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Molecular Pharmacology

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OtherPerspective

Transient Receptor Potential Channels and Caveolin-1: Good Friends in Tight Spaces

Carmelle V. Remillard and Jason X.-J. Yuan
Molecular Pharmacology October 2006, 70 (4) 1151-1154; DOI: https://doi.org/10.1124/mol.106.029280
Carmelle V. Remillard
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Jason X.-J. Yuan
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Abstract

Caveolae formation has raised the concept of energy efficiency to new heights. The ultimate purpose of caveolae formation is to colocalize signaling proteins with membrane microdomains in order to facilitate their interaction and improve signal transduction efficiency. Although we know that the main structural protein of caveolae is caveolin, how caveolin interacts with membrane proteins to facilitate their integration into lipid raft domains is unclear. A caveolin-scaffolding domain (CSD) on caveolin itself can associate with membrane proteins such as G proteins and endothelial nitric oxide synthase. In this issue, Kwiatek et al. (p. 1174) report that the TRPC1 channel protein contains a C-terminal CSD-consensus binding sequence that allows for its physical and functional interaction with caveolin-1 in the caveolae of human pulmonary artery endothelial cells (PAEC). Competitive interaction with a CSD-conjugated peptide attenuates thrombin- and thapsigargin-induced Ca2+ influx via store-operated TRPC1 channels. Their data suggest that caveolin-1 can directly regulate TRPC1 function, extending its already ascribed role as a structural protein.

Footnotes

  • This work is supported by National Institutes of Health grants HL064945, HL054043, and HL066012.

  • Please see the related article on page 1174.

  • ABBREVIATIONS: GPCR, G protein-coupled receptor; eNOS, endothelial nitric oxide synthase; TRP, transient receptor potential; cav-1, caveolin-1; SOC, store-operated Ca2+ channels; PAEC, pulmonary artery endothelial cells; CCE, capacitative Ca2+ entry; IP3, inositol-1,4,5-trisphosphate; ER, endoplasmic reticulum; SR, sarcoplasmic reticulum; CBM, cav-1 binding motif; aa, amino acid(s); CSD, caveolin scaffolding domain; PDZ, postsynaptic density 95/disc-large/zona occludens; IP3R, inositol-1,4,5-trisphosphate receptors.

    • Received July 25, 2006.
    • Accepted July 27, 2006.
  • The American Society for Pharmacology and Experimental Therapeutics
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Molecular Pharmacology: 70 (4)
Molecular Pharmacology
Vol. 70, Issue 4
1 Oct 2006
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Transient Receptor Potential Channels and Caveolin-1: Good Friends in Tight Spaces

Carmelle V. Remillard and Jason X.-J. Yuan
Molecular Pharmacology October 1, 2006, 70 (4) 1151-1154; DOI: https://doi.org/10.1124/mol.106.029280

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Transient Receptor Potential Channels and Caveolin-1: Good Friends in Tight Spaces

Carmelle V. Remillard and Jason X.-J. Yuan
Molecular Pharmacology October 1, 2006, 70 (4) 1151-1154; DOI: https://doi.org/10.1124/mol.106.029280
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