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Molecular Pharmacology

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Table of Contents

September 01, 2006; Volume 70,Issue 3

MINIREVIEW

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    Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes
    Paul F. Pilch and Nils Bergenhem
    Molecular Pharmacology September 2006, 70 (3) 779-785; DOI: https://doi.org/10.1124/mol.106.026104

Accelerated Communications

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    Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling
    Joseph Tam, Orr Ofek, Ester Fride, Catherine Ledent, Yankel Gabet, Ralph Müller, Andreas Zimmer, Ken Mackie, Raphael Mechoulam, Esther Shohami and Itai Bab
    Molecular Pharmacology September 2006, 70 (3) 786-792; DOI: https://doi.org/10.1124/mol.106.026435
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    Negative Regulation of Superoxide Dismutase-1 Promoter by Thyroid Hormone
    Guilherme M. Santos, Valéry Afonso, Gustavo B. Barra, Marie Togashi, Paul Webb, Francisco A. R. Neves, Noureddine Lomri and Abderrahim Lomri
    Molecular Pharmacology September 2006, 70 (3) 793-800; DOI: https://doi.org/10.1124/mol.106.025627
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    Varenicline Is a Partial Agonist at α4β2 and a Full Agonist at α7 Neuronal Nicotinic Receptors
    Karla B. Mihalak, F. Ivy Carroll and Charles W. Luetje
    Molecular Pharmacology September 2006, 70 (3) 801-805; DOI: https://doi.org/10.1124/mol.106.025130

Articles

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    Functional Analysis of the Extracellular Cysteine Residues in the Human Organic Anion Transporting Polypeptide, OATP2B1
    Emanuel Hänggi, Anne Freimoser Grundschober, Simone Leuthold, Peter J. Meier and Marie V. St-Pierre
    Molecular Pharmacology September 2006, 70 (3) 806-817; DOI: https://doi.org/10.1124/mol.105.019547
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    Target Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (t-SNAREs) Differently Regulate Activation and Inactivation Gating of Kv2.2 and Kv2.1: Implications on Pancreatic Islet Cell Kv Channels
    Tami Wolf-Goldberg, Izhak Michaelevski, Laura Sheu, Herbert Y. Gaisano, Dodo Chikvashvili and Ilana Lotan
    Molecular Pharmacology September 2006, 70 (3) 818-828; DOI: https://doi.org/10.1124/mol.105.021717
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    Organic Cation/Carnitine Transporter OCTN2 (Slc22a5) Is Responsible for Carnitine Transport across Apical Membranes of Small Intestinal Epithelial Cells in Mouse
    Yukio Kato, Mikihiro Sugiura, Tomoko Sugiura, Tomohiko Wakayama, Yoshiyuki Kubo, Daisuke Kobayashi, Yoshimichi Sai, Ikumi Tamai, Shoichi Iseki and Akira Tsuji
    Molecular Pharmacology September 2006, 70 (3) 829-837; DOI: https://doi.org/10.1124/mol.106.024158
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    Mutagenesis within Helix 6 of the Human β1-Adrenergic Receptor Identifies Lysine324 as a Residue Involved in Imparting the High-Affinity Binding State of Agonists
    Omeima Zeitoun, Noel M. Delos Santos, Lidia A. Gardner, Stephen W. White and Suleiman W. Bahouth
    Molecular Pharmacology September 2006, 70 (3) 838-850; DOI: https://doi.org/10.1124/mol.106.025346
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    Purine Release from Spinal Cord Microglia after Elevation of Calcium by Glutamate
    Guo Jun Liu, Adrianna Kalous, Eryn L. Werry and Max R. Bennett
    Molecular Pharmacology September 2006, 70 (3) 851-859; DOI: https://doi.org/10.1124/mol.105.021436
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    Phospholipase C-β3 and -β1 Form Homodimers, but Not Heterodimers, through Catalytic and Carboxyl-Terminal Domains
    Yong Zhang, Walter K. Vogel, Jennifer S. McCullar, Jeffrey A. Greenwood and Theresa M. Filtz
    Molecular Pharmacology September 2006, 70 (3) 860-868; DOI: https://doi.org/10.1124/mol.105.021923
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    Genistein Inhibits Matrix Metalloproteinase Type 2 Activation and Prostate Cancer Cell Invasion by Blocking the Transforming Growth Factor β-Mediated Activation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2-27-kDa Heat Shock Protein Pathway
    Li Xu and Raymond C. Bergan
    Molecular Pharmacology September 2006, 70 (3) 869-877; DOI: https://doi.org/10.1124/mol.106.023861
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    Broad Specificity of Mammalian Adenylyl Cyclase for Interaction with 2′,3′-Substituted Purine- and Pyrimidine Nucleotide Inhibitors
    Tung-Chung Mou, Andreas Gille, Srividya Suryanarayana, Mark Richter, Roland Seifert and Stephen R. Sprang
    Molecular Pharmacology September 2006, 70 (3) 878-886; DOI: https://doi.org/10.1124/mol.106.026427
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    Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1α/β and DNA Methylation
    Ryota Kikuchi, Hiroyuki Kusuhara, Naka Hattori, Kunio Shiota, Insook Kim, Frank J. Gonzalez and Yuichi Sugiyama
    Molecular Pharmacology September 2006, 70 (3) 887-896; DOI: https://doi.org/10.1124/mol.106.025494
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    Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22phox and Nox4 Expression
    Robert J. McKallip, Wentao Jia, Jerome Schlomer, James W. Warren, Prakash S. Nagarkatti and Mitzi Nagarkatti
    Molecular Pharmacology September 2006, 70 (3) 897-908; DOI: https://doi.org/10.1124/mol.106.023937
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    Antitumor Activity of the Retinoid-Related Molecules (E)-3-(4′-Hydroxy-3′-adamantylbiphenyl-4-yl)acrylic Acid (ST1926) and 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) in F9 Teratocarcinoma: Role of Retinoic Acid Receptor γ and Retinoid-Independent Pathways
    Edoardo Parrella, Maurizio Giannì, Maddalena Fratelli, Maria Monica Barzago, Ivan Raska, Luisa Diomede, Mami Kurosaki, Claudio Pisano, Paolo Carminati, Lucio Merlini, Sabrina Dallavalle, Michele Tavecchio, Cecile Rochette-Egly, Mineko Terao and Enrico Garattini
    Molecular Pharmacology September 2006, 70 (3) 909-924; DOI: https://doi.org/10.1124/mol.106.023614
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    A Molecular Mechanism of Pyruvate Protection against Cytotoxicity of Reactive Oxygen Species in Osteoblasts
    Eiichi Hinoi, Takeshi Takarada, Yuriko Tsuchihashi, Sayumi Fujimori, Nobuaki Moriguchi, Liyang Wang, Kyosuke Uno and Yukio Yoneda
    Molecular Pharmacology September 2006, 70 (3) 925-935; DOI: https://doi.org/10.1124/mol.106.024398
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    Ghrelin Receptor Inverse Agonists: Identification of an Active Peptide Core and Its Interaction Epitopes on the Receptor
    Birgitte Holst, Manja Lang, Erik Brandt, Anders Bach, Andrew Howard, Thomas M. Frimurer, Annette Beck-Sickinger and Thue W. Schwartz
    Molecular Pharmacology September 2006, 70 (3) 936-946; DOI: https://doi.org/10.1124/mol.106.024422
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    Deletion of the α7, β2, or β4 Nicotinic Receptor Subunit Genes Identifies Highly Expressed Subtypes with Relatively Low Affinity for [3H]Epibatidine
    Michael J. Marks, Paul Whiteaker and Allan C. Collins
    Molecular Pharmacology September 2006, 70 (3) 947-959; DOI: https://doi.org/10.1124/mol.106.025338
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    Hexachlorophene Inhibits Wnt/β-Catenin Pathway by Promoting Siah-Mediated β-Catenin Degradation
    Seoyoung Park, Jungsug Gwak, Munju Cho, Taeyun Song, Jaejoon Won, Dong-Eun Kim, Jae-Gook Shin and Sangtaek Oh
    Molecular Pharmacology September 2006, 70 (3) 960-966; DOI: https://doi.org/10.1124/mol.106.024729
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    Characterization of Nicotinic Acetylcholine Receptors That Modulate Nicotine-Evoked [3H]Norepinephrine Release from Mouse Hippocampal Synaptosomes
    Layla Azam and J. Michael McIntosh
    Molecular Pharmacology September 2006, 70 (3) 967-976; DOI: https://doi.org/10.1124/mol.106.024513
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    Inhibition of Proinflammatory Tumor Necrosis Factor-α-Induced Inducible Nitric-Oxide Synthase by Xanthine-Based 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-Nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in Rat Trachea: The Involvement of Soluble Guanylate Cyclase and Protein Kinase G
    Bin-Nan Wu, Chien-Wen Chen, Shu-Fen Liou, Jwu-Lai Yeh, Hui-Hsuan Chung and Ing-Jun Chen
    Molecular Pharmacology September 2006, 70 (3) 977-985; DOI: https://doi.org/10.1124/mol.106.024919
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    Prolonged Recovery Rate of CB1 Receptor Adaptation after Cessation of Long-Term Cannabinoid Administration
    Laura J. Sim-Selley, Nicole S. Schechter, W. Kirk Rorrer, George D. Dalton, Jerry Hernandez, Billy R. Martin and Dana E. Selley
    Molecular Pharmacology September 2006, 70 (3) 986-996; DOI: https://doi.org/10.1124/mol.105.019612
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    Penta-Acetyl Geniposide Induce Apoptosis in C6 Glioma Cells by Modulating the Activation of Neutral Sphingomyelinase-Induced p75 Nerve Growth Factor Receptor and Protein Kinase Cδ Pathway
    Chiung-Huei Peng, Chien-Ning Huang, Shu-Ping Hsu and Chau-Jong Wang
    Molecular Pharmacology September 2006, 70 (3) 997-1004; DOI: https://doi.org/10.1124/mol.106.022178
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    Functional Mapping of the Transient Receptor Potential Vanilloid 1 Intracellular Binding Site
    Daniel M. Johnson, Elizabeth M. Garrett, Richard Rutter, Timothy P. Bonnert, Ying-Duo Gao, Richard E. Middleton and Kathy G. Sutton
    Molecular Pharmacology September 2006, 70 (3) 1005-1012; DOI: https://doi.org/10.1124/mol.106.023945
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    Regional Differences in the Coupling of 5-Hydroxytryptamine-1A Receptors to G Proteins in the Rat Brain
    Clotilde Mannoury la Cour, Salah El Mestikawy, Naïma Hanoun, Michel Hamon and Laurence Lanfumey
    Molecular Pharmacology September 2006, 70 (3) 1013-1021; DOI: https://doi.org/10.1124/mol.106.022756
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    Equilibrium Constants for (R)-[(S)-1-(4-Bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic Acid (NVP-AAM077) Acting at Recombinant NR1/NR2A and NR1/NR2B N-Methyl-d-aspartate Receptors: Implications for Studies of Synaptic Transmission
    Pamela A. Frizelle, Philip E. Chen and David J. A. Wyllie
    Molecular Pharmacology September 2006, 70 (3) 1022-1032; DOI: https://doi.org/10.1124/mol.106.024042
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    Apigenin Inhibits Immunostimulatory Function of Dendritic Cells: Implication of Immunotherapeutic Adjuvant
    Man-Soo Yoon, Jun Sik Lee, Byoung-Moon Choi, Young-Il Jeong, Chang-Min Lee, Jong-Hoon Park, Yuseok Moon, Si-Chan Sung, Sang Kwon Lee, Yun Hee Chang, Hae Young Chung and Yeong-Min Park
    Molecular Pharmacology September 2006, 70 (3) 1033-1044; DOI: https://doi.org/10.1124/mol.106.024547
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    Differential Roles of Phosphoinositide-Dependent Protein Kinase-1 and Akt1 Expression and Phosphorylation in Breast Cancer Cell Resistance to Paclitaxel, Doxorubicin, and Gemcitabine
    Ke Liang, Yang Lu, Xinqun Li, Xiao Zeng, Robert I. Glazer, Gordon B. Mills and Zhen Fan
    Molecular Pharmacology September 2006, 70 (3) 1045-1052; DOI: https://doi.org/10.1124/mol.106.023333
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    Mitochondrial NADP+-Dependent Isocitrate Dehydrogenase Protects Cadmium-Induced Apoptosis
    In Sup Kil, Seoung Woo Shin, Hyun Seok Yeo, Young Sup Lee and Jeen-Woo Park
    Molecular Pharmacology September 2006, 70 (3) 1053-1061; DOI: https://doi.org/10.1124/mol.106.023515
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    Regulation of the CYP1A1 Gene by 2,3,7,8-Tetrachlorodibenzo-p-dioxin but Not by β-Naphthoflavone or 3-Methylcholanthrene Is Altered in Hepatitis C Virus Replicon-Expressing Cells
    Garret R. Anderson, Aliya Hasan, Hao Yin, Ishtiaq Qadri and Linda C. Quattrochi
    Molecular Pharmacology September 2006, 70 (3) 1062-1070; DOI: https://doi.org/10.1124/mol.106.024125
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    Boswellic Acids Stimulate Arachidonic Acid Release and 12-Lipoxygenase Activity in Human Platelets Independent of Ca2+ and Differentially Interact with Platelet-Type 12-Lipoxygenase
    Daniel Poeckel, Lars Tausch, Nicole Kather, Johann Jauch and Oliver Werz
    Molecular Pharmacology September 2006, 70 (3) 1071-1078; DOI: https://doi.org/10.1124/mol.106.024836
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    A Potential Role for Cyclized Quinones Derived from Dopamine, DOPA, and 3,4-Dihydroxyphenylacetic Acid in Proteasomal Inhibition
    Khan Shoeb Zafar, David Siegel and David Ross
    Molecular Pharmacology September 2006, 70 (3) 1079-1086; DOI: https://doi.org/10.1124/mol.106.024703
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    HIV-1 Viral Envelope Glycoprotein gp120 Triggers an Inflammatory Response in Cultured Rat Astrocytes and Regulates the Functional Expression of P-Glycoprotein
    Patrick T. Ronaldson and Reina Bendayan
    Molecular Pharmacology September 2006, 70 (3) 1087-1098; DOI: https://doi.org/10.1124/mol.106.025973
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    Phorbol 12-Myristate 13-Acetate Protects against Tumor Necrosis Factor (TNF)-Induced Necrotic Cell Death by Modulating the Recruitment of TNF Receptor 1-Associated Death Domain and Receptor-Interacting Protein into the TNF Receptor 1 Signaling Complex: Implication for the Regulatory Role of Protein Kinase C
    Hee Sun Byun, Kyeong Ah Park, Minho Won, Keum-Jin Yang, Sanghee Shin, Longzhen Piao, Jin Young Kwak, Zee-Won Lee, Jongsun Park, Jeong Ho Seok, Zheng-Gang Liu and Gang Min Hur
    Molecular Pharmacology September 2006, 70 (3) 1099-1108; DOI: https://doi.org/10.1124/mol.106.025452
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    Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
    Smitha Antony, Keli K. Agama, Ze-Hong Miao, Melinda Hollingshead, Susan L. Holbeck, Mollie H. Wright, Lyuba Varticovski, Muthukaman Nagarajan, Andrew Morrell, Mark Cushman and Yves Pommier
    Molecular Pharmacology September 2006, 70 (3) 1109-1120; DOI: https://doi.org/10.1124/mol.106.024372
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    Comparison of Polyethylene Glycol-Conjugated Recombinant Human Acetylcholinesterase and Serum Human Butyrylcholinesterase as Bioscavengers of Organophosphate Compounds
    Ofer Cohen, Chanoch Kronman, Lily Raveh, Ohad Mazor, Arie Ordentlich and Avigdor Shafferman
    Molecular Pharmacology September 2006, 70 (3) 1121-1131; DOI: https://doi.org/10.1124/mol.106.026179
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    Distinct Roles for Protein Kinase C Isoforms in Regulating Platelet Purinergic Receptor Function
    Stuart J. Mundell, Matthew L. Jones, Adam R. Hardy, Johanna F. Barton, Stephanie M. Beaucourt, Pamela B. Conley and Alastair W. Poole
    Molecular Pharmacology September 2006, 70 (3) 1132-1142; DOI: https://doi.org/10.1124/mol.106.023549
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    A Naphthoquinone Derivative, Shikonin, Has Insulin-Like Actions by Inhibiting Both Phosphatase and Tensin Homolog Deleted on Chromosome 10 and Tyrosine Phosphatases
    Kiyomi Nigorikawa, Kyoko Yoshikawa, Tomo Sasaki, Eiji Iida, Mariko Tsukamoto, Hitomi Murakami, Tomohiko Maehama, Kaoru Hazeki and Osamu Hazeki
    Molecular Pharmacology September 2006, 70 (3) 1143-1149; DOI: https://doi.org/10.1124/mol.106.025809
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Molecular Pharmacology: 70 (3)
Molecular Pharmacology
Vol. 70, Issue 3
1 Sep 2006
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  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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