Distinct Signaling Profiles of β1 and β2 Adrenergic Receptor Ligands toward Adenylyl Cyclase and Mitogen-Activated Protein Kinase Reveals the Pluridimensionality of Efficacy

Department of Biochemistry and Groupe de Recherche Universitaire sur le Médicament, Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec, Canada

Address correspondence to:
Dr. Michel Bouvier, Department of Biochemistry, Groupe de Recherche Universitaire sur le Médicament and Institute for Research in Immunology and Cancer, Université de Montréal, C.P. 6128 Succursale Centre-Ville, Montréal, QC, Canada, H3C 3J7. E-mail: michel. bouvier{at}umontreal.ca

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2006 to June 2021

	Abstract	Full	Pdf
Aug 2006	64	0	222
Sep 2006	17	0	108
Oct 2006	165	53	253
Nov 2006	42	60	88
Dec 2006	22	37	48
Jan 2007	38	76	76
Feb 2007	15	73	62
Mar 2007	18	37	47
Apr 2007	14	33	34
May 2007	18	49	67
Jun 2007	20	33	26
Jul 2007	8	32	34
Aug 2007	16	35	28
Sep 2007	18	26	36
Oct 2007	26	60	64
Nov 2007	19	63	71
Dec 2007	11	36	35
Jan 2008	16	43	38
Feb 2008	10	53	41
Mar 2008	23	50	47
Apr 2008	21	35	30
May 2008	17	28	21
Jun 2008	9	52	37
Jul 2008	23	67	35
Aug 2008	34	45	22
Sep 2008	31	57	36
Oct 2008	15	45	36
Nov 2008	30	72	53
Dec 2008	8	26	14
Jan 2009	20	31	19
Feb 2009	12	24	23
Mar 2009	52	43	25
Apr 2009	25	38	25
May 2009	22	25	28
Jun 2009	18	22	25
Jul 2009	25	35	22
Aug 2009	23	37	32
Sep 2009	26	23	31
Oct 2009	31	38	37
Nov 2009	28	31	43
Dec 2009	33	27	36
Jan 2010	52	31	26
Feb 2010	39	37	24
Mar 2010	29	39	31
Apr 2010	24	46	21
May 2010	18	20	10
Jun 2010	18	35	25
Jul 2010	13	35	21
Aug 2010	36	31	19
Sep 2010	15	20	14
Oct 2010	15	20	15
Nov 2010	14	38	16
Dec 2010	14	21	19
Jan 2011	14	24	20
Feb 2011	17	26	12
Mar 2011	18	37	24
Apr 2011	16	27	21
May 2011	14	34	36
Jun 2011	13	20	13
Jul 2011	17	26	21
Aug 2011	24	21	20
Sep 2011	19	28	20
Oct 2011	26	40	27
Nov 2011	32	53	29
Dec 2011	22	25	16
Jan 2012	19	32	27
Feb 2012	12	32	24
Mar 2012	9	35	22
Apr 2012	14	30	26
May 2012	24	22	12
Jun 2012	22	12	11
Jul 2012	28	32	17
Aug 2012	17	26	16
Sep 2012	20	29	20
Oct 2012	14	30	25
Nov 2012	28	50	66
Dec 2012	37	28	23
Jan 2013	51	57	38
Feb 2013	29	36	23
Mar 2013	44	46	28
Apr 2013	44	37	33
May 2013	27	38	40
Jun 2013	13	15	23
Jul 2013	11	14	23
Aug 2013	6	24	15
Sep 2013	19	34	20
Oct 2013	15	32	20
Nov 2013	12	23	11
Dec 2013	13	29	14
Jan 2014	25	52	36
Feb 2014	23	33	19
Mar 2014	23	42	38
Apr 2014	19	41	17
May 2014	22	37	37
Jun 2014	27	36	23
Jul 2014	16	20	8
Aug 2014	14	21	12
Sep 2014	21	41	20
Oct 2014	50	98	31
Nov 2014	34	45	24
Dec 2014	16	20	16
Jan 2015	28	27	17
Feb 2015	17	18	9
Mar 2015	34	40	18
Apr 2015	17	27	12
May 2015	20	19	11
Jun 2015	15	31	15
Jul 2015	26	21	16
Aug 2015	8	18	4
Sep 2015	20	38	19
Oct 2015	17	21	18
Nov 2015	20	13	15
Dec 2015	16	20	12
Jan 2016	35	24	13
Feb 2016	58	26	32
Mar 2016	25	27	18
Apr 2016	18	19	18
May 2016	17	23	17
Jun 2016	13	18	10
Jul 2016	13	22	12
Aug 2016	17	29	15
Sep 2016	13	18	11
Oct 2016	7	21	9
Nov 2016	6	43	12
Dec 2016	4	16	7
Jan 2017	4	42	11
Feb 2017	0	23	5
Mar 2017	8	45	18
Apr 2017	4	20	9
May 2017	10	33	24
Jun 2017	2	23	2
Jul 2017	0	16	1
Aug 2017	7	35	21
Sep 2017	2	31	17
Oct 2017	2	51	21
Nov 2017	10	152	6
Dec 2017	4	355	19
Jan 2018	3	276	8
Feb 2018	8	194	20
Mar 2018	3	135	16
Apr 2018	0	118	15
May 2018	1	109	15
Jun 2018	0	73	19
Jul 2018	0	52	21
Aug 2018	1	74	18
Sep 2018	0	72	21
Oct 2018	0	65	24
Nov 2018	0	92	28
Dec 2018	57	23	16
Jan 2019	68	5	17
Feb 2019	60	0	9
Mar 2019	28	8	10
Apr 2019	21	4	6
May 2019	19	14	12
Jun 2019	14	8	24
Jul 2019	45	14	30
Aug 2019	39	10	13
Sep 2019	32	14	15
Oct 2019	32	24	30
Nov 2019	45	20	14
Dec 2019	38	12	11
Jan 2020	13	9	1
Feb 2020	18	8	1
Mar 2020	26	18	8
Apr 2020	34	8	3
May 2020	18	15	8
Jun 2020	11	5	3
Jul 2020	17	9	2
Aug 2020	18	9	4
Sep 2020	33	14	6
Oct 2020	38	14	9
Nov 2020	30	7	10
Dec 2020	31	15	8
Jan 2021	61	35	9
Feb 2021	30	39	6
Mar 2021	33	9	5
Apr 2021	25	7	6
May 2021	21	20	6
Jun 2021	7	16	1