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Molecular Pharmacology

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Table of Contents

January 01, 2007; Volume 71,Issue 1

EDITOR'S NOTE

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    Molecular Pharmacology in the Postgenomic Era
    P. Jeffrey Conn
    Molecular Pharmacology January 2007, 71 (1) 1-2; DOI: https://doi.org/10.1124/mol.71.1.1

Accelerated Communication

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    Carbohydrate-Binding Agents Efficiently Prevent Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin (DC-SIGN)-Directed HIV-1 Transmission to T Lymphocytes
    Jan Balzarini, Yven Van Herrewege, Kurt Vermeire, Guido Vanham and Dominique Schols
    Molecular Pharmacology January 2007, 71 (1) 3-11; DOI: https://doi.org/10.1124/mol.106.030155

Articles

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    μ-Opioid Receptor Activation Modulates Transient Receptor Potential Vanilloid 1 (TRPV1) Currents in Sensory Neurons in A Model of Inflammatory Pain
    Jeannette Endres-Becker, Paul A. Heppenstall, Shaaban A. Mousa, Dominika Labuz, Alexander Oksche, Michael Schäfer, Christoph Stein and Christian Zöllner
    Molecular Pharmacology January 2007, 71 (1) 12-18; DOI: https://doi.org/10.1124/mol.106.026740
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    In Vivo Responsiveness to Ezetimibe Correlates with Niemann-Pick C1 Like-1 (NPC1L1) Binding Affinity: Comparison of Multiple Species NPC1L1 Orthologs
    Brian E. Hawes, Kim A. O'Neill, Xiaorui Yao, James H. Crona, Harry R. Davis, Michael P. Graziano and Scott W. Altmann
    Molecular Pharmacology January 2007, 71 (1) 19-29; DOI: https://doi.org/10.1124/mol.106.027896
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    Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis
    Toni Ahtoniemi, Gundars Goldsteins, Velta Keksa-Goldsteine, Tarja Malm, Katja Kanninen, Antero Salminen and Jari Koistinaho
    Molecular Pharmacology January 2007, 71 (1) 30-37; DOI: https://doi.org/10.1124/mol.106.028415
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    Structural Determinants for High-Affinity Zolpidem Binding to GABA-A receptors
    Feyza Sancar, Spencer S. Ericksen, Amy M. Kucken, Jeremy A. Teissére and Cynthia Czajkowski
    Molecular Pharmacology January 2007, 71 (1) 38-46; DOI: https://doi.org/10.1124/mol.106.029595
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    Characterization of β2-Adrenergic Receptor Dephosphorylation: Comparison with the Rate of Resensitization
    Tuan M. Tran, Jacqueline Friedman, Faiza Baameur, Brian J. Knoll, Robert H. Moore and Richard B. Clark
    Molecular Pharmacology January 2007, 71 (1) 47-60; DOI: https://doi.org/10.1124/mol.106.028456
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    c-Abl Kinase Regulates Curcumin-Induced Cell Death through Activation of c-Jun N-Terminal Kinase
    Ravindra Kamath, Zhihua Jiang, Guoming Sun, Jack C. Yalowich and R. Baskaran
    Molecular Pharmacology January 2007, 71 (1) 61-72; DOI: https://doi.org/10.1124/mol.106.026575
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    The Positional Influence of the Helical Geometry of the Heteroduplex Substrate on Human RNase H1 Catalysis
    Walt F. Lima, John B. Rose, Josh G. Nichols, Hongjiang Wu, Michael T. Migawa, Tadeusz K. Wyrzykiewicz, Guillermo Vasquez, Eric E. Swayze and Stanley T. Crooke
    Molecular Pharmacology January 2007, 71 (1) 73-82; DOI: https://doi.org/10.1124/mol.106.025429
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    Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate
    Walt F. Lima, John B. Rose, Josh G. Nichols, Hongjiang Wu, Michael T. Migawa, Tadeusz K. Wyrzykiewicz, Andrew M. Siwkowski and Stanley T. Crooke
    Molecular Pharmacology January 2007, 71 (1) 83-91; DOI: https://doi.org/10.1124/mol.106.025015
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    Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP
    Mark T. Young, Pablo Pelegrin and Annmarie Surprenant
    Molecular Pharmacology January 2007, 71 (1) 92-100; DOI: https://doi.org/10.1124/mol.106.030163
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    Down-Regulation of Inhibitor of Apoptosis Proteins by Deguelin Selectively Induces Apoptosis in Breast Cancer Cells
    Xiang-Hong Peng, Prasanthi Karna, Ruth M. O'Regan, XiuJu Liu, Rajesh Naithani, Robert M. Moriarty, William C. Wood, Ho-Young Lee and Lily Yang
    Molecular Pharmacology January 2007, 71 (1) 101-111; DOI: https://doi.org/10.1124/mol.106.027367
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    Subunit-Specific Roles of Glycine-Binding Domains in Activation of NR1/NR3 N-Methyl-d-aspartate Receptors
    Marc Awobuluyi, Jin Yang, Yuzhen Ye, Jon E. Chatterton, Adam Godzik, Stuart A. Lipton and Dongxian Zhang
    Molecular Pharmacology January 2007, 71 (1) 112-122; DOI: https://doi.org/10.1124/mol.106.030700
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    Interaction of the μ-Opioid Receptor with Synaptophysin Influences Receptor Trafficking and Signaling
    Ying-Jian Liang, Dai-Fei Wu, Li-Quan Yang, Volker Höllt and Thomas Koch
    Molecular Pharmacology January 2007, 71 (1) 123-131; DOI: https://doi.org/10.1124/mol.106.026062
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    Estrogen Receptor Antagonist Fulvestrant (ICI 182,780) Inhibits the Anti-Inflammatory Effect of Glucocorticoids
    Salvatore Cuzzocrea, Stefano Bruscoli, Concetta Crisafulli, Emanuela Mazzon, Massimiliano Agostini, Carmelo Muià, Emanuela Esposito, Rosa Di Virgilio, Rosaria Meli, Elisabetta Vegeto, Adriana Maggi and Carlo Riccardi
    Molecular Pharmacology January 2007, 71 (1) 132-144; DOI: https://doi.org/10.1124/mol.106.029629
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    Role of Dioxin Response Element and Nuclear Factor-κB Motifs in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Regulation of Fas and Fas Ligand Expression
    Narendra P. Singh, Mitzi Nagarkatti and Prakash S. Nagarkatti
    Molecular Pharmacology January 2007, 71 (1) 145-157; DOI: https://doi.org/10.1124/mol.106.028365
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    In Silico Prediction of Pregnane X Receptor Activators by Machine Learning Approache
    C. Y. Ung, H. Li, C. W. Yap and Y. Z. Chen
    Molecular Pharmacology January 2007, 71 (1) 158-168; DOI: https://doi.org/10.1124/mol.106.027623
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    Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay
    David L. Roman, Jeffery N. Talbot, Rebecca A. Roof, Roger K. Sunahara, John R. Traynor and Richard R. Neubig
    Molecular Pharmacology January 2007, 71 (1) 169-175; DOI: https://doi.org/10.1124/mol.106.028670
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    Regulation of Human Cone Cyclic Nucleotide-Gated Channels by Endogenous Phospholipids and Exogenously Applied Phosphatidylinositol 3,4,5-trisphosphate
    Scott R. Bright, Elizabeth D. Rich and Michael D. Varnum
    Molecular Pharmacology January 2007, 71 (1) 176-183; DOI: https://doi.org/10.1124/mol.106.026401
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    Independent Mechanistic Inhibition of Cdc25 Phosphatases by a Natural Product Caulibugulone
    Marni Brisson, Caleb Foster, Peter Wipf, Beomjun Joo, Robert J. Tomko, Theresa Nguyen and John S. Lazo
    Molecular Pharmacology January 2007, 71 (1) 184-192; DOI: https://doi.org/10.1124/mol.106.028589
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    Motexafin Gadolinium-Induced Cell Death Correlates with Heme oxygenase-1 Expression and Inhibition of P450 Reductase-Dependent Activities
    John P. Evans, Fengyun Xu, Mint Sirisawad, Richard Miller, Louie Naumovski and Paul R. Ortiz de Montellano
    Molecular Pharmacology January 2007, 71 (1) 193-200; DOI: https://doi.org/10.1124/mol.106.028407
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    Repression of Human GSTA1 by Interleukin-1β Is Mediated by Variant Hepatic Nuclear Factor-1C
    Lorraine Ng, Kathleen Nichols, Kelly O'Rourke, Ann Maslen and Gordon M. Kirby
    Molecular Pharmacology January 2007, 71 (1) 201-208; DOI: https://doi.org/10.1124/mol.106.028563
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    Embelin, an Inhibitor of X Chromosome-Linked Inhibitor-of-Apoptosis Protein, Blocks Nuclear Factor-κB (NF-κB) Signaling Pathway Leading to Suppression of NF-κB-Regulated Antiapoptotic and Metastatic Gene Products
    Kwang Seok Ahn, Gautam Sethi and Bharat B. Aggarwal
    Molecular Pharmacology January 2007, 71 (1) 209-219; DOI: https://doi.org/10.1124/mol.106.028787
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    The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor
    Changcheng Zhou, Emma-Jane Poulton, Felix Grün, Theo K. Bammler, Bruce Blumberg, Kenneth E. Thummel and David L. Eaton
    Molecular Pharmacology January 2007, 71 (1) 220-229; DOI: https://doi.org/10.1124/mol.106.029264
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    Amphetamine Induces a Calcium/Calmodulin-Dependent Protein Kinase II-Dependent Reduction in Norepinephrine Transporter Surface Expression Linked to Changes in Syntaxin 1A/Transporter Complexes
    Concetta Dipace, Uhna Sung, Francesca Binda, Randy D. Blakely and Aurelio Galli
    Molecular Pharmacology January 2007, 71 (1) 230-239; DOI: https://doi.org/10.1124/mol.106.026690
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    The Effect of Low pH on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport of Methotrexate, 7-Hydroxymethotrexate, Methotrexate Diglutamate, Folic Acid, Mitoxantrone, Topotecan, and Resveratrol in In Vitro Drug Transport Models
    Pauline Breedveld, Dick Pluim, Greta Cipriani, Femke Dahlhaus, Maria A. J. van Eijndhoven, Cornelia J. F. de Wolf, Annemieke Kuil, Jos H. Beijnen, George L. Scheffer, Gerrit Jansen, Piet Borst and Jan H. M. Schellens
    Molecular Pharmacology January 2007, 71 (1) 240-249; DOI: https://doi.org/10.1124/mol.106.028167
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    Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic Acid Receptor α Agonists in Colitis
    Makoto Osanai, Nami Nishikiori, Masaki Murata, Hideki Chiba, Takashi Kojima and Norimasa Sawada
    Molecular Pharmacology January 2007, 71 (1) 250-258; DOI: https://doi.org/10.1124/mol.106.029579
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    Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival after Irradiation or HMG CoA Reductase Inhibitor Treatment
    Adly Yacoub, William Hawkins, David Hanna, Hong Young, Margaret A. Park, Mark Grant, John D. Roberts, David T. Curiel, Paul B. Fisher, Kristoffer Valerie, Steven Grant, Michael P. Hagan and Paul Dent
    Molecular Pharmacology January 2007, 71 (1) 259-275; DOI: https://doi.org/10.1124/mol.106.031153
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    Molecular Basis for the Antiproliferative Effect of Agmatine in Tumor Cells of Colonic, Hepatic, and Neuronal Origin
    C. Wolf, M. Brüss, B. Hänisch, M. Göthert, I. von Kügelgen and G. J. Molderings
    Molecular Pharmacology January 2007, 71 (1) 276-283; DOI: https://doi.org/10.1124/mol.106.028449
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    Neurokinin 1 Receptors Trigger Overlapping Stimulation and Inhibition of CaV2.3 (R-Type) Calcium Channels
    Ulises Meza, Ashish Thapliyal, Roger A. Bannister and Brett A. Adams
    Molecular Pharmacology January 2007, 71 (1) 284-293; DOI: https://doi.org/10.1124/mol.106.028530
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    Characterization of the Tritium-Labeled Analog of L-threo-β-Benzyloxyaspartate Binding to Glutamate Transporters
    Keiko Shimamoto, Yasuto Otsubo, Yasushi Shigeri, Yoshimi Yasuda-Kamatani, Masamichi Satoh, Shuji Kaneko and Takayuki Nakagawa
    Molecular Pharmacology January 2007, 71 (1) 294-302; DOI: https://doi.org/10.1124/mol.106.027250
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    Phosphorylation of Gα11 Protein Contributes to Agonist-Induced Desensitization of 5-HT2A Receptor Signaling
    Ju Shi, Bozena Zemaitaitis and Nancy A. Muma
    Molecular Pharmacology January 2007, 71 (1) 303-313; DOI: https://doi.org/10.1124/mol.106.028241
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    RasGRP1 Confers the Phorbol Ester-Sensitive Phenotype to EL4 Lymphoma Cells
    Shujie Han, Stewart M. Knoepp, Mark A. Hallman and Kathryn E. Meier
    Molecular Pharmacology January 2007, 71 (1) 314-322; DOI: https://doi.org/10.1124/mol.106.028639
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    Short Polybasic Peptide Sequences Are Potent Inhibitors of PC5/6 and PC7: Use of Positional Scanning-Synthetic Peptide Combinatorial Libraries as a Tool for the Optimization of Inhibitory Sequences
    Martin Fugere, Jon Appel, Richard A. Houghten, Iris Lindberg and Robert Day
    Molecular Pharmacology January 2007, 71 (1) 323-332; DOI: https://doi.org/10.1124/mol.106.027946
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    Zoledronic Acid Activates the DNA S-Phase Checkpoint and Induces Osteosarcoma Cell Death Characterized by Apoptosis-Inducing Factor and Endonuclease-G Translocation Independently of p53 and Retinoblastoma Status
    B. Ory, F. Blanchard, S. Battaglia, F. Gouin, F. Rédini and D. Heymann
    Molecular Pharmacology January 2007, 71 (1) 333-343; DOI: https://doi.org/10.1124/mol.106.028837
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    Geldanamycin Interferes with the 90-kDa Heat Shock Protein, Affecting Lipopolysaccharide-Mediated Interleukin-1 Expression and Apoptosis within Macrophages
    Hsien-Yeh Hsu, Hua-Lin Wu, Sai-Koong Tan, Vivian Pei-Hsin Li, Wei-Ting Wang, Jason Hsu and Ching-Hsun Cheng
    Molecular Pharmacology January 2007, 71 (1) 344-356; DOI: https://doi.org/10.1124/mol.106.024240
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    Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but Not Hydroxylamine Ligands
    Stefanie Zorbas-Seifried, Michael A. Jakupec, Nikolay V. Kukushkin, Michael Groessl, Christian G. Hartinger, Olga Semenova, Haralabos Zorbas, Vadim Yu. Kukushkin and Bernhard K. Keppler
    Molecular Pharmacology January 2007, 71 (1) 357-365; DOI: https://doi.org/10.1124/mol.106.030726
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    An Extract from the Medicinal Plant Phyllanthus acidus and Its Isolated Compounds Induce Airway Chloride Secretion: A Potential Treatment for Cystic Fibrosis
    Marisa Sousa, Jiraporn Ousingsawat, Roswitha Seitz, Supaporn Puntheeranurak, Ana Regalado, André Schmidt, Tiago Grego, Chaweewan Jansakul, Margarida D. Amaral, Rainer Schreiber and Karl Kunzelmann
    Molecular Pharmacology January 2007, 71 (1) 366-376; DOI: https://doi.org/10.1124/mol.106.025262
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    Translational Regulation of Rat Multidrug Resistance-Associated Protein 2 Expression Is Mediated by Upstream Open Reading Frames in the 5′ Untranslated Region
    Yuanyuan Zhang, Wei Li and Mary Vore
    Molecular Pharmacology January 2007, 71 (1) 377-383; DOI: https://doi.org/10.1124/mol.106.029793

Letters to the Editor

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    Comments on “Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor”
    Richard S. Pollenz
    Molecular Pharmacology January 2007, 71 (1) 384-385; DOI: https://doi.org/10.1124/mol.106.031963
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    Response to Comments on “Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor”
    Sakina E. Eltom and Yolanda Dale
    Molecular Pharmacology January 2007, 71 (1) 386-387; DOI: https://doi.org/10.1124/mol.106.031971

NOTICE OF RETRACTION

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    Re: Henschler R, Brennscheidt U, Mertelsmann R, and Herrmann F (1991) Induction of c-jun expression in the myeloid leukemia cell line KG-1 by 1-β-d-arabinofuranosylcytosine. Mol Pharmacol 39:171-176
    Molecular Pharmacology January 2007, 71 (1) 388; DOI: https://doi.org/10.1124/mol.71.1.388
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Molecular Pharmacology: 71 (1)
Molecular Pharmacology
Vol. 71, Issue 1
1 Jan 2007
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  • The Orphan Human Pregnane X Receptor Mediates the Transcriptional Activation of CYP3A4 by Rifampicin through a Distal Enhancer Module
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