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The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 through a Transcriptional Mechanism

Ning Gao, Lora Kramer, Mohamed Rahmani, Paul Dent and Steven Grant
Molecular Pharmacology August 2006, 70 (2) 645-655; DOI: https://doi.org/10.1124/mol.106.024505

Article Information

vol. 70 no. 2 645-655
DOI 
https://doi.org/10.1124/mol.106.024505
PubMed 
16672643
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 16, 2006
  • Accepted May 3, 2006
  • Published online July 18, 2006.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ning Gao,
  2. Lora Kramer,
  3. Mohamed Rahmani,
  4. Paul Dent and
  5. Steven Grant
  1. Departments of Medicine (N.G., L.K., M.R., S.G.), Biochemistry (S.G., P.D.), and Pharmacology, Virginia Commonwealth University and Massey Cancer Center, Richmond, Virginia (S.G.)
  1. Address correspondence to:
    Dr. Steven Grant, Division of Hematology/Oncology, MCV Station Box 230, Virginia Commonwealth University/Medical College of Virginia, Richmond, VA 23298. E-mail: stgrant{at}hsc.vcu.edu
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The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 through a Transcriptional Mechanism

Ning Gao, Lora Kramer, Mohamed Rahmani, Paul Dent and Steven Grant
Molecular Pharmacology August 1, 2006, 70 (2) 645-655; DOI: https://doi.org/10.1124/mol.106.024505
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