Table of Contents

Articles

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  Bafilomycin Induces the p21-Mediated Growth Inhibition of Cancer Cells under Hypoxic Conditions by Expressing Hypoxia-Inducible Factor-1α

  Ji-Hong Lim, Jong-Wan Park, Myung-Suk Kim, Sang-Ki Park, Randall S. Johnson and Yang-Sook Chun

  Molecular Pharmacology December 2006, 70 (6) 1856-1865; DOI: https://doi.org/10.1124/mol.106.028076
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  Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin

  Donnette A. Dabydeen, James C. Burnett, Ruoli Bai, Pascal Verdier-Pinard, Sarah J. H. Hickford, George R. Pettit, John W. Blunt, Murray H. G. Munro, Rick Gussio and Ernest Hamel

  Molecular Pharmacology December 2006, 70 (6) 1866-1875; DOI: https://doi.org/10.1124/mol.106.026641
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  Pharmacological Inhibition of Histone Deacetylases by Suberoylanilide Hydroxamic Acid Specifically Alters Gene Expression and Reduces Ischemic Injury in the Mouse Brain

  Giuseppe Faraco, Tristano Pancani, Laura Formentini, Paolo Mascagni, Gianluca Fossati, Flavio Leoni, Flavio Moroni and Alberto Chiarugi

  Molecular Pharmacology December 2006, 70 (6) 1876-1884; DOI: https://doi.org/10.1124/mol.106.027912
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  Rapid and Robust Protection against Cocaine-Induced Lethality in Rats by the Bacterial Cocaine Esterase

  Ziva D. Cooper, Diwahar Narasimhan, Roger K. Sunahara, Pawel Mierzejewski, Emily M. Jutkiewicz, Nicholas A. Larsen, Ian A. Wilson, Donald W. Landry and James H. Woods

  Molecular Pharmacology December 2006, 70 (6) 1885-1891; DOI: https://doi.org/10.1124/mol.106.025999
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  Conformational Constraining of Inactive and Active States of a Seven Transmembrane Receptor by Metal Ion Site Engineering in the Extracellular End of Transmembrane Segment V

  Mette M. Rosenkilde, Ralf David, Ilka Oerlecke, Tau Benned-Jensen, Ulf Geumann, Anette G. Beck-Sickinger and Thue W. Schwartz

  Molecular Pharmacology December 2006, 70 (6) 1892-1901; DOI: https://doi.org/10.1124/mol.106.027425
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  2,3,7,8-Tetrachlorodibenzo-p-dioxin and Epidermal Growth Factor Cooperatively Suppress Peroxisome Proliferator-Activated Receptor-γ1 Stimulation and Restore Focal Adhesion Complexes during Adipogenesis: Selective Contributions of Src, Rho, and Erk Distinguish These Overlapping Processes in C3H10T1/2 Cells

  Xueqing Liu and Colin Jefcoate

  Molecular Pharmacology December 2006, 70 (6) 1902-1915; DOI: https://doi.org/10.1124/mol.106.026534
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  Ginsenoside Re, a Main Phytosterol of Panax ginseng, Activates Cardiac Potassium Channels via a Nongenomic Pathway of Sex Hormones

  Tetsushi Furukawa, Chang-Xi Bai, Asami Kaihara, Eri Ozaki, Takashi Kawano, Yutaka Nakaya, Muhammad Awais, Moritoshi Sato, Yoshio Umezawa and Junko Kurokawa

  Molecular Pharmacology December 2006, 70 (6) 1916-1924; DOI: https://doi.org/10.1124/mol.106.028134
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  Stimulation of AMP-Activated Protein Kinase Is Essential for the Induction of Drug Metabolizing Enzymes by Phenobarbital in Human and Mouse Liver

  Franck Rencurel, Marc Foretz, Michel R. Kaufmann, Deborah Stroka, Renate Looser, Isabelle Leclerc, Gabriela da Silva Xavier, Guy A. Rutter, Benoit Viollet and Urs A. Meyer

  Molecular Pharmacology December 2006, 70 (6) 1925-1934; DOI: https://doi.org/10.1124/mol.106.029421
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  Insights into the Cholecystokinin 2 Receptor Binding Site and Processes of Activation

  Michaël R. Paillasse, Céline Deraeve, Philippe de Medina, Loubna Mhamdi, Gilles Favre, Marc Poirot and Sandrine Silvente-Poirot

  Molecular Pharmacology December 2006, 70 (6) 1935-1945; DOI: https://doi.org/10.1124/mol.106.029967
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  Eriocalyxin B Inhibits Nuclear Factor-κB Activation by Interfering with the Binding of Both p65 and p50 to the Response Element in a Noncompetitive Manner

  Chung-Hang Leung, Susan P. Grill, Wing Lam, Wenli Gao, Han-Dong Sun and Yung-Chi Cheng

  Molecular Pharmacology December 2006, 70 (6) 1946-1955; DOI: https://doi.org/10.1124/mol.106.028480
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  Molecular Interaction of Serotonin 5-HT_2A Receptor Residues Phe339^(6.51) and Phe340^(6.52) with Superpotent N-Benzyl Phenethylamine Agonists

  Michael R. Braden, Jason C. Parrish, John C. Naylor and David E. Nichols

  Molecular Pharmacology December 2006, 70 (6) 1956-1964; DOI: https://doi.org/10.1124/mol.106.028720
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  Dissecting the Roles of Checkpoint Kinase 1/CDC2 and Mitogen-Activated Protein Kinase Kinase 1/2/Extracellular Signal-Regulated Kinase 1/2 in Relation to 7-Hydroxystaurosporine-Induced Apoptosis in Human Multiple Myeloma Cells

  Xin-Yan Pei, Weiqun Li, Yun Dai, Paul Dent and Steven Grant

  Molecular Pharmacology December 2006, 70 (6) 1965-1973; DOI: https://doi.org/10.1124/mol.106.028373
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  Structural Requirements of Transmembrane Domain 3 for Activation by the M₁ Muscarinic Receptor Agonists AC-42, AC-260584, Clozapine, and N-Desmethylclozapine: Evidence for Three Distinct Modes of Receptor Activation

  Tracy A. Spalding, Jian-Nong Ma, Thomas R. Ott, Mikael Friberg, Abhishek Bajpai, Stefania Risso Bradley, Robert E. Davis, Mark R. Brann and Ethan S. Burstein

  Molecular Pharmacology December 2006, 70 (6) 1974-1983; DOI: https://doi.org/10.1124/mol.106.024901
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  Determinants of 1-Piperidinecarboxamide, N-[2-[[5-Amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) Affinity for Calcitonin Gene-Related Peptide and Amylin Receptors—The Role of Receptor Activity Modifying Protein 1

  Debbie L. Hay, George Christopoulos, Arthur Christopoulos and Patrick M. Sexton

  Molecular Pharmacology December 2006, 70 (6) 1984-1991; DOI: https://doi.org/10.1124/mol.106.027953
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  cAMP Inhibits Transforming Growth Factor-β-Stimulated Collagen Synthesis via Inhibition of Extracellular Signal-Regulated Kinase 1/2 and Smad Signaling in Cardiac Fibroblasts

  Xiaoqiu Liu, Shu Qiang Sun, Aviv Hassid and Rennolds S. Ostrom

  Molecular Pharmacology December 2006, 70 (6) 1992-2003; DOI: https://doi.org/10.1124/mol.106.028951
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  Essential Role of C-Rel in Nitric-Oxide Synthase-2 Transcriptional Activation: Time-Dependent Control by Salicylate

  Katarzyna A. Cieslik, Wu-Guo Deng and Kenneth K. Wu

  Molecular Pharmacology December 2006, 70 (6) 2004-2014; DOI: https://doi.org/10.1124/mol.106.026054
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  2,3-Butanedione Monoxime Affects Cystic Fibrosis Transmembrane Conductance Regulator Channel Function through Phosphorylation-Dependent and Phosphorylation-Independent Mechanisms: The Role of Bilayer Material Properties

  Pablo Artigas, Subhi J. Al'Aref, E. Ashley Hobart, Laín F. Díaz, Masayuki Sakaguchi, Samuel Straw and Olaf S. Andersen

  Molecular Pharmacology December 2006, 70 (6) 2015-2026; DOI: https://doi.org/10.1124/mol.106.026070
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  Point Mutations in the Transmembrane Region of GABA_B2 Facilitate Activation by the Positive Modulator N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the Absence of the GABA_B1 Subunit

  Delphine S. Dupuis, Dinko Relkovic, Loic Lhuillier, Johannes Mosbacher and Klemens Kaupmann

  Molecular Pharmacology December 2006, 70 (6) 2027-2036; DOI: https://doi.org/10.1124/mol.106.028183
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  Role of the Agonist Binding Site in Up-Regulation of Neuronal Nicotinic α4β2 Receptors

  Masashi Kishi and Joe Henry Steinbach

  Molecular Pharmacology December 2006, 70 (6) 2037-2044; DOI: https://doi.org/10.1124/mol.106.029298
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  Molecular Changes Evoked by Triethylenetetramine Treatment in the Extracellular Matrix of the Heart and Aorta in Diabetic Rats

  Deming Gong, Jun Lu, Xiuyin Chen, Soon Y. Choong, Shaoping Zhang, Yih-Kai Chan, Sarah Glyn-Jones, Gregory D. Gamble, Anthony R. J. Phillips and Garth J. S. Cooper

  Molecular Pharmacology December 2006, 70 (6) 2045-2051; DOI: https://doi.org/10.1124/mol.106.028605
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  The Mechanism of Activity-Dependent Sodium Channel Inhibition by the Antidepressants Fluoxetine and Desipramine

  N. Lenkey, R. Karoly, J. P. Kiss, B. K. Szasz, E. S. Vizi and A. Mike

  Molecular Pharmacology December 2006, 70 (6) 2052-2063; DOI: https://doi.org/10.1124/mol.106.026419
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  Methamphetamine-Induced Sensitization Differentially Alters pCREB and ΔFosB throughout the Limbic Circuit of the Mammalian Brain

  John McDaid, Martin P. Graham and T. Celeste Napier

  Molecular Pharmacology December 2006, 70 (6) 2064-2074; DOI: https://doi.org/10.1124/mol.106.023051
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  YM-244769, a Novel Na⁺/Ca²⁺ Exchange Inhibitor That Preferentially Inhibits NCX3, Efficiently Protects against Hypoxia/Reoxygenation-Induced SH-SY5Y Neuronal Cell Damage

  Takahiro Iwamoto and Satomi Kita

  Molecular Pharmacology December 2006, 70 (6) 2075-2083; DOI: https://doi.org/10.1124/mol.106.028464
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  Analysis of the Dissociated Steroid RU24858 Does Not Exclude a Role for Inducible Genes in the Anti-Inflammatory Actions of Glucocorticoids

  Joanna E. Chivers, Wei Gong, Elizabeth M. King, Joachim Seybold, Judith C. Mak, Louise E. Donnelly, Neil S. Holden and Robert Newton

  Molecular Pharmacology December 2006, 70 (6) 2084-2095; DOI: https://doi.org/10.1124/mol.106.025841
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  Endogenous Hepatic Expression of the Hepatitis B Virus X-Associated Protein 2 Is Adequate for Maximal Association with Aryl Hydrocarbon Receptor-90-kDa Heat Shock Protein Complexes

  Brett D. Hollingshead, Rushang D. Patel and Gary H. Perdew

  Molecular Pharmacology December 2006, 70 (6) 2096-2107; DOI: https://doi.org/10.1124/mol.106.029215
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  The H⁺-Linked Monocarboxylate Transporter (MCT1/SLC16A1): A Potential Therapeutic Target for High-Risk Neuroblastoma

  Jun Fang, Quintin J. Quinones, Trevor L. Holman, Michael J. Morowitz, Qun Wang, Huaqing Zhao, Frank Sivo, John M. Maris and Miriam L. Wahl

  Molecular Pharmacology December 2006, 70 (6) 2108-2115; DOI: https://doi.org/10.1124/mol.106.026245
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  Neurotoxicity of Domoic Acid in Cerebellar Granule Neurons in a Genetic Model of Glutathione Deficiency

  G. Giordano, C. C. White, L. A. McConnachie, C. Fernandez, T. J. Kavanagh and L. G. Costa

  Molecular Pharmacology December 2006, 70 (6) 2116-2126; DOI: https://doi.org/10.1124/mol.106.027748
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  The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice

  Maciej J. Zamek-Gliszczynski, Ken-ichi Nezasa, Xianbin Tian, J. Cory Kalvass, Nita J. Patel, Thomas J. Raub and Kim L. R. Brouwer

  Molecular Pharmacology December 2006, 70 (6) 2127-2133; DOI: https://doi.org/10.1124/mol.106.026955