Molecular Pharmacology: 71 (1)

January 01, 2007; Volume 71,Issue 1

EDITOR'S NOTE

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Molecular Pharmacology in the Postgenomic Era
P. Jeffrey Conn

Molecular Pharmacology January 2007, 71 (1) 1-2; DOI: https://doi.org/10.1124/mol.71.1.1

Accelerated Communication

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Carbohydrate-Binding Agents Efficiently Prevent Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin (DC-SIGN)-Directed HIV-1 Transmission to T Lymphocytes
Jan Balzarini, Yven Van Herrewege, Kurt Vermeire, Guido Vanham and Dominique Schols

Molecular Pharmacology January 2007, 71 (1) 3-11; DOI: https://doi.org/10.1124/mol.106.030155

Articles

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μ-Opioid Receptor Activation Modulates Transient Receptor Potential Vanilloid 1 (TRPV1) Currents in Sensory Neurons in A Model of Inflammatory Pain
Jeannette Endres-Becker, Paul A. Heppenstall, Shaaban A. Mousa, Dominika Labuz, Alexander Oksche, Michael Schäfer, Christoph Stein and Christian Zöllner

Molecular Pharmacology January 2007, 71 (1) 12-18; DOI: https://doi.org/10.1124/mol.106.026740
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In Vivo Responsiveness to Ezetimibe Correlates with Niemann-Pick C1 Like-1 (NPC1L1) Binding Affinity: Comparison of Multiple Species NPC1L1 Orthologs
Brian E. Hawes, Kim A. O'Neill, Xiaorui Yao, James H. Crona, Harry R. Davis, Michael P. Graziano and Scott W. Altmann

Molecular Pharmacology January 2007, 71 (1) 19-29; DOI: https://doi.org/10.1124/mol.106.027896
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Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis
Toni Ahtoniemi, Gundars Goldsteins, Velta Keksa-Goldsteine, Tarja Malm, Katja Kanninen, Antero Salminen and Jari Koistinaho

Molecular Pharmacology January 2007, 71 (1) 30-37; DOI: https://doi.org/10.1124/mol.106.028415
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Structural Determinants for High-Affinity Zolpidem Binding to GABA-A receptors
Feyza Sancar, Spencer S. Ericksen, Amy M. Kucken, Jeremy A. Teissére and Cynthia Czajkowski

Molecular Pharmacology January 2007, 71 (1) 38-46; DOI: https://doi.org/10.1124/mol.106.029595
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Characterization of β₂-Adrenergic Receptor Dephosphorylation: Comparison with the Rate of Resensitization
Tuan M. Tran, Jacqueline Friedman, Faiza Baameur, Brian J. Knoll, Robert H. Moore and Richard B. Clark

Molecular Pharmacology January 2007, 71 (1) 47-60; DOI: https://doi.org/10.1124/mol.106.028456
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c-Abl Kinase Regulates Curcumin-Induced Cell Death through Activation of c-Jun N-Terminal Kinase
Ravindra Kamath, Zhihua Jiang, Guoming Sun, Jack C. Yalowich and R. Baskaran

Molecular Pharmacology January 2007, 71 (1) 61-72; DOI: https://doi.org/10.1124/mol.106.026575
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The Positional Influence of the Helical Geometry of the Heteroduplex Substrate on Human RNase H1 Catalysis
Walt F. Lima, John B. Rose, Josh G. Nichols, Hongjiang Wu, Michael T. Migawa, Tadeusz K. Wyrzykiewicz, Guillermo Vasquez, Eric E. Swayze and Stanley T. Crooke

Molecular Pharmacology January 2007, 71 (1) 73-82; DOI: https://doi.org/10.1124/mol.106.025429
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Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate
Walt F. Lima, John B. Rose, Josh G. Nichols, Hongjiang Wu, Michael T. Migawa, Tadeusz K. Wyrzykiewicz, Andrew M. Siwkowski and Stanley T. Crooke

Molecular Pharmacology January 2007, 71 (1) 83-91; DOI: https://doi.org/10.1124/mol.106.025015
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Amino Acid Residues in the P2X₇ Receptor that Mediate Differential Sensitivity to ATP and BzATP
Mark T. Young, Pablo Pelegrin and Annmarie Surprenant

Molecular Pharmacology January 2007, 71 (1) 92-100; DOI: https://doi.org/10.1124/mol.106.030163
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Down-Regulation of Inhibitor of Apoptosis Proteins by Deguelin Selectively Induces Apoptosis in Breast Cancer Cells
Xiang-Hong Peng, Prasanthi Karna, Ruth M. O'Regan, XiuJu Liu, Rajesh Naithani, Robert M. Moriarty, William C. Wood, Ho-Young Lee and Lily Yang

Molecular Pharmacology January 2007, 71 (1) 101-111; DOI: https://doi.org/10.1124/mol.106.027367
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Subunit-Specific Roles of Glycine-Binding Domains in Activation of NR1/NR3 N-Methyl-d-aspartate Receptors
Marc Awobuluyi, Jin Yang, Yuzhen Ye, Jon E. Chatterton, Adam Godzik, Stuart A. Lipton and Dongxian Zhang

Molecular Pharmacology January 2007, 71 (1) 112-122; DOI: https://doi.org/10.1124/mol.106.030700
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Interaction of the μ-Opioid Receptor with Synaptophysin Influences Receptor Trafficking and Signaling
Ying-Jian Liang, Dai-Fei Wu, Li-Quan Yang, Volker Höllt and Thomas Koch

Molecular Pharmacology January 2007, 71 (1) 123-131; DOI: https://doi.org/10.1124/mol.106.026062
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Estrogen Receptor Antagonist Fulvestrant (ICI 182,780) Inhibits the Anti-Inflammatory Effect of Glucocorticoids
Salvatore Cuzzocrea, Stefano Bruscoli, Concetta Crisafulli, Emanuela Mazzon, Massimiliano Agostini, Carmelo Muià, Emanuela Esposito, Rosa Di Virgilio, Rosaria Meli, Elisabetta Vegeto, Adriana Maggi and Carlo Riccardi

Molecular Pharmacology January 2007, 71 (1) 132-144; DOI: https://doi.org/10.1124/mol.106.029629
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Role of Dioxin Response Element and Nuclear Factor-κB Motifs in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Regulation of Fas and Fas Ligand Expression
Narendra P. Singh, Mitzi Nagarkatti and Prakash S. Nagarkatti

Molecular Pharmacology January 2007, 71 (1) 145-157; DOI: https://doi.org/10.1124/mol.106.028365
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In Silico Prediction of Pregnane X Receptor Activators by Machine Learning Approache
C. Y. Ung, H. Li, C. W. Yap and Y. Z. Chen

Molecular Pharmacology January 2007, 71 (1) 158-168; DOI: https://doi.org/10.1124/mol.106.027623
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Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay
David L. Roman, Jeffery N. Talbot, Rebecca A. Roof, Roger K. Sunahara, John R. Traynor and Richard R. Neubig

Molecular Pharmacology January 2007, 71 (1) 169-175; DOI: https://doi.org/10.1124/mol.106.028670
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Regulation of Human Cone Cyclic Nucleotide-Gated Channels by Endogenous Phospholipids and Exogenously Applied Phosphatidylinositol 3,4,5-trisphosphate
Scott R. Bright, Elizabeth D. Rich and Michael D. Varnum

Molecular Pharmacology January 2007, 71 (1) 176-183; DOI: https://doi.org/10.1124/mol.106.026401
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Independent Mechanistic Inhibition of Cdc25 Phosphatases by a Natural Product Caulibugulone
Marni Brisson, Caleb Foster, Peter Wipf, Beomjun Joo, Robert J. Tomko, Theresa Nguyen and John S. Lazo

Molecular Pharmacology January 2007, 71 (1) 184-192; DOI: https://doi.org/10.1124/mol.106.028589
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Motexafin Gadolinium-Induced Cell Death Correlates with Heme oxygenase-1 Expression and Inhibition of P450 Reductase-Dependent Activities
John P. Evans, Fengyun Xu, Mint Sirisawad, Richard Miller, Louie Naumovski and Paul R. Ortiz de Montellano

Molecular Pharmacology January 2007, 71 (1) 193-200; DOI: https://doi.org/10.1124/mol.106.028407
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Repression of Human GSTA1 by Interleukin-1β Is Mediated by Variant Hepatic Nuclear Factor-1C
Lorraine Ng, Kathleen Nichols, Kelly O'Rourke, Ann Maslen and Gordon M. Kirby

Molecular Pharmacology January 2007, 71 (1) 201-208; DOI: https://doi.org/10.1124/mol.106.028563
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Embelin, an Inhibitor of X Chromosome-Linked Inhibitor-of-Apoptosis Protein, Blocks Nuclear Factor-κB (NF-κB) Signaling Pathway Leading to Suppression of NF-κB-Regulated Antiapoptotic and Metastatic Gene Products
Kwang Seok Ahn, Gautam Sethi and Bharat B. Aggarwal

Molecular Pharmacology January 2007, 71 (1) 209-219; DOI: https://doi.org/10.1124/mol.106.028787
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The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor
Changcheng Zhou, Emma-Jane Poulton, Felix Grün, Theo K. Bammler, Bruce Blumberg, Kenneth E. Thummel and David L. Eaton

Molecular Pharmacology January 2007, 71 (1) 220-229; DOI: https://doi.org/10.1124/mol.106.029264
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Amphetamine Induces a Calcium/Calmodulin-Dependent Protein Kinase II-Dependent Reduction in Norepinephrine Transporter Surface Expression Linked to Changes in Syntaxin 1A/Transporter Complexes
Concetta Dipace, Uhna Sung, Francesca Binda, Randy D. Blakely and Aurelio Galli

Molecular Pharmacology January 2007, 71 (1) 230-239; DOI: https://doi.org/10.1124/mol.106.026690
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The Effect of Low pH on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport of Methotrexate, 7-Hydroxymethotrexate, Methotrexate Diglutamate, Folic Acid, Mitoxantrone, Topotecan, and Resveratrol in In Vitro Drug Transport Models
Pauline Breedveld, Dick Pluim, Greta Cipriani, Femke Dahlhaus, Maria A. J. van Eijndhoven, Cornelia J. F. de Wolf, Annemieke Kuil, Jos H. Beijnen, George L. Scheffer, Gerrit Jansen, Piet Borst and Jan H. M. Schellens

Molecular Pharmacology January 2007, 71 (1) 240-249; DOI: https://doi.org/10.1124/mol.106.028167
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Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic Acid Receptor α Agonists in Colitis
Makoto Osanai, Nami Nishikiori, Masaki Murata, Hideki Chiba, Takashi Kojima and Norimasa Sawada

Molecular Pharmacology January 2007, 71 (1) 250-258; DOI: https://doi.org/10.1124/mol.106.029579
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Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival after Irradiation or HMG CoA Reductase Inhibitor Treatment
Adly Yacoub, William Hawkins, David Hanna, Hong Young, Margaret A. Park, Mark Grant, John D. Roberts, David T. Curiel, Paul B. Fisher, Kristoffer Valerie, Steven Grant, Michael P. Hagan and Paul Dent

Molecular Pharmacology January 2007, 71 (1) 259-275; DOI: https://doi.org/10.1124/mol.106.031153
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Molecular Basis for the Antiproliferative Effect of Agmatine in Tumor Cells of Colonic, Hepatic, and Neuronal Origin
C. Wolf, M. Brüss, B. Hänisch, M. Göthert, I. von Kügelgen and G. J. Molderings

Molecular Pharmacology January 2007, 71 (1) 276-283; DOI: https://doi.org/10.1124/mol.106.028449
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Neurokinin 1 Receptors Trigger Overlapping Stimulation and Inhibition of Ca_V2.3 (R-Type) Calcium Channels
Ulises Meza, Ashish Thapliyal, Roger A. Bannister and Brett A. Adams

Molecular Pharmacology January 2007, 71 (1) 284-293; DOI: https://doi.org/10.1124/mol.106.028530
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Characterization of the Tritium-Labeled Analog of L-threo-β-Benzyloxyaspartate Binding to Glutamate Transporters
Keiko Shimamoto, Yasuto Otsubo, Yasushi Shigeri, Yoshimi Yasuda-Kamatani, Masamichi Satoh, Shuji Kaneko and Takayuki Nakagawa

Molecular Pharmacology January 2007, 71 (1) 294-302; DOI: https://doi.org/10.1124/mol.106.027250
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Phosphorylation of G_α11 Protein Contributes to Agonist-Induced Desensitization of 5-HT_2A Receptor Signaling
Ju Shi, Bozena Zemaitaitis and Nancy A. Muma

Molecular Pharmacology January 2007, 71 (1) 303-313; DOI: https://doi.org/10.1124/mol.106.028241
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RasGRP1 Confers the Phorbol Ester-Sensitive Phenotype to EL4 Lymphoma Cells
Shujie Han, Stewart M. Knoepp, Mark A. Hallman and Kathryn E. Meier

Molecular Pharmacology January 2007, 71 (1) 314-322; DOI: https://doi.org/10.1124/mol.106.028639
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Short Polybasic Peptide Sequences Are Potent Inhibitors of PC5/6 and PC7: Use of Positional Scanning-Synthetic Peptide Combinatorial Libraries as a Tool for the Optimization of Inhibitory Sequences
Martin Fugere, Jon Appel, Richard A. Houghten, Iris Lindberg and Robert Day

Molecular Pharmacology January 2007, 71 (1) 323-332; DOI: https://doi.org/10.1124/mol.106.027946
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Zoledronic Acid Activates the DNA S-Phase Checkpoint and Induces Osteosarcoma Cell Death Characterized by Apoptosis-Inducing Factor and Endonuclease-G Translocation Independently of p53 and Retinoblastoma Status
B. Ory, F. Blanchard, S. Battaglia, F. Gouin, F. Rédini and D. Heymann

Molecular Pharmacology January 2007, 71 (1) 333-343; DOI: https://doi.org/10.1124/mol.106.028837
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Geldanamycin Interferes with the 90-kDa Heat Shock Protein, Affecting Lipopolysaccharide-Mediated Interleukin-1 Expression and Apoptosis within Macrophages
Hsien-Yeh Hsu, Hua-Lin Wu, Sai-Koong Tan, Vivian Pei-Hsin Li, Wei-Ting Wang, Jason Hsu and Ching-Hsun Cheng

Molecular Pharmacology January 2007, 71 (1) 344-356; DOI: https://doi.org/10.1124/mol.106.024240
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Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but Not Hydroxylamine Ligands
Stefanie Zorbas-Seifried, Michael A. Jakupec, Nikolay V. Kukushkin, Michael Groessl, Christian G. Hartinger, Olga Semenova, Haralabos Zorbas, Vadim Yu. Kukushkin and Bernhard K. Keppler

Molecular Pharmacology January 2007, 71 (1) 357-365; DOI: https://doi.org/10.1124/mol.106.030726
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An Extract from the Medicinal Plant Phyllanthus acidus and Its Isolated Compounds Induce Airway Chloride Secretion: A Potential Treatment for Cystic Fibrosis
Marisa Sousa, Jiraporn Ousingsawat, Roswitha Seitz, Supaporn Puntheeranurak, Ana Regalado, André Schmidt, Tiago Grego, Chaweewan Jansakul, Margarida D. Amaral, Rainer Schreiber and Karl Kunzelmann

Molecular Pharmacology January 2007, 71 (1) 366-376; DOI: https://doi.org/10.1124/mol.106.025262
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Translational Regulation of Rat Multidrug Resistance-Associated Protein 2 Expression Is Mediated by Upstream Open Reading Frames in the 5′ Untranslated Region
Yuanyuan Zhang, Wei Li and Mary Vore

Molecular Pharmacology January 2007, 71 (1) 377-383; DOI: https://doi.org/10.1124/mol.106.029793

Letters to the Editor

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Comments on “Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor”
Richard S. Pollenz

Molecular Pharmacology January 2007, 71 (1) 384-385; DOI: https://doi.org/10.1124/mol.106.031963
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Response to Comments on “Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor”
Sakina E. Eltom and Yolanda Dale

Molecular Pharmacology January 2007, 71 (1) 386-387; DOI: https://doi.org/10.1124/mol.106.031971

NOTICE OF RETRACTION

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Re: Henschler R, Brennscheidt U, Mertelsmann R, and Herrmann F (1991) Induction of c-jun expression in the myeloid leukemia cell line KG-1 by 1-β-d-arabinofuranosylcytosine. Mol Pharmacol 39:171-176
Molecular Pharmacology January 2007, 71 (1) 388; DOI: https://doi.org/10.1124/mol.71.1.388

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EDITOR'S NOTE

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