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Molecular Pharmacology

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Table of Contents

November 01, 2006; Volume 70,Issue 5

MINIREVIEW

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    Hypoxia-Inducible Factor-1 (HIF-1)
    Qingdong Ke and Max Costa
    Molecular Pharmacology November 2006, 70 (5) 1469-1480; DOI: https://doi.org/10.1124/mol.106.027029

Accelerated Communications

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    Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor
    Yolanda R. Dale and Sakina E. Eltom
    Molecular Pharmacology November 2006, 70 (5) 1481-1487; DOI: https://doi.org/10.1124/mol.106.027474
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    Circumventing Recombination Events Encountered with Production of a Clinical-Grade Adenoviral Vector with a Double-Expression Cassette
    Natalya Belousova, Raymond Harris, Kurt Zinn, Mary Ann Rhodes-Selser, Alexander Kotov, Olga Kotova, Minghui Wang, Rosemarie Aurigemma, Zeng B. Zhu, David T. Curiel and Ronald D. Alvarez
    Molecular Pharmacology November 2006, 70 (5) 1488-1493; DOI: https://doi.org/10.1124/mol.106.025619

Articles

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    Enhancement of Hippocampal Pyramidal Cell Excitability by the Novel Selective Slow-Afterhyperpolarization Channel Blocker 3-(Triphenylmethylaminomethyl)pyridine (UCL2077)
    Mala M. Shah, Mazyar Javadzadeh-Tabatabaie, David C. H. Benton, C. Robin Ganellin and Dennis G. Haylett
    Molecular Pharmacology November 2006, 70 (5) 1494-1502; DOI: https://doi.org/10.1124/mol.106.026625
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    A Three-Dimensional Quantitative Structure-Activity Relationship Study of the Inhibition of the ATPase Activity and the Strand Passing Catalytic Activity of Topoisomerase IIα by Substituted Purine Analogs
    Lars H. Jensen, Hong Liang, Robert Shoemaker, Morten Grauslund, Maxwell Sehested and Brian B. Hasinoff
    Molecular Pharmacology November 2006, 70 (5) 1503-1513; DOI: https://doi.org/10.1124/mol.106.026856
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    An Inner Pore Residue (Asn406) in the Nav1.5 Channel Controls Slow Inactivation and Enhances Mibefradil Block to T-Type Ca2+ Channel Levels
    Megan M. McNulty, John W. Kyle, Gregory M. Lipkind and Dorothy A. Hanck
    Molecular Pharmacology November 2006, 70 (5) 1514-1523; DOI: https://doi.org/10.1124/mol.106.027177
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    Inhibition of in Vivo Glioma Growth and Invasion by Peroxisome Proliferator-Activated Receptor γ Agonist Treatment
    Christian Grommes, Gary E. Landreth, Magdalena Sastre, Martina Beck, Douglas L. Feinstein, Andreas H. Jacobs, Uwe Schlegel and Michael T. Heneka
    Molecular Pharmacology November 2006, 70 (5) 1524-1533; DOI: https://doi.org/10.1124/mol.106.022194
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    Overcoming Trastuzumab Resistance in HER2-Overexpressing Breast Cancer Cells by Using a Novel Celecoxib-Derived Phosphoinositide-Dependent Kinase-1 Inhibitor
    Ping-Hui Tseng, Yu-Chieh Wang, Shu-Chuan Weng, Jing-Ru Weng, Chang-Shi Chen, Robert W. Brueggemeier, Charles L. Shapiro, Ching-Yu Chen, Sandra E. Dunn, Michael Pollak and Ching-Shih Chen
    Molecular Pharmacology November 2006, 70 (5) 1534-1541; DOI: https://doi.org/10.1124/mol.106.023911
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    The Concerted Contribution of the S4-S5 Linker and the S6 Segment to the Modulation of a Kv Channel by 1-Alkanols
    Aditya Bhattacharji, Benjamin Kaplan, Thanawath Harris, Xiaoguang Qu, Markus W. Germann and Manuel Covarrubias
    Molecular Pharmacology November 2006, 70 (5) 1542-1554; DOI: https://doi.org/10.1124/mol.106.026187
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    Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly
    Ernest Hamel, Billy W. Day, John H. Miller, M. Katherine Jung, Peter T. Northcote, Arun K. Ghosh, Dennis P. Curran, Mark Cushman, K. C. Nicolaou, Ian Paterson and Erik J. Sorensen
    Molecular Pharmacology November 2006, 70 (5) 1555-1564; DOI: https://doi.org/10.1124/mol.106.027847
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    Transmembrane Domain VII of the Human Apical Sodium-Dependent Bile Acid Transporter ASBT (SLC10A2) Lines the Substrate Translocation Pathway
    Naissan Hussainzada, Antara Banerjee and Peter W. Swaan
    Molecular Pharmacology November 2006, 70 (5) 1565-1574; DOI: https://doi.org/10.1124/mol.106.028647
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    Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy
    Ségolène Galandrin and Michel Bouvier
    Molecular Pharmacology November 2006, 70 (5) 1575-1584; DOI: https://doi.org/10.1124/mol.106.026716
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    Roles for the Trypanosoma brucei P2 Transporter in DB75 Uptake and Resistance
    Charlotte A. Lanteri, Mhairi L. Stewart, Janice M. Brock, Vincent P. Alibu, Steven R. Meshnick, Richard R. Tidwell and Michael P. Barrett
    Molecular Pharmacology November 2006, 70 (5) 1585-1592; DOI: https://doi.org/10.1124/mol.106.024653
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    Salvicine Functions as Novel Topoisomerase II Poison by Binding to ATP Pocket
    Chao-Xin Hu, Zhi-Li Zuo, Bing Xiong, Jin-Gui Ma, Mei-Yu Geng, Li-Ping Lin, Hua-Liang Jiang and Jian Ding
    Molecular Pharmacology November 2006, 70 (5) 1593-1601; DOI: https://doi.org/10.1124/mol.106.027714
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    Functional Genetic Diversity in the High-Affinity Carnitine Transporter OCTN2 (SLC22A5)
    Thomas J. Urban, Renata C. Gallagher, Chaline Brown, Richard A. Castro, Leah L. Lagpacan, Claire M. Brett, Travis R. Taylor, Elaine J. Carlson, Thomas E. Ferrin, Esteban G. Burchard, Seymour Packman and Kathleen M. Giacomini
    Molecular Pharmacology November 2006, 70 (5) 1602-1611; DOI: https://doi.org/10.1124/mol.106.028126
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    Cannabinoid Receptor-Mediated Apoptosis Induced by R(+)-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
    Kristin Gustafsson, Birger Christensson, Birgitta Sander and Jenny Flygare
    Molecular Pharmacology November 2006, 70 (5) 1612-1620; DOI: https://doi.org/10.1124/mol.106.025981
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    A Single Decoy Oligodeoxynucleotides Targeting Multiple Oncoproteins Produces Strong Anticancer Effects
    Huanhuan Gao, Jiening Xiao, Qiang Sun, Huixian Lin, Yunlong Bai, Long Yang, Baofeng Yang, Huizhen Wang and Zhiguo Wang
    Molecular Pharmacology November 2006, 70 (5) 1621-1629; DOI: https://doi.org/10.1124/mol.106.024273
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    A Comprehensive Structure-Based Alignment of Prokaryotic and Eukaryotic Neurotransmitter/Na+ Symporters (NSS) Aids in the Use of the LeuT Structure to Probe NSS Structure and Function
    Thijs Beuming, Lei Shi, Jonathan A. Javitch and Harel Weinstein
    Molecular Pharmacology November 2006, 70 (5) 1630-1642; DOI: https://doi.org/10.1124/mol.106.026120
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    Intersectin Regulates Epidermal Growth Factor Receptor Endocytosis, Ubiquitylation, and Signaling
    Negin P. Martin, Robert P. Mohney, Sara Dunn, Margaret Das, Erica Scappini and John P. O'Bryan
    Molecular Pharmacology November 2006, 70 (5) 1643-1653; DOI: https://doi.org/10.1124/mol.106.028274
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    Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content
    Yajaira Suárez, Laura González-Santiago, Natasha Zarich, Alberto Dávalos, Juan F. Aranda, Miguel A. Alonso, Miguel A. Lasunción, José María Rojas and Alberto Muñoz
    Molecular Pharmacology November 2006, 70 (5) 1654-1663; DOI: https://doi.org/10.1124/mol.106.025569
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    Curcumin Inhibits Hypoxia-Inducible Factor-1 by Degrading Aryl Hydrocarbon Receptor Nuclear Translocator: A Mechanism of Tumor Growth Inhibition
    Hyunsung Choi, Yang-Sook Chun, Seung-Won Kim, Myung-Suk Kim and Jong-Wan Park
    Molecular Pharmacology November 2006, 70 (5) 1664-1671; DOI: https://doi.org/10.1124/mol.106.025817
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    Electron Spin Resonance and Chemiluminescence Analyses to Elucidate the Vasodilating Mechanism of Sodium Nitroprusside
    Giancarlo Aldini, Federica Pirrone, Mariangela Albertini, Marica Orioli, Angela Piccoli, Silvia Mazzola, Maria Giovanna Clement and Marina Carini
    Molecular Pharmacology November 2006, 70 (5) 1672-1680; DOI: https://doi.org/10.1124/mol.106.027870
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    Transcriptional Activation of CYP2C9, CYP1A1, and CYP1A2 by Hepatocyte Nuclear Factor 4α Requires Coactivators Peroxisomal Proliferator Activated Receptor-γ Coactivator 1α and Steroid Receptor Coactivator 1
    Celia P. Martínez-Jiménez, José V. Castell, M. José Gómez-Lechón and Ramiro Jover
    Molecular Pharmacology November 2006, 70 (5) 1681-1692; DOI: https://doi.org/10.1124/mol.106.025403
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    Heterogeneity of Nicotinic Cholinergic Receptors in Rat Superior Cervical and Nodose Ganglia
    Danyan Mao, Robert P. Yasuda, Hong Fan, Barry B. Wolfe and Kenneth J. Kellar
    Molecular Pharmacology November 2006, 70 (5) 1693-1699; DOI: https://doi.org/10.1124/mol.106.027458
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    Adenylyl Cyclase 6 Overexpression Decreases the Permeability of Endothelial Monolayers via Preferential Enhancement of Prostacyclin Receptor Function
    Richard A. Bundey and Paul A. Insel
    Molecular Pharmacology November 2006, 70 (5) 1700-1707; DOI: https://doi.org/10.1124/mol.106.028035
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    Molecular Aspects of Antitumor Effects of a New Platinum(IV) Drug
    Jana Kaspárková, Olga Nováková, Oldřich Vrána, Francesco Intini, Giovanni Natile and Viktor Brabec
    Molecular Pharmacology November 2006, 70 (5) 1708-1719; DOI: https://doi.org/10.1124/mol.106.027730
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    Involvement of Tissue Plasminogen Activator-Plasmin System in Depolarization-Evoked Dopamine Release in the Nucleus Accumbens of Mice
    Mina Ito, Taku Nagai, Hiroyuki Kamei, Noritaka Nakamichi, Toshitaka Nabeshima, Kazuhiro Takuma and Kiyofumi Yamada
    Molecular Pharmacology November 2006, 70 (5) 1720-1725; DOI: https://doi.org/10.1124/mol.106.022467
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    Corticostriatal Up-Regulation of Activity-Regulated Cytoskeletal-Associated Protein Expression after Repeated Exposure to Cocaine
    Fabio Fumagalli, Francesco Bedogni, Angelisa Frasca, Laura Di Pasquale, Giorgio Racagni and Marco Andrea Riva
    Molecular Pharmacology November 2006, 70 (5) 1726-1734; DOI: https://doi.org/10.1124/mol.106.026302
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    Modification of OATP2B1-Mediated Transport by Steroid Hormones
    Markus Grube, Kathleen Köck, Susanne Karner, Sebastian Reuther, Christoph A. Ritter, Gabriele Jedlitschky and Heyo K. Kroemer
    Molecular Pharmacology November 2006, 70 (5) 1735-1741; DOI: https://doi.org/10.1124/mol.106.026450
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    Calmodulin-Stimulated Adenylyl Cyclase Gene Deletion Affects Morphine Responses
    Shuang Li, Michael L. Lee, Michael R. Bruchas, Guy C. Chan, Daniel R. Storm and Charles Chavkin
    Molecular Pharmacology November 2006, 70 (5) 1742-1749; DOI: https://doi.org/10.1124/mol.106.025783
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    A Critical Role for the Short Intracellular C Terminus in Receptor Activity-Modifying Protein Function
    Madhara Udawela, George Christopoulos, Maria Morfis, Arthur Christopoulos, Siying Ye, Nanda Tilakaratne and Patrick M. Sexton
    Molecular Pharmacology November 2006, 70 (5) 1750-1760; DOI: https://doi.org/10.1124/mol.106.024257
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    Voltage-Dependent Block of N-Methyl-D-aspartate Receptors by Dopamine D1 Receptor Ligands
    Changhai Cui, Ming Xu and Marco Atzori
    Molecular Pharmacology November 2006, 70 (5) 1761-1770; DOI: https://doi.org/10.1124/mol.106.028332
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    Inhibitory Gating Modulation of Small Conductance Ca2+-Activated K+ Channels by the Synthetic Compound (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) Reduces Afterhyperpolarizing Current in Hippocampal CA1 Neurons
    Dorte Strøbæk, Charlotte Hougaard, Tina H. Johansen, Ulrik S. Sørensen, Elsebet Ø. Nielsen, Karin S. Nielsen, Ruth D. T. Taylor, Paola Pedarzani and Palle Christophersen
    Molecular Pharmacology November 2006, 70 (5) 1771-1782; DOI: https://doi.org/10.1124/mol.106.027110
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    Probing the Existence of G Protein-Coupled Receptor Dimers by Positive and Negative Ligand-Dependent Cooperative Binding
    Laura Albizu, Marie-Noëlle Balestre, Christophe Breton, Jean-Philippe Pin, Maurice Manning, Bernard Mouillac, Claude Barberis and Thierry Durroux
    Molecular Pharmacology November 2006, 70 (5) 1783-1791; DOI: https://doi.org/10.1124/mol.106.025684
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    Nerve Growth Factor Regulates Adrenergic Expression
    T. C. Tai, David C. Wong-Faull, Robert Claycomb and Dona L. Wong
    Molecular Pharmacology November 2006, 70 (5) 1792-1801; DOI: https://doi.org/10.1124/mol.106.026237
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    Monitoring the Activation State of Insulin/Insulin-Like Growth Factor-1 Hybrid Receptors Using Bioluminescence Resonance Energy Transfer
    Christophe Blanquart, Carmen Gonzalez-Yanes and Tarik Issad
    Molecular Pharmacology November 2006, 70 (5) 1802-1811; DOI: https://doi.org/10.1124/mol.106.026989
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    Induction of Apoptosis in Estrogen Receptor-Negative Breast Cancer Cells by Natural and Synthetic Cyclopentenones: Role of the IκB Kinase/Nuclear Factor-κB Pathway
    Alessandra Ciucci, Patrizia Gianferretti, Roberto Piva, Thierry Guyot, Timothy J. Snape, Stanley M. Roberts and M. Gabriella Santoro
    Molecular Pharmacology November 2006, 70 (5) 1812-1821; DOI: https://doi.org/10.1124/mol.106.025759
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    A 46-Amino Acid Segment in Phosphodiesterase-5 GAF-B Domain Provides for High Vardenafil Potency over Sildenafil and Tadalafil and Is Involved in Phosphodiesterase-5 Dimerization
    Mitsi A. Blount, Roya Zoraghi, Hengming Ke, Emmanuel P. Bessay, Jackie D. Corbin and Sharron H. Francis
    Molecular Pharmacology November 2006, 70 (5) 1822-1831; DOI: https://doi.org/10.1124/mol.106.028688
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    A New Mechanism of Methotrexate Action Revealed by Target Screening with Affinity Beads
    Hitoshi Uga, Chikanori Kuramori, Akiko Ohta, Yasunori Tsuboi, Hiroshi Tanaka, Mamoru Hatakeyama, Yuki Yamaguchi, Takashi Takahashi, Masahiro Kizaki and Hiroshi Handa
    Molecular Pharmacology November 2006, 70 (5) 1832-1839; DOI: https://doi.org/10.1124/mol.106.025866

CORRECTION

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    Correction to “Aryl Hydrocarbon Receptor Regulates Distinct Dioxin-Dependent and Dioxin-Independent Gene Batteries”
    Molecular Pharmacology November 2006, 70 (5) 1840; DOI: https://doi.org/10.1124/mol.70.5.1840
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Molecular Pharmacology: 70 (5)
Molecular Pharmacology
Vol. 70, Issue 5
1 Nov 2006
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  • SB-431542 Is a Potent and Specific Inhibitor of Transforming Growth Factor-β Superfamily Type I Activin Receptor-Like Kinase (ALK) Receptors ALK4, ALK5, and ALK7
  • The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
  • Pharmacological Properties of Y-27632, a Specific Inhibitor of Rho-Associated Kinases
  • Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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