Table of Contents

Articles

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  Enhancement of Hippocampal Pyramidal Cell Excitability by the Novel Selective Slow-Afterhyperpolarization Channel Blocker 3-(Triphenylmethylaminomethyl)pyridine (UCL2077)

  Mala M. Shah, Mazyar Javadzadeh-Tabatabaie, David C. H. Benton, C. Robin Ganellin and Dennis G. Haylett

  Molecular Pharmacology November 2006, 70 (5) 1494-1502; DOI: https://doi.org/10.1124/mol.106.026625
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  A Three-Dimensional Quantitative Structure-Activity Relationship Study of the Inhibition of the ATPase Activity and the Strand Passing Catalytic Activity of Topoisomerase IIα by Substituted Purine Analogs

  Lars H. Jensen, Hong Liang, Robert Shoemaker, Morten Grauslund, Maxwell Sehested and Brian B. Hasinoff

  Molecular Pharmacology November 2006, 70 (5) 1503-1513; DOI: https://doi.org/10.1124/mol.106.026856
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  An Inner Pore Residue (Asn406) in the Na_v1.5 Channel Controls Slow Inactivation and Enhances Mibefradil Block to T-Type Ca²⁺ Channel Levels

  Megan M. McNulty, John W. Kyle, Gregory M. Lipkind and Dorothy A. Hanck

  Molecular Pharmacology November 2006, 70 (5) 1514-1523; DOI: https://doi.org/10.1124/mol.106.027177
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  Inhibition of in Vivo Glioma Growth and Invasion by Peroxisome Proliferator-Activated Receptor γ Agonist Treatment

  Christian Grommes, Gary E. Landreth, Magdalena Sastre, Martina Beck, Douglas L. Feinstein, Andreas H. Jacobs, Uwe Schlegel and Michael T. Heneka

  Molecular Pharmacology November 2006, 70 (5) 1524-1533; DOI: https://doi.org/10.1124/mol.106.022194
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  Overcoming Trastuzumab Resistance in HER2-Overexpressing Breast Cancer Cells by Using a Novel Celecoxib-Derived Phosphoinositide-Dependent Kinase-1 Inhibitor

  Ping-Hui Tseng, Yu-Chieh Wang, Shu-Chuan Weng, Jing-Ru Weng, Chang-Shi Chen, Robert W. Brueggemeier, Charles L. Shapiro, Ching-Yu Chen, Sandra E. Dunn, Michael Pollak and Ching-Shih Chen

  Molecular Pharmacology November 2006, 70 (5) 1534-1541; DOI: https://doi.org/10.1124/mol.106.023911
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  The Concerted Contribution of the S4-S5 Linker and the S6 Segment to the Modulation of a K_v Channel by 1-Alkanols

  Aditya Bhattacharji, Benjamin Kaplan, Thanawath Harris, Xiaoguang Qu, Markus W. Germann and Manuel Covarrubias

  Molecular Pharmacology November 2006, 70 (5) 1542-1554; DOI: https://doi.org/10.1124/mol.106.026187
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  Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly

  Ernest Hamel, Billy W. Day, John H. Miller, M. Katherine Jung, Peter T. Northcote, Arun K. Ghosh, Dennis P. Curran, Mark Cushman, K. C. Nicolaou, Ian Paterson and Erik J. Sorensen

  Molecular Pharmacology November 2006, 70 (5) 1555-1564; DOI: https://doi.org/10.1124/mol.106.027847
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  Transmembrane Domain VII of the Human Apical Sodium-Dependent Bile Acid Transporter ASBT (SLC10A2) Lines the Substrate Translocation Pathway

  Naissan Hussainzada, Antara Banerjee and Peter W. Swaan

  Molecular Pharmacology November 2006, 70 (5) 1565-1574; DOI: https://doi.org/10.1124/mol.106.028647
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  Distinct Signaling Profiles of β₁ and β₂ Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy

  Ségolène Galandrin and Michel Bouvier

  Molecular Pharmacology November 2006, 70 (5) 1575-1584; DOI: https://doi.org/10.1124/mol.106.026716
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  Roles for the Trypanosoma brucei P2 Transporter in DB75 Uptake and Resistance

  Charlotte A. Lanteri, Mhairi L. Stewart, Janice M. Brock, Vincent P. Alibu, Steven R. Meshnick, Richard R. Tidwell and Michael P. Barrett

  Molecular Pharmacology November 2006, 70 (5) 1585-1592; DOI: https://doi.org/10.1124/mol.106.024653
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  Salvicine Functions as Novel Topoisomerase II Poison by Binding to ATP Pocket

  Chao-Xin Hu, Zhi-Li Zuo, Bing Xiong, Jin-Gui Ma, Mei-Yu Geng, Li-Ping Lin, Hua-Liang Jiang and Jian Ding

  Molecular Pharmacology November 2006, 70 (5) 1593-1601; DOI: https://doi.org/10.1124/mol.106.027714
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  Functional Genetic Diversity in the High-Affinity Carnitine Transporter OCTN2 (SLC22A5)

  Thomas J. Urban, Renata C. Gallagher, Chaline Brown, Richard A. Castro, Leah L. Lagpacan, Claire M. Brett, Travis R. Taylor, Elaine J. Carlson, Thomas E. Ferrin, Esteban G. Burchard, Seymour Packman and Kathleen M. Giacomini

  Molecular Pharmacology November 2006, 70 (5) 1602-1611; DOI: https://doi.org/10.1124/mol.106.028126
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  Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma

  Kristin Gustafsson, Birger Christensson, Birgitta Sander and Jenny Flygare

  Molecular Pharmacology November 2006, 70 (5) 1612-1620; DOI: https://doi.org/10.1124/mol.106.025981
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  A Single Decoy Oligodeoxynucleotides Targeting Multiple Oncoproteins Produces Strong Anticancer Effects

  Huanhuan Gao, Jiening Xiao, Qiang Sun, Huixian Lin, Yunlong Bai, Long Yang, Baofeng Yang, Huizhen Wang and Zhiguo Wang

  Molecular Pharmacology November 2006, 70 (5) 1621-1629; DOI: https://doi.org/10.1124/mol.106.024273
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  A Comprehensive Structure-Based Alignment of Prokaryotic and Eukaryotic Neurotransmitter/Na⁺ Symporters (NSS) Aids in the Use of the LeuT Structure to Probe NSS Structure and Function

  Thijs Beuming, Lei Shi, Jonathan A. Javitch and Harel Weinstein

  Molecular Pharmacology November 2006, 70 (5) 1630-1642; DOI: https://doi.org/10.1124/mol.106.026120
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  Intersectin Regulates Epidermal Growth Factor Receptor Endocytosis, Ubiquitylation, and Signaling

  Negin P. Martin, Robert P. Mohney, Sara Dunn, Margaret Das, Erica Scappini and John P. O'Bryan

  Molecular Pharmacology November 2006, 70 (5) 1643-1653; DOI: https://doi.org/10.1124/mol.106.028274
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  Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content

  Yajaira Suárez, Laura González-Santiago, Natasha Zarich, Alberto Dávalos, Juan F. Aranda, Miguel A. Alonso, Miguel A. Lasunción, José María Rojas and Alberto Muñoz

  Molecular Pharmacology November 2006, 70 (5) 1654-1663; DOI: https://doi.org/10.1124/mol.106.025569
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  Curcumin Inhibits Hypoxia-Inducible Factor-1 by Degrading Aryl Hydrocarbon Receptor Nuclear Translocator: A Mechanism of Tumor Growth Inhibition

  Hyunsung Choi, Yang-Sook Chun, Seung-Won Kim, Myung-Suk Kim and Jong-Wan Park

  Molecular Pharmacology November 2006, 70 (5) 1664-1671; DOI: https://doi.org/10.1124/mol.106.025817
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  Electron Spin Resonance and Chemiluminescence Analyses to Elucidate the Vasodilating Mechanism of Sodium Nitroprusside

  Giancarlo Aldini, Federica Pirrone, Mariangela Albertini, Marica Orioli, Angela Piccoli, Silvia Mazzola, Maria Giovanna Clement and Marina Carini

  Molecular Pharmacology November 2006, 70 (5) 1672-1680; DOI: https://doi.org/10.1124/mol.106.027870
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  Transcriptional Activation of CYP2C9, CYP1A1, and CYP1A2 by Hepatocyte Nuclear Factor 4α Requires Coactivators Peroxisomal Proliferator Activated Receptor-γ Coactivator 1α and Steroid Receptor Coactivator 1

  Celia P. Martínez-Jiménez, José V. Castell, M. José Gómez-Lechón and Ramiro Jover

  Molecular Pharmacology November 2006, 70 (5) 1681-1692; DOI: https://doi.org/10.1124/mol.106.025403
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  Heterogeneity of Nicotinic Cholinergic Receptors in Rat Superior Cervical and Nodose Ganglia

  Danyan Mao, Robert P. Yasuda, Hong Fan, Barry B. Wolfe and Kenneth J. Kellar

  Molecular Pharmacology November 2006, 70 (5) 1693-1699; DOI: https://doi.org/10.1124/mol.106.027458
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  Adenylyl Cyclase 6 Overexpression Decreases the Permeability of Endothelial Monolayers via Preferential Enhancement of Prostacyclin Receptor Function

  Richard A. Bundey and Paul A. Insel

  Molecular Pharmacology November 2006, 70 (5) 1700-1707; DOI: https://doi.org/10.1124/mol.106.028035
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  Molecular Aspects of Antitumor Effects of a New Platinum(IV) Drug

  Jana Kaspárková, Olga Nováková, Oldřich Vrána, Francesco Intini, Giovanni Natile and Viktor Brabec

  Molecular Pharmacology November 2006, 70 (5) 1708-1719; DOI: https://doi.org/10.1124/mol.106.027730
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  Involvement of Tissue Plasminogen Activator-Plasmin System in Depolarization-Evoked Dopamine Release in the Nucleus Accumbens of Mice

  Mina Ito, Taku Nagai, Hiroyuki Kamei, Noritaka Nakamichi, Toshitaka Nabeshima, Kazuhiro Takuma and Kiyofumi Yamada

  Molecular Pharmacology November 2006, 70 (5) 1720-1725; DOI: https://doi.org/10.1124/mol.106.022467
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  Corticostriatal Up-Regulation of Activity-Regulated Cytoskeletal-Associated Protein Expression after Repeated Exposure to Cocaine

  Fabio Fumagalli, Francesco Bedogni, Angelisa Frasca, Laura Di Pasquale, Giorgio Racagni and Marco Andrea Riva

  Molecular Pharmacology November 2006, 70 (5) 1726-1734; DOI: https://doi.org/10.1124/mol.106.026302
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  Modification of OATP2B1-Mediated Transport by Steroid Hormones

  Markus Grube, Kathleen Köck, Susanne Karner, Sebastian Reuther, Christoph A. Ritter, Gabriele Jedlitschky and Heyo K. Kroemer

  Molecular Pharmacology November 2006, 70 (5) 1735-1741; DOI: https://doi.org/10.1124/mol.106.026450
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  Calmodulin-Stimulated Adenylyl Cyclase Gene Deletion Affects Morphine Responses

  Shuang Li, Michael L. Lee, Michael R. Bruchas, Guy C. Chan, Daniel R. Storm and Charles Chavkin

  Molecular Pharmacology November 2006, 70 (5) 1742-1749; DOI: https://doi.org/10.1124/mol.106.025783
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  A Critical Role for the Short Intracellular C Terminus in Receptor Activity-Modifying Protein Function

  Madhara Udawela, George Christopoulos, Maria Morfis, Arthur Christopoulos, Siying Ye, Nanda Tilakaratne and Patrick M. Sexton

  Molecular Pharmacology November 2006, 70 (5) 1750-1760; DOI: https://doi.org/10.1124/mol.106.024257
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  Voltage-Dependent Block of N-Methyl-D-aspartate Receptors by Dopamine D1 Receptor Ligands

  Changhai Cui, Ming Xu and Marco Atzori

  Molecular Pharmacology November 2006, 70 (5) 1761-1770; DOI: https://doi.org/10.1124/mol.106.028332
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  Inhibitory Gating Modulation of Small Conductance Ca²⁺-Activated K⁺ Channels by the Synthetic Compound (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) Reduces Afterhyperpolarizing Current in Hippocampal CA1 Neurons

  Dorte Strøbæk, Charlotte Hougaard, Tina H. Johansen, Ulrik S. Sørensen, Elsebet Ø. Nielsen, Karin S. Nielsen, Ruth D. T. Taylor, Paola Pedarzani and Palle Christophersen

  Molecular Pharmacology November 2006, 70 (5) 1771-1782; DOI: https://doi.org/10.1124/mol.106.027110
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  Probing the Existence of G Protein-Coupled Receptor Dimers by Positive and Negative Ligand-Dependent Cooperative Binding

  Laura Albizu, Marie-Noëlle Balestre, Christophe Breton, Jean-Philippe Pin, Maurice Manning, Bernard Mouillac, Claude Barberis and Thierry Durroux

  Molecular Pharmacology November 2006, 70 (5) 1783-1791; DOI: https://doi.org/10.1124/mol.106.025684
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  Nerve Growth Factor Regulates Adrenergic Expression

  T. C. Tai, David C. Wong-Faull, Robert Claycomb and Dona L. Wong

  Molecular Pharmacology November 2006, 70 (5) 1792-1801; DOI: https://doi.org/10.1124/mol.106.026237
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  Monitoring the Activation State of Insulin/Insulin-Like Growth Factor-1 Hybrid Receptors Using Bioluminescence Resonance Energy Transfer

  Christophe Blanquart, Carmen Gonzalez-Yanes and Tarik Issad

  Molecular Pharmacology November 2006, 70 (5) 1802-1811; DOI: https://doi.org/10.1124/mol.106.026989
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  Induction of Apoptosis in Estrogen Receptor-Negative Breast Cancer Cells by Natural and Synthetic Cyclopentenones: Role of the IκB Kinase/Nuclear Factor-κB Pathway

  Alessandra Ciucci, Patrizia Gianferretti, Roberto Piva, Thierry Guyot, Timothy J. Snape, Stanley M. Roberts and M. Gabriella Santoro

  Molecular Pharmacology November 2006, 70 (5) 1812-1821; DOI: https://doi.org/10.1124/mol.106.025759
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  A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization

  Mitsi A. Blount, Roya Zoraghi, Hengming Ke, Emmanuel P. Bessay, Jackie D. Corbin and Sharron H. Francis

  Molecular Pharmacology November 2006, 70 (5) 1822-1831; DOI: https://doi.org/10.1124/mol.106.028688
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  A New Mechanism of Methotrexate Action Revealed by Target Screening with Affinity Beads

  Hitoshi Uga, Chikanori Kuramori, Akiko Ohta, Yasunori Tsuboi, Hiroshi Tanaka, Mamoru Hatakeyama, Yuki Yamaguchi, Takashi Takahashi, Masahiro Kizaki and Hiroshi Handa

  Molecular Pharmacology November 2006, 70 (5) 1832-1839; DOI: https://doi.org/10.1124/mol.106.025866