Table of Contents

Articles

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  Functional Analysis of the Extracellular Cysteine Residues in the Human Organic Anion Transporting Polypeptide, OATP2B1

  Emanuel Hänggi, Anne Freimoser Grundschober, Simone Leuthold, Peter J. Meier and Marie V. St-Pierre

  Molecular Pharmacology September 2006, 70 (3) 806-817; DOI: https://doi.org/10.1124/mol.105.019547
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  Target Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (t-SNAREs) Differently Regulate Activation and Inactivation Gating of Kv2.2 and Kv2.1: Implications on Pancreatic Islet Cell Kv Channels

  Tami Wolf-Goldberg, Izhak Michaelevski, Laura Sheu, Herbert Y. Gaisano, Dodo Chikvashvili and Ilana Lotan

  Molecular Pharmacology September 2006, 70 (3) 818-828; DOI: https://doi.org/10.1124/mol.105.021717
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  Organic Cation/Carnitine Transporter OCTN2 (Slc22a5) Is Responsible for Carnitine Transport across Apical Membranes of Small Intestinal Epithelial Cells in Mouse

  Yukio Kato, Mikihiro Sugiura, Tomoko Sugiura, Tomohiko Wakayama, Yoshiyuki Kubo, Daisuke Kobayashi, Yoshimichi Sai, Ikumi Tamai, Shoichi Iseki and Akira Tsuji

  Molecular Pharmacology September 2006, 70 (3) 829-837; DOI: https://doi.org/10.1124/mol.106.024158
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  Mutagenesis within Helix 6 of the Human β₁-Adrenergic Receptor Identifies Lysine³²⁴ as a Residue Involved in Imparting the High-Affinity Binding State of Agonists

  Omeima Zeitoun, Noel M. Delos Santos, Lidia A. Gardner, Stephen W. White and Suleiman W. Bahouth

  Molecular Pharmacology September 2006, 70 (3) 838-850; DOI: https://doi.org/10.1124/mol.106.025346
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  Purine Release from Spinal Cord Microglia after Elevation of Calcium by Glutamate

  Guo Jun Liu, Adrianna Kalous, Eryn L. Werry and Max R. Bennett

  Molecular Pharmacology September 2006, 70 (3) 851-859; DOI: https://doi.org/10.1124/mol.105.021436
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  Phospholipase C-β3 and -β1 Form Homodimers, but Not Heterodimers, through Catalytic and Carboxyl-Terminal Domains

  Yong Zhang, Walter K. Vogel, Jennifer S. McCullar, Jeffrey A. Greenwood and Theresa M. Filtz

  Molecular Pharmacology September 2006, 70 (3) 860-868; DOI: https://doi.org/10.1124/mol.105.021923
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  Genistein Inhibits Matrix Metalloproteinase Type 2 Activation and Prostate Cancer Cell Invasion by Blocking the Transforming Growth Factor β-Mediated Activation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2-27-kDa Heat Shock Protein Pathway

  Li Xu and Raymond C. Bergan

  Molecular Pharmacology September 2006, 70 (3) 869-877; DOI: https://doi.org/10.1124/mol.106.023861
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  Broad Specificity of Mammalian Adenylyl Cyclase for Interaction with 2′,3′-Substituted Purine- and Pyrimidine Nucleotide Inhibitors

  Tung-Chung Mou, Andreas Gille, Srividya Suryanarayana, Mark Richter, Roland Seifert and Stephen R. Sprang

  Molecular Pharmacology September 2006, 70 (3) 878-886; DOI: https://doi.org/10.1124/mol.106.026427
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  Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1α/β and DNA Methylation

  Ryota Kikuchi, Hiroyuki Kusuhara, Naka Hattori, Kunio Shiota, Insook Kim, Frank J. Gonzalez and Yuichi Sugiyama

  Molecular Pharmacology September 2006, 70 (3) 887-896; DOI: https://doi.org/10.1124/mol.106.025494
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  Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22^phox and Nox4 Expression

  Robert J. McKallip, Wentao Jia, Jerome Schlomer, James W. Warren, Prakash S. Nagarkatti and Mitzi Nagarkatti

  Molecular Pharmacology September 2006, 70 (3) 897-908; DOI: https://doi.org/10.1124/mol.106.023937
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  Antitumor Activity of the Retinoid-Related Molecules (E)-3-(4′-Hydroxy-3′-adamantylbiphenyl-4-yl)acrylic Acid (ST1926) and 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) in F9 Teratocarcinoma: Role of Retinoic Acid Receptor γ and Retinoid-Independent Pathways

  Edoardo Parrella, Maurizio Giannì, Maddalena Fratelli, Maria Monica Barzago, Ivan Raska, Luisa Diomede, Mami Kurosaki, Claudio Pisano, Paolo Carminati, Lucio Merlini, Sabrina Dallavalle, Michele Tavecchio, Cecile Rochette-Egly, Mineko Terao and Enrico Garattini

  Molecular Pharmacology September 2006, 70 (3) 909-924; DOI: https://doi.org/10.1124/mol.106.023614
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  A Molecular Mechanism of Pyruvate Protection against Cytotoxicity of Reactive Oxygen Species in Osteoblasts

  Eiichi Hinoi, Takeshi Takarada, Yuriko Tsuchihashi, Sayumi Fujimori, Nobuaki Moriguchi, Liyang Wang, Kyosuke Uno and Yukio Yoneda

  Molecular Pharmacology September 2006, 70 (3) 925-935; DOI: https://doi.org/10.1124/mol.106.024398
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  Ghrelin Receptor Inverse Agonists: Identification of an Active Peptide Core and Its Interaction Epitopes on the Receptor

  Birgitte Holst, Manja Lang, Erik Brandt, Anders Bach, Andrew Howard, Thomas M. Frimurer, Annette Beck-Sickinger and Thue W. Schwartz

  Molecular Pharmacology September 2006, 70 (3) 936-946; DOI: https://doi.org/10.1124/mol.106.024422
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  Deletion of the α7, β2, or β4 Nicotinic Receptor Subunit Genes Identifies Highly Expressed Subtypes with Relatively Low Affinity for [³H]Epibatidine

  Michael J. Marks, Paul Whiteaker and Allan C. Collins

  Molecular Pharmacology September 2006, 70 (3) 947-959; DOI: https://doi.org/10.1124/mol.106.025338
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  Hexachlorophene Inhibits Wnt/β-Catenin Pathway by Promoting Siah-Mediated β-Catenin Degradation

  Seoyoung Park, Jungsug Gwak, Munju Cho, Taeyun Song, Jaejoon Won, Dong-Eun Kim, Jae-Gook Shin and Sangtaek Oh

  Molecular Pharmacology September 2006, 70 (3) 960-966; DOI: https://doi.org/10.1124/mol.106.024729
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  Characterization of Nicotinic Acetylcholine Receptors That Modulate Nicotine-Evoked [³H]Norepinephrine Release from Mouse Hippocampal Synaptosomes

  Layla Azam and J. Michael McIntosh

  Molecular Pharmacology September 2006, 70 (3) 967-976; DOI: https://doi.org/10.1124/mol.106.024513
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  Inhibition of Proinflammatory Tumor Necrosis Factor-α-Induced Inducible Nitric-Oxide Synthase by Xanthine-Based 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-Nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in Rat Trachea: The Involvement of Soluble Guanylate Cyclase and Protein Kinase G

  Bin-Nan Wu, Chien-Wen Chen, Shu-Fen Liou, Jwu-Lai Yeh, Hui-Hsuan Chung and Ing-Jun Chen

  Molecular Pharmacology September 2006, 70 (3) 977-985; DOI: https://doi.org/10.1124/mol.106.024919
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  Prolonged Recovery Rate of CB₁ Receptor Adaptation after Cessation of Long-Term Cannabinoid Administration

  Laura J. Sim-Selley, Nicole S. Schechter, W. Kirk Rorrer, George D. Dalton, Jerry Hernandez, Billy R. Martin and Dana E. Selley

  Molecular Pharmacology September 2006, 70 (3) 986-996; DOI: https://doi.org/10.1124/mol.105.019612
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  Penta-Acetyl Geniposide Induce Apoptosis in C6 Glioma Cells by Modulating the Activation of Neutral Sphingomyelinase-Induced p75 Nerve Growth Factor Receptor and Protein Kinase Cδ Pathway

  Chiung-Huei Peng, Chien-Ning Huang, Shu-Ping Hsu and Chau-Jong Wang

  Molecular Pharmacology September 2006, 70 (3) 997-1004; DOI: https://doi.org/10.1124/mol.106.022178
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  Functional Mapping of the Transient Receptor Potential Vanilloid 1 Intracellular Binding Site

  Daniel M. Johnson, Elizabeth M. Garrett, Richard Rutter, Timothy P. Bonnert, Ying-Duo Gao, Richard E. Middleton and Kathy G. Sutton

  Molecular Pharmacology September 2006, 70 (3) 1005-1012; DOI: https://doi.org/10.1124/mol.106.023945
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  Regional Differences in the Coupling of 5-Hydroxytryptamine-1A Receptors to G Proteins in the Rat Brain

  Clotilde Mannoury la Cour, Salah El Mestikawy, Naïma Hanoun, Michel Hamon and Laurence Lanfumey

  Molecular Pharmacology September 2006, 70 (3) 1013-1021; DOI: https://doi.org/10.1124/mol.106.022756
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  Equilibrium Constants for (R)-[(S)-1-(4-Bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic Acid (NVP-AAM077) Acting at Recombinant NR1/NR2A and NR1/NR2B N-Methyl-d-aspartate Receptors: Implications for Studies of Synaptic Transmission

  Pamela A. Frizelle, Philip E. Chen and David J. A. Wyllie

  Molecular Pharmacology September 2006, 70 (3) 1022-1032; DOI: https://doi.org/10.1124/mol.106.024042
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  Apigenin Inhibits Immunostimulatory Function of Dendritic Cells: Implication of Immunotherapeutic Adjuvant

  Man-Soo Yoon, Jun Sik Lee, Byoung-Moon Choi, Young-Il Jeong, Chang-Min Lee, Jong-Hoon Park, Yuseok Moon, Si-Chan Sung, Sang Kwon Lee, Yun Hee Chang, Hae Young Chung and Yeong-Min Park

  Molecular Pharmacology September 2006, 70 (3) 1033-1044; DOI: https://doi.org/10.1124/mol.106.024547
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  Differential Roles of Phosphoinositide-Dependent Protein Kinase-1 and Akt1 Expression and Phosphorylation in Breast Cancer Cell Resistance to Paclitaxel, Doxorubicin, and Gemcitabine

  Ke Liang, Yang Lu, Xinqun Li, Xiao Zeng, Robert I. Glazer, Gordon B. Mills and Zhen Fan

  Molecular Pharmacology September 2006, 70 (3) 1045-1052; DOI: https://doi.org/10.1124/mol.106.023333
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  Mitochondrial NADP⁺-Dependent Isocitrate Dehydrogenase Protects Cadmium-Induced Apoptosis

  In Sup Kil, Seoung Woo Shin, Hyun Seok Yeo, Young Sup Lee and Jeen-Woo Park

  Molecular Pharmacology September 2006, 70 (3) 1053-1061; DOI: https://doi.org/10.1124/mol.106.023515
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  Regulation of the CYP1A1 Gene by 2,3,7,8-Tetrachlorodibenzo-p-dioxin but Not by β-Naphthoflavone or 3-Methylcholanthrene Is Altered in Hepatitis C Virus Replicon-Expressing Cells

  Garret R. Anderson, Aliya Hasan, Hao Yin, Ishtiaq Qadri and Linda C. Quattrochi

  Molecular Pharmacology September 2006, 70 (3) 1062-1070; DOI: https://doi.org/10.1124/mol.106.024125
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  Boswellic Acids Stimulate Arachidonic Acid Release and 12-Lipoxygenase Activity in Human Platelets Independent of Ca²⁺ and Differentially Interact with Platelet-Type 12-Lipoxygenase

  Daniel Poeckel, Lars Tausch, Nicole Kather, Johann Jauch and Oliver Werz

  Molecular Pharmacology September 2006, 70 (3) 1071-1078; DOI: https://doi.org/10.1124/mol.106.024836
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  A Potential Role for Cyclized Quinones Derived from Dopamine, DOPA, and 3,4-Dihydroxyphenylacetic Acid in Proteasomal Inhibition

  Khan Shoeb Zafar, David Siegel and David Ross

  Molecular Pharmacology September 2006, 70 (3) 1079-1086; DOI: https://doi.org/10.1124/mol.106.024703
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  HIV-1 Viral Envelope Glycoprotein gp120 Triggers an Inflammatory Response in Cultured Rat Astrocytes and Regulates the Functional Expression of P-Glycoprotein

  Patrick T. Ronaldson and Reina Bendayan

  Molecular Pharmacology September 2006, 70 (3) 1087-1098; DOI: https://doi.org/10.1124/mol.106.025973
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  Phorbol 12-Myristate 13-Acetate Protects against Tumor Necrosis Factor (TNF)-Induced Necrotic Cell Death by Modulating the Recruitment of TNF Receptor 1-Associated Death Domain and Receptor-Interacting Protein into the TNF Receptor 1 Signaling Complex: Implication for the Regulatory Role of Protein Kinase C

  Hee Sun Byun, Kyeong Ah Park, Minho Won, Keum-Jin Yang, Sanghee Shin, Longzhen Piao, Jin Young Kwak, Zee-Won Lee, Jongsun Park, Jeong Ho Seok, Zheng-Gang Liu and Gang Min Hur

  Molecular Pharmacology September 2006, 70 (3) 1099-1108; DOI: https://doi.org/10.1124/mol.106.025452
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  Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity

  Smitha Antony, Keli K. Agama, Ze-Hong Miao, Melinda Hollingshead, Susan L. Holbeck, Mollie H. Wright, Lyuba Varticovski, Muthukaman Nagarajan, Andrew Morrell, Mark Cushman and Yves Pommier

  Molecular Pharmacology September 2006, 70 (3) 1109-1120; DOI: https://doi.org/10.1124/mol.106.024372
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  Comparison of Polyethylene Glycol-Conjugated Recombinant Human Acetylcholinesterase and Serum Human Butyrylcholinesterase as Bioscavengers of Organophosphate Compounds

  Ofer Cohen, Chanoch Kronman, Lily Raveh, Ohad Mazor, Arie Ordentlich and Avigdor Shafferman

  Molecular Pharmacology September 2006, 70 (3) 1121-1131; DOI: https://doi.org/10.1124/mol.106.026179
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  Distinct Roles for Protein Kinase C Isoforms in Regulating Platelet Purinergic Receptor Function

  Stuart J. Mundell, Matthew L. Jones, Adam R. Hardy, Johanna F. Barton, Stephanie M. Beaucourt, Pamela B. Conley and Alastair W. Poole

  Molecular Pharmacology September 2006, 70 (3) 1132-1142; DOI: https://doi.org/10.1124/mol.106.023549
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  A Naphthoquinone Derivative, Shikonin, Has Insulin-Like Actions by Inhibiting Both Phosphatase and Tensin Homolog Deleted on Chromosome 10 and Tyrosine Phosphatases

  Kiyomi Nigorikawa, Kyoko Yoshikawa, Tomo Sasaki, Eiji Iida, Mariko Tsukamoto, Hitomi Murakami, Tomohiko Maehama, Kaoru Hazeki and Osamu Hazeki

  Molecular Pharmacology September 2006, 70 (3) 1143-1149; DOI: https://doi.org/10.1124/mol.106.025809