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Structural Requirements of Transmembrane Domain 3 for Activation by the M1 Muscarinic Receptor Agonists AC-42, AC-260584, Clozapine, and N-Desmethylclozapine: Evidence for Three Distinct Modes of Receptor Activation

Tracy A. Spalding, Jian-Nong Ma, Thomas R. Ott, Mikael Friberg, Abhishek Bajpai, Stefania Risso Bradley, Robert E. Davis, Mark R. Brann and Ethan S. Burstein
Molecular Pharmacology December 2006, 70 (6) 1974-1983; DOI: https://doi.org/10.1124/mol.106.024901

Article Information

vol. 70 no. 6 1974-1983
DOI 
https://doi.org/10.1124/mol.106.024901
PubMed 
16959945
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Received March 23, 2006
  • Accepted August 31, 2006
  • Published online November 16, 2006.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tracy A. Spalding,
  2. Jian-Nong Ma,
  3. Thomas R. Ott,
  4. Mikael Friberg,
  5. Abhishek Bajpai,
  6. Stefania Risso Bradley,
  7. Robert E. Davis,
  8. Mark R. Brann and
  9. Ethan S. Burstein
  1. ACADIA Pharmaceuticals, Inc., San Diego, California
  1. Address correspondence to:
    Dr. Ethan S. Burstein, ACADIA Pharmaceuticals, Inc., 3911 Sorrento Valley Boulevard, San Diego, CA 92121. E-mail: eburstein{at}acadia-pharm.com
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Research ArticleArticle

Structural Requirements of Transmembrane Domain 3 for Activation by the M1 Muscarinic Receptor Agonists AC-42, AC-260584, Clozapine, and N-Desmethylclozapine: Evidence for Three Distinct Modes of Receptor Activation

Tracy A. Spalding, Jian-Nong Ma, Thomas R. Ott, Mikael Friberg, Abhishek Bajpai, Stefania Risso Bradley, Robert E. Davis, Mark R. Brann and Ethan S. Burstein
Molecular Pharmacology December 1, 2006, 70 (6) 1974-1983; DOI: https://doi.org/10.1124/mol.106.024901
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