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Molecular Pharmacology

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Table of Contents

October 01, 2006; Volume 70,Issue 4

Perspectives

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    Transient Receptor Potential Channels and Caveolin-1: Good Friends in Tight Spaces
    Carmelle V. Remillard and Jason X.-J. Yuan
    Molecular Pharmacology October 2006, 70 (4) 1151-1154; DOI: https://doi.org/10.1124/mol.106.029280
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    Is It Go or NO Go for S-Nitrosylation Modification-Based Therapies of Cystic Fibrosis Transmembrane Regulator Trafficking?
    Pamela L. Zeitlin
    Molecular Pharmacology October 2006, 70 (4) 1155-1158; DOI: https://doi.org/10.1124/mol.106.029207

Accelerated Communication

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    Role of Ectodomain Lysines in the Subunits of the Heteromeric P2X2/3 Receptor
    William J. Wilkinson, Lin-Hua Jiang, Annmarie Surprenant and R. Alan North
    Molecular Pharmacology October 2006, 70 (4) 1159-1163; DOI: https://doi.org/10.1124/mol.106.026658

Articles

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    The Farnesoid X Receptor Promotes Adipocyte Differentiation and Regulates Adipose Cell Function in Vivo
    Giovanni Rizzo, Moises Disante, Andrea Mencarelli, Barbara Renga, Antimo Gioiello, Roberto Pellicciari and Stefano Fiorucci
    Molecular Pharmacology October 2006, 70 (4) 1164-1173; DOI: https://doi.org/10.1124/mol.106.023820
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    Caveolin-1 Regulates Store-Operated Ca2+ Influx by Binding of Its Scaffolding Domain to Transient Receptor Potential Channel-1 in Endothelial Cells
    Angela M. Kwiatek, Richard D. Minshall, David R. Cool, Randal A. Skidgel, Asrar B. Malik and Chinnaswamy Tiruppathi
    Molecular Pharmacology October 2006, 70 (4) 1174-1183; DOI: https://doi.org/10.1124/mol.105.021741
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    Antioxidant Down-Regulates Interleukin-18 Expression in Asthma
    Kyung Sun Lee, So Ri Kim, Seoung Ju Park, Kyung Hoon Min, Ka Young Lee, Sun Mi Jin, Wan Hee Yoo and Yong Chul Lee
    Molecular Pharmacology October 2006, 70 (4) 1184-1193; DOI: https://doi.org/10.1124/mol.106.024737
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    The Bioreduction of a Series of Benzoquinone Ansamycins by NAD(P)H:Quinone Oxidoreductase 1 to More Potent Heat Shock Protein 90 Inhibitors, the Hydroquinone Ansamycins
    Wenchang Guo, Philip Reigan, David Siegel, Joseph Zirrolli, Daniel Gustafson and David Ross
    Molecular Pharmacology October 2006, 70 (4) 1194-1203; DOI: https://doi.org/10.1124/mol.106.025643
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    Binding Site of a Novel Kv1.5 Blocker: A “Foot in the Door” against Atrial Fibrillation
    Niels Decher, Pradeep Kumar, Teresa Gonzalez, Bernard Pirard and Michael C. Sanguinetti
    Molecular Pharmacology October 2006, 70 (4) 1204-1211; DOI: https://doi.org/10.1124/mol.106.026203
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    In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation
    Björn Bauer, Xiaodong Yang, Anika M. S. Hartz, Emily R. Olson, Rong Zhao, J. Cory Kalvass, Gary M. Pollack and David S. Miller
    Molecular Pharmacology October 2006, 70 (4) 1212-1219; DOI: https://doi.org/10.1124/mol.106.023796
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    Effects of Potent Inhibitors of the Retinoid Cycle on Visual Function and Photoreceptor Protection from Light Damage in Mice
    Akiko Maeda, Tadao Maeda, Marcin Golczak, Yoshikazu Imanishi, Patrick Leahy, Ryo Kubota and Krzysztof Palczewski
    Molecular Pharmacology October 2006, 70 (4) 1220-1229; DOI: https://doi.org/10.1124/mol.106.026823
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    Solution NMR of Acetylcholine Binding Protein Reveals Agonist-Mediated Conformational Change of the C-Loop
    Fan Gao, Georges Mer, Marco Tonelli, Scott B. Hansen, Thomas P. Burghardt, Palmer Taylor and Steven M. Sine
    Molecular Pharmacology October 2006, 70 (4) 1230-1235; DOI: https://doi.org/10.1124/mol.106.027185
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    CB1 Receptor Antagonism Increases Hippocampal Acetylcholine Release: Site and Mechanism of Action
    Aldemar Degroot, Attila Köfalvi, Mark R. Wade, Richard J. Davis, Ricardo J. Rodrigues, Nelson Rebola, Rodrigo A. Cunha and George G. Nomikos
    Molecular Pharmacology October 2006, 70 (4) 1236-1245; DOI: https://doi.org/10.1124/mol.106.024661
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    Diabetes-Induced Mechanical Hyperalgesia Involves Spinal Mitogen-Activated Protein Kinase Activation in Neurons and Microglia via N-Methyl-D-aspartate-Dependent Mechanisms
    Laurence Daulhac, Christophe Mallet, Christine Courteix, Monique Etienne, Eliane Duroux, Anne-Marie Privat, Alain Eschalier and Joseph Fialip
    Molecular Pharmacology October 2006, 70 (4) 1246-1254; DOI: https://doi.org/10.1124/mol.106.025478
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    Role in the Selectivity of Neonicotinoids of Insect-Specific Basic Residues in Loop D of the Nicotinic Acetylcholine Receptor Agonist Binding Site
    Masaru Shimomura, Maiko Yokota, Makoto Ihara, Miki Akamatsu, David B. Sattelle and Kazuhiko Matsuda
    Molecular Pharmacology October 2006, 70 (4) 1255-1263; DOI: https://doi.org/10.1124/mol.106.026815
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    Risperidone Irreversibly Binds to and Inactivates the h5-HT7 Serotonin Receptor
    Carol Smith, Tariq Rahman, Nicole Toohey, Joseph Mazurkiewicz, Katharine Herrick-Davis and Milt Teitler
    Molecular Pharmacology October 2006, 70 (4) 1264-1270; DOI: https://doi.org/10.1124/mol.106.024612
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    On the Mechanism of Action of 9-O-Arylalkyloxime Derivatives of 6-O-Mycaminosyltylonolide, a New Class of 16-Membered Macrolide Antibiotics
    Panagiotis Karahalios, Dimitrios L. Kalpaxis, Hong Fu, Leonard Katz, Daniel N. Wilson and George P. Dinos
    Molecular Pharmacology October 2006, 70 (4) 1271-1280; DOI: https://doi.org/10.1124/mol.106.026567
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    Regulation of Mouse Hepatic α-Amino-β-Carboxymuconate-ϵ-Semialdehyde Decarboxylase, a Key Enzyme in the Tryptophan-Nicotinamide Adenine Dinucleotide Pathway, by Hepatocyte Nuclear Factor 4α and Peroxisome Proliferator-Activated Receptor α
    Mariko Shin, Insook Kim, Yusuke Inoue, Shioko Kimura and Frank J. Gonzalez
    Molecular Pharmacology October 2006, 70 (4) 1281-1290; DOI: https://doi.org/10.1124/mol.106.026294
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    Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression
    Xingguo Cheng, Jonathan Maher, Hong Lu and Curtis D. Klaassen
    Molecular Pharmacology October 2006, 70 (4) 1291-1297; DOI: https://doi.org/10.1124/mol.106.025122
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    The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Human Breast Cancer Cell Proliferation through a Lipid Raft-Mediated Mechanism
    Daniela Sarnataro, Simona Pisanti, Antonietta Santoro, Patrizia Gazzerro, Anna Maria Malfitano, Chiara Laezza and Maurizio Bifulco
    Molecular Pharmacology October 2006, 70 (4) 1298-1306; DOI: https://doi.org/10.1124/mol.106.025601
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    Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
    Mariana Bartos, Diego Rayes and Cecilia Bouzat
    Molecular Pharmacology October 2006, 70 (4) 1307-1318; DOI: https://doi.org/10.1124/mol.106.026336
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    Biophysical Characterization of the New Human Ether-A-Go-Go-Related Gene Channel Opener NS3623 [N-(4-Bromo-2-(1H-tetrazol-5-yl)-phenyl)-N′-(3′-trifluoromethylphenyl)urea]
    Rie Schultz Hansen, Thomas Goldin Diness, Torsten Christ, Erich Wettwer, Ursula Ravens, Søren-Peter Olesen and Morten Grunnet
    Molecular Pharmacology October 2006, 70 (4) 1319-1329; DOI: https://doi.org/10.1124/mol.106.026492
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    Focal Adhesion Kinase and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells
    Maroesja J. van Nimwegen, Merei Huigsloot, Annamarie Camier, Ine B. Tijdens and Bob van de Water
    Molecular Pharmacology October 2006, 70 (4) 1330-1339; DOI: https://doi.org/10.1124/mol.106.026195
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    Liver X Receptor (LXR)-β Regulation in LXRα-Deficient Mice: Implications for Therapeutic Targeting
    Elaine M. Quinet, Dawn A. Savio, Anita R. Halpern, Liang Chen, Gertrude U. Schuster, Jan-Åke Gustafsson, Mike D. Basso and Ponnal Nambi
    Molecular Pharmacology October 2006, 70 (4) 1340-1349; DOI: https://doi.org/10.1124/mol.106.022608
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    Incorporation of the β3 Subunit Has a Dominant-Negative Effect on the Function of Recombinant Central-Type Neuronal Nicotinic Receptors
    Steven Broadbent, Paul J. Groot-Kormelink, Paraskevi A. Krashia, Patricia C. Harkness, Neil S. Millar, Marco Beato and Lucia G. Sivilotti
    Molecular Pharmacology October 2006, 70 (4) 1350-1357; DOI: https://doi.org/10.1124/mol.106.026682
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    β3 Subunits Promote Expression and Nicotine-Induced Up-Regulation of Human Nicotinic α6* Nicotinic Acetylcholine Receptors Expressed in Transfected Cell Lines
    Prem Tumkosit, Alexander Kuryatov, Jie Luo and Jon Lindstrom
    Molecular Pharmacology October 2006, 70 (4) 1358-1368; DOI: https://doi.org/10.1124/mol.106.027326
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    Role of Endogenous XAP2 Protein on the Localization and Nucleocytoplasmic Shuttling of the Endogenous Mouse Ahb-1 Receptor in the Presence and Absence of Ligand
    Richard S. Pollenz, Sarah E. Wilson and Edward J. Dougherty
    Molecular Pharmacology October 2006, 70 (4) 1369-1379; DOI: https://doi.org/10.1124/mol.106.027672
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    Prevention of Platelet Glycoprotein IIb/IIIa Activation by 3,4-Methylenedioxy-β-Nitrostyrene, A Novel Tyrosine Kinase Inhibitor
    Wei-Ya Wang, Yang-Chang Wu and Chin-Chung Wu
    Molecular Pharmacology October 2006, 70 (4) 1380-1389; DOI: https://doi.org/10.1124/mol.106.023986
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    Contribution of the Major Copper Influx Transporter CTR1 to the Cellular Accumulation of Cisplatin, Carboplatin, and Oxaliplatin
    Alison K. Holzer, Gerald H. Manorek and Stephen B. Howell
    Molecular Pharmacology October 2006, 70 (4) 1390-1394; DOI: https://doi.org/10.1124/mol.106.022624
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    JX401, A p38α Inhibitor Containing a 4-Benzylpiperidine Motif, Identified via a Novel Screening System in Yeast
    Yael Friedmann, Anat Shriki, Estelle R. Bennett, Stella Golos, Ron Diskin, Irit Marbach, Eyal Bengal and David Engelberg
    Molecular Pharmacology October 2006, 70 (4) 1395-1405; DOI: https://doi.org/10.1124/mol.106.022962
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    Point Mutations in Either Subunit of the GABAB Receptor Confer Constitutive Activity to the Heterodimer
    Richa S. Mukherjee, Edward W. McBride, Martin Beinborn, Kathleen Dunlap and Alan S. Kopin
    Molecular Pharmacology October 2006, 70 (4) 1406-1413; DOI: https://doi.org/10.1124/mol.106.024463
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    17β-Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30
    Adele Vivacqua, Daniela Bonofiglio, Lidia Albanito, Antonio Madeo, Vittoria Rago, Amalia Carpino, Anna Maria Musti, Didier Picard, Sebastiano Andò and Marcello Maggiolini
    Molecular Pharmacology October 2006, 70 (4) 1414-1423; DOI: https://doi.org/10.1124/mol.106.026344
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    Inhibition of Ca2+ Influx Is Required for Mitochondrial Reactive Oxygen Species-Induced Endoplasmic Reticulum Ca2+ Depletion and Cell Death in Leukemia Cells
    Yicheng Zhang, Jonathan Soboloff, Ziping Zhu and Stuart A. Berger
    Molecular Pharmacology October 2006, 70 (4) 1424-1434; DOI: https://doi.org/10.1124/mol.106.024323
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    S-Nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial Cells
    Khalequz Zaman, Silvia Carraro, Joseph Doherty, Edward M. Henderson, Elizabeth Lendermon, Lei Liu, George Verghese, Molly Zigler, Mark Ross, Edward Park, Lisa A. Palmer, Allan Doctor, Jonathan S. Stamler and Benjamin Gaston
    Molecular Pharmacology October 2006, 70 (4) 1435-1442; DOI: https://doi.org/10.1124/mol.106.023242
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    Ras-Dependent Recruitment of c-Myc for Transcriptional Activation of Nucleophosmin/B23 in Highly Malignant U1 Bladder Cancer Cells
    Chun-Wei Yeh, Sheng-Shun Huang, Ru-Ping Lee and Benjamin Yat-Ming Yung
    Molecular Pharmacology October 2006, 70 (4) 1443-1453; DOI: https://doi.org/10.1124/mol.106.024810
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    Sazetidine-A, A Novel Ligand That Desensitizes α4β2 Nicotinic Acetylcholine Receptors without Activating Them
    Yingxian Xiao, Hong Fan, John L. Musachio, Zhi-Liang Wei, Sheela K. Chellappan, Alan P. Kozikowski and Kenneth J. Kellar
    Molecular Pharmacology October 2006, 70 (4) 1454-1460; DOI: https://doi.org/10.1124/mol.106.027318
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    The Regulator of G Protein Signaling Domain of Axin Selectively Interacts with Gα12 but Not Gα13
    Laura N. Stemmle, Timothy A. Fields and Patrick J. Casey
    Molecular Pharmacology October 2006, 70 (4) 1461-1468; DOI: https://doi.org/10.1124/mol.106.023705
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Molecular Pharmacology: 70 (4)
Molecular Pharmacology
Vol. 70, Issue 4
1 Oct 2006
  • Table of Contents
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  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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