactions Required for High-Affinity Binding of Dihydropyridine Antagonists to CaV1.1 Channels Are Modulated by Calcium in the Pore
    Blaise Z. Peterson and William A. Catterall
    Molecular Pharmacology August 2006, 70 (2) 667-675; DOI: https://doi.org/10.1124/mol.105.020644
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    Agonist-Selective Mechanisms of μ-Opioid Receptor Desensitization in Human Embryonic Kidney 293 Cells
    Elizabeth A. Johnson, Sue Oldfield, Ellen Braksator, Ana Gonzalez-Cuello, Daniel Couch, Kellie J. Hall, Stuart J. Mundell, Chris P. Bailey, Eamonn Kelly and Graeme Henderson
    Molecular Pharmacology August 2006, 70 (2) 676-685; DOI: https://doi.org/10.1124/mol.106.022376
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    Simultaneous Activation of the δ Opioid Receptor (δOR)/Sensory Neuron-Specific Receptor-4 (SNSR-4) Hetero-Oligomer by the Mixed Bivalent Agonist Bovine Adrenal Medulla Peptide 22 Activates SNSR-4 but Inhibits δOR Signaling
    Andreas Breit, Khatuna Gagnidze, Lakshmi A. Devi, Monique Lagacé and Michel Bouvier
    Molecular Pharmacology August 2006, 70 (2) 686-696; DOI: https://doi.org/10.1124/mol.106.022897
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    Validation of the Anti-Inflammatory Properties of Small-Molecule IκB Kinase (IKK)-2 Inhibitors by Comparison with Adenoviral-Mediated Delivery of Dominant-Negative IKK1 and IKK2 in Human Airways Smooth Muscle
    Matthew C. Catley, Maria B. Sukkar, K. Fan Chung, Bruce Jaffee, Sha-Mei Liao, Anthony J. Coyle, El-Bdaoui Haddad, Peter J. Barnes and Robert Newton
    Molecular Pharmacology August 2006, 70 (2) 697-705; DOI: https://doi.org/10.1124/mol.106.023150
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    Mechanisms of Cardiolipin Oxidation by Cytochrome c: Relevance to Pro- and Antiapoptotic Functions of Etoposide
    Yulia Y. Tyurina, Vidisha Kini, Vladimir A. Tyurin, Irina I. Vlasova, Jianfei Jiang, Alexander A. Kapralov, Natalia A. Belikova, Jack C. Yalowich, Igor V. Kurnikov and Valerian E. Kagan
    Molecular Pharmacology August 2006, 70 (2) 706-717; DOI: https://doi.org/10.1124/mol.106.022731
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    State-Dependent Verapamil Block of the Cloned Human Cav3.1 T-Type Ca2+ Channel
    Benjamin S. Freeze, Megan M. McNulty and Dorothy A. Hanck
    Molecular Pharmacology August 2006, 70 (2) 718-726; DOI: https://doi.org/10.1124/mol.106.023473
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    Cross-Talk between Gs- and Gq-Coupled Pathways in Regulation of Interleukin-4 by A2B Adenosine Receptors in Human Mast Cells
    Sergey Ryzhov, Anna E. Goldstein, Italo Biaggioni and Igor Feoktistov
    Molecular Pharmacology August 2006, 70 (2) 727-735; DOI: https://doi.org/10.1124/mol.106.022780
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    Interaction Studies of Multiple Binding Sites on M4 Muscarinic Acetylcholine Receptors
    Alfred A. Lanzafame, Patrick M. Sexton and Arthur Christopoulos
    Molecular Pharmacology August 2006, 70 (2) 736-746; DOI: https://doi.org/10.1124/mol.106.024711
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    Divergent Activities of Human Glutathione Transferases in the Bioactivation of Azathioprine
    Birgitta I. Eklund, My Moberg, Jonas Bergquist and Bengt Mannervik
    Molecular Pharmacology August 2006, 70 (2) 747-754; DOI: https://doi.org/10.1124/mol.106.025288
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    α4β2 Nicotinic Receptors with High and Low Acetylcholine Sensitivity: Pharmacology, Stoichiometry, and Sensitivity to Long-Term Exposure to Nicotine
    Mirko Moroni, Ruud Zwart, Emanuele Sher, Bruce K. Cassels and Isabel Bermudez
    Molecular Pharmacology August 2006, 70 (2) 755-768; DOI: https://doi.org/10.1124/mol.106.023044
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    Capacitative and 1-Oleyl-2-acetyl-sn-glycerol-Activated Ca2+ Entry Distinguished Using Adenylyl Cyclase Type 8
    Agnes C. L. Martin and Dermot M. F. Cooper
    Molecular Pharmacology August 2006, 70 (2) 769-777; DOI: https://doi.org/10.1124/mol.106.025213
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In this issue

Molecular Pharmacology: 70 (2)
Molecular Pharmacology
Vol. 70, Issue 2
1 Aug 2006
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
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  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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