Table of Contents

Articles

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  The Farnesoid X Receptor Promotes Adipocyte Differentiation and Regulates Adipose Cell Function in Vivo

  Giovanni Rizzo, Moises Disante, Andrea Mencarelli, Barbara Renga, Antimo Gioiello, Roberto Pellicciari and Stefano Fiorucci

  Molecular Pharmacology October 2006, 70 (4) 1164-1173; DOI: https://doi.org/10.1124/mol.106.023820
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  Caveolin-1 Regulates Store-Operated Ca²⁺ Influx by Binding of Its Scaffolding Domain to Transient Receptor Potential Channel-1 in Endothelial Cells

  Angela M. Kwiatek, Richard D. Minshall, David R. Cool, Randal A. Skidgel, Asrar B. Malik and Chinnaswamy Tiruppathi

  Molecular Pharmacology October 2006, 70 (4) 1174-1183; DOI: https://doi.org/10.1124/mol.105.021741
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  Antioxidant Down-Regulates Interleukin-18 Expression in Asthma

  Kyung Sun Lee, So Ri Kim, Seoung Ju Park, Kyung Hoon Min, Ka Young Lee, Sun Mi Jin, Wan Hee Yoo and Yong Chul Lee

  Molecular Pharmacology October 2006, 70 (4) 1184-1193; DOI: https://doi.org/10.1124/mol.106.024737
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  The Bioreduction of a Series of Benzoquinone Ansamycins by NAD(P)H:Quinone Oxidoreductase 1 to More Potent Heat Shock Protein 90 Inhibitors, the Hydroquinone Ansamycins

  Wenchang Guo, Philip Reigan, David Siegel, Joseph Zirrolli, Daniel Gustafson and David Ross

  Molecular Pharmacology October 2006, 70 (4) 1194-1203; DOI: https://doi.org/10.1124/mol.106.025643
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  Binding Site of a Novel Kv1.5 Blocker: A “Foot in the Door” against Atrial Fibrillation

  Niels Decher, Pradeep Kumar, Teresa Gonzalez, Bernard Pirard and Michael C. Sanguinetti

  Molecular Pharmacology October 2006, 70 (4) 1204-1211; DOI: https://doi.org/10.1124/mol.106.026203
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  In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation

  Björn Bauer, Xiaodong Yang, Anika M. S. Hartz, Emily R. Olson, Rong Zhao, J. Cory Kalvass, Gary M. Pollack and David S. Miller

  Molecular Pharmacology October 2006, 70 (4) 1212-1219; DOI: https://doi.org/10.1124/mol.106.023796
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  Effects of Potent Inhibitors of the Retinoid Cycle on Visual Function and Photoreceptor Protection from Light Damage in Mice

  Akiko Maeda, Tadao Maeda, Marcin Golczak, Yoshikazu Imanishi, Patrick Leahy, Ryo Kubota and Krzysztof Palczewski

  Molecular Pharmacology October 2006, 70 (4) 1220-1229; DOI: https://doi.org/10.1124/mol.106.026823
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  Solution NMR of Acetylcholine Binding Protein Reveals Agonist-Mediated Conformational Change of the C-Loop

  Fan Gao, Georges Mer, Marco Tonelli, Scott B. Hansen, Thomas P. Burghardt, Palmer Taylor and Steven M. Sine

  Molecular Pharmacology October 2006, 70 (4) 1230-1235; DOI: https://doi.org/10.1124/mol.106.027185
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  CB₁ Receptor Antagonism Increases Hippocampal Acetylcholine Release: Site and Mechanism of Action

  Aldemar Degroot, Attila Köfalvi, Mark R. Wade, Richard J. Davis, Ricardo J. Rodrigues, Nelson Rebola, Rodrigo A. Cunha and George G. Nomikos

  Molecular Pharmacology October 2006, 70 (4) 1236-1245; DOI: https://doi.org/10.1124/mol.106.024661
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  Diabetes-Induced Mechanical Hyperalgesia Involves Spinal Mitogen-Activated Protein Kinase Activation in Neurons and Microglia via N-Methyl-D-aspartate-Dependent Mechanisms

  Laurence Daulhac, Christophe Mallet, Christine Courteix, Monique Etienne, Eliane Duroux, Anne-Marie Privat, Alain Eschalier and Joseph Fialip

  Molecular Pharmacology October 2006, 70 (4) 1246-1254; DOI: https://doi.org/10.1124/mol.106.025478
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  Role in the Selectivity of Neonicotinoids of Insect-Specific Basic Residues in Loop D of the Nicotinic Acetylcholine Receptor Agonist Binding Site

  Masaru Shimomura, Maiko Yokota, Makoto Ihara, Miki Akamatsu, David B. Sattelle and Kazuhiko Matsuda

  Molecular Pharmacology October 2006, 70 (4) 1255-1263; DOI: https://doi.org/10.1124/mol.106.026815
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  Risperidone Irreversibly Binds to and Inactivates the h5-HT₇ Serotonin Receptor

  Carol Smith, Tariq Rahman, Nicole Toohey, Joseph Mazurkiewicz, Katharine Herrick-Davis and Milt Teitler

  Molecular Pharmacology October 2006, 70 (4) 1264-1270; DOI: https://doi.org/10.1124/mol.106.024612
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  On the Mechanism of Action of 9-O-Arylalkyloxime Derivatives of 6-O-Mycaminosyltylonolide, a New Class of 16-Membered Macrolide Antibiotics

  Panagiotis Karahalios, Dimitrios L. Kalpaxis, Hong Fu, Leonard Katz, Daniel N. Wilson and George P. Dinos

  Molecular Pharmacology October 2006, 70 (4) 1271-1280; DOI: https://doi.org/10.1124/mol.106.026567
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  Regulation of Mouse Hepatic α-Amino-β-Carboxymuconate-ϵ-Semialdehyde Decarboxylase, a Key Enzyme in the Tryptophan-Nicotinamide Adenine Dinucleotide Pathway, by Hepatocyte Nuclear Factor 4α and Peroxisome Proliferator-Activated Receptor α

  Mariko Shin, Insook Kim, Yusuke Inoue, Shioko Kimura and Frank J. Gonzalez

  Molecular Pharmacology October 2006, 70 (4) 1281-1290; DOI: https://doi.org/10.1124/mol.106.026294
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  Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression

  Xingguo Cheng, Jonathan Maher, Hong Lu and Curtis D. Klaassen

  Molecular Pharmacology October 2006, 70 (4) 1291-1297; DOI: https://doi.org/10.1124/mol.106.025122
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  The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Human Breast Cancer Cell Proliferation through a Lipid Raft-Mediated Mechanism

  Daniela Sarnataro, Simona Pisanti, Antonietta Santoro, Patrizia Gazzerro, Anna Maria Malfitano, Chiara Laezza and Maurizio Bifulco

  Molecular Pharmacology October 2006, 70 (4) 1298-1306; DOI: https://doi.org/10.1124/mol.106.025601
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  Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors

  Mariana Bartos, Diego Rayes and Cecilia Bouzat

  Molecular Pharmacology October 2006, 70 (4) 1307-1318; DOI: https://doi.org/10.1124/mol.106.026336
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  Biophysical Characterization of the New Human Ether-A-Go-Go-Related Gene Channel Opener NS3623 [N-(4-Bromo-2-(1H-tetrazol-5-yl)-phenyl)-N′-(3′-trifluoromethylphenyl)urea]

  Rie Schultz Hansen, Thomas Goldin Diness, Torsten Christ, Erich Wettwer, Ursula Ravens, Søren-Peter Olesen and Morten Grunnet

  Molecular Pharmacology October 2006, 70 (4) 1319-1329; DOI: https://doi.org/10.1124/mol.106.026492
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  Focal Adhesion Kinase and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells

  Maroesja J. van Nimwegen, Merei Huigsloot, Annamarie Camier, Ine B. Tijdens and Bob van de Water

  Molecular Pharmacology October 2006, 70 (4) 1330-1339; DOI: https://doi.org/10.1124/mol.106.026195
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  Liver X Receptor (LXR)-β Regulation in LXRα-Deficient Mice: Implications for Therapeutic Targeting

  Elaine M. Quinet, Dawn A. Savio, Anita R. Halpern, Liang Chen, Gertrude U. Schuster, Jan-Åke Gustafsson, Mike D. Basso and Ponnal Nambi

  Molecular Pharmacology October 2006, 70 (4) 1340-1349; DOI: https://doi.org/10.1124/mol.106.022608
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  Incorporation of the β3 Subunit Has a Dominant-Negative Effect on the Function of Recombinant Central-Type Neuronal Nicotinic Receptors

  Steven Broadbent, Paul J. Groot-Kormelink, Paraskevi A. Krashia, Patricia C. Harkness, Neil S. Millar, Marco Beato and Lucia G. Sivilotti

  Molecular Pharmacology October 2006, 70 (4) 1350-1357; DOI: https://doi.org/10.1124/mol.106.026682
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  β3 Subunits Promote Expression and Nicotine-Induced Up-Regulation of Human Nicotinic α6^* Nicotinic Acetylcholine Receptors Expressed in Transfected Cell Lines

  Prem Tumkosit, Alexander Kuryatov, Jie Luo and Jon Lindstrom

  Molecular Pharmacology October 2006, 70 (4) 1358-1368; DOI: https://doi.org/10.1124/mol.106.027326
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  Role of Endogenous XAP2 Protein on the Localization and Nucleocytoplasmic Shuttling of the Endogenous Mouse Ah^b-1 Receptor in the Presence and Absence of Ligand

  Richard S. Pollenz, Sarah E. Wilson and Edward J. Dougherty

  Molecular Pharmacology October 2006, 70 (4) 1369-1379; DOI: https://doi.org/10.1124/mol.106.027672
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  Prevention of Platelet Glycoprotein IIb/IIIa Activation by 3,4-Methylenedioxy-β-Nitrostyrene, A Novel Tyrosine Kinase Inhibitor

  Wei-Ya Wang, Yang-Chang Wu and Chin-Chung Wu

  Molecular Pharmacology October 2006, 70 (4) 1380-1389; DOI: https://doi.org/10.1124/mol.106.023986
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  Contribution of the Major Copper Influx Transporter CTR1 to the Cellular Accumulation of Cisplatin, Carboplatin, and Oxaliplatin

  Alison K. Holzer, Gerald H. Manorek and Stephen B. Howell

  Molecular Pharmacology October 2006, 70 (4) 1390-1394; DOI: https://doi.org/10.1124/mol.106.022624
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  JX401, A p38α Inhibitor Containing a 4-Benzylpiperidine Motif, Identified via a Novel Screening System in Yeast

  Yael Friedmann, Anat Shriki, Estelle R. Bennett, Stella Golos, Ron Diskin, Irit Marbach, Eyal Bengal and David Engelberg

  Molecular Pharmacology October 2006, 70 (4) 1395-1405; DOI: https://doi.org/10.1124/mol.106.022962
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  Point Mutations in Either Subunit of the GABA_B Receptor Confer Constitutive Activity to the Heterodimer

  Richa S. Mukherjee, Edward W. McBride, Martin Beinborn, Kathleen Dunlap and Alan S. Kopin

  Molecular Pharmacology October 2006, 70 (4) 1406-1413; DOI: https://doi.org/10.1124/mol.106.024463
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  17β-Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30

  Adele Vivacqua, Daniela Bonofiglio, Lidia Albanito, Antonio Madeo, Vittoria Rago, Amalia Carpino, Anna Maria Musti, Didier Picard, Sebastiano Andò and Marcello Maggiolini

  Molecular Pharmacology October 2006, 70 (4) 1414-1423; DOI: https://doi.org/10.1124/mol.106.026344
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  Inhibition of Ca²⁺ Influx Is Required for Mitochondrial Reactive Oxygen Species-Induced Endoplasmic Reticulum Ca²⁺ Depletion and Cell Death in Leukemia Cells

  Yicheng Zhang, Jonathan Soboloff, Ziping Zhu and Stuart A. Berger

  Molecular Pharmacology October 2006, 70 (4) 1424-1434; DOI: https://doi.org/10.1124/mol.106.024323
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  S-Nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial Cells

  Khalequz Zaman, Silvia Carraro, Joseph Doherty, Edward M. Henderson, Elizabeth Lendermon, Lei Liu, George Verghese, Molly Zigler, Mark Ross, Edward Park, Lisa A. Palmer, Allan Doctor, Jonathan S. Stamler and Benjamin Gaston

  Molecular Pharmacology October 2006, 70 (4) 1435-1442; DOI: https://doi.org/10.1124/mol.106.023242
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  Ras-Dependent Recruitment of c-Myc for Transcriptional Activation of Nucleophosmin/B23 in Highly Malignant U1 Bladder Cancer Cells

  Chun-Wei Yeh, Sheng-Shun Huang, Ru-Ping Lee and Benjamin Yat-Ming Yung

  Molecular Pharmacology October 2006, 70 (4) 1443-1453; DOI: https://doi.org/10.1124/mol.106.024810
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  Sazetidine-A, A Novel Ligand That Desensitizes α4β2 Nicotinic Acetylcholine Receptors without Activating Them

  Yingxian Xiao, Hong Fan, John L. Musachio, Zhi-Liang Wei, Sheela K. Chellappan, Alan P. Kozikowski and Kenneth J. Kellar

  Molecular Pharmacology October 2006, 70 (4) 1454-1460; DOI: https://doi.org/10.1124/mol.106.027318
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  The Regulator of G Protein Signaling Domain of Axin Selectively Interacts with Gα₁₂ but Not Gα₁₃

  Laura N. Stemmle, Timothy A. Fields and Patrick J. Casey

  Molecular Pharmacology October 2006, 70 (4) 1461-1468; DOI: https://doi.org/10.1124/mol.106.023705